Incidental Mutation 'R4854:Hecw1'
| ID |
373823 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Hecw1
|
| Ensembl Gene |
ENSMUSG00000021301 |
| Gene Name |
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 |
| Synonyms |
NEDL1, E130207I19Rik |
| MMRRC Submission |
042465-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4854 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
13 |
| Chromosomal Location |
14401023-14697813 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 14491477 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 92
(D92V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152215
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110516]
[ENSMUST00000220718]
|
| AlphaFold |
Q8K4P8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110516
AA Change: D505V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000106145
Gene: ENSMUSG00000021301
AA Change: D505V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:HECW_N
|
65 |
184 |
6.5e-62 |
PFAM |
|
C2
|
206 |
317 |
1.02e-12 |
SMART |
|
low complexity region
|
463 |
477 |
N/A |
INTRINSIC |
|
low complexity region
|
497 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
577 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
745 |
N/A |
INTRINSIC |
|
WW
|
827 |
859 |
8.66e-13 |
SMART |
|
coiled coil region
|
873 |
898 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
930 |
N/A |
INTRINSIC |
|
WW
|
1017 |
1049 |
5.59e-7 |
SMART |
|
Blast:HECTc
|
1137 |
1192 |
3e-26 |
BLAST |
|
low complexity region
|
1193 |
1208 |
N/A |
INTRINSIC |
|
low complexity region
|
1212 |
1223 |
N/A |
INTRINSIC |
|
HECTc
|
1267 |
1604 |
1.36e-185 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000220718
AA Change: D92V
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221863
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000222241
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.2%
|
| Validation Efficiency |
98% (103/105) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810064F22Rik |
T |
A |
9: 22,119,333 (GRCm39) |
|
noncoding transcript |
Het |
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| Abl1 |
T |
C |
2: 31,669,022 (GRCm39) |
Y110H |
probably damaging |
Het |
| Ablim2 |
C |
T |
5: 35,959,766 (GRCm39) |
R73C |
possibly damaging |
Het |
| Agbl3 |
G |
A |
6: 34,762,219 (GRCm39) |
R73Q |
probably damaging |
Het |
| Agl |
C |
T |
3: 116,572,267 (GRCm39) |
|
probably null |
Het |
| Amotl1 |
G |
A |
9: 14,504,747 (GRCm39) |
Q191* |
probably null |
Het |
| Apbb1ip |
A |
G |
2: 22,743,214 (GRCm39) |
K349E |
possibly damaging |
Het |
| Arhgap10 |
G |
A |
8: 78,146,718 (GRCm39) |
Q229* |
probably null |
Het |
| Aspm |
C |
T |
1: 139,405,810 (GRCm39) |
Q1566* |
probably null |
Het |
| B3gnt3 |
G |
A |
8: 72,145,517 (GRCm39) |
R284C |
probably damaging |
Het |
| Bltp3b |
T |
G |
10: 89,630,346 (GRCm39) |
V382G |
probably damaging |
Het |
| Brd4 |
A |
G |
17: 32,439,211 (GRCm39) |
V423A |
probably damaging |
Het |
| Btbd9 |
A |
T |
17: 30,743,839 (GRCm39) |
I221N |
probably damaging |
Het |
| Camp |
A |
G |
9: 109,676,519 (GRCm39) |
V168A |
probably benign |
Het |
| Cd1d2 |
T |
A |
3: 86,896,556 (GRCm39) |
|
probably null |
Het |
| Cdkn2d |
A |
T |
9: 21,202,223 (GRCm39) |
V8D |
probably benign |
Het |
| Cimap1a |
A |
G |
7: 140,429,375 (GRCm39) |
Y168C |
probably damaging |
Het |
| Clec4g |
T |
C |
8: 3,766,534 (GRCm39) |
N256D |
probably damaging |
Het |
| Clspn |
A |
G |
4: 126,469,743 (GRCm39) |
I771V |
probably benign |
Het |
| Cntn6 |
A |
G |
6: 104,836,436 (GRCm39) |
E862G |
possibly damaging |
Het |
| Col6a5 |
T |
C |
9: 105,775,950 (GRCm39) |
T1702A |
probably benign |
Het |
| Dnah7a |
T |
C |
1: 53,745,888 (GRCm39) |
|
probably benign |
Het |
| Dubr |
T |
C |
16: 50,552,886 (GRCm39) |
|
noncoding transcript |
Het |
| Dusp26 |
G |
A |
8: 31,584,165 (GRCm39) |
V91M |
probably damaging |
Het |
| Edc4 |
A |
T |
8: 106,614,557 (GRCm39) |
|
probably benign |
Het |
| F5 |
C |
T |
1: 164,019,715 (GRCm39) |
A730V |
probably damaging |
Het |
| Foxf1 |
A |
G |
8: 121,813,553 (GRCm39) |
T358A |
probably benign |
Het |
| Frem1 |
A |
T |
4: 82,834,995 (GRCm39) |
N1810K |
possibly damaging |
Het |
| Galc |
A |
T |
12: 98,223,136 (GRCm39) |
F87I |
probably damaging |
Het |
| Gars1 |
A |
G |
6: 55,023,403 (GRCm39) |
D66G |
probably damaging |
Het |
| Gbp11 |
G |
A |
5: 105,473,374 (GRCm39) |
L460F |
probably damaging |
Het |
| Gdf7 |
T |
C |
12: 8,348,014 (GRCm39) |
I436V |
probably damaging |
Het |
| Gigyf2 |
C |
T |
1: 87,282,135 (GRCm39) |
|
probably benign |
Het |
| Gm12239 |
T |
C |
11: 55,906,779 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5592 |
A |
C |
7: 40,866,895 (GRCm39) |
|
probably benign |
Het |
| Gp2 |
A |
T |
7: 119,051,422 (GRCm39) |
D264E |
possibly damaging |
Het |
| Gphn |
G |
A |
12: 78,673,984 (GRCm39) |
V526M |
probably damaging |
Het |
| Grid1 |
A |
G |
14: 35,043,598 (GRCm39) |
I318V |
probably benign |
Het |
| Grm2 |
C |
A |
9: 106,531,331 (GRCm39) |
V53F |
possibly damaging |
Het |
| Gtpbp1 |
T |
C |
15: 79,603,406 (GRCm39) |
S632P |
probably benign |
Het |
| H2-M1 |
A |
G |
17: 36,980,950 (GRCm39) |
F329L |
probably benign |
Het |
| Hgh1 |
T |
C |
15: 76,253,382 (GRCm39) |
L76P |
probably damaging |
Het |
| Idi2 |
C |
A |
13: 9,007,879 (GRCm39) |
N63K |
probably benign |
Het |
| Ift122 |
A |
G |
6: 115,839,707 (GRCm39) |
T25A |
possibly damaging |
Het |
| Itgb2l |
A |
T |
16: 96,227,317 (GRCm39) |
C575* |
probably null |
Het |
| Jup |
A |
G |
11: 100,273,867 (GRCm39) |
S225P |
possibly damaging |
Het |
| Kcng3 |
A |
T |
17: 83,895,735 (GRCm39) |
C244S |
probably damaging |
Het |
| Klhl2 |
T |
A |
8: 65,287,111 (GRCm39) |
M46L |
possibly damaging |
Het |
| Ksr1 |
A |
T |
11: 78,918,528 (GRCm39) |
I460N |
probably damaging |
Het |
| Lama3 |
T |
A |
18: 12,544,599 (GRCm39) |
F314Y |
probably benign |
Het |
| Lbp |
T |
C |
2: 158,169,438 (GRCm39) |
V421A |
possibly damaging |
Het |
| Lcp1 |
G |
A |
14: 75,437,929 (GRCm39) |
G113D |
probably damaging |
Het |
| Lrp1b |
A |
T |
2: 41,001,089 (GRCm39) |
L2045H |
probably damaging |
Het |
| Mbd2 |
G |
T |
18: 70,701,806 (GRCm39) |
D107Y |
unknown |
Het |
| Ms4a14 |
C |
T |
19: 11,287,733 (GRCm39) |
V96I |
possibly damaging |
Het |
| N4bp2l2 |
C |
T |
5: 150,585,516 (GRCm39) |
E155K |
probably benign |
Het |
| Nbeal2 |
T |
G |
9: 110,460,464 (GRCm39) |
H1790P |
probably damaging |
Het |
| Nsg2 |
G |
A |
11: 31,981,806 (GRCm39) |
G84R |
probably benign |
Het |
| Or10ad1b |
A |
C |
15: 98,125,425 (GRCm39) |
F34V |
possibly damaging |
Het |
| Or12e10 |
A |
G |
2: 87,640,934 (GRCm39) |
T257A |
probably damaging |
Het |
| P2rx2 |
T |
C |
5: 110,488,793 (GRCm39) |
N224D |
probably damaging |
Het |
| P2rx5 |
A |
T |
11: 73,062,605 (GRCm39) |
E438V |
probably benign |
Het |
| Paip1 |
C |
A |
13: 119,586,425 (GRCm39) |
|
probably benign |
Het |
| Pik3c2g |
T |
A |
6: 139,714,505 (GRCm39) |
V219E |
probably damaging |
Het |
| Ppp1r12b |
T |
C |
1: 134,801,689 (GRCm39) |
E509G |
probably damaging |
Het |
| Ppp1r15a |
T |
C |
7: 45,174,797 (GRCm39) |
S4G |
probably benign |
Het |
| Ppp5c |
T |
C |
7: 16,742,947 (GRCm39) |
S224G |
probably benign |
Het |
| Prr30 |
T |
G |
14: 101,435,879 (GRCm39) |
I228L |
probably benign |
Het |
| Purg |
A |
G |
8: 33,877,342 (GRCm39) |
I327V |
possibly damaging |
Het |
| Ralb |
T |
C |
1: 119,403,645 (GRCm39) |
T161A |
probably benign |
Het |
| Ripor3 |
T |
C |
2: 167,834,733 (GRCm39) |
R253G |
probably benign |
Het |
| Scgb2b6 |
T |
C |
7: 31,317,257 (GRCm39) |
|
noncoding transcript |
Het |
| Setd5 |
G |
T |
6: 113,128,360 (GRCm39) |
G1438W |
probably damaging |
Het |
| Sh3rf3 |
T |
A |
10: 58,649,545 (GRCm39) |
L50Q |
possibly damaging |
Het |
| Sipa1l2 |
G |
T |
8: 126,200,340 (GRCm39) |
T662K |
probably damaging |
Het |
| Skint5 |
A |
G |
4: 113,437,725 (GRCm39) |
L1021S |
unknown |
Het |
| Slc22a23 |
T |
C |
13: 34,387,924 (GRCm39) |
S391G |
probably benign |
Het |
| Slc4a5 |
G |
A |
6: 83,247,999 (GRCm39) |
V402I |
probably benign |
Het |
| Slco4c1 |
G |
A |
1: 96,768,953 (GRCm39) |
P303L |
probably damaging |
Het |
| Spink5 |
A |
T |
18: 44,153,908 (GRCm39) |
*1018C |
probably null |
Het |
| Stag3 |
T |
A |
5: 138,294,956 (GRCm39) |
|
probably null |
Het |
| Tmem117 |
T |
C |
15: 94,992,569 (GRCm39) |
F410L |
probably damaging |
Het |
| Tmod1 |
A |
G |
4: 46,090,920 (GRCm39) |
K158E |
possibly damaging |
Het |
| Tpsb2 |
GGCTGCTGCTGCTGCTG |
GGCTGCTGCTGCTG |
17: 25,585,536 (GRCm39) |
|
probably benign |
Het |
| Traf4 |
G |
A |
11: 78,052,346 (GRCm39) |
Q100* |
probably null |
Het |
| Trpc4 |
A |
G |
3: 54,209,639 (GRCm39) |
Y668C |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,597,927 (GRCm39) |
N11335I |
possibly damaging |
Het |
| Usp39 |
A |
T |
6: 72,302,665 (GRCm39) |
V463E |
probably benign |
Het |
| Vmn1r6 |
A |
C |
6: 56,979,683 (GRCm39) |
Y115S |
probably benign |
Het |
| Vmn2r44 |
A |
G |
7: 8,383,300 (GRCm39) |
I98T |
possibly damaging |
Het |
| Zfp462 |
A |
G |
4: 55,010,668 (GRCm39) |
Y878C |
probably damaging |
Het |
| Zfp474 |
T |
C |
18: 52,771,503 (GRCm39) |
I52T |
possibly damaging |
Het |
|
| Other mutations in Hecw1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00591:Hecw1
|
APN |
13 |
14,440,565 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL00813:Hecw1
|
APN |
13 |
14,452,961 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL00843:Hecw1
|
APN |
13 |
14,422,158 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00942:Hecw1
|
APN |
13 |
14,515,325 (GRCm39) |
splice site |
probably benign |
|
|
IGL00976:Hecw1
|
APN |
13 |
14,493,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01289:Hecw1
|
APN |
13 |
14,438,719 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Hecw1
|
APN |
13 |
14,409,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01783:Hecw1
|
APN |
13 |
14,452,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01941:Hecw1
|
APN |
13 |
14,490,895 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02170:Hecw1
|
APN |
13 |
14,438,743 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL02172:Hecw1
|
APN |
13 |
14,438,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02214:Hecw1
|
APN |
13 |
14,474,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Hecw1
|
APN |
13 |
14,422,923 (GRCm39) |
splice site |
probably null |
|
|
IGL02357:Hecw1
|
APN |
13 |
14,422,923 (GRCm39) |
splice site |
probably null |
|
|
IGL02372:Hecw1
|
APN |
13 |
14,438,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02591:Hecw1
|
APN |
13 |
14,531,821 (GRCm39) |
splice site |
probably benign |
|
|
IGL02718:Hecw1
|
APN |
13 |
14,481,520 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02795:Hecw1
|
APN |
13 |
14,497,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02941:Hecw1
|
APN |
13 |
14,552,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03256:Hecw1
|
APN |
13 |
14,455,070 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL03256:Hecw1
|
APN |
13 |
14,455,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03366:Hecw1
|
APN |
13 |
14,552,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
deflated
|
UTSW |
13 |
14,422,205 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
Demoralized
|
UTSW |
13 |
14,491,403 (GRCm39) |
nonsense |
probably null |
|
|
Letdown
|
UTSW |
13 |
14,491,077 (GRCm39) |
missense |
probably benign |
0.40 |
|
BB001:Hecw1
|
UTSW |
13 |
14,497,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB011:Hecw1
|
UTSW |
13 |
14,497,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03014:Hecw1
|
UTSW |
13 |
14,420,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Hecw1
|
UTSW |
13 |
14,552,368 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0555:Hecw1
|
UTSW |
13 |
14,411,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0617:Hecw1
|
UTSW |
13 |
14,455,027 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1476:Hecw1
|
UTSW |
13 |
14,480,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1479:Hecw1
|
UTSW |
13 |
14,491,077 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1551:Hecw1
|
UTSW |
13 |
14,491,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1579:Hecw1
|
UTSW |
13 |
14,552,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1584:Hecw1
|
UTSW |
13 |
14,515,328 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1735:Hecw1
|
UTSW |
13 |
14,552,350 (GRCm39) |
missense |
probably null |
0.09 |
|
R1872:Hecw1
|
UTSW |
13 |
14,455,034 (GRCm39) |
nonsense |
probably null |
|
|
R1897:Hecw1
|
UTSW |
13 |
14,552,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2054:Hecw1
|
UTSW |
13 |
14,471,998 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2085:Hecw1
|
UTSW |
13 |
14,438,672 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2134:Hecw1
|
UTSW |
13 |
14,552,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2172:Hecw1
|
UTSW |
13 |
14,552,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2258:Hecw1
|
UTSW |
13 |
14,490,723 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2274:Hecw1
|
UTSW |
13 |
14,520,653 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2275:Hecw1
|
UTSW |
13 |
14,520,653 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2937:Hecw1
|
UTSW |
13 |
14,420,421 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3830:Hecw1
|
UTSW |
13 |
14,520,643 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3971:Hecw1
|
UTSW |
13 |
14,411,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4065:Hecw1
|
UTSW |
13 |
14,491,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4066:Hecw1
|
UTSW |
13 |
14,491,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4235:Hecw1
|
UTSW |
13 |
14,491,724 (GRCm39) |
missense |
probably benign |
0.42 |
|
R4366:Hecw1
|
UTSW |
13 |
14,490,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4382:Hecw1
|
UTSW |
13 |
14,490,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4385:Hecw1
|
UTSW |
13 |
14,490,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Hecw1
|
UTSW |
13 |
14,531,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4511:Hecw1
|
UTSW |
13 |
14,531,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4558:Hecw1
|
UTSW |
13 |
14,422,190 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4804:Hecw1
|
UTSW |
13 |
14,480,570 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5104:Hecw1
|
UTSW |
13 |
14,515,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5113:Hecw1
|
UTSW |
13 |
14,520,614 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5167:Hecw1
|
UTSW |
13 |
14,460,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5392:Hecw1
|
UTSW |
13 |
14,420,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Hecw1
|
UTSW |
13 |
14,497,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5504:Hecw1
|
UTSW |
13 |
14,515,487 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5764:Hecw1
|
UTSW |
13 |
14,497,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6038:Hecw1
|
UTSW |
13 |
14,520,647 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6038:Hecw1
|
UTSW |
13 |
14,520,647 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6228:Hecw1
|
UTSW |
13 |
14,520,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6247:Hecw1
|
UTSW |
13 |
14,409,010 (GRCm39) |
nonsense |
probably null |
|
|
R6252:Hecw1
|
UTSW |
13 |
14,446,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6291:Hecw1
|
UTSW |
13 |
14,697,592 (GRCm39) |
unclassified |
probably benign |
|
|
R6321:Hecw1
|
UTSW |
13 |
14,697,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6325:Hecw1
|
UTSW |
13 |
14,491,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6328:Hecw1
|
UTSW |
13 |
14,422,205 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6557:Hecw1
|
UTSW |
13 |
14,491,231 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6566:Hecw1
|
UTSW |
13 |
14,471,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6597:Hecw1
|
UTSW |
13 |
14,491,403 (GRCm39) |
nonsense |
probably null |
|
|
R6821:Hecw1
|
UTSW |
13 |
14,438,719 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6914:Hecw1
|
UTSW |
13 |
14,491,423 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7078:Hecw1
|
UTSW |
13 |
14,609,044 (GRCm39) |
start codon destroyed |
probably null |
0.21 |
|
R7114:Hecw1
|
UTSW |
13 |
14,486,356 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7140:Hecw1
|
UTSW |
13 |
14,491,118 (GRCm39) |
missense |
probably benign |
|
|
R7150:Hecw1
|
UTSW |
13 |
14,609,045 (GRCm39) |
start codon destroyed |
probably benign |
|
|
R7288:Hecw1
|
UTSW |
13 |
14,490,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7447:Hecw1
|
UTSW |
13 |
14,531,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7479:Hecw1
|
UTSW |
13 |
14,515,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7552:Hecw1
|
UTSW |
13 |
14,490,835 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7590:Hecw1
|
UTSW |
13 |
14,438,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7787:Hecw1
|
UTSW |
13 |
14,493,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7803:Hecw1
|
UTSW |
13 |
14,408,927 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7924:Hecw1
|
UTSW |
13 |
14,497,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7967:Hecw1
|
UTSW |
13 |
14,552,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8176:Hecw1
|
UTSW |
13 |
14,422,286 (GRCm39) |
splice site |
probably null |
|
|
R8195:Hecw1
|
UTSW |
13 |
14,480,692 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8252:Hecw1
|
UTSW |
13 |
14,515,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8696:Hecw1
|
UTSW |
13 |
14,531,743 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8827:Hecw1
|
UTSW |
13 |
14,438,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8867:Hecw1
|
UTSW |
13 |
14,422,275 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8914:Hecw1
|
UTSW |
13 |
14,422,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8942:Hecw1
|
UTSW |
13 |
14,481,395 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9126:Hecw1
|
UTSW |
13 |
14,546,608 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9185:Hecw1
|
UTSW |
13 |
14,491,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9203:Hecw1
|
UTSW |
13 |
14,491,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9236:Hecw1
|
UTSW |
13 |
14,490,643 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9291:Hecw1
|
UTSW |
13 |
14,491,522 (GRCm39) |
missense |
probably benign |
|
|
R9312:Hecw1
|
UTSW |
13 |
14,546,567 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9438:Hecw1
|
UTSW |
13 |
14,481,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9502:Hecw1
|
UTSW |
13 |
14,546,567 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9642:Hecw1
|
UTSW |
13 |
14,515,394 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF001:Hecw1
|
UTSW |
13 |
14,472,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0020:Hecw1
|
UTSW |
13 |
14,405,308 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
X0066:Hecw1
|
UTSW |
13 |
14,455,045 (GRCm39) |
missense |
probably benign |
0.13 |
|
Z1176:Hecw1
|
UTSW |
13 |
14,474,918 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGCGGATATAATGGGTTCTCG -3'
(R):5'- ATGTCTCTGAAGCACCCGAAG -3'
Sequencing Primer
(F):5'- GTTCTCGGGGTCTCAGCATC -3'
(R):5'- AGAGCTTCAGGACCCAGAGC -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation