Incidental Mutation 'R4831:Clip1'
| ID |
372799 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Clip1
|
| Ensembl Gene |
ENSMUSG00000049550 |
| Gene Name |
CAP-GLY domain containing linker protein 1 |
| Synonyms |
Rsn, CLIP-170, 4631429H07Rik, restin, Clip 170, 1110007I12Rik, Clip50, cytoplasmic linker protein 50 |
| MMRRC Submission |
042447-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4831 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
123715857-123822527 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to G
at 123721664 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Proline
at position 1182
(A1182P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107192
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031382]
[ENSMUST00000063905]
[ENSMUST00000111561]
[ENSMUST00000111564]
[ENSMUST00000111566]
|
| AlphaFold |
Q922J3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000031382
AA Change: A1228P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000031382
Gene: ENSMUSG00000049550
AA Change: A1228P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
2.28e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
2.28e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
451 |
N/A |
INTRINSIC |
|
coiled coil region
|
474 |
535 |
N/A |
INTRINSIC |
|
coiled coil region
|
581 |
620 |
N/A |
INTRINSIC |
|
coiled coil region
|
652 |
1352 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1373 |
N/A |
INTRINSIC |
|
Pfam:CLIP1_ZNF
|
1375 |
1392 |
5.8e-9 |
PFAM |
|
ZnF_C2HC
|
1417 |
1433 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000063905
AA Change: A1109P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000068241
Gene: ENSMUSG00000049550
AA Change: A1109P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
3.3e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
3.3e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
524 |
N/A |
INTRINSIC |
|
coiled coil region
|
570 |
609 |
N/A |
INTRINSIC |
|
coiled coil region
|
641 |
1075 |
N/A |
INTRINSIC |
|
coiled coil region
|
1115 |
1235 |
N/A |
INTRINSIC |
|
low complexity region
|
1245 |
1256 |
N/A |
INTRINSIC |
|
ZnF_C2HC
|
1300 |
1316 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000111561
AA Change: A1217P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000107186
Gene: ENSMUSG00000049550
AA Change: A1217P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
1.93e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
1.93e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
524 |
N/A |
INTRINSIC |
|
coiled coil region
|
570 |
609 |
N/A |
INTRINSIC |
|
coiled coil region
|
641 |
1341 |
N/A |
INTRINSIC |
|
low complexity region
|
1351 |
1362 |
N/A |
INTRINSIC |
|
ZnF_C2HC
|
1406 |
1422 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000111564
AA Change: A1106P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000107190
Gene: ENSMUSG00000049550
AA Change: A1106P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
2.5e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
2.5e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
489 |
N/A |
INTRINSIC |
|
coiled coil region
|
535 |
574 |
N/A |
INTRINSIC |
|
coiled coil region
|
606 |
1230 |
N/A |
INTRINSIC |
|
low complexity region
|
1240 |
1251 |
N/A |
INTRINSIC |
|
ZnF_C2HC
|
1295 |
1311 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000111566
AA Change: A1182P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000107192
Gene: ENSMUSG00000049550
