Incidental Mutation 'R4864:Lcor'
ID |
374796 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Lcor
|
Ensembl Gene |
ENSMUSG00000025019 |
Gene Name |
ligand dependent nuclear receptor corepressor |
Synonyms |
LOC381224, A630025C20Rik, Gm340, 3110023F06Rik, Mlr2 |
MMRRC Submission |
042474-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.468)
|
Stock # |
R4864 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
19 |
Chromosomal Location |
41471076-41574975 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to T
at 41573803 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Alanine to Serine
at position 853
(A853S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000128083
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172371]
|
AlphaFold |
Q6ZPI3 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000172371
AA Change: A853S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000128083 Gene: ENSMUSG00000090673 AA Change: A853S
Domain | Start | End | E-Value | Type |
low complexity region
|
10 |
17 |
N/A |
INTRINSIC |
low complexity region
|
438 |
450 |
N/A |
INTRINSIC |
low complexity region
|
710 |
724 |
N/A |
INTRINSIC |
low complexity region
|
768 |
779 |
N/A |
INTRINSIC |
Pfam:DUF4553
|
787 |
1241 |
9.7e-179 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183602
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.8%
|
Validation Efficiency |
99% (93/94) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 85 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930578I06Rik |
C |
T |
14: 64,210,658 (GRCm39) |
R190H |
probably benign |
Het |
Acp6 |
T |
C |
3: 97,066,683 (GRCm39) |
|
probably null |
Het |
Adora3 |
T |
A |
3: 105,815,131 (GRCm39) |
Y148N |
probably damaging |
Het |
Ahnak2 |
G |
A |
12: 112,740,040 (GRCm39) |
S538L |
probably damaging |
Het |
Aox3 |
T |
G |
1: 58,215,646 (GRCm39) |
V1026G |
probably damaging |
Het |
Ap3d1 |
TTCTCTCTCTCTCTCTCT |
TTCTCTCTCTCTCTCT |
10: 80,548,612 (GRCm39) |
|
probably null |
Het |
Arhgef37 |
G |
A |
18: 61,627,996 (GRCm39) |
A649V |
probably benign |
Het |
Atp5f1a |
G |
A |
18: 77,869,015 (GRCm39) |
R413H |
possibly damaging |
Het |
Bace1 |
A |
T |
9: 45,766,109 (GRCm39) |
I179F |
probably damaging |
Het |
Brinp1 |
A |
G |
4: 68,717,123 (GRCm39) |
F242L |
probably damaging |
Het |
Brk1 |
T |
C |
6: 113,592,805 (GRCm39) |
Y63H |
possibly damaging |
Het |
Ccdc74a |
A |
G |
16: 17,466,736 (GRCm39) |
T148A |
probably benign |
Het |
Cenpc1 |
T |
A |
5: 86,193,180 (GRCm39) |
L236F |
probably damaging |
Het |
Col13a1 |
C |
T |
10: 61,698,439 (GRCm39) |
E541K |
unknown |
Het |
Copg1 |
T |
A |
6: 87,866,678 (GRCm39) |
C44S |
probably damaging |
Het |
D130043K22Rik |
A |
G |
13: 25,047,595 (GRCm39) |
E380G |
probably damaging |
Het |
Dchs1 |
T |
C |
7: 105,404,460 (GRCm39) |
D2694G |
probably damaging |
Het |
Dgkd |
A |
T |
1: 87,844,560 (GRCm39) |
N242I |
possibly damaging |
Het |
Dnah2 |
C |
T |
11: 69,313,416 (GRCm39) |
V4248I |
probably damaging |
Het |
Dpy19l3 |
T |
A |
7: 35,411,607 (GRCm39) |
K376* |
probably null |
Het |
Eef1d |
A |
G |
15: 75,775,255 (GRCm39) |
S135P |
possibly damaging |
Het |
Epc2 |
T |
A |
2: 49,427,177 (GRCm39) |
S574T |
probably benign |
Het |
Eps15 |
G |
A |
4: 109,223,727 (GRCm39) |
|
probably benign |
Het |
Eps8 |
T |
C |
6: 137,455,967 (GRCm39) |
|
probably benign |
Het |
Exoc5 |
A |
T |
14: 49,289,839 (GRCm39) |
V13E |
probably benign |
Het |
Fbn1 |
A |
T |
2: 125,214,317 (GRCm39) |
C765S |
possibly damaging |
Het |
Fbxo5 |
A |
T |
10: 5,752,392 (GRCm39) |
C74S |
probably benign |
Het |
Fbxw9 |
T |
C |
8: 85,792,530 (GRCm39) |
S322P |
probably damaging |
Het |
Fmo5 |
T |
A |
3: 97,553,195 (GRCm39) |
I381N |
probably damaging |
Het |
Fmo6 |
T |
C |
1: 162,751,964 (GRCm39) |
D175G |
probably benign |
Het |
Gm7361 |
A |
G |
5: 26,467,008 (GRCm39) |
|
probably null |
Het |
Gm9961 |
G |
A |
16: 11,720,899 (GRCm39) |
|
probably benign |
Het |
Golga7b |
T |
A |
19: 42,255,405 (GRCm39) |
|
probably null |
Het |
Gorab |
T |
C |
1: 163,213,967 (GRCm39) |
E321G |
probably benign |
Het |
Gpx1 |
T |
A |
9: 108,216,594 (GRCm39) |
V28E |
probably benign |
Het |
H2-T15 |
T |
A |
17: 36,369,253 (GRCm39) |
|
probably benign |
Het |
H3c14 |
T |
C |
3: 96,154,575 (GRCm39) |
I125T |
probably damaging |
Het |
Hk1 |
T |
C |
10: 62,178,318 (GRCm39) |
S8G |
probably benign |
Het |
Iqsec1 |
C |
T |
6: 90,641,038 (GRCm39) |
R1026H |
probably damaging |
Het |
Kdm4b |
A |
T |
17: 56,660,091 (GRCm39) |
Y86F |
probably benign |
Het |
Kprp |
C |
T |
3: 92,731,829 (GRCm39) |
R407Q |
unknown |
Het |
Lamb1 |
C |
T |
12: 31,371,005 (GRCm39) |
T1400M |
probably benign |
Het |
Lrriq3 |
T |
A |
3: 154,893,447 (GRCm39) |
Y383N |
possibly damaging |
Het |
Map3k21 |
T |
C |
8: 126,654,294 (GRCm39) |
I371T |
probably benign |
Het |
Mllt1 |
A |
T |
17: 57,212,819 (GRCm39) |
F105I |
probably damaging |
Het |
Nfatc2 |
A |
G |
2: 168,378,312 (GRCm39) |
M451T |
probably damaging |
Het |
Nfkbiz |
A |
C |
16: 55,638,787 (GRCm39) |
N224K |
probably damaging |
Het |
Nlrp4d |
A |
G |
7: 10,115,088 (GRCm39) |
V531A |
noncoding transcript |
Het |
Noc3l |
A |
G |
19: 38,778,081 (GRCm39) |
Y778H |
probably benign |
Het |
Nup98 |
C |
A |
7: 101,802,403 (GRCm39) |
A734S |
possibly damaging |
Het |
Or2ag18 |
T |
C |
7: 106,405,171 (GRCm39) |
Y166C |
probably damaging |
Het |
Or4k2 |
T |
A |
14: 50,424,039 (GRCm39) |
I212F |
probably damaging |
Het |
Or9g20 |
A |
G |
2: 85,630,033 (GRCm39) |
Y194H |
probably damaging |
Het |
Or9r7 |
T |
A |
10: 129,962,756 (GRCm39) |
R57* |
probably null |
Het |
Pate4 |
A |
T |
9: 35,519,535 (GRCm39) |
C52S |
probably damaging |
Het |
Pecr |
C |
A |
1: 72,316,490 (GRCm39) |
A72S |
probably benign |
Het |
Pomt1 |
A |
G |
2: 32,142,004 (GRCm39) |
N578S |
probably benign |
Het |
Ppm1a |
T |
C |
12: 72,830,738 (GRCm39) |
S88P |
probably benign |
Het |
Ppm1l |
T |
A |
3: 69,449,844 (GRCm39) |
|
probably benign |
Het |
Prdm13 |
A |
G |
4: 21,685,543 (GRCm39) |
S86P |
unknown |
Het |
Prph2 |
T |
C |
17: 47,221,848 (GRCm39) |
S76P |
probably benign |
Het |
Sarnp |
G |
A |
10: 128,669,212 (GRCm39) |
R23H |
probably damaging |
Het |
Septin1 |
T |
C |
7: 126,816,064 (GRCm39) |
|
probably benign |
Het |
Serpini1 |
T |
C |
3: 75,520,481 (GRCm39) |
I26T |
probably benign |
Het |
Setdb2 |
A |
G |
14: 59,646,715 (GRCm39) |
I616T |
probably benign |
Het |
Slc2a10 |
T |
C |
2: 165,356,541 (GRCm39) |
F67S |
probably benign |
Het |
Slc38a6 |
T |
A |
12: 73,390,424 (GRCm39) |
|
probably null |
Het |
Smg6 |
T |
C |
11: 74,820,988 (GRCm39) |
S420P |
possibly damaging |
Het |
Srp72 |
T |
A |
5: 77,132,009 (GRCm39) |
H229Q |
probably benign |
Het |
Ston2 |
A |
G |
12: 91,615,448 (GRCm39) |
V320A |
possibly damaging |
Het |
Stx3 |
A |
T |
19: 11,754,515 (GRCm39) |
I269N |
possibly damaging |
Het |
Tdg-ps |
A |
G |
15: 82,400,843 (GRCm39) |
|
noncoding transcript |
Het |
Tecpr1 |
T |
A |
5: 144,150,935 (GRCm39) |
N291I |
probably benign |
Het |
Tmem177 |
A |
G |
1: 119,838,553 (GRCm39) |
V42A |
probably benign |
Het |
Trim26 |
T |
A |
17: 37,168,886 (GRCm39) |
|
probably benign |
Het |
Ttc17 |
A |
G |
2: 94,196,980 (GRCm39) |
S456P |
probably benign |
Het |
Tubgcp6 |
T |
C |
15: 88,988,021 (GRCm39) |
Y984C |
probably benign |
Het |
Unc5cl |
A |
G |
17: 48,766,872 (GRCm39) |
E82G |
possibly damaging |
Het |
Uncx |
T |
C |
5: 139,529,875 (GRCm39) |
S43P |
probably damaging |
Het |
Vmn1r1 |
A |
G |
1: 181,985,332 (GRCm39) |
V111A |
probably benign |
Het |
Vmn1r168 |
A |
G |
7: 23,240,907 (GRCm39) |
I255V |
probably damaging |
Het |
Vwce |
A |
G |
19: 10,628,000 (GRCm39) |
T487A |
probably benign |
Het |
Xaf1 |
A |
G |
11: 72,197,682 (GRCm39) |
|
probably benign |
Het |
Zfp27 |
G |
T |
7: 29,594,261 (GRCm39) |
P568Q |
probably damaging |
Het |
Zfp382 |
A |
T |
7: 29,832,885 (GRCm39) |
I179F |
possibly damaging |
Het |
|
Other mutations in Lcor |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00737:Lcor
|
APN |
19 |
41,541,139 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02079:Lcor
|
APN |
19 |
41,544,126 (GRCm39) |
missense |
probably benign |
0.40 |
IGL02100:Lcor
|
APN |
19 |
41,547,193 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL02444:Lcor
|
APN |
19 |
41,547,450 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02578:Lcor
|
APN |
19 |
41,547,589 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03072:Lcor
|
APN |
19 |
41,547,253 (GRCm39) |
missense |
possibly damaging |
0.85 |
IGL03118:Lcor
|
APN |
19 |
41,546,808 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03153:Lcor
|
APN |
19 |
41,546,795 (GRCm39) |
missense |
probably damaging |
0.98 |
BB003:Lcor
|
UTSW |
19 |
41,571,008 (GRCm39) |
missense |
probably benign |
|
BB013:Lcor
|
UTSW |
19 |
41,571,008 (GRCm39) |
missense |
probably benign |
|
R0006:Lcor
|
UTSW |
19 |
41,573,338 (GRCm39) |
missense |
probably benign |
0.00 |
R0686:Lcor
|
UTSW |
19 |
41,570,811 (GRCm39) |
missense |
possibly damaging |
0.73 |
R1104:Lcor
|
UTSW |
19 |
41,574,502 (GRCm39) |
missense |
probably damaging |
0.99 |
R1278:Lcor
|
UTSW |
19 |
41,573,122 (GRCm39) |
missense |
probably benign |
0.07 |
R1606:Lcor
|
UTSW |
19 |
41,573,513 (GRCm39) |
missense |
probably benign |
0.35 |
R1756:Lcor
|
UTSW |
19 |
41,547,705 (GRCm39) |
missense |
probably benign |
|
R1833:Lcor
|
UTSW |
19 |
41,573,387 (GRCm39) |
missense |
probably benign |
0.00 |
R1889:Lcor
|
UTSW |
19 |
41,547,567 (GRCm39) |
missense |
probably damaging |
0.99 |
R1905:Lcor
|
UTSW |
19 |
41,572,013 (GRCm39) |
missense |
possibly damaging |
0.73 |
R1913:Lcor
|
UTSW |
19 |
41,546,913 (GRCm39) |
missense |
probably benign |
0.40 |
R1983:Lcor
|
UTSW |
19 |
41,546,806 (GRCm39) |
missense |
probably damaging |
0.98 |
R2697:Lcor
|
UTSW |
19 |
41,572,466 (GRCm39) |
missense |
probably benign |
0.43 |
R2881:Lcor
|
UTSW |
19 |
41,571,488 (GRCm39) |
missense |
probably damaging |
1.00 |
R3885:Lcor
|
UTSW |
19 |
41,546,795 (GRCm39) |
missense |
probably damaging |
0.98 |
R3886:Lcor
|
UTSW |
19 |
41,546,795 (GRCm39) |
missense |
probably damaging |
0.98 |
R3888:Lcor
|
UTSW |
19 |
41,546,795 (GRCm39) |
missense |
probably damaging |
0.98 |
R3889:Lcor
|
UTSW |
19 |
41,546,795 (GRCm39) |
missense |
probably damaging |
0.98 |
R4720:Lcor
|
UTSW |
19 |
41,574,334 (GRCm39) |
missense |
probably benign |
0.04 |
R4908:Lcor
|
UTSW |
19 |
41,572,601 (GRCm39) |
missense |
probably benign |
0.00 |
R5160:Lcor
|
UTSW |
19 |
41,544,053 (GRCm39) |
missense |
probably damaging |
0.99 |
R5193:Lcor
|
UTSW |
19 |
41,570,969 (GRCm39) |
missense |
probably damaging |
1.00 |
R5215:Lcor
|
UTSW |
19 |
41,574,371 (GRCm39) |
missense |
probably damaging |
1.00 |
R5276:Lcor
|
UTSW |
19 |
41,573,478 (GRCm39) |
missense |
probably damaging |
0.98 |
R5319:Lcor
|
UTSW |
19 |
41,574,791 (GRCm39) |
missense |
probably damaging |
0.99 |
R5321:Lcor
|
UTSW |
19 |
41,573,643 (GRCm39) |
missense |
probably damaging |
1.00 |
R5432:Lcor
|
UTSW |
19 |
41,573,042 (GRCm39) |
missense |
probably damaging |
1.00 |
R5605:Lcor
|
UTSW |
19 |
41,571,302 (GRCm39) |
missense |
probably damaging |
1.00 |
R5941:Lcor
|
UTSW |
19 |
41,574,839 (GRCm39) |
missense |
probably damaging |
1.00 |
R6020:Lcor
|
UTSW |
19 |
41,571,986 (GRCm39) |
missense |
possibly damaging |
0.88 |
R6024:Lcor
|
UTSW |
19 |
41,572,396 (GRCm39) |
missense |
possibly damaging |
0.84 |
R6112:Lcor
|
UTSW |
19 |
41,547,520 (GRCm39) |
missense |
possibly damaging |
0.92 |
R6149:Lcor
|
UTSW |
19 |
41,573,641 (GRCm39) |
missense |
probably damaging |
1.00 |
R6260:Lcor
|
UTSW |
19 |
41,570,810 (GRCm39) |
missense |
possibly damaging |
0.73 |
R6260:Lcor
|
UTSW |
19 |
41,570,809 (GRCm39) |
missense |
probably null |
0.91 |
R6476:Lcor
|
UTSW |
19 |
41,571,518 (GRCm39) |
missense |
probably benign |
0.04 |
R7051:Lcor
|
UTSW |
19 |
41,574,191 (GRCm39) |
missense |
probably benign |
0.05 |
R7285:Lcor
|
UTSW |
19 |
41,572,754 (GRCm39) |
missense |
possibly damaging |
0.91 |
R7372:Lcor
|
UTSW |
19 |
41,573,945 (GRCm39) |
missense |
probably damaging |
1.00 |
R7762:Lcor
|
UTSW |
19 |
41,572,106 (GRCm39) |
missense |
probably benign |
0.02 |
R7777:Lcor
|
UTSW |
19 |
41,547,234 (GRCm39) |
missense |
probably benign |
0.33 |
R7833:Lcor
|
UTSW |
19 |
41,573,024 (GRCm39) |
missense |
probably benign |
0.02 |
R7926:Lcor
|
UTSW |
19 |
41,571,008 (GRCm39) |
missense |
probably benign |
|
R8164:Lcor
|
UTSW |
19 |
41,573,849 (GRCm39) |
missense |
probably damaging |
1.00 |
R8319:Lcor
|
UTSW |
19 |
41,571,343 (GRCm39) |
missense |
probably damaging |
1.00 |
R8323:Lcor
|
UTSW |
19 |
41,572,036 (GRCm39) |
missense |
probably benign |
0.01 |
R8327:Lcor
|
UTSW |
19 |
41,570,996 (GRCm39) |
missense |
probably damaging |
1.00 |
R8423:Lcor
|
UTSW |
19 |
41,573,888 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8556:Lcor
|
UTSW |
19 |
41,546,863 (GRCm39) |
frame shift |
probably null |
|
R8780:Lcor
|
UTSW |
19 |
41,573,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R8781:Lcor
|
UTSW |
19 |
41,573,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R8788:Lcor
|
UTSW |
19 |
41,573,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R8798:Lcor
|
UTSW |
19 |
41,573,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R9013:Lcor
|
UTSW |
19 |
41,573,189 (GRCm39) |
missense |
probably damaging |
1.00 |
R9035:Lcor
|
UTSW |
19 |
41,573,399 (GRCm39) |
missense |
probably benign |
0.00 |
R9065:Lcor
|
UTSW |
19 |
41,573,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R9067:Lcor
|
UTSW |
19 |
41,573,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R9083:Lcor
|
UTSW |
19 |
41,574,839 (GRCm39) |
missense |
probably damaging |
0.99 |
R9105:Lcor
|
UTSW |
19 |
41,573,311 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9487:Lcor
|
UTSW |
19 |
41,573,685 (GRCm39) |
missense |
probably damaging |
1.00 |
R9573:Lcor
|
UTSW |
19 |
41,573,471 (GRCm39) |
missense |
probably damaging |
1.00 |
R9704:Lcor
|
UTSW |
19 |
41,572,498 (GRCm39) |
missense |
possibly damaging |
0.61 |
X0013:Lcor
|
UTSW |
19 |
41,572,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Predicted Primers |
PCR Primer
(F):5'- GCAGCCCAAGTTCATAGGATG -3'
(R):5'- CTGCCTGTAGTGAACTAGGG -3'
Sequencing Primer
(F):5'- CCCAAGTTCATAGGATGGTGTGC -3'
(R):5'- CCTGTAGTGAACTAGGGTACATG -3'
|
Posted On |
2016-03-17 |