Incidental Mutation 'R4882:Opcml'
ID 375333
Institutional Source Beutler Lab
Gene Symbol Opcml
Ensembl Gene ENSMUSG00000062257
Gene Name opioid binding protein/cell adhesion molecule-like
Synonyms 2900075O15Rik, B930023M13Rik, Obcam, LOC235104
MMRRC Submission 042490-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R4882 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 27702071-28836706 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 28812886 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 193 (E193K)
Ref Sequence ENSEMBL: ENSMUSP00000110898 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073822] [ENSMUST00000115243]
AlphaFold G5E8G3
Predicted Effect probably damaging
Transcript: ENSMUST00000073822
AA Change: E201K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073493
Gene: ENSMUSG00000062257
AA Change: E201K

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
IG 42 133 2.94e-10 SMART
IGc2 148 209 2.91e-14 SMART
IGc2 235 303 2e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000115243
AA Change: E193K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110898
Gene: ENSMUSG00000062257
AA Change: E193K

DomainStartEndE-ValueType
IG 35 126 2.94e-10 SMART
IGc2 141 201 1.36e-14 SMART
IGc2 227 295 2e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215483
Meta Mutation Damage Score 0.4280 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.9%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap3 A G 4: 155,990,112 (GRCm39) D764G probably damaging Het
Adgrg6 T A 10: 14,310,081 (GRCm39) I775F possibly damaging Het
Ahnak T A 19: 8,983,261 (GRCm39) M1515K probably damaging Het
Aqp4 A G 18: 15,531,311 (GRCm39) V150A possibly damaging Het
Axdnd1 A T 1: 156,223,129 (GRCm39) probably null Het
Bap1 C T 14: 30,973,678 (GRCm39) probably benign Het
BB014433 A G 8: 15,092,016 (GRCm39) V279A probably benign Het
Cacng8 T C 7: 3,460,669 (GRCm39) Y151H probably damaging Het
Caskin1 T C 17: 24,723,389 (GRCm39) S726P probably damaging Het
Cd200 T C 16: 45,217,380 (GRCm39) T104A probably benign Het
Cdk12 C T 11: 98,101,272 (GRCm39) R377C unknown Het
Ceacam13 A G 7: 17,746,997 (GRCm39) H150R probably benign Het
Cebpzos T C 17: 79,227,220 (GRCm39) Y65H probably benign Het
Cgnl1 T A 9: 71,624,683 (GRCm39) M630L probably benign Het
Dop1b G T 16: 93,549,802 (GRCm39) R247L possibly damaging Het
Dqx1 A G 6: 83,043,069 (GRCm39) probably null Het
Etaa1 T C 11: 17,896,174 (GRCm39) S648G probably benign Het
Flnb A G 14: 7,929,936 (GRCm38) D2022G possibly damaging Het
Gpr158 T A 2: 21,830,059 (GRCm39) N701K probably damaging Het
H2-Eb2 C T 17: 34,553,230 (GRCm39) H139Y probably benign Het
Hbb-bh2 A T 7: 103,488,455 (GRCm39) V114E probably damaging Het
Ifna9 T A 4: 88,510,540 (GRCm39) Q28L probably benign Het
Inca1 T C 11: 70,579,566 (GRCm39) T188A probably benign Het
Irf9 G T 14: 55,846,496 (GRCm39) probably benign Het
Kdm1b T A 13: 47,214,369 (GRCm39) H238Q probably benign Het
Lpin1 G C 12: 16,588,537 (GRCm39) F851L probably damaging Het
Map3k9 C T 12: 81,770,936 (GRCm39) R884Q probably damaging Het
Mcm3ap C T 10: 76,320,495 (GRCm39) Q818* probably null Het
Mcm7 A T 5: 138,164,173 (GRCm39) probably null Het
Npdc1 G A 2: 25,298,957 (GRCm39) D284N probably damaging Het
Nppa G T 4: 148,085,544 (GRCm39) M50I probably benign Het
Phf14 T A 6: 11,988,756 (GRCm39) N665K possibly damaging Het
Plekhh3 G A 11: 101,056,009 (GRCm39) A47V probably damaging Het
Plekhh3 T A 11: 101,058,764 (GRCm39) E156V probably null Het
Prpf19 T C 19: 10,876,323 (GRCm39) probably benign Het
Rev3l T A 10: 39,697,456 (GRCm39) V651E possibly damaging Het
Sgpl1 T C 10: 60,948,044 (GRCm39) N171S probably damaging Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Slx4 T C 16: 3,798,860 (GRCm39) probably null Het
Smchd1 T A 17: 71,665,234 (GRCm39) probably benign Het
Snca A G 6: 60,792,719 (GRCm39) V63A probably benign Het
Taok3 A T 5: 117,390,695 (GRCm39) Q92L probably damaging Het
Uhrf1 T C 17: 56,616,401 (GRCm39) V73A probably damaging Het
Usp38 G A 8: 81,708,606 (GRCm39) Q991* probably null Het
Vmn2r96 T A 17: 18,817,866 (GRCm39) V673E probably damaging Het
Zan A G 5: 137,436,710 (GRCm39) Y2048H unknown Het
Zfp759 T A 13: 67,287,354 (GRCm39) Y302N probably damaging Het
Other mutations in Opcml
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00864:Opcml APN 9 28,812,887 (GRCm39) missense probably damaging 1.00
IGL00864:Opcml APN 9 28,812,886 (GRCm39) missense probably damaging 1.00
IGL00956:Opcml APN 9 28,586,624 (GRCm39) missense possibly damaging 0.86
IGL02391:Opcml APN 9 28,586,560 (GRCm39) missense probably damaging 0.96
IGL03210:Opcml APN 9 28,812,833 (GRCm39) missense probably damaging 0.99
R0373:Opcml UTSW 9 28,724,694 (GRCm39) missense possibly damaging 0.48
R1037:Opcml UTSW 9 28,814,595 (GRCm39) missense probably damaging 1.00
R1564:Opcml UTSW 9 28,814,612 (GRCm39) missense probably damaging 1.00
R2094:Opcml UTSW 9 28,812,886 (GRCm39) missense probably damaging 1.00
R2268:Opcml UTSW 9 28,814,651 (GRCm39) missense possibly damaging 0.91
R2426:Opcml UTSW 9 28,814,663 (GRCm39) critical splice donor site probably null
R2938:Opcml UTSW 9 27,702,682 (GRCm39) start codon destroyed probably null 0.00
R3746:Opcml UTSW 9 28,812,826 (GRCm39) missense possibly damaging 0.54
R4058:Opcml UTSW 9 28,812,884 (GRCm39) missense probably damaging 1.00
R4173:Opcml UTSW 9 28,814,654 (GRCm39) missense probably benign
R5335:Opcml UTSW 9 28,586,621 (GRCm39) missense possibly damaging 0.88
R7058:Opcml UTSW 9 28,586,507 (GRCm39) nonsense probably null
R7559:Opcml UTSW 9 28,814,620 (GRCm39) missense probably benign
R8050:Opcml UTSW 9 28,724,640 (GRCm39) missense probably damaging 0.97
R8250:Opcml UTSW 9 28,586,566 (GRCm39) missense probably damaging 1.00
R8350:Opcml UTSW 9 28,813,463 (GRCm39) missense probably benign 0.00
R8772:Opcml UTSW 9 27,702,707 (GRCm39) missense probably benign 0.04
R8879:Opcml UTSW 9 28,813,447 (GRCm39) missense probably damaging 1.00
R9355:Opcml UTSW 9 28,814,650 (GRCm39) missense probably benign 0.00
R9364:Opcml UTSW 9 28,814,624 (GRCm39) missense probably damaging 1.00
R9385:Opcml UTSW 9 28,586,459 (GRCm39) missense possibly damaging 0.62
Z1177:Opcml UTSW 9 28,315,673 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGTGTTGAGCCCCATTCTATG -3'
(R):5'- CACAGGCGATGAGAACAACCTG -3'

Sequencing Primer
(F):5'- GGCCATGCCTCTTCTGC -3'
(R):5'- GACAAAACTCTGCACTTTCTGTTGG -3'
Posted On 2016-03-17