Incidental Mutation 'R4863:Abcc12'
| ID |
374664 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Abcc12
|
| Ensembl Gene |
ENSMUSG00000036872 |
| Gene Name |
ATP-binding cassette, sub-family C member 12 |
| Synonyms |
MRP9, 4930467B22Rik |
| MMRRC Submission |
042473-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.061)
|
| Stock # |
R4863 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
87231197-87307317 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 87265005 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 647
(I647F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123578
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080115]
[ENSMUST00000129898]
[ENSMUST00000131423]
[ENSMUST00000131806]
[ENSMUST00000152438]
[ENSMUST00000156610]
|
| AlphaFold |
Q80WJ6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000080115
AA Change: I647F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000079014
Gene: ENSMUSG00000036872
AA Change: I647F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
123 |
392 |
3.6e-19 |
PFAM |
|
AAA
|
506 |
679 |
3.33e-13 |
SMART |
|
low complexity region
|
739 |
752 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
791 |
1079 |
1.3e-26 |
PFAM |
|
AAA
|
1153 |
1346 |
1.07e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000129898
AA Change: I647F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000122577
Gene: ENSMUSG00000036872
AA Change: I647F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
123 |
392 |
1.2e-19 |
PFAM |
|
AAA
|
506 |
679 |
3.33e-13 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000131423
AA Change: I647F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000122402
Gene: ENSMUSG00000036872
AA Change: I647F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
123 |
392 |
1.1e-21 |
PFAM |
|
AAA
|
506 |
679 |
3.33e-13 |
SMART |
|
low complexity region
|
739 |
752 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
792 |
1077 |
1.6e-34 |
PFAM |
|
AAA
|
1153 |
1346 |
1.07e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000131806
AA Change: I647F
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000116866
Gene: ENSMUSG00000036872
AA Change: I647F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
123 |
392 |
1.3e-19 |
PFAM |
|
AAA
|
506 |
679 |
3.33e-13 |
SMART |
|
low complexity region
|
739 |
752 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000152438
AA Change: I647F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000114582
Gene: ENSMUSG00000036872
AA Change: I647F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
123 |
392 |
1.2e-19 |
PFAM |
|
AAA
|
506 |
679 |
3.33e-13 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156066
|
| SMART Domains |
Protein: ENSMUSP00000120282
Gene: ENSMUSG00000036872
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
25 |
38 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
78 |
363 |
3.8e-35 |
PFAM |
|
Pfam:ABC_tran
|
430 |
508 |
5.7e-16 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000156610
AA Change: I647F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000123578
Gene: ENSMUSG00000036872
AA Change: I647F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
123 |
392 |
5.9e-20 |
PFAM |
|
AAA
|
506 |
661 |
1.07e-7 |
SMART |
|
| Meta Mutation Damage Score |
0.4094 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.2%
|
| Validation Efficiency |
99% (105/106) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930578I06Rik |
C |
T |
14: 64,210,658 (GRCm39) |
R190H |
probably benign |
Het |
| Acnat2 |
C |
A |
4: 49,380,172 (GRCm39) |
W384L |
probably damaging |
Het |
| Acvr1 |
A |
G |
2: 58,367,723 (GRCm39) |
L146P |
possibly damaging |
Het |
| Ankrd16 |
T |
A |
2: 11,789,127 (GRCm39) |
M238K |
probably benign |
Het |
| Clmn |
A |
T |
12: 104,763,353 (GRCm39) |
I91N |
probably damaging |
Het |
| Cog8 |
A |
T |
8: 107,776,806 (GRCm39) |
L523H |
probably damaging |
Het |
| Cpxm2 |
T |
A |
7: 131,661,476 (GRCm39) |
K437M |
probably benign |
Het |
| Dhx57 |
A |
T |
17: 80,560,540 (GRCm39) |
V999E |
probably damaging |
Het |
| Dnpep |
T |
C |
1: 75,285,874 (GRCm39) |
|
probably benign |
Het |
| Dok3 |
G |
A |
13: 55,671,270 (GRCm39) |
R434W |
probably damaging |
Het |
| Dpysl5 |
C |
T |
5: 30,941,687 (GRCm39) |
H275Y |
probably benign |
Het |
| Ednra |
A |
T |
8: 78,394,012 (GRCm39) |
N361K |
probably damaging |
Het |
| Ei24 |
A |
T |
9: 36,695,861 (GRCm39) |
S210R |
probably damaging |
Het |
| Erich3 |
T |
A |
3: 154,470,441 (GRCm39) |
V158E |
unknown |
Het |
| Fam193a |
T |
A |
5: 34,623,549 (GRCm39) |
V1379E |
possibly damaging |
Het |
| Fasn |
A |
G |
11: 120,699,654 (GRCm39) |
V2304A |
probably damaging |
Het |
| Fcgbp |
A |
C |
7: 27,785,769 (GRCm39) |
D402A |
probably benign |
Het |
| Fkbp14 |
T |
C |
6: 54,562,930 (GRCm39) |
|
probably benign |
Het |
| Fnip1 |
G |
A |
11: 54,406,382 (GRCm39) |
V1160I |
possibly damaging |
Het |
| Fsd2 |
T |
C |
7: 81,202,712 (GRCm39) |
K289R |
probably null |
Het |
| Fuca2 |
A |
T |
10: 13,381,651 (GRCm39) |
D188V |
probably damaging |
Het |
| Gfpt2 |
T |
C |
11: 49,701,797 (GRCm39) |
V116A |
probably benign |
Het |
| Gm10770 |
T |
A |
2: 150,020,816 (GRCm39) |
K234* |
probably null |
Het |
| Gm9887 |
A |
G |
12: 69,418,763 (GRCm39) |
|
probably benign |
Het |
| Gtf3c2 |
A |
G |
5: 31,316,577 (GRCm39) |
|
probably benign |
Het |
| H2-M10.3 |
T |
C |
17: 36,677,528 (GRCm39) |
D250G |
probably damaging |
Het |
| Hapln4 |
G |
A |
8: 70,537,142 (GRCm39) |
V26M |
possibly damaging |
Het |
| Hook3 |
G |
A |
8: 26,528,057 (GRCm39) |
A611V |
probably damaging |
Het |
| Hr |
T |
C |
14: 70,809,412 (GRCm39) |
L1141P |
probably damaging |
Het |
| Ifngr1 |
T |
C |
10: 19,485,164 (GRCm39) |
S388P |
probably damaging |
Het |
| Itga3 |
T |
A |
11: 94,952,793 (GRCm39) |
Q326L |
probably damaging |
Het |
| Itgb3 |
T |
A |
11: 104,556,346 (GRCm39) |
I729N |
probably damaging |
Het |
| Kcnab2 |
A |
G |
4: 152,486,403 (GRCm39) |
S132P |
probably damaging |
Het |
| Lama3 |
C |
T |
18: 12,672,850 (GRCm39) |
A2481V |
probably damaging |
Het |
| Lama3 |
T |
C |
18: 12,631,735 (GRCm39) |
|
probably benign |
Het |
| Lce1e |
A |
T |
3: 92,615,178 (GRCm39) |
C56* |
probably null |
Het |
| Lmcd1 |
T |
C |
6: 112,264,832 (GRCm39) |
|
probably benign |
Het |
| Lrrc14 |
T |
A |
15: 76,597,562 (GRCm39) |
|
probably null |
Het |
| Lypd8l |
A |
T |
11: 58,503,338 (GRCm39) |
|
probably null |
Het |
| Map4k5 |
G |
A |
12: 69,865,212 (GRCm39) |
P591L |
probably benign |
Het |
| Mapk13 |
C |
A |
17: 28,995,284 (GRCm39) |
D168E |
probably damaging |
Het |
| Marf1 |
A |
C |
16: 13,950,529 (GRCm39) |
H952Q |
possibly damaging |
Het |
| Megf6 |
T |
C |
4: 154,338,738 (GRCm39) |
|
probably null |
Het |
| Mical3 |
T |
C |
6: 121,010,748 (GRCm39) |
I411M |
probably damaging |
Het |
| Myo5a |
A |
T |
9: 75,124,789 (GRCm39) |
K1781N |
probably damaging |
Het |
| N4bp2 |
T |
C |
5: 65,965,473 (GRCm39) |
V1174A |
probably benign |
Het |
| Ncdn |
A |
T |
4: 126,644,216 (GRCm39) |
L202Q |
probably damaging |
Het |
| Ncor1 |
T |
A |
11: 62,283,464 (GRCm39) |
M408L |
possibly damaging |
Het |
| Nf1 |
T |
C |
11: 79,300,235 (GRCm39) |
L249P |
probably damaging |
Het |
| Nlrp9b |
T |
A |
7: 19,783,521 (GRCm39) |
|
probably null |
Het |
| Nxpe3 |
A |
T |
16: 55,669,996 (GRCm39) |
Y370N |
probably damaging |
Het |
| P2rx2 |
T |
A |
5: 110,489,434 (GRCm39) |
T167S |
probably benign |
Het |
| Pcdhb19 |
G |
T |
18: 37,632,161 (GRCm39) |
R652L |
probably benign |
Het |
| Pcdhga12 |
T |
C |
18: 37,901,334 (GRCm39) |
L722P |
probably benign |
Het |
| Pde6a |
A |
T |
18: 61,378,663 (GRCm39) |
I329F |
probably damaging |
Het |
| Pdpr |
T |
A |
8: 111,828,583 (GRCm39) |
S29T |
probably benign |
Het |
| Pfkfb3 |
T |
C |
2: 11,491,123 (GRCm39) |
D173G |
probably benign |
Het |
| Plcd4 |
A |
G |
1: 74,604,961 (GRCm39) |
|
probably null |
Het |
| Polr1g |
T |
A |
7: 19,091,684 (GRCm39) |
Q141L |
probably damaging |
Het |
| Pou2f2 |
A |
G |
7: 24,796,533 (GRCm39) |
|
probably benign |
Het |
| Ppp1r14c |
TGGCGGCGGCGGCGGCGG |
TGGCGGCGGCGGCGG |
10: 3,316,702 (GRCm39) |
|
probably benign |
Het |
| Ppp1r42 |
T |
C |
1: 10,073,611 (GRCm39) |
|
probably benign |
Het |
| Ptpre |
C |
T |
7: 135,270,861 (GRCm39) |
H346Y |
probably benign |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Rab12 |
A |
T |
17: 66,805,103 (GRCm39) |
Y142N |
probably damaging |
Het |
| Rai14 |
A |
C |
15: 10,572,556 (GRCm39) |
M857R |
probably damaging |
Het |
| Ranbp2 |
A |
G |
10: 58,328,243 (GRCm39) |
K2753R |
probably damaging |
Het |
| Rasa4 |
A |
T |
5: 136,132,765 (GRCm39) |
K6* |
probably null |
Het |
| Rasgef1a |
A |
G |
6: 118,066,100 (GRCm39) |
M438V |
probably benign |
Het |
| Recql |
T |
G |
6: 142,304,732 (GRCm39) |
|
probably benign |
Het |
| Rftn2 |
A |
G |
1: 55,211,198 (GRCm39) |
V425A |
probably benign |
Het |
| Ror1 |
A |
G |
4: 100,267,001 (GRCm39) |
Y234C |
probably damaging |
Het |
| Sap30l |
T |
A |
11: 57,696,880 (GRCm39) |
L70Q |
probably damaging |
Het |
| Scn4a |
T |
C |
11: 106,210,828 (GRCm39) |
R1730G |
probably damaging |
Het |
| Serinc5 |
T |
G |
13: 92,827,488 (GRCm39) |
I268R |
probably damaging |
Het |
| Sin3b |
G |
A |
8: 73,471,576 (GRCm39) |
V432I |
possibly damaging |
Het |
| Slc30a6 |
T |
C |
17: 74,719,649 (GRCm39) |
M203T |
possibly damaging |
Het |
| Soat1 |
T |
C |
1: 156,259,898 (GRCm39) |
N481S |
probably damaging |
Het |
| Sos2 |
G |
A |
12: 69,686,928 (GRCm39) |
T206I |
probably benign |
Het |
| Sp100 |
G |
T |
1: 85,632,724 (GRCm39) |
A132S |
probably benign |
Het |
| Sp140l1 |
C |
T |
1: 85,066,521 (GRCm39) |
|
probably benign |
Het |
| Spata31d1c |
T |
A |
13: 65,183,604 (GRCm39) |
L382* |
probably null |
Het |
| Stard9 |
T |
A |
2: 120,531,341 (GRCm39) |
W2533R |
probably benign |
Het |
| Tas2r126 |
A |
G |
6: 42,412,324 (GRCm39) |
T286A |
probably benign |
Het |
| Tedc2 |
T |
A |
17: 24,436,910 (GRCm39) |
K275M |
probably damaging |
Het |
| Ten1 |
A |
T |
11: 116,109,057 (GRCm39) |
K242N |
probably benign |
Het |
| Thoc2l |
A |
T |
5: 104,665,616 (GRCm39) |
D46V |
possibly damaging |
Het |
| Tial1 |
C |
T |
7: 128,056,752 (GRCm39) |
V1I |
probably damaging |
Het |
| Tle2 |
G |
A |
10: 81,424,725 (GRCm39) |
R649H |
possibly damaging |
Het |
| Tmem178 |
A |
G |
17: 81,252,374 (GRCm39) |
D86G |
probably benign |
Het |
| Trim29 |
T |
A |
9: 43,240,872 (GRCm39) |
D528E |
possibly damaging |
Het |
| Vmn2r61 |
A |
T |
7: 41,950,132 (GRCm39) |
T851S |
probably benign |
Het |
| Vmn2r72 |
T |
A |
7: 85,399,806 (GRCm39) |
Q414H |
possibly damaging |
Het |
| Yars1 |
A |
T |
4: 129,083,675 (GRCm39) |
|
probably benign |
Het |
| Yipf4 |
A |
G |
17: 74,801,087 (GRCm39) |
Q135R |
probably damaging |
Het |
| Zfp341 |
G |
A |
2: 154,487,786 (GRCm39) |
|
probably benign |
Het |
| Zfp426 |
T |
C |
9: 20,381,334 (GRCm39) |
Y536C |
probably damaging |
Het |
| Zp2 |
T |
G |
7: 119,734,995 (GRCm39) |
Y430S |
probably damaging |
Het |
|
| Other mutations in Abcc12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01362:Abcc12
|
APN |
8 |
87,261,322 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL01504:Abcc12
|
APN |
8 |
87,284,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01593:Abcc12
|
APN |
8 |
87,284,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02164:Abcc12
|
APN |
8 |
87,254,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02173:Abcc12
|
APN |
8 |
87,293,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02175:Abcc12
|
APN |
8 |
87,261,642 (GRCm39) |
splice site |
probably null |
|
|
IGL02405:Abcc12
|
APN |
8 |
87,284,782 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02620:Abcc12
|
APN |
8 |
87,231,943 (GRCm39) |
splice site |
probably null |
|
|
IGL02635:Abcc12
|
APN |
8 |
87,236,311 (GRCm39) |
splice site |
probably benign |
|
|
IGL03241:Abcc12
|
APN |
8 |
87,236,436 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
PIT4544001:Abcc12
|
UTSW |
8 |
87,231,875 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R0023:Abcc12
|
UTSW |
8 |
87,264,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0023:Abcc12
|
UTSW |
8 |
87,264,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0116:Abcc12
|
UTSW |
8 |
87,261,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0131:Abcc12
|
UTSW |
8 |
87,258,197 (GRCm39) |
missense |
probably benign |
|
|
R0131:Abcc12
|
UTSW |
8 |
87,258,197 (GRCm39) |
missense |
probably benign |
|
|
R0132:Abcc12
|
UTSW |
8 |
87,258,197 (GRCm39) |
missense |
probably benign |
|
|
R0308:Abcc12
|
UTSW |
8 |
87,284,381 (GRCm39) |
splice site |
probably benign |
|
|
R0589:Abcc12
|
UTSW |
8 |
87,287,101 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1451:Abcc12
|
UTSW |
8 |
87,284,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1564:Abcc12
|
UTSW |
8 |
87,244,115 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1740:Abcc12
|
UTSW |
8 |
87,236,400 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1740:Abcc12
|
UTSW |
8 |
87,232,126 (GRCm39) |
nonsense |
probably null |
|
|
R1970:Abcc12
|
UTSW |
8 |
87,253,910 (GRCm39) |
missense |
probably benign |
0.27 |
|
R2017:Abcc12
|
UTSW |
8 |
87,290,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2026:Abcc12
|
UTSW |
8 |
87,284,862 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2402:Abcc12
|
UTSW |
8 |
87,235,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3085:Abcc12
|
UTSW |
8 |
87,270,536 (GRCm39) |
splice site |
probably benign |
|
|
R3115:Abcc12
|
UTSW |
8 |
87,266,653 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3176:Abcc12
|
UTSW |
8 |
87,233,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3276:Abcc12
|
UTSW |
8 |
87,233,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3847:Abcc12
|
UTSW |
8 |
87,280,020 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3911:Abcc12
|
UTSW |
8 |
87,255,048 (GRCm39) |
splice site |
probably benign |
|
|
R4031:Abcc12
|
UTSW |
8 |
87,244,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4297:Abcc12
|
UTSW |
8 |
87,258,154 (GRCm39) |
splice site |
probably null |
|
|
R4298:Abcc12
|
UTSW |
8 |
87,258,154 (GRCm39) |
splice site |
probably null |
|
|
R4299:Abcc12
|
UTSW |
8 |
87,258,154 (GRCm39) |
splice site |
probably null |
|
|
R4688:Abcc12
|
UTSW |
8 |
87,275,323 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4810:Abcc12
|
UTSW |
8 |
87,287,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4892:Abcc12
|
UTSW |
8 |
87,236,431 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5288:Abcc12
|
UTSW |
8 |
87,293,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5303:Abcc12
|
UTSW |
8 |
87,236,415 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5332:Abcc12
|
UTSW |
8 |
87,251,459 (GRCm39) |
splice site |
probably null |
|
|
R5386:Abcc12
|
UTSW |
8 |
87,244,118 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5457:Abcc12
|
UTSW |
8 |
87,236,473 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5900:Abcc12
|
UTSW |
8 |
87,293,149 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6035:Abcc12
|
UTSW |
8 |
87,244,033 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Abcc12
|
UTSW |
8 |
87,244,033 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6291:Abcc12
|
UTSW |
8 |
87,293,173 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R6518:Abcc12
|
UTSW |
8 |
87,235,718 (GRCm39) |
|
|
|
|
R6677:Abcc12
|
UTSW |
8 |
87,261,381 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7258:Abcc12
|
UTSW |
8 |
87,287,486 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7411:Abcc12
|
UTSW |
8 |
87,287,479 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7619:Abcc12
|
UTSW |
8 |
87,293,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7808:Abcc12
|
UTSW |
8 |
87,234,568 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7828:Abcc12
|
UTSW |
8 |
87,254,904 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7834:Abcc12
|
UTSW |
8 |
87,284,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7834:Abcc12
|
UTSW |
8 |
87,258,179 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7939:Abcc12
|
UTSW |
8 |
87,275,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7989:Abcc12
|
UTSW |
8 |
87,232,108 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8290:Abcc12
|
UTSW |
8 |
87,238,911 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8681:Abcc12
|
UTSW |
8 |
87,231,908 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8795:Abcc12
|
UTSW |
8 |
87,258,213 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8811:Abcc12
|
UTSW |
8 |
87,280,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8939:Abcc12
|
UTSW |
8 |
87,243,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8940:Abcc12
|
UTSW |
8 |
87,287,440 (GRCm39) |
missense |
probably benign |
0.45 |
|
R9711:Abcc12
|
UTSW |
8 |
87,275,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Abcc12
|
UTSW |
8 |
87,279,920 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Abcc12
|
UTSW |
8 |
87,286,908 (GRCm39) |
splice site |
probably null |
|
|
Z1176:Abcc12
|
UTSW |
8 |
87,277,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Abcc12
|
UTSW |
8 |
87,254,013 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCCTGTTCAGGTAAAGCCAC -3'
(R):5'- CTCCTGATATACAAAGACCATGGGG -3'
Sequencing Primer
(F):5'- CCTACTGGTGGAAATGGCATATTTAG -3'
(R):5'- CAGACTTAATAATGATGGGCAGTGC -3'
|
| Posted On |
2016-03-17 |
Incidental Mutation