Incidental Mutation 'R4849:Corin'
| ID |
373377 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Corin
|
| Ensembl Gene |
ENSMUSG00000005220 |
| Gene Name |
corin, serine peptidase |
| Synonyms |
Lrp4 |
| MMRRC Submission |
042461-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.267)
|
| Stock # |
R4849 (G1)
|
| Quality Score |
220 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
72457368-72661816 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 72460178 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 1035
(M1035L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000005352
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005352]
[ENSMUST00000094710]
[ENSMUST00000126664]
[ENSMUST00000167460]
[ENSMUST00000176974]
[ENSMUST00000175766]
[ENSMUST00000177290]
|
| AlphaFold |
Q9Z319 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000005352
AA Change: M1035L
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000005352
Gene: ENSMUSG00000005220
AA Change: M1035L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
15 |
N/A |
INTRINSIC |
|
transmembrane domain
|
113 |
135 |
N/A |
INTRINSIC |
|
FRI
|
205 |
318 |
6.15e-11 |
SMART |
|
LDLa
|
336 |
372 |
1.31e-8 |
SMART |
|
LDLa
|
373 |
408 |
1.5e-8 |
SMART |
|
LDLa
|
409 |
447 |
5.47e-11 |
SMART |
|
LDLa
|
448 |
484 |
1.22e-8 |
SMART |
|
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
|
FRI
|
522 |
643 |
2.75e-31 |
SMART |
|
LDLa
|
647 |
684 |
2.19e-10 |
SMART |
|
LDLa
|
685 |
722 |
1.76e-5 |
SMART |
|
LDLa
|
723 |
759 |
4.18e-7 |
SMART |
|
SR
|
758 |
853 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
868 |
1097 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094710
|
| SMART Domains |
Protein: ENSMUSP00000142749
Gene: ENSMUSG00000046808
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1eula_
|
5 |
180 |
9e-15 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126664
|
| SMART Domains |
Protein: ENSMUSP00000143594
Gene: ENSMUSG00000046808
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:PhoLip_ATPase_N
|
111 |
176 |
1.2e-21 |
PFAM |
|
Pfam:E1-E2_ATPase
|
181 |
450 |
3e-10 |
PFAM |
|
low complexity region
|
523 |
534 |
N/A |
INTRINSIC |
|
low complexity region
|
684 |
696 |
N/A |
INTRINSIC |
|
Pfam:Cation_ATPase
|
739 |
859 |
3.4e-7 |
PFAM |
|
Pfam:HAD
|
754 |
1114 |
1.3e-12 |
PFAM |
|
Pfam:PhoLip_ATPase_C
|
1131 |
1376 |
4.3e-77 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136350
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146393
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000158570
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000167460
AA Change: M969L
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000127389
Gene: ENSMUSG00000005220
AA Change: M969L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
342 |
1.5e-8 |
SMART |
|
LDLa
|
343 |
381 |
5.47e-11 |
SMART |
|
LDLa
|
382 |
418 |
1.22e-8 |
SMART |
|
low complexity region
|
442 |
455 |
N/A |
INTRINSIC |
|
FRI
|
456 |
577 |
2.75e-31 |
SMART |
|
LDLa
|
581 |
618 |
2.19e-10 |
SMART |
|
LDLa
|
619 |
656 |
1.76e-5 |
SMART |
|
LDLa
|
657 |
693 |
4.18e-7 |
SMART |
|
SR
|
692 |
787 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
802 |
1031 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176974
AA Change: M932L
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000135722
Gene: ENSMUSG00000005220
AA Change: M932L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
344 |
3.86e-11 |
SMART |
|
LDLa
|
345 |
381 |
1.22e-8 |
SMART |
|
low complexity region
|
405 |
418 |
N/A |
INTRINSIC |
|
FRI
|
419 |
540 |
2.75e-31 |
SMART |
|
LDLa
|
544 |
581 |
2.19e-10 |
SMART |
|
LDLa
|
582 |
619 |
1.76e-5 |
SMART |
|
LDLa
|
620 |
656 |
4.18e-7 |
SMART |
|
SR
|
655 |
750 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
765 |
994 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000175766
AA Change: M894L
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000135889
Gene: ENSMUSG00000005220
AA Change: M894L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
45 |
67 |
N/A |
INTRINSIC |
|
FRI
|
137 |
250 |
6.15e-11 |
SMART |
|
LDLa
|
268 |
304 |
1.31e-8 |
SMART |
|
LDLa
|
305 |
343 |
2.07e-11 |
SMART |
|
low complexity region
|
367 |
380 |
N/A |
INTRINSIC |
|
FRI
|
381 |
502 |
2.75e-31 |
SMART |
|
LDLa
|
506 |
543 |
2.19e-10 |
SMART |
|
LDLa
|
544 |
581 |
1.76e-5 |
SMART |
|
LDLa
|
582 |
618 |
4.18e-7 |
SMART |
|
SR
|
617 |
712 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
727 |
956 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177290
AA Change: M902L
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000135511
Gene: ENSMUSG00000005220
AA Change: M902L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
72 |
185 |
6.15e-11 |
SMART |
|
LDLa
|
203 |
239 |
1.31e-8 |
SMART |
|
LDLa
|
240 |
275 |
1.5e-8 |
SMART |
|
LDLa
|
276 |
314 |
5.47e-11 |
SMART |
|
LDLa
|
315 |
351 |
1.22e-8 |
SMART |
|
low complexity region
|
375 |
388 |
N/A |
INTRINSIC |
|
FRI
|
389 |
510 |
2.75e-31 |
SMART |
|
LDLa
|
514 |
551 |
2.19e-10 |
SMART |
|
LDLa
|
552 |
589 |
1.76e-5 |
SMART |
|
LDLa
|
590 |
626 |
4.18e-7 |
SMART |
|
SR
|
625 |
720 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
735 |
964 |
5.45e-76 |
SMART |
|
| Meta Mutation Damage Score |
0.3599 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.2%
|
| Validation Efficiency |
98% (90/92) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
PHENOTYPE: Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acp7 |
G |
T |
7: 28,314,877 (GRCm39) |
R239S |
possibly damaging |
Het |
| Angptl1 |
C |
A |
1: 156,684,735 (GRCm39) |
N301K |
probably benign |
Het |
| Ankrd26 |
T |
A |
6: 118,509,257 (GRCm39) |
T603S |
probably benign |
Het |
| App |
T |
C |
16: 84,853,322 (GRCm39) |
D252G |
unknown |
Het |
| Atxn3 |
A |
G |
12: 101,900,627 (GRCm39) |
S219P |
probably benign |
Het |
| Birc6 |
T |
C |
17: 74,954,383 (GRCm39) |
S3397P |
probably damaging |
Het |
| Bivm |
A |
G |
1: 44,182,033 (GRCm39) |
I414V |
possibly damaging |
Het |
| Cemip |
A |
G |
7: 83,584,945 (GRCm39) |
F1324L |
possibly damaging |
Het |
| Ckap5 |
T |
A |
2: 91,445,616 (GRCm39) |
N1724K |
probably damaging |
Het |
| Ctnna3 |
T |
C |
10: 64,709,094 (GRCm39) |
I711T |
probably damaging |
Het |
| Cts6 |
A |
T |
13: 61,349,415 (GRCm39) |
W98R |
probably null |
Het |
| Dip2a |
A |
G |
10: 76,130,367 (GRCm39) |
S580P |
probably damaging |
Het |
| Dock6 |
A |
G |
9: 21,723,068 (GRCm39) |
|
probably null |
Het |
| Dusp15 |
T |
A |
2: 152,791,002 (GRCm39) |
T32S |
probably damaging |
Het |
| Eogt |
T |
A |
6: 97,093,016 (GRCm39) |
N387I |
probably damaging |
Het |
| Evx2 |
T |
C |
2: 74,489,675 (GRCm39) |
D29G |
probably benign |
Het |
| Fat1 |
A |
G |
8: 45,466,007 (GRCm39) |
N1422S |
probably benign |
Het |
| Fat2 |
T |
C |
11: 55,201,463 (GRCm39) |
D537G |
probably damaging |
Het |
| Fat3 |
A |
C |
9: 16,289,244 (GRCm39) |
I93S |
probably benign |
Het |
| Fem1b |
T |
C |
9: 62,704,576 (GRCm39) |
E228G |
probably damaging |
Het |
| Fh1 |
A |
G |
1: 175,448,072 (GRCm39) |
T25A |
probably benign |
Het |
| Fndc3b |
A |
G |
3: 27,514,097 (GRCm39) |
W695R |
probably damaging |
Het |
| Gaa |
G |
A |
11: 119,163,813 (GRCm39) |
V222I |
possibly damaging |
Het |
| Ggnbp1 |
T |
C |
17: 27,251,947 (GRCm39) |
|
probably null |
Het |
| Gipc1 |
A |
G |
8: 84,388,756 (GRCm39) |
Y154C |
probably benign |
Het |
| Gm5356 |
G |
T |
8: 89,913,670 (GRCm39) |
|
noncoding transcript |
Het |
| Gnl1 |
T |
A |
17: 36,298,603 (GRCm39) |
|
probably null |
Het |
| Gpcpd1 |
C |
T |
2: 132,376,019 (GRCm39) |
G605R |
probably damaging |
Het |
| Guca1a |
T |
C |
17: 47,705,662 (GRCm39) |
T177A |
possibly damaging |
Het |
| Ifit1bl1 |
T |
C |
19: 34,572,076 (GRCm39) |
E127G |
probably damaging |
Het |
| Ift81 |
A |
T |
5: 122,729,282 (GRCm39) |
I350N |
probably damaging |
Het |
| Ikbke |
GCC |
G |
1: 131,203,004 (GRCm39) |
|
probably null |
Het |
| Ing4 |
A |
G |
6: 125,020,946 (GRCm39) |
R23G |
probably damaging |
Het |
| Ins1 |
A |
G |
19: 52,253,384 (GRCm39) |
N108S |
probably damaging |
Het |
| Iqce |
A |
T |
5: 140,679,214 (GRCm39) |
M72K |
possibly damaging |
Het |
| Itga3 |
C |
A |
11: 94,967,097 (GRCm39) |
M22I |
probably benign |
Het |
| Kctd18 |
T |
C |
1: 58,001,152 (GRCm39) |
E201G |
probably damaging |
Het |
| Klc1 |
A |
G |
12: 111,748,129 (GRCm39) |
N344S |
probably damaging |
Het |
| Klrb1f |
A |
T |
6: 129,033,347 (GRCm39) |
I192F |
probably damaging |
Het |
| Klrg2 |
A |
T |
6: 38,607,214 (GRCm39) |
|
probably null |
Het |
| Kntc1 |
A |
C |
5: 123,897,128 (GRCm39) |
I164L |
probably benign |
Het |
| Ltf |
T |
A |
9: 110,855,058 (GRCm39) |
I357K |
probably benign |
Het |
| Mr1 |
T |
C |
1: 155,006,436 (GRCm39) |
T304A |
probably benign |
Het |
| Msh6 |
C |
T |
17: 88,290,947 (GRCm39) |
R178C |
possibly damaging |
Het |
| Mtch1 |
T |
C |
17: 29,566,565 (GRCm39) |
D66G |
probably benign |
Het |
| Mtmr7 |
A |
G |
8: 41,062,040 (GRCm39) |
V15A |
probably benign |
Het |
| Mtss2 |
A |
T |
8: 111,452,875 (GRCm39) |
H40L |
possibly damaging |
Het |
| Mxra8 |
A |
G |
4: 155,925,331 (GRCm39) |
|
probably benign |
Het |
| Myo3b |
T |
C |
2: 70,075,253 (GRCm39) |
L535P |
probably damaging |
Het |
| Neurl2 |
T |
A |
2: 164,674,739 (GRCm39) |
|
probably null |
Het |
| Nfia |
A |
C |
4: 97,970,048 (GRCm39) |
T503P |
probably damaging |
Het |
| Noa1 |
T |
C |
5: 77,454,179 (GRCm39) |
E487G |
possibly damaging |
Het |
| Nuak1 |
A |
T |
10: 84,211,143 (GRCm39) |
V315D |
probably damaging |
Het |
| Nup205 |
A |
G |
6: 35,207,505 (GRCm39) |
N1519S |
possibly damaging |
Het |
| Or10x1 |
T |
A |
1: 174,196,966 (GRCm39) |
I161K |
probably damaging |
Het |
| Or1l4b |
T |
C |
2: 37,036,266 (GRCm39) |
L14P |
probably damaging |
Het |
| Or1o1 |
T |
C |
17: 37,716,589 (GRCm39) |
V50A |
probably benign |
Het |
| Or51f1e |
A |
G |
7: 102,747,526 (GRCm39) |
I193V |
possibly damaging |
Het |
| Or6b13 |
G |
T |
7: 139,782,340 (GRCm39) |
C114* |
probably null |
Het |
| Or9s18 |
G |
A |
13: 65,300,493 (GRCm39) |
V152M |
possibly damaging |
Het |
| Peli1 |
T |
A |
11: 21,098,528 (GRCm39) |
|
probably benign |
Het |
| Ppp6r1 |
A |
G |
7: 4,646,206 (GRCm39) |
L175P |
probably damaging |
Het |
| Prkcd |
A |
G |
14: 30,321,700 (GRCm39) |
L498P |
probably damaging |
Het |
| Prss30 |
T |
A |
17: 24,191,769 (GRCm39) |
I251F |
probably benign |
Het |
| Psme3 |
A |
T |
11: 101,207,907 (GRCm39) |
N21Y |
probably benign |
Het |
| Ptpra |
T |
C |
2: 130,374,081 (GRCm39) |
Y271H |
probably damaging |
Het |
| Ralgapa1 |
T |
A |
12: 55,745,588 (GRCm39) |
N1303Y |
probably damaging |
Het |
| Rims4 |
T |
C |
2: 163,707,463 (GRCm39) |
I121V |
probably benign |
Het |
| Rnf123 |
A |
T |
9: 107,933,290 (GRCm39) |
L1149Q |
probably damaging |
Het |
| Ryr3 |
T |
A |
2: 112,738,807 (GRCm39) |
L593F |
probably damaging |
Het |
| Sec23b |
T |
C |
2: 144,427,519 (GRCm39) |
F582S |
probably damaging |
Het |
| Sgpl1 |
T |
C |
10: 60,940,297 (GRCm39) |
K335R |
probably benign |
Het |
| Sirpa |
C |
T |
2: 129,451,163 (GRCm39) |
T141I |
probably damaging |
Het |
| Slit1 |
G |
T |
19: 41,637,983 (GRCm39) |
A270E |
probably benign |
Het |
| Snap91 |
T |
C |
9: 86,674,613 (GRCm39) |
T533A |
possibly damaging |
Het |
| Sphkap |
T |
G |
1: 83,255,105 (GRCm39) |
E881D |
probably benign |
Het |
| Sptan1 |
C |
A |
2: 29,901,054 (GRCm39) |
R1407S |
probably damaging |
Het |
| Tfdp1 |
A |
G |
8: 13,423,895 (GRCm39) |
T353A |
probably benign |
Het |
| Ttyh1 |
A |
G |
7: 4,125,533 (GRCm39) |
I62V |
possibly damaging |
Het |
| Vwde |
A |
T |
6: 13,196,047 (GRCm39) |
V326D |
possibly damaging |
Het |
| Zfp398 |
T |
C |
6: 47,836,446 (GRCm39) |
I82T |
possibly damaging |
Het |
| Zp1 |
A |
G |
19: 10,896,198 (GRCm39) |
Y176H |
possibly damaging |
Het |
|
| Other mutations in Corin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Corin
|
APN |
5 |
72,462,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01114:Corin
|
APN |
5 |
72,462,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01351:Corin
|
APN |
5 |
72,496,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Corin
|
APN |
5 |
72,611,830 (GRCm39) |
nonsense |
probably null |
|
|
IGL01785:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01786:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01845:Corin
|
APN |
5 |
72,511,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02097:Corin
|
APN |
5 |
72,529,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02629:Corin
|
APN |
5 |
72,490,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Corin
|
APN |
5 |
72,511,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Corin
|
APN |
5 |
72,518,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03150:Corin
|
APN |
5 |
72,460,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03183:Corin
|
APN |
5 |
72,458,929 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03185:Corin
|
APN |
5 |
72,490,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03408:Corin
|
APN |
5 |
72,500,304 (GRCm39) |
missense |
probably benign |
0.40 |
|
alpaca
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0078:Corin
|
UTSW |
5 |
72,611,816 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0724:Corin
|
UTSW |
5 |
72,490,138 (GRCm39) |
splice site |
probably benign |
|
|
R1065:Corin
|
UTSW |
5 |
72,458,993 (GRCm39) |
nonsense |
probably null |
|
|
R1301:Corin
|
UTSW |
5 |
72,462,276 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1520:Corin
|
UTSW |
5 |
72,488,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1584:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1617:Corin
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1912:Corin
|
UTSW |
5 |
72,515,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2059:Corin
|
UTSW |
5 |
72,473,394 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R2173:Corin
|
UTSW |
5 |
72,661,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2242:Corin
|
UTSW |
5 |
72,490,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2373:Corin
|
UTSW |
5 |
72,496,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2850:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3683:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3684:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3790:Corin
|
UTSW |
5 |
72,592,641 (GRCm39) |
missense |
probably benign |
0.38 |
|
R3847:Corin
|
UTSW |
5 |
72,579,508 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3926:Corin
|
UTSW |
5 |
72,529,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3939:Corin
|
UTSW |
5 |
72,497,222 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3945:Corin
|
UTSW |
5 |
72,515,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4079:Corin
|
UTSW |
5 |
72,661,226 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4224:Corin
|
UTSW |
5 |
72,500,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4473:Corin
|
UTSW |
5 |
72,496,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4586:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4926:Corin
|
UTSW |
5 |
72,529,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5080:Corin
|
UTSW |
5 |
72,511,194 (GRCm39) |
intron |
probably benign |
|
|
R5138:Corin
|
UTSW |
5 |
72,496,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5262:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5268:Corin
|
UTSW |
5 |
72,500,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5302:Corin
|
UTSW |
5 |
72,473,441 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5307:Corin
|
UTSW |
5 |
72,514,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5324:Corin
|
UTSW |
5 |
72,592,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5352:Corin
|
UTSW |
5 |
72,462,376 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5373:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5374:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Corin
|
UTSW |
5 |
72,515,827 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5502:Corin
|
UTSW |
5 |
72,473,449 (GRCm39) |
nonsense |
probably null |
|
|
R5544:Corin
|
UTSW |
5 |
72,462,357 (GRCm39) |
nonsense |
probably null |
|
|
R5682:Corin
|
UTSW |
5 |
72,579,497 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5818:Corin
|
UTSW |
5 |
72,592,738 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5992:Corin
|
UTSW |
5 |
72,473,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6115:Corin
|
UTSW |
5 |
72,518,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6181:Corin
|
UTSW |
5 |
72,529,439 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6317:Corin
|
UTSW |
5 |
72,496,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7053:Corin
|
UTSW |
5 |
72,458,870 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7242:Corin
|
UTSW |
5 |
72,462,398 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7452:Corin
|
UTSW |
5 |
72,592,590 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7783:Corin
|
UTSW |
5 |
72,458,967 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7903:Corin
|
UTSW |
5 |
72,458,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7956:Corin
|
UTSW |
5 |
72,579,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8007:Corin
|
UTSW |
5 |
72,473,446 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8125:Corin
|
UTSW |
5 |
72,515,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8215:Corin
|
UTSW |
5 |
72,462,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Corin
|
UTSW |
5 |
72,514,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8364:Corin
|
UTSW |
5 |
72,462,274 (GRCm39) |
missense |
probably benign |
|
|
R8505:Corin
|
UTSW |
5 |
72,592,750 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8746:Corin
|
UTSW |
5 |
72,592,695 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8887:Corin
|
UTSW |
5 |
72,486,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9484:Corin
|
UTSW |
5 |
72,497,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9640:Corin
|
UTSW |
5 |
72,592,597 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Corin
|
UTSW |
5 |
72,611,836 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAAGGAGATGGGTTGTCTCAAC -3'
(R):5'- AGGGAATTGATGTGCTTCTCTC -3'
Sequencing Primer
(F):5'- GGAGATGGGTTGTCTCAACTCTCC -3'
(R):5'- CTCGGTGTTATGAAAATATTCCTGC -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation