Incidental Mutation 'R4852:Nudc'
ID 373613
Institutional Source Beutler Lab
Gene Symbol Nudc
Ensembl Gene ENSMUSG00000028851
Gene Name nudC nuclear distribution protein
Synonyms NudC, Silg92
MMRRC Submission 042464-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.957) question?
Stock # R4852 (G1)
Quality Score 176
Status Not validated
Chromosome 4
Chromosomal Location 133259853-133273307 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 133261660 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 208 (L208P)
Ref Sequence ENSEMBL: ENSMUSP00000030665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030665] [ENSMUST00000042919] [ENSMUST00000105901] [ENSMUST00000121797]
AlphaFold O35685
PDB Structure Nuclear move domain of nuclear distribution gene C homolog [SOLUTION NMR]
Solution structure of nuclear move domain of nuclear distribution gene C [SOLUTION NMR]
Predicted Effect probably damaging
Transcript: ENSMUST00000030665
AA Change: L208P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000030665
Gene: ENSMUSG00000028851
AA Change: L208P

DomainStartEndE-ValueType
Pfam:Nudc_N 9 60 3.7e-16 PFAM
Pfam:NuDC 96 157 9.5e-23 PFAM
Pfam:CS 171 248 3.1e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000042919
SMART Domains Protein: ENSMUSP00000048768
Gene: ENSMUSG00000037600

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
Pfam:DUF4656 34 397 5.4e-182 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105901
SMART Domains Protein: ENSMUSP00000101521
Gene: ENSMUSG00000037600

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
Pfam:DUF4656 29 397 4e-216 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000121797
SMART Domains Protein: ENSMUSP00000113590
Gene: ENSMUSG00000037600

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
Pfam:DUF4656 29 375 1.4e-199 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141860
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148612
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
4921524L21Rik C G 18: 6,623,487 (GRCm39) L66V possibly damaging Het
4921524L21Rik T A 18: 6,623,488 (GRCm39) L66Q probably damaging Het
Abca6 A G 11: 110,135,029 (GRCm39) V252A probably benign Het
Ablim2 C T 5: 35,959,766 (GRCm39) R73C possibly damaging Het
Acap1 C T 11: 69,775,202 (GRCm39) V354M probably benign Het
Accs T C 2: 93,674,605 (GRCm39) D99G probably damaging Het
Adam9 T C 8: 25,493,317 (GRCm39) Y97C probably damaging Het
Akap6 T C 12: 53,151,458 (GRCm39) V1174A probably damaging Het
Aknad1 C A 3: 108,659,056 (GRCm39) D23E probably damaging Het
Ano2 T C 6: 125,959,886 (GRCm39) C666R possibly damaging Het
Atp4a G A 7: 30,423,693 (GRCm39) A933T probably benign Het
Atxn2 T C 5: 121,952,474 (GRCm39) L224P probably damaging Het
Bin2 T C 15: 100,543,169 (GRCm39) E338G probably damaging Het
Bloc1s5 T C 13: 38,818,960 (GRCm39) K20E probably damaging Het
Bst1 A T 5: 43,977,867 (GRCm39) D72V probably benign Het
Cacna1i T C 15: 80,272,680 (GRCm39) F1631L probably damaging Het
Capn13 GCA G 17: 73,658,501 (GRCm39) probably null Het
Cfap43 A G 19: 47,885,550 (GRCm39) I355T possibly damaging Het
Chuk A T 19: 44,077,197 (GRCm39) M383K possibly damaging Het
Cnga4 A G 7: 105,054,937 (GRCm39) I174V probably benign Het
Cpd T C 11: 76,675,976 (GRCm39) K1226E probably benign Het
Crip2 T C 12: 113,104,204 (GRCm39) C5R probably damaging Het
Cyp3a11 T A 5: 145,797,305 (GRCm39) D358V probably damaging Het
Ebag9 T C 15: 44,487,915 (GRCm39) F21S probably damaging Het
Ercc1 A T 7: 19,084,629 (GRCm39) H70L probably damaging Het
Exoc3 G A 13: 74,347,764 (GRCm39) R69C probably damaging Het
Fgfr4 A T 13: 55,308,969 (GRCm39) R363S possibly damaging Het
Gas2l3 CACTCGTCATACT CACT 10: 89,266,820 (GRCm39) probably benign Het
Gm7489 T A 15: 53,749,434 (GRCm39) probably benign Het
Gphn G A 12: 78,673,984 (GRCm39) V526M probably damaging Het
Gpr152 G A 19: 4,193,790 (GRCm39) V444I probably benign Het
Gss T C 2: 155,406,785 (GRCm39) E330G probably benign Het
Hbs1l A G 10: 21,234,287 (GRCm39) D556G possibly damaging Het
Helz2 T C 2: 180,871,913 (GRCm39) T2619A probably damaging Het
Hk3 A G 13: 55,160,409 (GRCm39) F304L probably damaging Het
Itgad A T 7: 127,797,702 (GRCm39) N906Y probably damaging Het
Jakmip2 T C 18: 43,710,465 (GRCm39) E246G probably damaging Het
L3mbtl4 A T 17: 68,866,748 (GRCm39) H329L probably damaging Het
Mau2 A G 8: 70,485,827 (GRCm39) probably null Het
Myo16 T C 8: 10,423,474 (GRCm39) L270P probably damaging Het
Naa25 T C 5: 121,568,755 (GRCm39) S606P probably damaging Het
Nags T A 11: 102,037,447 (GRCm39) C179* probably null Het
Naip2 A G 13: 100,298,044 (GRCm39) M664T probably benign Het
Ndufv3 T C 17: 31,747,043 (GRCm39) I311T probably benign Het
Nipsnap1 G T 11: 4,841,468 (GRCm39) E258* probably null Het
Or1e32 T C 11: 73,705,074 (GRCm39) Y278C probably benign Het
Or51a39 A T 7: 102,362,750 (GRCm39) V290E probably damaging Het
Oscp1 A G 4: 125,970,652 (GRCm39) D137G possibly damaging Het
Pcdhb5 C T 18: 37,455,524 (GRCm39) P635S probably benign Het
Pcdhgb2 T A 18: 37,825,103 (GRCm39) I698N probably damaging Het
Pde4b A G 4: 102,454,967 (GRCm39) Y399C probably damaging Het
Pdf A T 8: 107,774,812 (GRCm39) V140E probably damaging Het
Pglyrp2 T C 17: 32,634,823 (GRCm39) N513S probably benign Het
Ranbp2 T A 10: 58,312,878 (GRCm39) D1199E possibly damaging Het
Rell2 G T 18: 38,089,621 (GRCm39) probably null Het
Rgl2 A G 17: 34,156,147 (GRCm39) H745R probably benign Het
Rnf121 A G 7: 101,672,592 (GRCm39) C264R probably damaging Het
Rnf181 A G 6: 72,338,499 (GRCm39) F3S probably damaging Het
Rsrc1 T A 3: 67,262,935 (GRCm39) D296E probably damaging Het
Rubcn A T 16: 32,663,678 (GRCm39) D319E probably damaging Het
Scaf8 T C 17: 3,228,494 (GRCm39) S431P unknown Het
Septin11 T A 5: 93,310,112 (GRCm39) M305K possibly damaging Het
Serpinb12 A G 1: 106,884,132 (GRCm39) K293E probably benign Het
Sh3bp1 T A 15: 78,788,538 (GRCm39) H229Q probably benign Het
Slco4c1 G A 1: 96,768,953 (GRCm39) P303L probably damaging Het
Specc1 T A 11: 62,102,510 (GRCm39) V952E probably damaging Het
Spint2 G A 7: 28,956,211 (GRCm39) T158I probably benign Het
St8sia4 A T 1: 95,588,623 (GRCm39) W71R probably damaging Het
Tex48 C T 4: 63,530,151 (GRCm39) V23I possibly damaging Het
Tmc5 G A 7: 118,244,562 (GRCm39) G480D probably benign Het
Tmem8b T A 4: 43,689,713 (GRCm39) M330K probably damaging Het
Tnrc18 C T 5: 142,717,095 (GRCm39) R2453Q probably damaging Het
Trank1 A T 9: 111,220,963 (GRCm39) N2567Y possibly damaging Het
Trps1 T C 15: 50,709,705 (GRCm39) D211G probably damaging Het
Ttn T C 2: 76,555,503 (GRCm39) R30501G probably damaging Het
Ttn T A 2: 76,573,247 (GRCm39) Y25882F probably damaging Het
Unc79 T A 12: 103,139,725 (GRCm39) V2495E probably damaging Het
Uqcr10 T A 11: 4,652,198 (GRCm39) H58L possibly damaging Het
Usp7 A T 16: 8,574,708 (GRCm39) C58* probably null Het
Vmn1r36 A T 6: 66,693,872 (GRCm39) M1K probably null Het
Wdr7 T A 18: 63,911,020 (GRCm39) M804K probably damaging Het
Zfp131 A C 13: 120,250,394 (GRCm39) probably null Het
Zfp507 A G 7: 35,493,480 (GRCm39) V521A probably benign Het
Other mutations in Nudc
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3427:Nudc UTSW 4 133,261,568 (GRCm39) missense probably benign 0.00
R4719:Nudc UTSW 4 133,260,576 (GRCm39) missense probably damaging 0.99
R7182:Nudc UTSW 4 133,261,776 (GRCm39) missense possibly damaging 0.56
R7463:Nudc UTSW 4 133,261,714 (GRCm39) missense possibly damaging 0.90
R9166:Nudc UTSW 4 133,273,165 (GRCm39) missense probably damaging 0.99
R9558:Nudc UTSW 4 133,260,776 (GRCm39) missense probably benign 0.05
R9576:Nudc UTSW 4 133,262,989 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- CCCTGACTGTAAAGAGAACAGAGTG -3'
(R):5'- AGTCACTGAGCTTCCCTGAC -3'

Sequencing Primer
(F):5'- TGAGGAATAAACCCACAAGGC -3'
(R):5'- TGAGCTTCCCTGACTGAACAG -3'
Posted On 2016-03-01