Incidental Mutation 'R0280:Or4g16'
ID 37439
Institutional Source Beutler Lab
Gene Symbol Or4g16
Ensembl Gene ENSMUSG00000109813
Gene Name olfactory receptor family 4 subfamily G member 16
Synonyms Olfr1279, MOR245-12, GA_x6K02T2Q125-72357646-72358581
MMRRC Submission 038502-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.186) question?
Stock # R0280 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 111136546-111137487 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 111137417 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 289 (F289S)
Ref Sequence ENSEMBL: ENSMUSP00000149972 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062407] [ENSMUST00000090329] [ENSMUST00000213823] [ENSMUST00000216697]
AlphaFold Q8VF38
Predicted Effect
SMART Domains Protein: ENSMUSP00000052153
Gene: ENSMUSG00000108931
AA Change: F289S

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 7.2e-45 PFAM
Pfam:7TM_GPCR_Srsx 34 302 2.4e-5 PFAM
Pfam:7tm_1 41 287 2e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000090329
AA Change: F291S

PolyPhen 2 Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000087801
Gene: ENSMUSG00000109813
AA Change: F291S

DomainStartEndE-ValueType
Pfam:7tm_4 33 306 1.7e-44 PFAM
Pfam:7TM_GPCR_Srsx 36 300 3.2e-5 PFAM
Pfam:7tm_1 43 289 7.4e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213823
AA Change: F289S

PolyPhen 2 Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216697
AA Change: F289S

PolyPhen 2 Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 96.9%
  • 20x: 94.6%
Validation Efficiency 96% (55/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg3 T A 17: 57,192,169 (GRCm39) Y577* probably null Het
Adam18 C T 8: 25,164,070 (GRCm39) G38R probably benign Het
Ankrd16 T G 2: 11,786,312 (GRCm39) V187G probably damaging Het
Ccdc110 A T 8: 46,396,487 (GRCm39) N793Y probably benign Het
Ccdc170 T C 10: 4,508,663 (GRCm39) I629T possibly damaging Het
Clcn6 A G 4: 148,093,172 (GRCm39) L836P probably damaging Het
Colgalt2 G T 1: 152,384,312 (GRCm39) A551S possibly damaging Het
Crocc T C 4: 140,755,737 (GRCm39) E1097G probably damaging Het
Csmd1 A T 8: 16,321,616 (GRCm39) V494E probably damaging Het
Drg1 A T 11: 3,206,537 (GRCm39) probably null Het
Dscam T C 16: 96,840,206 (GRCm39) K134E possibly damaging Het
Dyrk1b T C 7: 27,883,737 (GRCm39) Y198H probably damaging Het
Esr1 A G 10: 4,806,951 (GRCm39) D289G probably benign Het
Esr1 G T 10: 4,889,289 (GRCm39) V396F probably damaging Het
Evi5l T C 8: 4,243,133 (GRCm39) V339A probably damaging Het
Fat4 A T 3: 38,944,965 (GRCm39) Q1286L probably benign Het
Fcsk A T 8: 111,621,380 (GRCm39) V188D probably damaging Het
Frem1 T C 4: 82,887,681 (GRCm39) H1118R probably damaging Het
Fut9 C T 4: 25,619,852 (GRCm39) D321N probably benign Het
Gaa T G 11: 119,175,373 (GRCm39) V917G probably damaging Het
Gm973 GCC GC 1: 59,583,839 (GRCm39) probably null Het
Kidins220 A G 12: 25,060,140 (GRCm39) T767A probably damaging Het
Kif7 A G 7: 79,348,571 (GRCm39) S1257P probably benign Het
Ltn1 A G 16: 87,194,726 (GRCm39) L1391P probably damaging Het
Mast3 A G 8: 71,240,564 (GRCm39) V291A possibly damaging Het
Mast3 A G 8: 71,236,439 (GRCm39) Y681H probably damaging Het
Metrn C T 17: 26,014,109 (GRCm39) R239H probably benign Het
Mphosph10 C A 7: 64,026,451 (GRCm39) K666N possibly damaging Het
Mtbp C T 15: 55,449,857 (GRCm39) T433I probably benign Het
Mtmr2 A G 9: 13,710,545 (GRCm39) K365E probably damaging Het
Nanog A G 6: 122,690,357 (GRCm39) D229G probably damaging Het
Nkapd1 T C 9: 50,520,679 (GRCm39) T123A probably damaging Het
Npepps T C 11: 97,131,840 (GRCm39) N338S possibly damaging Het
Nphp4 T A 4: 152,636,393 (GRCm39) probably benign Het
Odad4 A T 11: 100,441,091 (GRCm39) K107N probably damaging Het
Plcl2 A G 17: 50,914,062 (GRCm39) E357G probably damaging Het
Polb A T 8: 23,130,408 (GRCm39) Y173N probably damaging Het
R3hdm1 T A 1: 128,090,512 (GRCm39) S74T probably benign Het
Raet1d T A 10: 22,246,782 (GRCm39) C37S probably damaging Het
Reln G A 5: 22,432,511 (GRCm39) probably benign Het
Rps6kc1 T C 1: 190,541,197 (GRCm39) S369G probably damaging Het
Sgf29 A G 7: 126,270,743 (GRCm39) E108G probably benign Het
Sh3tc1 A G 5: 35,863,361 (GRCm39) L942P probably damaging Het
Slc22a27 A T 19: 7,874,187 (GRCm39) L188* probably null Het
Slc9a3 T A 13: 74,307,543 (GRCm39) I445N probably damaging Het
Sufu A T 19: 46,439,112 (GRCm39) probably benign Het
Tomm40 G A 7: 19,447,676 (GRCm39) T118I probably damaging Het
Ttn C T 2: 76,570,823 (GRCm39) R26690H probably damaging Het
Vmn2r16 A G 5: 109,488,005 (GRCm39) I293V possibly damaging Het
Vmn2r68 T A 7: 84,882,457 (GRCm39) probably benign Het
Vmn2r68 C G 7: 84,882,466 (GRCm39) probably null Het
Vsig8 A G 1: 172,389,105 (GRCm39) D119G probably benign Het
Other mutations in Or4g16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01095:Or4g16 APN 2 111,136,966 (GRCm39) missense probably benign 0.19
IGL01355:Or4g16 APN 2 111,137,438 (GRCm39) missense probably benign 0.00
IGL01864:Or4g16 APN 2 111,137,400 (GRCm39) missense probably damaging 1.00
IGL02160:Or4g16 APN 2 111,137,143 (GRCm39) missense probably benign 0.02
IGL02183:Or4g16 APN 2 111,136,763 (GRCm39) missense probably damaging 0.98
PIT4377001:Or4g16 UTSW 2 111,137,225 (GRCm39) missense probably damaging 1.00
R0636:Or4g16 UTSW 2 111,136,757 (GRCm39) missense probably benign 0.06
R0732:Or4g16 UTSW 2 111,137,325 (GRCm39) nonsense probably null
R1661:Or4g16 UTSW 2 111,137,116 (GRCm39) missense probably damaging 1.00
R1665:Or4g16 UTSW 2 111,137,116 (GRCm39) missense probably damaging 1.00
R2251:Or4g16 UTSW 2 111,136,655 (GRCm39) missense probably damaging 1.00
R2252:Or4g16 UTSW 2 111,136,655 (GRCm39) missense probably damaging 1.00
R2253:Or4g16 UTSW 2 111,136,655 (GRCm39) missense probably damaging 1.00
R2473:Or4g16 UTSW 2 111,137,236 (GRCm39) missense probably damaging 1.00
R3408:Or4g16 UTSW 2 111,136,850 (GRCm39) missense probably damaging 1.00
R5020:Or4g16 UTSW 2 111,136,637 (GRCm39) missense probably benign 0.01
R5634:Or4g16 UTSW 2 111,137,437 (GRCm39) missense probably benign
R5647:Or4g16 UTSW 2 111,137,392 (GRCm39) missense possibly damaging 0.67
R6782:Or4g16 UTSW 2 111,137,090 (GRCm39) missense probably damaging 1.00
R6911:Or4g16 UTSW 2 111,136,618 (GRCm39) missense probably benign 0.00
R7135:Or4g16 UTSW 2 111,137,365 (GRCm39) missense probably benign 0.05
R7167:Or4g16 UTSW 2 111,136,793 (GRCm39) missense probably benign 0.10
R7452:Or4g16 UTSW 2 111,137,266 (GRCm39) missense probably damaging 1.00
R7563:Or4g16 UTSW 2 111,137,134 (GRCm39) missense probably benign 0.00
R7582:Or4g16 UTSW 2 111,136,793 (GRCm39) missense probably damaging 0.97
R8949:Or4g16 UTSW 2 111,137,379 (GRCm39) missense probably damaging 1.00
X0021:Or4g16 UTSW 2 111,136,933 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCGACTTCCCTCGGATCATACAAC -3'
(R):5'- ACTAGGTTTTGTCACCTGCTGCTG -3'

Sequencing Primer
(F):5'- TCGGATCATACAACTGGCGTG -3'
(R):5'- TCTGCTACAAACAGCCCTTT -3'
Posted On 2013-05-23