Incidental Mutation 'R4824:Nav2'
| ID |
374215 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nav2
|
| Ensembl Gene |
ENSMUSG00000052512 |
| Gene Name |
neuron navigator 2 |
| Synonyms |
Rainb1, Unc53H2, 5330421F07Rik, POMFIL2, HELAD1, RAINB2 |
| MMRRC Submission |
042440-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.550)
|
| Stock # |
R4824 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
48608796-49259838 bp(+) (GRCm39) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
A to T
at 49058749 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139045
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064395]
[ENSMUST00000183659]
[ENSMUST00000184124]
[ENSMUST00000184945]
|
| AlphaFold |
E9Q842 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000064383
|
| SMART Domains |
Protein: ENSMUSP00000066835
Gene: ENSMUSG00000052512
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:CH
|
18 |
79 |
2e-35 |
BLAST |
|
PDB:2YRN|A
|
18 |
80 |
3e-33 |
PDB |
|
SCOP:d1dxxa1
|
29 |
81 |
4e-15 |
SMART |
|
low complexity region
|
94 |
102 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
202 |
N/A |
INTRINSIC |
|
low complexity region
|
229 |
240 |
N/A |
INTRINSIC |
|
low complexity region
|
304 |
316 |
N/A |
INTRINSIC |
|
coiled coil region
|
378 |
408 |
N/A |
INTRINSIC |
|
low complexity region
|
472 |
483 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
517 |
N/A |
INTRINSIC |
|
low complexity region
|
532 |
554 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000064395
|
| SMART Domains |
Protein: ENSMUSP00000067448
Gene: ENSMUSG00000052512
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
84 |
187 |
1.58e-13 |
SMART |
|
low complexity region
|
202 |
210 |
N/A |
INTRINSIC |
|
low complexity region
|
297 |
310 |
N/A |
INTRINSIC |
|
low complexity region
|
337 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
412 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
486 |
516 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
591 |
N/A |
INTRINSIC |
|
low complexity region
|
613 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
640 |
662 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
947 |
967 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1004 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1074 |
N/A |
INTRINSIC |
|
low complexity region
|
1343 |
1360 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1385 |
N/A |
INTRINSIC |
|
low complexity region
|
1417 |
1432 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1526 |
1540 |
N/A |
INTRINSIC |
|
low complexity region
|
1614 |
1628 |
N/A |
INTRINSIC |
|
coiled coil region
|
1630 |
1717 |
N/A |
INTRINSIC |
|
low complexity region
|
1789 |
1800 |
N/A |
INTRINSIC |
|
coiled coil region
|
1841 |
1909 |
N/A |
INTRINSIC |
|
AAA
|
2093 |
2247 |
1.69e-5 |
SMART |
|
low complexity region
|
2404 |
2430 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183659
|
| SMART Domains |
Protein: ENSMUSP00000139309
Gene: ENSMUSG00000052512
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
11 |
N/A |
INTRINSIC |
|
CH
|
23 |
126 |
6.19e-16 |
SMART |
|
low complexity region
|
141 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
236 |
249 |
N/A |
INTRINSIC |
|
low complexity region
|
276 |
287 |
N/A |
INTRINSIC |
|
low complexity region
|
351 |
363 |
N/A |
INTRINSIC |
|
coiled coil region
|
425 |
455 |
N/A |
INTRINSIC |
|
low complexity region
|
519 |
530 |
N/A |
INTRINSIC |
|
low complexity region
|
552 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
579 |
601 |
N/A |
INTRINSIC |
|