AA Change: A1182P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
2e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
2e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
489 |
N/A |
INTRINSIC |
|
coiled coil region
|
535 |
574 |
N/A |
INTRINSIC |
|
coiled coil region
|
606 |
1306 |
N/A |
INTRINSIC |
|
low complexity region
|
1316 |
1327 |
N/A |
INTRINSIC |
|
ZnF_C2HC
|
1371 |
1387 |
1.45e0 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125340
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133545
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000154672
AA Change: A1029P
|
| SMART Domains |
Protein: ENSMUSP00000122064
Gene: ENSMUSG00000049550
AA Change: A1029P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
59 |
N/A |
INTRINSIC |
|
low complexity region
|
165 |
176 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
352 |
375 |
1.56e-8 |
PROSPERO |
|
internal_repeat_3
|
358 |
377 |
5.32e-6 |
PROSPERO |
|
internal_repeat_1
|
450 |
473 |
1.56e-8 |
PROSPERO |
|
internal_repeat_3
|
544 |
563 |
5.32e-6 |
PROSPERO |
|
internal_repeat_2
|
553 |
575 |
2.88e-7 |
PROSPERO |
|
low complexity region
|
735 |
744 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
781 |
803 |
2.88e-7 |
PROSPERO |
|
low complexity region
|
819 |
830 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
977 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1110 |
1121 |
N/A |
INTRINSIC |
|
low complexity region
|
1164 |
1175 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137602
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000137363
AA Change: A854P
|
| SMART Domains |
Protein: ENSMUSP00000121425
Gene: ENSMUSG00000049550
AA Change: A854P
| Domain | Start | End | E-Value | Type |
|---|
|
CAP_GLY
|
2 |
31 |
2.59e0 |
SMART |
|
low complexity region
|
39 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
58 |
84 |
N/A |
INTRINSIC |
|
coiled coil region
|
101 |
276 |
N/A |
INTRINSIC |
|
coiled coil region
|
322 |
361 |
N/A |
INTRINSIC |
|
coiled coil region
|
393 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
991 |
1002 |
N/A |
INTRINSIC |
|
Pfam:CLIP1_ZNF
|
1004 |
1021 |
4.2e-9 |
PFAM |
|
ZnF_C2HC
|
1046 |
1062 |
1.45e0 |
SMART |
|
| Meta Mutation Damage Score |
0.1387 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.3%
|
| Validation Efficiency |
99% (96/97) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a targeted allele display reduced male fertility and teratozoospermia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810408A11Rik |
C |
T |
11: 69,791,403 (GRCm39) |
V59I |
possibly damaging |
Het |
| 4930544M13Rik |
T |
G |
13: 114,744,183 (GRCm39) |
|
noncoding transcript |
Het |
| Abca13 |
A |
T |
11: 9,492,077 (GRCm39) |
K4373* |
probably null |
Het |
| Abtb2 |
A |
T |
2: 103,513,820 (GRCm39) |
T410S |
probably benign |
Het |
| Adamts13 |
T |
C |
2: 26,873,142 (GRCm39) |
|
probably null |
Het |
| Ahnak2 |
C |
G |
12: 112,742,183 (GRCm39) |
D630H |
probably damaging |
Het |
| Aox3 |
T |
C |
1: 58,191,725 (GRCm39) |
S426P |
probably damaging |
Het |
| Atxn10 |
C |
T |
15: 85,271,260 (GRCm39) |
S266F |
probably benign |
Het |
| B4galnt4 |
G |
T |
7: 140,647,634 (GRCm39) |
M407I |
probably damaging |
Het |
| B4galnt4 |
T |
A |
7: 140,644,470 (GRCm39) |
|
probably null |
Het |
| Bclaf1 |
T |
A |
10: 20,197,872 (GRCm39) |
|
probably benign |
Het |
| C4b |
C |
T |
17: 34,955,864 (GRCm39) |
|
probably null |
Het |
| Cdc42bpg |
T |
C |
19: 6,361,365 (GRCm39) |
F297S |
probably damaging |
Het |
| Cdh10 |
A |
T |
15: 19,013,664 (GRCm39) |
T755S |
probably benign |
Het |
| Ceacam12 |
T |
A |
7: 17,811,305 (GRCm39) |
|
probably null |
Het |
| Cfap65 |
C |
A |
1: 74,956,454 (GRCm39) |
V1042F |
possibly damaging |
Het |
| Cfap77 |
T |
C |
2: 28,875,844 (GRCm39) |
I89V |
probably benign |
Het |
| Cfh |
T |
C |
1: 140,014,125 (GRCm39) |
D688G |
probably benign |
Het |
| Cyp2b10 |
T |
A |
7: 25,614,921 (GRCm39) |
Y309* |
probably null |
Het |
| Dcaf5 |
T |
C |
12: 80,385,858 (GRCm39) |
E756G |
probably benign |
Het |
| Dctn1 |
A |
T |
6: 83,176,753 (GRCm39) |
Q1231L |
possibly damaging |
Het |
| Dennd1c |
T |
A |
17: 57,373,428 (GRCm39) |
R682* |
probably null |
Het |
| Eml6 |
C |
A |
11: 29,727,052 (GRCm39) |
E1319* |
probably null |
Het |
| Erap1 |
T |
C |
13: 74,838,766 (GRCm39) |
I904T |
probably damaging |
Het |
| Eri1 |
A |
T |
8: 35,943,673 (GRCm39) |
I207N |
possibly damaging |
Het |
| Farp1 |
G |
A |
14: 121,514,469 (GRCm39) |
A933T |
probably damaging |
Het |
| Fcna |
T |
A |
2: 25,515,353 (GRCm39) |
Q210L |
probably benign |
Het |
| Fhad1 |
A |
T |
4: 141,643,378 (GRCm39) |
|
probably null |
Het |
| Fut8 |
T |
G |
12: 77,440,603 (GRCm39) |
Y197D |
probably damaging |
Het |
| Garem1 |
G |
A |
18: 21,262,825 (GRCm39) |
T663I |
probably benign |
Het |
| Gfm2 |
T |
C |
13: 97,301,546 (GRCm39) |
S450P |
probably damaging |
Het |
| Gstk1 |
T |
G |
6: 42,222,938 (GRCm39) |
|
probably benign |
Het |
| Helz2 |
C |
T |
2: 180,879,210 (GRCm39) |
A803T |
probably damaging |
Het |
| Igsf9 |
T |
A |
1: 172,319,455 (GRCm39) |
I280N |
probably damaging |
Het |
| Klhl10 |
A |
G |
11: 100,336,669 (GRCm39) |
K219E |
probably benign |
Het |
| L3mbtl4 |
T |
A |
17: 68,768,558 (GRCm39) |
V222D |
probably damaging |
Het |
| Lrrc9 |
A |
T |
12: 72,546,453 (GRCm39) |
N1214Y |
probably damaging |
Het |
| Ltbp2 |
C |
T |
12: 84,840,414 (GRCm39) |
E1051K |
possibly damaging |
Het |
| Mettl17 |
T |
C |
14: 52,122,440 (GRCm39) |
F13S |
probably benign |
Het |
| Mettl24 |
C |
A |
10: 40,559,413 (GRCm39) |
A21D |
possibly damaging |
Het |
| Mfsd6l |
T |
A |
11: 68,447,331 (GRCm39) |
C61S |
probably benign |
Het |
| Mob4 |
T |
G |
1: 55,191,899 (GRCm39) |
D204E |
probably benign |
Het |
| Mtus1 |
C |
G |
8: 41,536,189 (GRCm39) |
R509T |
probably damaging |
Het |
| Nlrp4a |
T |
A |
7: 26,149,844 (GRCm39) |
F484I |
possibly damaging |
Het |
| Nsrp1 |
T |
C |
11: 76,941,444 (GRCm39) |
N88S |
probably benign |
Het |
| Odad2 |
G |
T |
18: 7,222,564 (GRCm39) |
H568Q |
possibly damaging |
Het |
| Or10d5 |
C |
T |
9: 39,861,408 (GRCm39) |
V220I |
probably benign |
Het |
| Or2g25 |
T |
A |
17: 37,970,969 (GRCm39) |
H85L |
probably benign |
Het |
| Or51b6b |
T |
C |
7: 103,309,678 (GRCm39) |
T260A |
probably benign |
Het |
| Or6c2 |
T |
A |
10: 129,362,449 (GRCm39) |
Y118N |
probably damaging |
Het |
| Parg |
A |
G |
14: 31,924,408 (GRCm39) |
N69S |
probably benign |
Het |
| Pcdh9 |
A |
C |
14: 94,125,377 (GRCm39) |
N264K |
probably damaging |
Het |
| Pcdhb22 |
G |
T |
18: 37,653,615 (GRCm39) |
L694F |
probably damaging |
Het |
| Pcnt |
T |
C |
10: 76,248,335 (GRCm39) |
E928G |
probably damaging |
Het |
| Pdzk1 |
G |
A |
3: 96,775,751 (GRCm39) |
G373D |
probably benign |
Het |
| Pea15a |
A |
G |
1: 172,026,740 (GRCm39) |
I89T |
probably damaging |
Het |
| Phc1 |
T |
A |
6: 122,313,964 (GRCm39) |
|
probably benign |
Het |
| Pikfyve |
T |
A |
1: 65,235,900 (GRCm39) |
C191S |
probably damaging |
Het |
| Pitpnm1 |
T |
A |
19: 4,158,130 (GRCm39) |
D573E |
probably damaging |
Het |
| Pld5 |
A |
G |
1: 176,102,450 (GRCm39) |
|
probably benign |
Het |
| Plscr2 |
A |
T |
9: 92,173,130 (GRCm39) |
N89I |
possibly damaging |
Het |
| Pm20d2 |
A |
C |
4: 33,179,293 (GRCm39) |
N315K |
probably damaging |
Het |
| Pnpla1 |
T |
A |
17: 29,097,518 (GRCm39) |
M228K |
probably benign |
Het |
| Prim2 |
T |
C |
1: 33,709,217 (GRCm39) |
|
probably benign |
Het |
| Ralgapa2 |
A |
G |
2: 146,246,987 (GRCm39) |
|
probably benign |
Het |
| Rgs22 |
G |
T |
15: 36,050,294 (GRCm39) |
H719N |
probably benign |
Het |
| Ror2 |
C |
T |
13: 53,272,880 (GRCm39) |
D250N |
probably damaging |
Het |
| Saal1 |
A |
G |
7: 46,349,071 (GRCm39) |
V281A |
probably benign |
Het |
| Selenof |
A |
T |
3: 144,296,411 (GRCm39) |
K94N |
probably damaging |
Het |
| Slamf9 |
T |
A |
1: 172,304,831 (GRCm39) |
C148* |
probably null |
Het |
| Slc4a7 |
T |
C |
14: 14,772,699 (GRCm38) |
|
probably null |
Het |
| Slco1a5 |
A |
G |
6: 142,180,431 (GRCm39) |
I657T |
probably benign |
Het |
| St3gal2 |
A |
T |
8: 111,684,480 (GRCm39) |
H46L |
probably benign |
Het |
| Sucnr1 |
T |
G |
3: 59,994,069 (GRCm39) |
M199R |
probably damaging |
Het |
| Taok1 |
T |
A |
11: 77,444,500 (GRCm39) |
E525V |
probably null |
Het |
| Tbc1d10c |
T |
A |
19: 4,235,445 (GRCm39) |
E298V |
probably damaging |
Het |
| Tll2 |
T |
A |
19: 41,118,951 (GRCm39) |
H259L |
probably damaging |
Het |
| Tpcn1 |
A |
T |
5: 120,691,554 (GRCm39) |
F300Y |
probably damaging |
Het |
| Uba6 |
T |
A |
5: 86,279,197 (GRCm39) |
I642L |
probably benign |
Het |
| Ubqln5 |
T |
A |
7: 103,778,829 (GRCm39) |
|
probably benign |
Het |
| Vmn1r27 |
A |
T |
6: 58,192,827 (GRCm39) |
L9Q |
possibly damaging |
Het |
| Vmn2r100 |
C |
T |
17: 19,741,672 (GRCm39) |
T128I |
probably benign |
Het |
| Vmn2r109 |
C |
T |
17: 20,761,494 (GRCm39) |
G621D |
probably benign |
Het |
| Vmn2r49 |
C |
T |
7: 9,720,352 (GRCm39) |
D380N |
probably benign |
Het |
| Vps13a |
C |
T |
19: 16,655,356 (GRCm39) |
V1891I |
probably benign |
Het |
| Wbp2 |
G |
T |
11: 115,971,463 (GRCm39) |
Y147* |
probably null |
Het |
| Wdr46 |
T |
A |
17: 34,160,810 (GRCm39) |
N191K |
probably benign |
Het |
| Wdr46 |
T |
C |
17: 34,168,373 (GRCm39) |
|
probably benign |
Het |
| Wnt2 |
A |
C |
6: 18,023,285 (GRCm39) |
F121L |
probably benign |
Het |
| Xpnpep1 |
T |
A |
19: 53,003,053 (GRCm39) |
D100V |
probably benign |
Het |
| Xpo4 |
T |
C |
14: 57,827,559 (GRCm39) |
Y879C |
probably damaging |
Het |
| Zswim4 |
A |
T |
8: 84,938,948 (GRCm39) |
V978D |
probably damaging |
Het |
|
| Other mutations in Clip1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Clip1
|
APN |
5 |
123,741,717 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01067:Clip1
|
APN |
5 |
123,768,867 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01524:Clip1
|
APN |
5 |
123,717,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01632:Clip1
|
APN |
5 |
123,755,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01798:Clip1
|
APN |
5 |
123,721,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01874:Clip1
|
APN |
5 |
123,741,729 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01908:Clip1
|
APN |
5 |
123,761,270 (GRCm39) |
splice site |
probably benign |
|
|
IGL02120:Clip1
|
APN |
5 |
123,785,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02309:Clip1
|
APN |
5 |
123,755,763 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02555:Clip1
|
APN |
5 |
123,759,857 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03027:Clip1
|
APN |
5 |
123,759,919 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03336:Clip1
|
APN |
5 |
123,791,633 (GRCm39) |
nonsense |
probably null |
|
|
IGL03365:Clip1
|
APN |
5 |
123,721,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02802:Clip1
|
UTSW |
5 |
123,769,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4812001:Clip1
|
UTSW |
5 |
123,768,738 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0254:Clip1
|
UTSW |
5 |
123,755,395 (GRCm39) |
splice site |
probably benign |
|
|
R0401:Clip1
|
UTSW |
5 |
123,791,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0530:Clip1
|
UTSW |
5 |
123,778,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0744:Clip1
|
UTSW |
5 |
123,768,784 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0833:Clip1
|
UTSW |
5 |
123,768,784 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1116:Clip1
|
UTSW |
5 |
123,717,554 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1182:Clip1
|
UTSW |
5 |
123,785,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1656:Clip1
|
UTSW |
5 |
123,768,466 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1700:Clip1
|
UTSW |
5 |
123,768,433 (GRCm39) |
missense |
probably benign |
|
|
R1889:Clip1
|
UTSW |
5 |
123,791,559 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1975:Clip1
|
UTSW |
5 |
123,761,281 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2406:Clip1
|
UTSW |
5 |
123,741,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3545:Clip1
|
UTSW |
5 |
123,769,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3547:Clip1
|
UTSW |
5 |
123,769,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3548:Clip1
|
UTSW |
5 |
123,769,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3911:Clip1
|
UTSW |
5 |
123,728,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Clip1
|
UTSW |
5 |
123,755,892 (GRCm39) |
unclassified |
probably benign |
|
|
R4660:Clip1
|
UTSW |
5 |
123,717,437 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4784:Clip1
|
UTSW |
5 |
123,717,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4785:Clip1
|
UTSW |
5 |
123,717,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4824:Clip1
|
UTSW |
5 |
123,769,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4951:Clip1
|
UTSW |
5 |
123,768,408 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4960:Clip1
|
UTSW |
5 |
123,792,066 (GRCm39) |
nonsense |
probably null |
|
|
R5014:Clip1
|
UTSW |
5 |
123,755,793 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5116:Clip1
|
UTSW |
5 |
123,768,770 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5212:Clip1
|
UTSW |
5 |
123,768,744 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5238:Clip1
|
UTSW |
5 |
123,785,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5318:Clip1
|
UTSW |
5 |
123,751,147 (GRCm39) |
unclassified |
probably benign |
|
|
R5372:Clip1
|
UTSW |
5 |
123,768,303 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5701:Clip1
|
UTSW |
5 |
123,751,366 (GRCm39) |
unclassified |
probably benign |
|
|
R5734:Clip1
|
UTSW |
5 |
123,753,217 (GRCm39) |
unclassified |
probably benign |
|
|
R5757:Clip1
|
UTSW |
5 |
123,765,460 (GRCm39) |
missense |
probably benign |
0.21 |
|
R6024:Clip1
|
UTSW |
5 |
123,753,152 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6160:Clip1
|
UTSW |
5 |
123,751,604 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6177:Clip1
|
UTSW |
5 |
123,751,897 (GRCm39) |
unclassified |
probably benign |
|
|
R6183:Clip1
|
UTSW |
5 |
123,780,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6377:Clip1
|
UTSW |
5 |
123,741,717 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6436:Clip1
|
UTSW |
5 |
123,779,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6471:Clip1
|
UTSW |
5 |
123,778,612 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6766:Clip1
|
UTSW |
5 |
123,752,827 (GRCm39) |
unclassified |
probably benign |
|
|
R7015:Clip1
|
UTSW |
5 |
123,751,675 (GRCm39) |
unclassified |
probably benign |
|
|
R7094:Clip1
|
UTSW |
5 |
123,761,333 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7143:Clip1
|
UTSW |
5 |
123,791,673 (GRCm39) |
missense |
probably benign |
|
|
R7222:Clip1
|
UTSW |
5 |
123,749,904 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7233:Clip1
|
UTSW |
5 |
123,749,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7238:Clip1
|
UTSW |
5 |
123,751,328 (GRCm39) |
missense |
|
|
|
R7249:Clip1
|
UTSW |
5 |
123,741,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7283:Clip1
|
UTSW |
5 |
123,751,857 (GRCm39) |
missense |
|
|
|
R7295:Clip1
|
UTSW |
5 |
123,765,419 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7447:Clip1
|
UTSW |
5 |
123,791,696 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7458:Clip1
|
UTSW |
5 |
123,778,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7483:Clip1
|
UTSW |
5 |
123,755,447 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7516:Clip1
|
UTSW |
5 |
123,721,448 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7619:Clip1
|
UTSW |
5 |
123,752,342 (GRCm39) |
missense |
|
|
|
R7831:Clip1
|
UTSW |
5 |
123,751,342 (GRCm39) |
missense |
|
|
|
R7897:Clip1
|
UTSW |
5 |
123,760,861 (GRCm39) |
missense |
probably benign |
|
|
R8155:Clip1
|
UTSW |
5 |
123,751,699 (GRCm39) |
missense |
|
|
|
R8157:Clip1
|
UTSW |
5 |
123,768,782 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8232:Clip1
|
UTSW |
5 |
123,785,981 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8396:Clip1
|
UTSW |
5 |
123,780,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8446:Clip1
|
UTSW |
5 |
123,794,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8486:Clip1
|
UTSW |
5 |
123,752,770 (GRCm39) |
unclassified |
probably benign |
|
|
R8511:Clip1
|
UTSW |
5 |
123,791,969 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8731:Clip1
|
UTSW |
5 |
123,752,756 (GRCm39) |
missense |
|
|
|
R8889:Clip1
|
UTSW |
5 |
123,717,565 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8892:Clip1
|
UTSW |
5 |
123,717,565 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9058:Clip1
|
UTSW |
5 |
123,752,645 (GRCm39) |
missense |
|
|
|
R9106:Clip1
|
UTSW |
5 |
123,753,223 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9212:Clip1
|
UTSW |
5 |
123,721,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9217:Clip1
|
UTSW |
5 |
123,717,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Clip1
|
UTSW |
5 |
123,784,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9325:Clip1
|
UTSW |
5 |
123,751,186 (GRCm39) |
missense |
|
|
|
R9752:Clip1
|
UTSW |
5 |
123,760,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Clip1
|
UTSW |
5 |
123,755,413 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGCACTGTGACCTGCAAC -3'
(R):5'- GCGCGCAGTAAGTAACATC -3'
Sequencing Primer
(F):5'- AACGCAGATGCTGGGCTC -3'
(R):5'- CTCCAGTCTGTTCTGGAA -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation