Incidental Mutation 'R4855:Herc4'
| ID |
374547 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Herc4
|
| Ensembl Gene |
ENSMUSG00000020064 |
| Gene Name |
hect domain and RLD 4 |
| Synonyms |
4921531D01Rik, 1700056O17Rik, 9530080M15Rik |
| MMRRC Submission |
042466-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.867)
|
| Stock # |
R4855 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
63079589-63153657 bp(+) (GRCm39) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
A to G
at 63151437 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000151886
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020257]
[ENSMUST00000020258]
[ENSMUST00000020258]
[ENSMUST00000020258]
[ENSMUST00000020258]
[ENSMUST00000105442]
[ENSMUST00000120239]
[ENSMUST00000146028]
[ENSMUST00000177694]
[ENSMUST00000219577]
[ENSMUST00000219577]
|
| AlphaFold |
Q6PAV2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020257
|
| SMART Domains |
Protein: ENSMUSP00000020257
Gene: ENSMUSG00000020063
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
46 |
94 |
N/A |
INTRINSIC |
|
low complexity region
|
108 |
131 |
N/A |
INTRINSIC |
|
low complexity region
|
136 |
148 |
N/A |
INTRINSIC |
|
Pfam:SIR2
|
253 |
439 |
1.3e-62 |
PFAM |
|
PDB:4KXQ|B
|
629 |
648 |
4e-6 |
PDB |
|
low complexity region
|
649 |
667 |
N/A |
INTRINSIC |
|
low complexity region
|
672 |
687 |
N/A |
INTRINSIC |
|
low complexity region
|
702 |
713 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000020258
|
| SMART Domains |
Protein: ENSMUSP00000020258
Gene: ENSMUSG00000020064
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
1 |
49 |
5.1e-11 |
PFAM |
|
Pfam:RCC1_2
|
36 |
65 |
1.2e-9 |
PFAM |
|
Pfam:RCC1
|
52 |
99 |
7.9e-16 |
PFAM |
|
Pfam:RCC1_2
|
86 |
115 |
2.8e-11 |
PFAM |
|
Pfam:RCC1
|
102 |
152 |
7.6e-18 |
PFAM |
|
Pfam:RCC1_2
|
139 |
168 |
9.9e-14 |
PFAM |
|
Pfam:RCC1
|
156 |
205 |
2.2e-15 |
PFAM |
|
Pfam:RCC1_2
|
194 |
221 |
4.9e-10 |
PFAM |
|
Pfam:RCC1
|
208 |
257 |
3.5e-17 |
PFAM |
|
Pfam:RCC1
|
260 |
309 |
9.4e-14 |
PFAM |
|
Pfam:RCC1
|
313 |
376 |
2.7e-8 |
PFAM |
|
HECTc
|
720 |
1049 |
1.19e-135 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000020258
|
| SMART Domains |
Protein: ENSMUSP00000020258
Gene: ENSMUSG00000020064
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
1 |
49 |
5.1e-11 |
PFAM |
|
Pfam:RCC1_2
|
36 |
65 |
1.2e-9 |
PFAM |
|
Pfam:RCC1
|
52 |
99 |
7.9e-16 |
PFAM |
|
Pfam:RCC1_2
|
86 |
115 |
2.8e-11 |
PFAM |
|
Pfam:RCC1
|
102 |
152 |
7.6e-18 |
PFAM |
|
Pfam:RCC1_2
|
139 |
168 |
9.9e-14 |
PFAM |
|
Pfam:RCC1
|
156 |
205 |
2.2e-15 |
PFAM |
|
Pfam:RCC1_2
|
194 |
221 |
4.9e-10 |
PFAM |
|
Pfam:RCC1
|
208 |
257 |
3.5e-17 |
PFAM |
|
Pfam:RCC1
|
260 |
309 |
9.4e-14 |
PFAM |
|
Pfam:RCC1
|
313 |
376 |
2.7e-8 |
PFAM |
|
HECTc
|
720 |
1049 |
1.19e-135 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000020258
|
| SMART Domains |
Protein: ENSMUSP00000020258
Gene: ENSMUSG00000020064
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
1 |
49 |
5.1e-11 |
PFAM |
|
Pfam:RCC1_2
|
36 |
65 |
1.2e-9 |
PFAM |
|
Pfam:RCC1
|
52 |
99 |
7.9e-16 |
PFAM |
|
Pfam:RCC1_2
|
86 |
115 |
2.8e-11 |
PFAM |
|
Pfam:RCC1
|
102 |
152 |
7.6e-18 |
PFAM |
|
Pfam:RCC1_2
|
139 |
168 |
9.9e-14 |
PFAM |
|
Pfam:RCC1
|
156 |
205 |
2.2e-15 |
PFAM |
|
Pfam:RCC1_2
|
194 |
221 |
4.9e-10 |
PFAM |
|
Pfam:RCC1
|
208 |
257 |
3.5e-17 |
PFAM |
|
Pfam:RCC1
|
260 |
309 |
9.4e-14 |
PFAM |
|
Pfam:RCC1
|
313 |
376 |
2.7e-8 |
PFAM |
|
HECTc
|
720 |
1049 |
1.19e-135 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000020258
|
| SMART Domains |
Protein: ENSMUSP00000020258
Gene: ENSMUSG00000020064
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
1 |
49 |
5.1e-11 |
PFAM |
|
Pfam:RCC1_2
|
36 |
65 |
1.2e-9 |
PFAM |
|
Pfam:RCC1
|
52 |
99 |
7.9e-16 |
PFAM |
|
Pfam:RCC1_2
|
86 |
115 |
2.8e-11 |
PFAM |
|
Pfam:RCC1
|
102 |
152 |
7.6e-18 |
PFAM |
|
Pfam:RCC1_2
|
139 |
168 |
9.9e-14 |
PFAM |
|
Pfam:RCC1
|
156 |
205 |
2.2e-15 |
PFAM |
|
Pfam:RCC1_2
|
194 |
221 |
4.9e-10 |
PFAM |
|
Pfam:RCC1
|
208 |
257 |
3.5e-17 |
PFAM |
|
Pfam:RCC1
|
260 |
309 |
9.4e-14 |
PFAM |
|
Pfam:RCC1
|
313 |
376 |
2.7e-8 |
PFAM |
|
HECTc
|
720 |
1049 |
1.19e-135 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105442
|
| SMART Domains |
Protein: ENSMUSP00000101082
Gene: ENSMUSG00000020063
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
46 |
94 |
N/A |
INTRINSIC |
|
low complexity region
|
108 |
131 |
N/A |
INTRINSIC |
|
Pfam:SIR2
|
214 |
400 |
4e-63 |
PFAM |
|
PDB:4KXQ|B
|
590 |
609 |
3e-6 |
PDB |
|
low complexity region
|
610 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
633 |
648 |
N/A |
INTRINSIC |
|
low complexity region
|
663 |
674 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000120239
|
| SMART Domains |
Protein: ENSMUSP00000112595
Gene: ENSMUSG00000020063
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
46 |
94 |
N/A |
INTRINSIC |
|
low complexity region
|
108 |
131 |
N/A |
INTRINSIC |
|
low complexity region
|
136 |
148 |
N/A |
INTRINSIC |
|
Pfam:SIR2
|
253 |
439 |
6.5e-64 |
PFAM |
|
PDB:4KXQ|B
|
629 |
648 |
4e-6 |
PDB |
|
low complexity region
|
649 |
667 |
N/A |
INTRINSIC |
|
low complexity region
|
672 |
687 |
N/A |
INTRINSIC |
|
low complexity region
|
702 |
713 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146028
|
| SMART Domains |
Protein: ENSMUSP00000117819
Gene: ENSMUSG00000020063
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:SIR2
|
83 |
140 |
1.9e-15 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177694
|
| SMART Domains |
Protein: ENSMUSP00000137565
Gene: ENSMUSG00000020063
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
46 |
94 |
N/A |
INTRINSIC |
|
low complexity region
|
108 |
131 |
N/A |
INTRINSIC |
|
low complexity region
|
136 |
148 |
N/A |
INTRINSIC |
|
Pfam:SIR2
|
253 |
439 |
7.3e-63 |
PFAM |
|
low complexity region
|
465 |
483 |
N/A |
INTRINSIC |
|
low complexity region
|
488 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
518 |
529 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219002
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000219577
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000219577
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219789
|
| Meta Mutation Damage Score |
0.9496 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.5%
|
| Validation Efficiency |
98% (93/95) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a gene-trapped allele display reduced male fertility associated with a high percentage of angulated sperm tails and impaired sperm motility. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| Ablim2 |
C |
T |
5: 35,959,766 (GRCm39) |
R73C |
possibly damaging |
Het |
| Adad1 |
G |
T |
3: 37,139,260 (GRCm39) |
L443F |
probably damaging |
Het |
| Amph |
T |
A |
13: 19,268,378 (GRCm39) |
M70K |
probably damaging |
Het |
| Ankra2 |
T |
A |
13: 98,409,919 (GRCm39) |
L306H |
probably damaging |
Het |
| Arc |
A |
C |
15: 74,543,592 (GRCm39) |
D210E |
probably benign |
Het |
| Arhgap10 |
A |
G |
8: 78,159,367 (GRCm39) |
|
probably null |
Het |
| Atp8b5 |
T |
A |
4: 43,344,449 (GRCm39) |
N445K |
probably benign |
Het |
| C1qc |
G |
T |
4: 136,617,746 (GRCm39) |
Q117K |
probably benign |
Het |
| Cadps |
T |
A |
14: 12,822,449 (GRCm38) |
E97V |
unknown |
Het |
| Capn13 |
GCA |
G |
17: 73,658,501 (GRCm39) |
|
probably null |
Het |
| Cdk13 |
A |
T |
13: 17,895,868 (GRCm39) |
W1014R |
probably damaging |
Het |
| Cltb |
C |
T |
13: 54,746,908 (GRCm39) |
E23K |
probably damaging |
Het |
| Clvs2 |
A |
T |
10: 33,498,642 (GRCm39) |
I96N |
probably damaging |
Het |
| Cwf19l1 |
A |
G |
19: 44,103,006 (GRCm39) |
V403A |
probably damaging |
Het |
| Ddr2 |
A |
T |
1: 169,816,066 (GRCm39) |
L547Q |
possibly damaging |
Het |
| Ebf1 |
A |
T |
11: 44,863,735 (GRCm39) |
K354* |
probably null |
Het |
| Fat4 |
A |
G |
3: 38,942,466 (GRCm39) |
Q453R |
probably benign |
Het |
| Gas2l3 |
CACTCGTCATACT |
CACT |
10: 89,266,820 (GRCm39) |
|
probably benign |
Het |
| Gata6 |
A |
G |
18: 11,054,497 (GRCm39) |
E142G |
possibly damaging |
Het |
| Gm14221 |
T |
C |
2: 160,416,600 (GRCm39) |
|
noncoding transcript |
Het |
| Gm42791 |
C |
A |
5: 148,896,247 (GRCm39) |
|
probably benign |
Het |
| Gm6370 |
G |
T |
5: 146,430,621 (GRCm39) |
V269L |
probably benign |
Het |
| Gphn |
G |
A |
12: 78,673,984 (GRCm39) |
V526M |
probably damaging |
Het |
| Gpt |
A |
T |
15: 76,583,485 (GRCm39) |
E206V |
probably damaging |
Het |
| Grm3 |
G |
A |
5: 9,620,047 (GRCm39) |
A399V |
probably damaging |
Het |
| Helq |
A |
T |
5: 100,931,025 (GRCm39) |
V575E |
possibly damaging |
Het |
| Ifi207 |
A |
T |
1: 173,557,381 (GRCm39) |
N452K |
probably damaging |
Het |
| Ikbke |
A |
G |
1: 131,184,848 (GRCm39) |
|
probably null |
Het |
| Kbtbd2 |
A |
G |
6: 56,756,687 (GRCm39) |
F350L |
probably benign |
Het |
| Kmt2c |
A |
G |
5: 25,519,555 (GRCm39) |
V2185A |
probably benign |
Het |
| Lgi2 |
T |
C |
5: 52,695,849 (GRCm39) |
Q362R |
probably damaging |
Het |
| Lrit1 |
G |
A |
14: 36,783,773 (GRCm39) |
G367E |
possibly damaging |
Het |
| Lrp1 |
G |
A |
10: 127,446,311 (GRCm39) |
H78Y |
probably benign |
Het |
| Matk |
A |
G |
10: 81,098,720 (GRCm39) |
|
probably benign |
Het |
| Med21 |
G |
A |
6: 146,549,690 (GRCm39) |
G24S |
probably damaging |
Het |
| Met |
G |
T |
6: 17,558,796 (GRCm39) |
L1141F |
probably damaging |
Het |
| Mroh3 |
A |
T |
1: 136,128,677 (GRCm39) |
|
probably null |
Het |
| Mrpl15 |
T |
C |
1: 4,844,683 (GRCm39) |
I203V |
probably benign |
Het |
| Naip1 |
T |
C |
13: 100,559,728 (GRCm39) |
|
probably null |
Het |
| Ndufa9 |
A |
C |
6: 126,804,505 (GRCm39) |
Y298* |
probably null |
Het |
| Neb |
T |
C |
2: 52,188,906 (GRCm39) |
E808G |
probably damaging |
Het |
| Nol4l |
C |
T |
2: 153,253,726 (GRCm39) |
G616S |
probably benign |
Het |
| Oprm1 |
T |
A |
10: 6,788,468 (GRCm39) |
C408S |
probably benign |
Het |
| Or2ag18 |
T |
C |
7: 106,405,463 (GRCm39) |
M69V |
probably benign |
Het |
| Or4f14 |
A |
G |
2: 111,742,444 (GRCm39) |
V277A |
probably benign |
Het |
| Or4k42 |
T |
G |
2: 111,320,293 (GRCm39) |
D70A |
probably damaging |
Het |
| Or52e7 |
T |
A |
7: 104,684,858 (GRCm39) |
I151N |
probably damaging |
Het |
| Or5ak20 |
T |
C |
2: 85,183,793 (GRCm39) |
N159S |
possibly damaging |
Het |
| Paqr3 |
A |
G |
5: 97,256,053 (GRCm39) |
I107T |
possibly damaging |
Het |
| Pex5l |
G |
A |
3: 33,196,989 (GRCm39) |
|
probably benign |
Het |
| Phf8-ps |
C |
T |
17: 33,285,713 (GRCm39) |
S363N |
probably benign |
Het |
| Pik3ap1 |
T |
C |
19: 41,316,284 (GRCm39) |
D326G |
probably benign |
Het |
| Plaa |
G |
T |
4: 94,474,645 (GRCm39) |
D252E |
probably damaging |
Het |
| Plxna2 |
G |
A |
1: 194,480,040 (GRCm39) |
V1404I |
probably benign |
Het |
| Ppargc1a |
G |
A |
5: 51,631,564 (GRCm39) |
A355V |
possibly damaging |
Het |
| Primpol |
A |
G |
8: 47,039,726 (GRCm39) |
S350P |
probably benign |
Het |
| Prlr |
T |
C |
15: 10,328,883 (GRCm39) |
S453P |
probably benign |
Het |
| Psmd5 |
T |
C |
2: 34,742,564 (GRCm39) |
|
probably benign |
Het |
| Robo2 |
A |
T |
16: 73,768,079 (GRCm39) |
V571E |
probably damaging |
Het |
| Sbspon |
A |
T |
1: 15,929,264 (GRCm39) |
S176T |
possibly damaging |
Het |
| Scyl2 |
G |
A |
10: 89,476,325 (GRCm39) |
|
probably benign |
Het |
| Sema3e |
T |
A |
5: 14,280,144 (GRCm39) |
V341E |
probably damaging |
Het |
| Serpinb3b |
A |
T |
1: 107,082,270 (GRCm39) |
F331L |
possibly damaging |
Het |
| Setd2 |
A |
G |
9: 110,401,022 (GRCm39) |
H1736R |
probably benign |
Het |
| Sidt2 |
A |
T |
9: 45,863,327 (GRCm39) |
D180E |
probably benign |
Het |
| Skint9 |
A |
T |
4: 112,248,208 (GRCm39) |
Y179N |
probably benign |
Het |
| Slc27a5 |
T |
C |
7: 12,722,560 (GRCm39) |
N638S |
probably benign |
Het |
| Slc6a4 |
T |
A |
11: 76,904,135 (GRCm39) |
W197R |
probably damaging |
Het |
| Spag17 |
A |
T |
3: 99,970,649 (GRCm39) |
M1278L |
probably benign |
Het |
| Sptbn1 |
T |
A |
11: 30,092,353 (GRCm39) |
I471F |
probably damaging |
Het |
| Tasor2 |
A |
T |
13: 3,616,680 (GRCm39) |
|
probably null |
Het |
| Teddm1a |
A |
G |
1: 153,768,382 (GRCm39) |
Q282R |
probably benign |
Het |
| Tex35 |
A |
G |
1: 156,927,295 (GRCm39) |
L160P |
probably damaging |
Het |
| Tfap2c |
T |
C |
2: 172,393,438 (GRCm39) |
Y118H |
probably damaging |
Het |
| Tpp1 |
T |
C |
7: 105,395,930 (GRCm39) |
Q533R |
probably benign |
Het |
| Ttc13 |
C |
T |
8: 125,401,174 (GRCm39) |
D730N |
probably damaging |
Het |
| Ufc1 |
A |
G |
1: 171,122,375 (GRCm39) |
|
probably benign |
Het |
| Vcpip1 |
A |
G |
1: 9,817,589 (GRCm39) |
W265R |
probably damaging |
Het |
| Wdr11 |
C |
G |
7: 129,202,158 (GRCm39) |
|
probably null |
Het |
| Xirp2 |
A |
G |
2: 67,341,408 (GRCm39) |
I1216M |
possibly damaging |
Het |
| Zswim2 |
A |
G |
2: 83,747,187 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Herc4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00927:Herc4
|
APN |
10 |
63,109,316 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00977:Herc4
|
APN |
10 |
63,147,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01455:Herc4
|
APN |
10 |
63,121,922 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01615:Herc4
|
APN |
10 |
63,126,461 (GRCm39) |
splice site |
probably benign |
|
|
IGL01974:Herc4
|
APN |
10 |
63,135,020 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02207:Herc4
|
APN |
10 |
63,135,023 (GRCm39) |
splice site |
probably null |
|
|
IGL02215:Herc4
|
APN |
10 |
63,109,345 (GRCm39) |
missense |
probably benign |
|
|
IGL02331:Herc4
|
APN |
10 |
63,099,939 (GRCm39) |
missense |
probably benign |
|
|
IGL02407:Herc4
|
APN |
10 |
63,142,203 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02444:Herc4
|
APN |
10 |
63,142,212 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02498:Herc4
|
APN |
10 |
63,109,244 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02797:Herc4
|
APN |
10 |
63,152,586 (GRCm39) |
splice site |
probably null |
|
|
IGL02804:Herc4
|
APN |
10 |
63,121,454 (GRCm39) |
missense |
probably benign |
0.10 |
|
Boosted
|
UTSW |
10 |
63,099,950 (GRCm39) |
nonsense |
probably null |
|
|
Factorial
|
UTSW |
10 |
63,121,847 (GRCm39) |
missense |
probably benign |
0.00 |
|
handout
|
UTSW |
10 |
63,151,437 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0499:Herc4
|
UTSW |
10 |
63,099,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0655:Herc4
|
UTSW |
10 |
63,109,350 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0722:Herc4
|
UTSW |
10 |
63,121,844 (GRCm39) |
missense |
probably null |
0.56 |
|
R0738:Herc4
|
UTSW |
10 |
63,124,928 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1742:Herc4
|
UTSW |
10 |
63,123,728 (GRCm39) |
missense |
probably benign |
0.16 |
|
R1776:Herc4
|
UTSW |
10 |
63,099,950 (GRCm39) |
nonsense |
probably null |
|
|
R1792:Herc4
|
UTSW |
10 |
63,081,680 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R1968:Herc4
|
UTSW |
10 |
63,109,304 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1992:Herc4
|
UTSW |
10 |
63,081,743 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2012:Herc4
|
UTSW |
10 |
63,079,817 (GRCm39) |
start gained |
probably benign |
|
|
R2077:Herc4
|
UTSW |
10 |
63,099,832 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2103:Herc4
|
UTSW |
10 |
63,081,889 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2363:Herc4
|
UTSW |
10 |
63,151,473 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R3833:Herc4
|
UTSW |
10 |
63,081,739 (GRCm39) |
missense |
probably benign |
|
|
R4014:Herc4
|
UTSW |
10 |
63,123,323 (GRCm39) |
missense |
probably benign |
|
|
R4084:Herc4
|
UTSW |
10 |
63,119,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4883:Herc4
|
UTSW |
10 |
63,121,433 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5215:Herc4
|
UTSW |
10 |
63,124,876 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5330:Herc4
|
UTSW |
10 |
63,143,578 (GRCm39) |
nonsense |
probably null |
|
|
R5331:Herc4
|
UTSW |
10 |
63,143,578 (GRCm39) |
nonsense |
probably null |
|
|
R5429:Herc4
|
UTSW |
10 |
63,110,792 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6058:Herc4
|
UTSW |
10 |
63,110,821 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6462:Herc4
|
UTSW |
10 |
63,124,880 (GRCm39) |
missense |
probably benign |
|
|
R6502:Herc4
|
UTSW |
10 |
63,153,197 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6669:Herc4
|
UTSW |
10 |
63,121,847 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7161:Herc4
|
UTSW |
10 |
63,144,194 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7267:Herc4
|
UTSW |
10 |
63,109,365 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7740:Herc4
|
UTSW |
10 |
63,105,457 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8515:Herc4
|
UTSW |
10 |
63,151,565 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8896:Herc4
|
UTSW |
10 |
63,147,286 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9117:Herc4
|
UTSW |
10 |
63,126,300 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9332:Herc4
|
UTSW |
10 |
63,144,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9388:Herc4
|
UTSW |
10 |
63,143,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9530:Herc4
|
UTSW |
10 |
63,126,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Herc4
|
UTSW |
10 |
63,143,528 (GRCm39) |
missense |
probably benign |
0.09 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTCCGTCCTACTGAGAAC -3'
(R):5'- GCACACAAGGGCTAGATTTCC -3'
Sequencing Primer
(F):5'- GCTCCGTCCTACTGAGAACAAGTAG -3'
(R):5'- GGGCTAGATTTCCAATAACGC -3'
|
| Posted On |
2016-03-16 |
Incidental Mutation