low complexity region
|
785 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
859 |
883 |
N/A |
INTRINSIC |
|
low complexity region
|
886 |
906 |
N/A |
INTRINSIC |
|
low complexity region
|
929 |
943 |
N/A |
INTRINSIC |
|
low complexity region
|
1001 |
1013 |
N/A |
INTRINSIC |
|
low complexity region
|
1282 |
1299 |
N/A |
INTRINSIC |
|
low complexity region
|
1307 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1356 |
1371 |
N/A |
INTRINSIC |
|
low complexity region
|
1393 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1465 |
1479 |
N/A |
INTRINSIC |
|
low complexity region
|
1553 |
1567 |
N/A |
INTRINSIC |
|
coiled coil region
|
1569 |
1656 |
N/A |
INTRINSIC |
|
low complexity region
|
1728 |
1739 |
N/A |
INTRINSIC |
|
coiled coil region
|
1780 |
1848 |
N/A |
INTRINSIC |
|
AAA
|
2032 |
2186 |
1.69e-5 |
SMART |
|
low complexity region
|
2343 |
2369 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184124
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184809
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184928
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184945
|
| SMART Domains |
Protein: ENSMUSP00000139045
Gene: ENSMUSG00000052512
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
84 |
187 |
1.58e-13 |
SMART |
|
low complexity region
|
202 |
210 |
N/A |
INTRINSIC |
|
low complexity region
|
297 |
310 |
N/A |
INTRINSIC |
|
low complexity region
|
337 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
412 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
486 |
516 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
591 |
N/A |
INTRINSIC |
|
low complexity region
|
613 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
640 |
662 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
947 |
967 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1004 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1074 |
N/A |
INTRINSIC |
|
low complexity region
|
1343 |
1360 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1385 |
N/A |
INTRINSIC |
|
low complexity region
|
1417 |
1432 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1526 |
1540 |
N/A |
INTRINSIC |
|
low complexity region
|
1614 |
1628 |
N/A |
INTRINSIC |
|
coiled coil region
|
1630 |
1717 |
N/A |
INTRINSIC |
|
low complexity region
|
1789 |
1800 |
N/A |
INTRINSIC |
|
coiled coil region
|
1841 |
1909 |
N/A |
INTRINSIC |
|
AAA
|
2093 |
2247 |
1.69e-5 |
SMART |
|
low complexity region
|
2404 |
2430 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184955
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000207743
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
98% (123/126) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous null mice display impaired olfaction and hearing, increased latency in a hot plate test, degeneration of the optic nerve, decreased exploration in new environments, and weight loss. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 107 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
G |
3: 137,771,437 (GRCm39) |
T209A |
probably benign |
Het |
| 1700086D15Rik |
T |
C |
11: 65,043,441 (GRCm39) |
|
probably benign |
Het |
| A130010J15Rik |
G |
A |
1: 192,856,965 (GRCm39) |
V106I |
probably benign |
Het |
| Abca16 |
C |
A |
7: 120,074,702 (GRCm39) |
N580K |
possibly damaging |
Het |
| Actrt2 |
A |
T |
4: 154,751,344 (GRCm39) |
F264Y |
probably damaging |
Het |
| Adh4 |
G |
A |
3: 138,134,807 (GRCm39) |
S327N |
possibly damaging |
Het |
| Alkbh5 |
T |
C |
11: 60,444,697 (GRCm39) |
|
probably null |
Het |
| Anapc1 |
T |
A |
2: 128,470,610 (GRCm39) |
T1507S |
possibly damaging |
Het |
| Anapc2 |
A |
G |
2: 25,167,764 (GRCm39) |
R444G |
probably damaging |
Het |
| Apoh |
G |
T |
11: 108,305,087 (GRCm39) |
W335L |
probably benign |
Het |
| B4galt7 |
A |
T |
13: 55,752,162 (GRCm39) |
H71L |
possibly damaging |
Het |
| Bicd2 |
A |
G |
13: 49,532,488 (GRCm39) |
E358G |
probably damaging |
Het |
| Bmper |
T |
A |
9: 23,134,956 (GRCm39) |
V7D |
possibly damaging |
Het |
| Brca2 |
T |
C |
5: 150,463,200 (GRCm39) |
F988S |
probably damaging |
Het |
| Brix1 |
A |
G |
15: 10,485,828 (GRCm39) |
V49A |
possibly damaging |
Het |
| Brpf3 |
T |
C |
17: 29,025,460 (GRCm39) |
S178P |
probably benign |
Het |
| Btaf1 |
A |
G |
19: 36,958,448 (GRCm39) |
Y655C |
possibly damaging |
Het |
| C1rl |
C |
G |
6: 124,486,040 (GRCm39) |
Y470* |
probably null |
Het |
| Cacnb4 |
A |
G |
2: 52,565,822 (GRCm39) |
V21A |
probably benign |
Het |
| Caskin1 |
C |
A |
17: 24,720,103 (GRCm39) |
P437T |
probably benign |
Het |
| Casz1 |
C |
A |
4: 149,029,028 (GRCm39) |
P1158T |
probably damaging |
Het |
| Ccdc141 |
T |
A |
2: 76,954,680 (GRCm39) |
Q189L |
probably damaging |
Het |
| Ccr3 |
T |
C |
9: 123,828,809 (GRCm39) |
V48A |
probably damaging |
Het |
| Cebpd |
G |
A |
16: 15,705,978 (GRCm39) |
G264S |
probably benign |
Het |
| Cert1 |
C |
T |
13: 96,752,995 (GRCm39) |
P350S |
probably benign |
Het |
| Cfap20dc |
A |
T |
14: 8,665,997 (GRCm38) |
M1K |
probably null |
Het |
| Chd1 |
C |
A |
17: 15,953,386 (GRCm39) |
S440R |
probably damaging |
Het |
| Clip1 |
T |
A |
5: 123,769,086 (GRCm39) |
E504D |
probably damaging |
Het |
| Cmya5 |
T |
C |
13: 93,230,082 (GRCm39) |
R1669G |
probably benign |
Het |
| Col11a2 |
T |
A |
17: 34,269,937 (GRCm39) |
F456I |
probably damaging |
Het |
| Ctnna2 |
A |
T |
6: 76,957,764 (GRCm39) |
M130K |
probably damaging |
Het |
| Elmo2 |
A |
T |
2: 165,133,922 (GRCm39) |
|
probably benign |
Het |
| F11 |
T |
C |
8: 45,708,379 (GRCm39) |
D27G |
probably damaging |
Het |
| Faap100 |
A |
T |
11: 120,266,412 (GRCm39) |
|
probably null |
Het |
| Fat1 |
A |
G |
8: 45,442,151 (GRCm39) |
E1151G |
probably damaging |
Het |
| Fbll1 |
T |
A |
11: 35,688,652 (GRCm39) |
I204F |
probably damaging |
Het |
| Gle1 |
T |
A |
2: 29,830,215 (GRCm39) |
V257D |
possibly damaging |
Het |
| Hoxc9 |
T |
A |
15: 102,890,225 (GRCm39) |
C47* |
probably null |
Het |
| Hsd17b6 |
A |
G |
10: 127,829,524 (GRCm39) |
V226A |
probably benign |
Het |
| Hsd17b7 |
C |
T |
1: 169,788,764 (GRCm39) |
R151Q |
probably benign |
Het |
| Hsh2d |
G |
A |
8: 72,954,304 (GRCm39) |
D229N |
probably benign |
Het |
| Ido2 |
A |
G |
8: 25,023,875 (GRCm39) |
I321T |
probably benign |
Het |
| Irf2bp2 |
T |
C |
8: 127,318,172 (GRCm39) |
T465A |
probably benign |
Het |
| Kdm2a |
A |
G |
19: 4,412,815 (GRCm39) |
M34T |
probably damaging |
Het |
| Klhl6 |
C |
T |
16: 19,775,778 (GRCm39) |
R260H |
probably damaging |
Het |
| Kntc1 |
T |
A |
5: 123,928,196 (GRCm39) |
L1231* |
probably null |
Het |
| Lca5l |
A |
C |
16: 95,963,229 (GRCm39) |
Y412* |
probably null |
Het |
| Lipt1 |
T |
C |
1: 37,914,513 (GRCm39) |
S190P |
possibly damaging |
Het |
| Ly6f |
T |
A |
15: 75,143,569 (GRCm39) |
V92D |
probably damaging |
Het |
| Matn4 |
T |
A |
2: 164,235,151 (GRCm39) |
M433L |
probably benign |
Het |
| Mbtd1 |
C |
A |
11: 93,816,528 (GRCm39) |
P370T |
probably benign |
Het |
| Mcph1 |
T |
A |
8: 18,682,703 (GRCm39) |
|
probably null |
Het |
| Muc5b |
T |
A |
7: 141,417,922 (GRCm39) |
C3623S |
probably damaging |
Het |
| Myt1l |
C |
A |
12: 29,899,399 (GRCm39) |
H134N |
probably benign |
Het |
| Ndufaf8 |
T |
C |
11: 119,989,992 (GRCm39) |
C35R |
probably damaging |
Het |
| Neb |
G |
A |
2: 52,094,891 (GRCm39) |
T5130I |
possibly damaging |
Het |
| Nlrp9c |
T |
C |
7: 26,079,989 (GRCm39) |
N624S |
possibly damaging |
Het |
| Nr0b2 |
C |
A |
4: 133,283,334 (GRCm39) |
H190Q |
probably damaging |
Het |
| Nrg4 |
A |
G |
9: 55,156,405 (GRCm39) |
|
probably benign |
Het |
| Nup88 |
A |
T |
11: 70,852,450 (GRCm39) |
V215E |
probably benign |
Het |
| Oas2 |
T |
G |
5: 120,876,411 (GRCm39) |
T511P |
probably benign |
Het |
| Or1e25 |
A |
G |
11: 73,493,426 (GRCm39) |
T7A |
possibly damaging |
Het |
| Or2t6 |
A |
G |
14: 14,175,885 (GRCm38) |
S66P |
probably damaging |
Het |
| Or5d14 |
A |
C |
2: 87,880,432 (GRCm39) |
F179V |
probably damaging |
Het |
| Or5w8 |
T |
C |
2: 87,687,621 (GRCm39) |
V34A |
probably benign |
Het |
| Or8g26 |
A |
G |
9: 39,095,501 (GRCm39) |
N9S |
probably benign |
Het |
| Or9q1 |
A |
C |
19: 13,805,718 (GRCm39) |
L14R |
probably damaging |
Het |
| Pcdhgb2 |
T |
A |
18: 37,823,502 (GRCm39) |
N164K |
probably damaging |
Het |
| Pde4d |
C |
G |
13: 109,253,400 (GRCm39) |
P76A |
probably benign |
Het |
| Phlda1 |
T |
C |
10: 111,343,516 (GRCm39) |
|
probably benign |
Het |
| Plekhh1 |
A |
G |
12: 79,101,577 (GRCm39) |
T216A |
probably benign |
Het |
| Plppr3 |
T |
A |
10: 79,701,507 (GRCm39) |
E445V |
possibly damaging |
Het |
| Prom1 |
A |
G |
5: 44,191,732 (GRCm39) |
V337A |
probably damaging |
Het |
| Prr14l |
T |
C |
5: 33,001,743 (GRCm39) |
|
probably benign |
Het |
| Psmd1 |
A |
G |
1: 86,064,820 (GRCm39) |
I951V |
probably benign |
Het |
| Rab35 |
T |
G |
5: 115,781,454 (GRCm39) |
I85M |
possibly damaging |
Het |
| Rad9a |
A |
T |
19: 4,250,536 (GRCm39) |
S93T |
probably benign |
Het |
| Ric1 |
G |
A |
19: 29,563,242 (GRCm39) |
C555Y |
probably damaging |
Het |
| Rnd2 |
C |
T |
11: 101,359,825 (GRCm39) |
L57F |
probably damaging |
Het |
| Ror2 |
T |
A |
13: 53,264,719 (GRCm39) |
Q791L |
probably benign |
Het |
| Rps8 |
G |
C |
4: 117,012,352 (GRCm39) |
|
probably benign |
Het |
| Sdr16c5 |
C |
T |
4: 4,016,216 (GRCm39) |
W70* |
probably null |
Het |
| Senp3 |
A |
G |
11: 69,568,821 (GRCm39) |
V408A |
probably benign |
Het |
| Sh2d4b |
C |
A |
14: 40,562,301 (GRCm39) |
W288L |
probably benign |
Het |
| Slc38a9 |
A |
T |
13: 112,859,832 (GRCm39) |
D422V |
probably damaging |
Het |
| Slc4a2 |
T |
C |
5: 24,645,141 (GRCm39) |
F1104L |
probably damaging |
Het |
| Slc4a3 |
A |
G |
1: 75,527,267 (GRCm39) |
K113E |
possibly damaging |
Het |
| Spata3 |
G |
A |
1: 85,952,048 (GRCm39) |
|
probably null |
Het |
| Spata31d1d |
A |
T |
13: 59,877,055 (GRCm39) |
V160E |
possibly damaging |
Het |
| Sprr2f |
A |
G |
3: 92,273,203 (GRCm39) |
M1V |
probably null |
Het |
| Sptbn1 |
A |
G |
11: 30,068,295 (GRCm39) |
V1733A |
possibly damaging |
Het |
| Syce1 |
C |
A |
7: 140,359,809 (GRCm39) |
L83F |
probably damaging |
Het |
| Tardbp |
A |
G |
4: 148,702,050 (GRCm39) |
I295T |
probably benign |
Het |
| Tmem212 |
A |
G |
3: 27,939,157 (GRCm39) |
S110P |
probably damaging |
Het |
| Tnc |
G |
A |
4: 63,935,857 (GRCm39) |
Q360* |
probably null |
Het |
| Tnrc6c |
C |
A |
11: 117,613,731 (GRCm39) |
Q630K |
probably damaging |
Het |
| Ttc19 |
G |
A |
11: 62,199,922 (GRCm39) |
R235H |
probably benign |
Het |
| Ube3b |
T |
A |
5: 114,553,787 (GRCm39) |
|
probably null |
Het |
| Vmn2r31 |
C |
T |
7: 7,390,062 (GRCm39) |
|
probably null |
Het |
| Vmn2r92 |
T |
A |
17: 18,372,183 (GRCm39) |
|
probably benign |
Het |
| Washc5 |
A |
T |
15: 59,205,485 (GRCm39) |
Y685* |
probably null |
Het |
| Wdr93 |
T |
A |
7: 79,399,817 (GRCm39) |
Y135* |
probably null |
Het |
| Wdr95 |
T |
A |
5: 149,518,797 (GRCm39) |
I546K |
probably damaging |
Het |
| Zbtb38 |
T |
A |
9: 96,570,254 (GRCm39) |
T277S |
probably benign |
Het |
| Zfp13 |
T |
C |
17: 23,795,797 (GRCm39) |
D258G |
possibly damaging |
Het |
| Zfp397 |
T |
A |
18: 24,093,249 (GRCm39) |
S245T |
probably benign |
Het |
| Zfp646 |
T |
C |
7: 127,482,907 (GRCm39) |
Y1695H |
probably benign |
Het |
|
| Other mutations in Nav2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Nav2
|
APN |
7 |
49,220,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01150:Nav2
|
APN |
7 |
49,102,269 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01649:Nav2
|
APN |
7 |
49,225,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01662:Nav2
|
APN |
7 |
49,220,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02297:Nav2
|
APN |
7 |
49,243,977 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02313:Nav2
|
APN |
7 |
49,208,521 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02441:Nav2
|
APN |
7 |
49,102,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02472:Nav2
|
APN |
7 |
49,195,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02477:Nav2
|
APN |
7 |
49,232,623 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02725:Nav2
|
APN |
7 |
49,214,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02944:Nav2
|
APN |
7 |
49,070,004 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02953:Nav2
|
APN |
7 |
49,198,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03105:Nav2
|
APN |
7 |
49,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03234:Nav2
|
APN |
7 |
49,111,756 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03274:Nav2
|
APN |
7 |
49,011,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03294:Nav2
|
APN |
7 |
49,141,205 (GRCm39) |
nonsense |
probably null |
|
|
R0006:Nav2
|
UTSW |
7 |
49,102,978 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R0070:Nav2
|
UTSW |
7 |
49,220,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0113:Nav2
|
UTSW |
7 |
49,185,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0306:Nav2
|
UTSW |
7 |
49,195,651 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0346:Nav2
|
UTSW |
7 |
49,254,333 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0539:Nav2
|
UTSW |
7 |
49,111,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0669:Nav2
|
UTSW |
7 |
49,058,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0785:Nav2
|
UTSW |
7 |
49,070,081 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0970:Nav2
|
UTSW |
7 |
49,233,901 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1162:Nav2
|
UTSW |
7 |
49,185,788 (GRCm39) |
splice site |
probably benign |
|
|
R1274:Nav2
|
UTSW |
7 |
49,254,178 (GRCm39) |
nonsense |
probably null |
|
|
R1463:Nav2
|
UTSW |
7 |
49,185,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1464:Nav2
|
UTSW |
7 |
49,011,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1464:Nav2
|
UTSW |
7 |
49,011,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1536:Nav2
|
UTSW |
7 |
49,195,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1612:Nav2
|
UTSW |
7 |
49,220,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Nav2
|
UTSW |
7 |
49,102,213 (GRCm39) |
missense |
probably benign |
|
|
R1731:Nav2
|
UTSW |
7 |
49,197,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1734:Nav2
|
UTSW |
7 |
49,225,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1865:Nav2
|
UTSW |
7 |
49,197,943 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1945:Nav2
|
UTSW |
7 |
49,114,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1997:Nav2
|
UTSW |
7 |
49,198,219 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2061:Nav2
|
UTSW |
7 |
49,248,645 (GRCm39) |
splice site |
probably benign |
|
|
R2117:Nav2
|
UTSW |
7 |
49,114,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2174:Nav2
|
UTSW |
7 |
49,102,411 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2182:Nav2
|
UTSW |
7 |
49,247,002 (GRCm39) |
missense |
probably benign |
0.38 |
|
R2251:Nav2
|
UTSW |
7 |
49,103,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2283:Nav2
|
UTSW |
7 |
49,141,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2343:Nav2
|
UTSW |
7 |
49,248,565 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R2472:Nav2
|
UTSW |
7 |
49,058,632 (GRCm39) |
missense |
probably benign |
|
|
R2568:Nav2
|
UTSW |
7 |
49,247,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2656:Nav2
|
UTSW |
7 |
49,195,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2964:Nav2
|
UTSW |
7 |
49,206,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2966:Nav2
|
UTSW |
7 |
49,206,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3817:Nav2
|
UTSW |
7 |
49,114,310 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3834:Nav2
|
UTSW |
7 |
49,195,606 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4207:Nav2
|
UTSW |
7 |
49,246,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4207:Nav2
|
UTSW |
7 |
49,222,046 (GRCm39) |
splice site |
probably null |
|
|
R4411:Nav2
|
UTSW |
7 |
49,047,857 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4413:Nav2
|
UTSW |
7 |
49,047,857 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4440:Nav2
|
UTSW |
7 |
49,225,011 (GRCm39) |
splice site |
probably benign |
|
|
R4440:Nav2
|
UTSW |
7 |
49,201,785 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4454:Nav2
|
UTSW |
7 |
49,198,292 (GRCm39) |
splice site |
probably null |
|
|
R4729:Nav2
|
UTSW |
7 |
49,102,567 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4801:Nav2
|
UTSW |
7 |
49,195,600 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4802:Nav2
|
UTSW |
7 |
49,195,600 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4887:Nav2
|
UTSW |
7 |
49,198,182 (GRCm39) |
nonsense |
probably null |
|
|
R4908:Nav2
|
UTSW |
7 |
49,254,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4952:Nav2
|
UTSW |
7 |
48,954,288 (GRCm39) |
intron |
probably benign |
|
|
R4965:Nav2
|
UTSW |
7 |
49,202,625 (GRCm39) |
nonsense |
probably null |
|
|
R5169:Nav2
|
UTSW |
7 |
49,198,231 (GRCm39) |
nonsense |
probably null |
|
|
R5224:Nav2
|
UTSW |
7 |
49,201,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5249:Nav2
|
UTSW |
7 |
49,185,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5285:Nav2
|
UTSW |
7 |
49,197,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5314:Nav2
|
UTSW |
7 |
49,058,440 (GRCm39) |
small deletion |
probably benign |
|
|
R5320:Nav2
|
UTSW |
7 |
49,141,121 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5377:Nav2
|
UTSW |
7 |
49,238,908 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5471:Nav2
|
UTSW |
7 |
49,197,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5754:Nav2
|
UTSW |
7 |
49,206,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Nav2
|
UTSW |
7 |
49,197,817 (GRCm39) |
splice site |
probably null |
|
|
R5884:Nav2
|
UTSW |
7 |
49,246,917 (GRCm39) |
nonsense |
probably null |
|
|
R5921:Nav2
|
UTSW |
7 |
48,954,324 (GRCm39) |
intron |
probably benign |
|
|
R6180:Nav2
|
UTSW |
7 |
49,107,915 (GRCm39) |
missense |
probably benign |
0.39 |
|
R6208:Nav2
|
UTSW |
7 |
49,213,851 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6373:Nav2
|
UTSW |
7 |
49,102,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6450:Nav2
|
UTSW |
7 |
49,244,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6522:Nav2
|
UTSW |
7 |
49,247,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6626:Nav2
|
UTSW |
7 |
49,244,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6695:Nav2
|
UTSW |
7 |
49,114,652 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6705:Nav2
|
UTSW |
7 |
49,201,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6842:Nav2
|
UTSW |
7 |
49,107,917 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6847:Nav2
|
UTSW |
7 |
49,141,204 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7287:Nav2
|
UTSW |
7 |
49,070,076 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7312:Nav2
|
UTSW |
7 |
49,111,672 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7315:Nav2
|
UTSW |
7 |
49,198,037 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7337:Nav2
|
UTSW |
7 |
49,201,521 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7366:Nav2
|
UTSW |
7 |
49,203,951 (GRCm39) |
splice site |
probably null |
|
|
R7451:Nav2
|
UTSW |
7 |
49,202,577 (GRCm39) |
splice site |
probably null |
|
|
R7545:Nav2
|
UTSW |
7 |
49,232,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7706:Nav2
|
UTSW |
7 |
49,244,067 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7730:Nav2
|
UTSW |
7 |
49,222,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7812:Nav2
|
UTSW |
7 |
49,246,921 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8097:Nav2
|
UTSW |
7 |
49,237,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8110:Nav2
|
UTSW |
7 |
49,201,698 (GRCm39) |
nonsense |
probably null |
|
|
R8119:Nav2
|
UTSW |
7 |
49,103,232 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8298:Nav2
|
UTSW |
7 |
49,204,009 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8306:Nav2
|
UTSW |
7 |
49,195,765 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8331:Nav2
|
UTSW |
7 |
49,102,371 (GRCm39) |
missense |
probably benign |
|
|
R8402:Nav2
|
UTSW |
7 |
49,103,185 (GRCm39) |
missense |
probably benign |
0.43 |
|
R8421:Nav2
|
UTSW |
7 |
49,102,269 (GRCm39) |
missense |
probably benign |
|
|
R8478:Nav2
|
UTSW |
7 |
49,111,733 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8724:Nav2
|
UTSW |
7 |
49,141,184 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8753:Nav2
|
UTSW |
7 |
49,102,320 (GRCm39) |
missense |
probably benign |
|
|
R8835:Nav2
|
UTSW |
7 |
49,248,551 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8933:Nav2
|
UTSW |
7 |
49,111,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8957:Nav2
|
UTSW |
7 |
49,220,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9069:Nav2
|
UTSW |
7 |
49,208,561 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9095:Nav2
|
UTSW |
7 |
49,254,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Nav2
|
UTSW |
7 |
49,202,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9261:Nav2
|
UTSW |
7 |
49,246,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Nav2
|
UTSW |
7 |
49,197,647 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
Z1177:Nav2
|
UTSW |
7 |
49,243,971 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Nav2
|
UTSW |
7 |
49,102,509 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAACCTCAAGGCCATTCTAGG -3'
(R):5'- CGTCATGGGCATTTCTACTGG -3'
Sequencing Primer
(F):5'- TGGCACTCCTCAGCATCAG -3'
(R):5'- CTGGACTTTCTCCTGAATCAAAAGC -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation