Incidental Mutation 'R4854:Zfp462'
| ID |
373771 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp462
|
| Ensembl Gene |
ENSMUSG00000060206 |
| Gene Name |
zinc finger protein 462 |
| Synonyms |
9430078C22Rik, Zfpip, Gt4-2 |
| MMRRC Submission |
042465-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.884)
|
| Stock # |
R4854 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
54945048-55083563 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 55010668 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 878
(Y878C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000095677
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030131]
[ENSMUST00000079605]
[ENSMUST00000098070]
[ENSMUST00000133895]
|
| AlphaFold |
B1AWL2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000030131
|
| SMART Domains |
Protein: ENSMUSP00000030131
Gene: ENSMUSG00000060206
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
35 |
58 |
4.81e0 |
SMART |
|
ZnF_C2H2
|
106 |
129 |
6.67e-2 |
SMART |
|
ZnF_C2H2
|
153 |
176 |
3.47e0 |
SMART |
|
ZnF_C2H2
|
210 |
233 |
7.29e0 |
SMART |
|
ZnF_C2H2
|
311 |
334 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
356 |
379 |
6.57e0 |
SMART |
|
ZnF_C2H2
|
418 |
441 |
5.34e-1 |
SMART |
|
low complexity region
|
450 |
463 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
501 |
524 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
538 |
561 |
5.34e0 |
SMART |
|
ZnF_C2H2
|
608 |
631 |
6.4e0 |
SMART |
|
low complexity region
|
655 |
676 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
687 |
711 |
3.05e1 |
SMART |
|
ZnF_C2H2
|
733 |
755 |
1.08e-1 |
SMART |
|
low complexity region
|
757 |
771 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
809 |
831 |
1.51e0 |
SMART |
|
ZnF_C2H2
|
892 |
914 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
926 |
948 |
4.11e-2 |
SMART |
|
ZnF_C2H2
|
955 |
978 |
4.98e-1 |
SMART |
|
ZnF_C2H2
|
984 |
1007 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
1092 |
1115 |
7.05e-1 |
SMART |
|
ZnF_C2H2
|
1121 |
1144 |
5.48e0 |
SMART |
|
ZnF_C2H2
|
1155 |
1177 |
6.13e-1 |
SMART |
|
ZnF_C2H2
|
1201 |
1223 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
1229 |
1252 |
2.02e-1 |
SMART |
|
low complexity region
|
1273 |
1296 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1315 |
1337 |
2.2e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079605
|
| SMART Domains |
Protein: ENSMUSP00000078555
Gene: ENSMUSG00000060206
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
35 |
58 |
4.81e0 |
SMART |
|
ZnF_C2H2
|
106 |
129 |
6.67e-2 |
SMART |
|
ZnF_C2H2
|
153 |
176 |
3.47e0 |
SMART |
|
ZnF_C2H2
|
210 |
233 |
7.29e0 |
SMART |
|
ZnF_C2H2
|
311 |
334 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
356 |
379 |
6.57e0 |
SMART |
|
ZnF_C2H2
|
418 |
441 |
5.34e-1 |
SMART |
|
low complexity region
|
450 |
463 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
501 |
524 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
538 |
561 |
5.34e0 |
SMART |
|
ZnF_C2H2
|
608 |
631 |
6.4e0 |
SMART |
|
low complexity region
|
655 |
676 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
687 |
711 |
3.05e1 |
SMART |
|
ZnF_C2H2
|
733 |
755 |
1.08e-1 |
SMART |
|
low complexity region
|
757 |
771 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
809 |
831 |
1.51e0 |
SMART |
|
ZnF_C2H2
|
893 |
915 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
927 |
949 |
4.11e-2 |
SMART |
|
ZnF_C2H2
|
956 |
979 |
4.98e-1 |
SMART |
|
ZnF_C2H2
|
985 |
1008 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
1093 |
1116 |
7.05e-1 |
SMART |
|
ZnF_C2H2
|
1122 |
1145 |
5.48e0 |
SMART |
|
ZnF_C2H2
|
1156 |
1178 |
6.13e-1 |
SMART |
|
ZnF_C2H2
|
1202 |
1224 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
1230 |
1253 |
2.02e-1 |
SMART |
|
low complexity region
|
1274 |
1297 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1316 |
1338 |
2.2e-2 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000098070
AA Change: Y878C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000095677
Gene: ENSMUSG00000060206
AA Change: Y878C
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
4 |
27 |
5.81e-2 |
SMART |
|
low complexity region
|
81 |
94 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
108 |
131 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
162 |
185 |
4.65e-1 |
SMART |
|
low complexity region
|
194 |
215 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
243 |
266 |
4.98e-1 |
SMART |
|
low complexity region
|
332 |
343 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
440 |
463 |
1.01e-1 |
SMART |
|
ZnF_C2H2
|
471 |
493 |
2.86e-1 |
SMART |
|
low complexity region
|
503 |
515 |
N/A |
INTRINSIC |
|
low complexity region
|
536 |
592 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
593 |
616 |
2.53e-2 |
SMART |
|
low complexity region
|
707 |
736 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
835 |
858 |
5.62e0 |
SMART |
|
ZnF_C2H2
|
878 |
900 |
2.14e0 |
SMART |
|
ZnF_C2H2
|
917 |
940 |
6.67e-2 |
SMART |
|
ZnF_C2H2
|
1023 |
1046 |
5.72e-1 |
SMART |
|
low complexity region
|
1092 |
1100 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1107 |
1130 |
4.23e0 |
SMART |
|
ZnF_C2H2
|
1183 |
1206 |
4.81e0 |
SMART |
|
ZnF_C2H2
|
1254 |
1277 |
6.67e-2 |
SMART |
|
ZnF_C2H2
|
1301 |
1324 |
3.47e0 |
SMART |
|
ZnF_C2H2
|
1358 |
1381 |
7.29e0 |
SMART |
|
ZnF_C2H2
|
1459 |
1482 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
1504 |
1527 |
6.57e0 |
SMART |
|
ZnF_C2H2
|
1566 |
1589 |
5.34e-1 |
SMART |
|
low complexity region
|
1598 |
1611 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1649 |
1672 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
1686 |
1709 |
5.34e0 |
SMART |
|
ZnF_C2H2
|
1756 |
1779 |
6.4e0 |
SMART |
|
low complexity region
|
1803 |
1824 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1835 |
1859 |
3.05e1 |
SMART |
|
ZnF_C2H2
|
1881 |
1903 |
1.08e-1 |
SMART |
|
low complexity region
|
1905 |
1919 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1957 |
1979 |
1.51e0 |
SMART |
|
ZnF_C2H2
|
2014 |
2036 |
4.11e-2 |
SMART |
|
ZnF_C2H2
|
2043 |
2066 |
4.98e-1 |
SMART |
|
ZnF_C2H2
|
2072 |
2095 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
2180 |
2203 |
7.05e-1 |
SMART |
|
ZnF_C2H2
|
2209 |
2232 |
5.48e0 |
SMART |
|
ZnF_C2H2
|
2243 |
2265 |
6.13e-1 |
SMART |
|
ZnF_C2H2
|
2289 |
2311 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
2317 |
2340 |
2.02e-1 |
SMART |
|
low complexity region
|
2361 |
2384 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
2403 |
2425 |
2.2e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000133895
|
| SMART Domains |
Protein: ENSMUSP00000122775
Gene: ENSMUSG00000060206
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
4 |
27 |
5.81e-2 |
SMART |
|
low complexity region
|
81 |
93 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.4186 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.2%
|
| Validation Efficiency |
98% (103/105) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to C2H2-type zinc finger family of proteins. It contains multiple C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810064F22Rik |
T |
A |
9: 22,119,333 (GRCm39) |
|
noncoding transcript |
Het |
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| Abl1 |
T |
C |
2: 31,669,022 (GRCm39) |
Y110H |
probably damaging |
Het |
| Ablim2 |
C |
T |
5: 35,959,766 (GRCm39) |
R73C |
possibly damaging |
Het |
| Agbl3 |
G |
A |
6: 34,762,219 (GRCm39) |
R73Q |
probably damaging |
Het |
| Agl |
C |
T |
3: 116,572,267 (GRCm39) |
|
probably null |
Het |
| Amotl1 |
G |
A |
9: 14,504,747 (GRCm39) |
Q191* |
probably null |
Het |
| Apbb1ip |
A |
G |
2: 22,743,214 (GRCm39) |
K349E |
possibly damaging |
Het |
| Arhgap10 |
G |
A |
8: 78,146,718 (GRCm39) |
Q229* |
probably null |
Het |
| Aspm |
C |
T |
1: 139,405,810 (GRCm39) |
Q1566* |
probably null |
Het |
| B3gnt3 |
G |
A |
8: 72,145,517 (GRCm39) |
R284C |
probably damaging |
Het |
| Bltp3b |
T |
G |
10: 89,630,346 (GRCm39) |
V382G |
probably damaging |
Het |
| Brd4 |
A |
G |
17: 32,439,211 (GRCm39) |
V423A |
probably damaging |
Het |
| Btbd9 |
A |
T |
17: 30,743,839 (GRCm39) |
I221N |
probably damaging |
Het |
| Camp |
A |
G |
9: 109,676,519 (GRCm39) |
V168A |
probably benign |
Het |
| Cd1d2 |
T |
A |
3: 86,896,556 (GRCm39) |
|
probably null |
Het |
| Cdkn2d |
A |
T |
9: 21,202,223 (GRCm39) |
V8D |
probably benign |
Het |
| Cimap1a |
A |
G |
7: 140,429,375 (GRCm39) |
Y168C |
probably damaging |
Het |
| Clec4g |
T |
C |
8: 3,766,534 (GRCm39) |
N256D |
probably damaging |
Het |
| Clspn |
A |
G |
4: 126,469,743 (GRCm39) |
I771V |
probably benign |
Het |
| Cntn6 |
A |
G |
6: 104,836,436 (GRCm39) |
E862G |
possibly damaging |
Het |
| Col6a5 |
T |
C |
9: 105,775,950 (GRCm39) |
T1702A |
probably benign |
Het |
| Dnah7a |
T |
C |
1: 53,745,888 (GRCm39) |
|
probably benign |
Het |
| Dubr |
T |
C |
16: 50,552,886 (GRCm39) |
|
noncoding transcript |
Het |
| Dusp26 |
G |
A |
8: 31,584,165 (GRCm39) |
V91M |
probably damaging |
Het |
| Edc4 |
A |
T |
8: 106,614,557 (GRCm39) |
|
probably benign |
Het |
| F5 |
C |
T |
1: 164,019,715 (GRCm39) |
A730V |
probably damaging |
Het |
| Foxf1 |
A |
G |
8: 121,813,553 (GRCm39) |
T358A |
probably benign |
Het |
| Frem1 |
A |
T |
4: 82,834,995 (GRCm39) |
N1810K |
possibly damaging |
Het |
| Galc |
A |
T |
12: 98,223,136 (GRCm39) |
F87I |
probably damaging |
Het |
| Gars1 |
A |
G |
6: 55,023,403 (GRCm39) |
D66G |
probably damaging |
Het |
| Gbp11 |
G |
A |
5: 105,473,374 (GRCm39) |
L460F |
probably damaging |
Het |
| Gdf7 |
T |
C |
12: 8,348,014 (GRCm39) |
I436V |
probably damaging |
Het |
| Gigyf2 |
C |
T |
1: 87,282,135 (GRCm39) |
|
probably benign |
Het |
| Gm12239 |
T |
C |
11: 55,906,779 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5592 |
A |
C |
7: 40,866,895 (GRCm39) |
|
probably benign |
Het |
| Gp2 |
A |
T |
7: 119,051,422 (GRCm39) |
D264E |
possibly damaging |
Het |
| Gphn |
G |
A |
12: 78,673,984 (GRCm39) |
V526M |
probably damaging |
Het |
| Grid1 |
A |
G |
14: 35,043,598 (GRCm39) |
I318V |
probably benign |
Het |
| Grm2 |
C |
A |
9: 106,531,331 (GRCm39) |
V53F |
possibly damaging |
Het |
| Gtpbp1 |
T |
C |
15: 79,603,406 (GRCm39) |
S632P |
probably benign |
Het |
| H2-M1 |
A |
G |
17: 36,980,950 (GRCm39) |
F329L |
probably benign |
Het |
| Hecw1 |
T |
A |
13: 14,491,477 (GRCm39) |
D92V |
probably benign |
Het |
| Hgh1 |
T |
C |
15: 76,253,382 (GRCm39) |
L76P |
probably damaging |
Het |
| Idi2 |
C |
A |
13: 9,007,879 (GRCm39) |
N63K |
probably benign |
Het |
| Ift122 |
A |
G |
6: 115,839,707 (GRCm39) |
T25A |
possibly damaging |
Het |
| Itgb2l |
A |
T |
16: 96,227,317 (GRCm39) |
C575* |
probably null |
Het |
| Jup |
A |
G |
11: 100,273,867 (GRCm39) |
S225P |
possibly damaging |
Het |
| Kcng3 |
A |
T |
17: 83,895,735 (GRCm39) |
C244S |
probably damaging |
Het |
| Klhl2 |
T |
A |
8: 65,287,111 (GRCm39) |
M46L |
possibly damaging |
Het |
| Ksr1 |
A |
T |
11: 78,918,528 (GRCm39) |
I460N |
probably damaging |
Het |
| Lama3 |
T |
A |
18: 12,544,599 (GRCm39) |
F314Y |
probably benign |
Het |
| Lbp |
T |
C |
2: 158,169,438 (GRCm39) |
V421A |
possibly damaging |
Het |
| Lcp1 |
G |
A |
14: 75,437,929 (GRCm39) |
G113D |
probably damaging |
Het |
| Lrp1b |
A |
T |
2: 41,001,089 (GRCm39) |
L2045H |
probably damaging |
Het |
| Mbd2 |
G |
T |
18: 70,701,806 (GRCm39) |
D107Y |
unknown |
Het |
| Ms4a14 |
C |
T |
19: 11,287,733 (GRCm39) |
V96I |
possibly damaging |
Het |
| N4bp2l2 |
C |
T |
5: 150,585,516 (GRCm39) |
E155K |
probably benign |
Het |
| Nbeal2 |
T |
G |
9: 110,460,464 (GRCm39) |
H1790P |
probably damaging |
Het |
| Nsg2 |
G |
A |
11: 31,981,806 (GRCm39) |
G84R |
probably benign |
Het |
| Or10ad1b |
A |
C |
15: 98,125,425 (GRCm39) |
F34V |
possibly damaging |
Het |
| Or12e10 |
A |
G |
2: 87,640,934 (GRCm39) |
T257A |
probably damaging |
Het |
| P2rx2 |
T |
C |
5: 110,488,793 (GRCm39) |
N224D |
probably damaging |
Het |
| P2rx5 |
A |
T |
11: 73,062,605 (GRCm39) |
E438V |
probably benign |
Het |
| Paip1 |
C |
A |
13: 119,586,425 (GRCm39) |
|
probably benign |
Het |
| Pik3c2g |
T |
A |
6: 139,714,505 (GRCm39) |
V219E |
probably damaging |
Het |
| Ppp1r12b |
T |
C |
1: 134,801,689 (GRCm39) |
E509G |
probably damaging |
Het |
| Ppp1r15a |
T |
C |
7: 45,174,797 (GRCm39) |
S4G |
probably benign |
Het |
| Ppp5c |
T |
C |
7: 16,742,947 (GRCm39) |
S224G |
probably benign |
Het |
| Prr30 |
T |
G |
14: 101,435,879 (GRCm39) |
I228L |
probably benign |
Het |
| Purg |
A |
G |
8: 33,877,342 (GRCm39) |
I327V |
possibly damaging |
Het |
| Ralb |
T |
C |
1: 119,403,645 (GRCm39) |
T161A |
probably benign |
Het |
| Ripor3 |
T |
C |
2: 167,834,733 (GRCm39) |
R253G |
probably benign |
Het |
| Scgb2b6 |
T |
C |
7: 31,317,257 (GRCm39) |
|
noncoding transcript |
Het |
| Setd5 |
G |
T |
6: 113,128,360 (GRCm39) |
G1438W |
probably damaging |
Het |
| Sh3rf3 |
T |
A |
10: 58,649,545 (GRCm39) |
L50Q |
possibly damaging |
Het |
| Sipa1l2 |
G |
T |
8: 126,200,340 (GRCm39) |
T662K |
probably damaging |
Het |
| Skint5 |
A |
G |
4: 113,437,725 (GRCm39) |
L1021S |
unknown |
Het |
| Slc22a23 |
T |
C |
13: 34,387,924 (GRCm39) |
S391G |
probably benign |
Het |
| Slc4a5 |
G |
A |
6: 83,247,999 (GRCm39) |
V402I |
probably benign |
Het |
| Slco4c1 |
G |
A |
1: 96,768,953 (GRCm39) |
P303L |
probably damaging |
Het |
| Spink5 |
A |
T |
18: 44,153,908 (GRCm39) |
*1018C |
probably null |
Het |
| Stag3 |
T |
A |
5: 138,294,956 (GRCm39) |
|
probably null |
Het |
| Tmem117 |
T |
C |
15: 94,992,569 (GRCm39) |
F410L |
probably damaging |
Het |
| Tmod1 |
A |
G |
4: 46,090,920 (GRCm39) |
K158E |
possibly damaging |
Het |
| Tpsb2 |
GGCTGCTGCTGCTGCTG |
GGCTGCTGCTGCTG |
17: 25,585,536 (GRCm39) |
|
probably benign |
Het |
| Traf4 |
G |
A |
11: 78,052,346 (GRCm39) |
Q100* |
probably null |
Het |
| Trpc4 |
A |
G |
3: 54,209,639 (GRCm39) |
Y668C |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,597,927 (GRCm39) |
N11335I |
possibly damaging |
Het |
| Usp39 |
A |
T |
6: 72,302,665 (GRCm39) |
V463E |
probably benign |
Het |
| Vmn1r6 |
A |
C |
6: 56,979,683 (GRCm39) |
Y115S |
probably benign |
Het |
| Vmn2r44 |
A |
G |
7: 8,383,300 (GRCm39) |
I98T |
possibly damaging |
Het |
| Zfp474 |
T |
C |
18: 52,771,503 (GRCm39) |
I52T |
possibly damaging |
Het |
|
| Other mutations in Zfp462 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00162:Zfp462
|
APN |
4 |
55,011,483 (GRCm39) |
splice site |
probably null |
|
|
IGL00421:Zfp462
|
APN |
4 |
55,023,576 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00899:Zfp462
|
APN |
4 |
55,007,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01549:Zfp462
|
APN |
4 |
55,013,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01627:Zfp462
|
APN |
4 |
55,008,912 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01715:Zfp462
|
APN |
4 |
55,008,586 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL01862:Zfp462
|
APN |
4 |
55,023,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01878:Zfp462
|
APN |
4 |
55,010,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01913:Zfp462
|
APN |
4 |
55,012,138 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02029:Zfp462
|
APN |
4 |
55,079,395 (GRCm39) |
splice site |
probably benign |
|
|
IGL02338:Zfp462
|
APN |
4 |
55,010,292 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02552:Zfp462
|
APN |
4 |
55,010,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02623:Zfp462
|
APN |
4 |
55,012,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02750:Zfp462
|
APN |
4 |
55,060,236 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL02815:Zfp462
|
APN |
4 |
55,051,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03204:Zfp462
|
APN |
4 |
55,080,785 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
FR4304:Zfp462
|
UTSW |
4 |
55,009,758 (GRCm39) |
unclassified |
probably benign |
|
|
FR4304:Zfp462
|
UTSW |
4 |
55,009,757 (GRCm39) |
unclassified |
probably benign |
|
|
FR4737:Zfp462
|
UTSW |
4 |
55,009,760 (GRCm39) |
unclassified |
probably benign |
|
|
FR4737:Zfp462
|
UTSW |
4 |
55,009,758 (GRCm39) |
unclassified |
probably benign |
|
|
FR4976:Zfp462
|
UTSW |
4 |
55,009,761 (GRCm39) |
unclassified |
probably benign |
|
|
FR4976:Zfp462
|
UTSW |
4 |
55,009,760 (GRCm39) |
unclassified |
probably benign |
|
|
P0035:Zfp462
|
UTSW |
4 |
55,009,086 (GRCm39) |
missense |
probably benign |
|
|
R0052:Zfp462
|
UTSW |
4 |
55,011,762 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0143:Zfp462
|
UTSW |
4 |
55,023,402 (GRCm39) |
splice site |
probably benign |
|
|
R0145:Zfp462
|
UTSW |
4 |
55,010,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0315:Zfp462
|
UTSW |
4 |
55,079,314 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0349:Zfp462
|
UTSW |
4 |
55,008,768 (GRCm39) |
missense |
probably benign |
|
|
R0359:Zfp462
|
UTSW |
4 |
55,013,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0413:Zfp462
|
UTSW |
4 |
55,010,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0554:Zfp462
|
UTSW |
4 |
55,013,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0616:Zfp462
|
UTSW |
4 |
55,011,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0631:Zfp462
|
UTSW |
4 |
55,007,563 (GRCm39) |
start codon destroyed |
possibly damaging |
0.60 |
|
R1086:Zfp462
|
UTSW |
4 |
55,013,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1499:Zfp462
|
UTSW |
4 |
55,060,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1509:Zfp462
|
UTSW |
4 |
55,007,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1526:Zfp462
|
UTSW |
4 |
55,009,002 (GRCm39) |
missense |
probably benign |
|
|
R1541:Zfp462
|
UTSW |
4 |
55,008,928 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1691:Zfp462
|
UTSW |
4 |
55,013,489 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1843:Zfp462
|
UTSW |
4 |
55,010,010 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2086:Zfp462
|
UTSW |
4 |
55,010,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Zfp462
|
UTSW |
4 |
55,008,496 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2148:Zfp462
|
UTSW |
4 |
55,013,670 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2179:Zfp462
|
UTSW |
4 |
55,009,524 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2325:Zfp462
|
UTSW |
4 |
55,013,712 (GRCm39) |
missense |
probably benign |
|
|
R2352:Zfp462
|
UTSW |
4 |
55,008,313 (GRCm39) |
missense |
probably null |
|
|
R2566:Zfp462
|
UTSW |
4 |
55,008,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3879:Zfp462
|
UTSW |
4 |
55,060,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3969:Zfp462
|
UTSW |
4 |
55,012,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4273:Zfp462
|
UTSW |
4 |
55,008,411 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4413:Zfp462
|
UTSW |
4 |
55,012,672 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4510:Zfp462
|
UTSW |
4 |
55,008,934 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4511:Zfp462
|
UTSW |
4 |
55,008,934 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4609:Zfp462
|
UTSW |
4 |
55,011,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4632:Zfp462
|
UTSW |
4 |
55,012,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4649:Zfp462
|
UTSW |
4 |
55,009,349 (GRCm39) |
missense |
probably benign |
|
|
R4682:Zfp462
|
UTSW |
4 |
55,011,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4696:Zfp462
|
UTSW |
4 |
55,008,612 (GRCm39) |
missense |
probably benign |
|
|
R4744:Zfp462
|
UTSW |
4 |
55,011,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4747:Zfp462
|
UTSW |
4 |
55,013,476 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4819:Zfp462
|
UTSW |
4 |
55,060,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4827:Zfp462
|
UTSW |
4 |
55,012,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4879:Zfp462
|
UTSW |
4 |
55,009,444 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4891:Zfp462
|
UTSW |
4 |
55,060,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Zfp462
|
UTSW |
4 |
55,051,204 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5118:Zfp462
|
UTSW |
4 |
55,010,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5171:Zfp462
|
UTSW |
4 |
55,016,986 (GRCm39) |
splice site |
probably null |
|
|
R5173:Zfp462
|
UTSW |
4 |
55,011,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5221:Zfp462
|
UTSW |
4 |
55,016,887 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5268:Zfp462
|
UTSW |
4 |
55,012,299 (GRCm39) |
missense |
probably benign |
|
|
R5314:Zfp462
|
UTSW |
4 |
55,013,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5429:Zfp462
|
UTSW |
4 |
55,060,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5518:Zfp462
|
UTSW |
4 |
55,009,818 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5525:Zfp462
|
UTSW |
4 |
55,050,281 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5620:Zfp462
|
UTSW |
4 |
55,013,464 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5775:Zfp462
|
UTSW |
4 |
55,010,590 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6126:Zfp462
|
UTSW |
4 |
55,023,573 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6280:Zfp462
|
UTSW |
4 |
55,010,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6325:Zfp462
|
UTSW |
4 |
55,080,680 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6542:Zfp462
|
UTSW |
4 |
55,023,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6612:Zfp462
|
UTSW |
4 |
55,012,324 (GRCm39) |
splice site |
probably null |
|
|
R6663:Zfp462
|
UTSW |
4 |
55,008,933 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6872:Zfp462
|
UTSW |
4 |
55,012,326 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6889:Zfp462
|
UTSW |
4 |
55,007,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6896:Zfp462
|
UTSW |
4 |
55,009,544 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R6913:Zfp462
|
UTSW |
4 |
55,007,775 (GRCm39) |
missense |
probably benign |
0.25 |
|
R6988:Zfp462
|
UTSW |
4 |
55,080,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7131:Zfp462
|
UTSW |
4 |
55,009,380 (GRCm39) |
missense |
probably benign |
|
|
R7151:Zfp462
|
UTSW |
4 |
55,051,271 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7684:Zfp462
|
UTSW |
4 |
55,008,908 (GRCm39) |
missense |
probably benign |
|
|
R7741:Zfp462
|
UTSW |
4 |
55,008,637 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7750:Zfp462
|
UTSW |
4 |
55,016,958 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7812:Zfp462
|
UTSW |
4 |
55,008,509 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7863:Zfp462
|
UTSW |
4 |
55,007,747 (GRCm39) |
missense |
probably benign |
|
|
R7898:Zfp462
|
UTSW |
4 |
55,012,995 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7993:Zfp462
|
UTSW |
4 |
55,011,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7995:Zfp462
|
UTSW |
4 |
55,011,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Zfp462
|
UTSW |
4 |
55,073,106 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8394:Zfp462
|
UTSW |
4 |
55,011,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8669:Zfp462
|
UTSW |
4 |
55,051,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8877:Zfp462
|
UTSW |
4 |
55,011,097 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8980:Zfp462
|
UTSW |
4 |
55,009,681 (GRCm39) |
unclassified |
probably benign |
|
|
R9023:Zfp462
|
UTSW |
4 |
55,007,563 (GRCm39) |
start codon destroyed |
probably null |
0.00 |
|
R9243:Zfp462
|
UTSW |
4 |
55,009,595 (GRCm39) |
nonsense |
probably null |
|
|
R9378:Zfp462
|
UTSW |
4 |
55,011,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9417:Zfp462
|
UTSW |
4 |
55,016,988 (GRCm39) |
missense |
probably benign |
0.26 |
|
R9476:Zfp462
|
UTSW |
4 |
55,080,735 (GRCm39) |
missense |
probably benign |
|
|
R9510:Zfp462
|
UTSW |
4 |
55,080,735 (GRCm39) |
missense |
probably benign |
|
|
R9610:Zfp462
|
UTSW |
4 |
55,009,545 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9628:Zfp462
|
UTSW |
4 |
55,009,423 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GATCAAGTGTCCAATGCGGC -3'
(R):5'- AATGCGGCATCAGGCTTCTG -3'
Sequencing Primer
(F):5'- AATGCGGCTCTGCTGAACAC -3'
(R):5'- TCTGACATTCGGGCTAGTGTAAGAAC -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation