Incidental Mutation 'R4882:Inca1'
ID 375341
Institutional Source Beutler Lab
Gene Symbol Inca1
Ensembl Gene ENSMUSG00000057054
Gene Name inhibitor of CDK, cyclin A1 interacting protein 1
Synonyms
MMRRC Submission 042490-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R4882 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 70579187-70590981 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 70579566 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 188 (T188A)
Ref Sequence ENSEMBL: ENSMUSP00000118761 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036299] [ENSMUST00000073625] [ENSMUST00000100933] [ENSMUST00000108541] [ENSMUST00000108542] [ENSMUST00000108543] [ENSMUST00000126114] [ENSMUST00000119120] [ENSMUST00000145823] [ENSMUST00000108545] [ENSMUST00000120261] [ENSMUST00000108544]
AlphaFold Q6PKN7
Predicted Effect probably benign
Transcript: ENSMUST00000036299
SMART Domains Protein: ENSMUSP00000043792
Gene: ENSMUSG00000040712

DomainStartEndE-ValueType
CG-1 34 155 1.07e-83 SMART
low complexity region 232 243 N/A INTRINSIC
low complexity region 273 291 N/A INTRINSIC
low complexity region 294 305 N/A INTRINSIC
low complexity region 314 329 N/A INTRINSIC
low complexity region 370 380 N/A INTRINSIC
low complexity region 417 435 N/A INTRINSIC
low complexity region 461 485 N/A INTRINSIC
low complexity region 501 514 N/A INTRINSIC
Pfam:TIG 541 621 6.2e-13 PFAM
low complexity region 660 679 N/A INTRINSIC
Blast:ANK 717 750 7e-12 BLAST
SCOP:d1myo__ 718 816 2e-15 SMART
Blast:ANK 762 792 4e-11 BLAST
low complexity region 829 839 N/A INTRINSIC
low complexity region 844 853 N/A INTRINSIC
low complexity region 861 882 N/A INTRINSIC
IQ 1053 1075 2.59e2 SMART
IQ 1076 1092 2.38e2 SMART
IQ 1106 1128 5.42e0 SMART
low complexity region 1140 1157 N/A INTRINSIC
low complexity region 1180 1190 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000073625
AA Change: T188A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000073311
Gene: ENSMUSG00000057054
AA Change: T188A

DomainStartEndE-ValueType
Pfam:INCA1 12 187 7.7e-94 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000100933
SMART Domains Protein: ENSMUSP00000098493
Gene: ENSMUSG00000040712

DomainStartEndE-ValueType
CG-1 36 152 8.08e-88 SMART
low complexity region 229 240 N/A INTRINSIC
low complexity region 270 288 N/A INTRINSIC
low complexity region 291 302 N/A INTRINSIC
low complexity region 311 326 N/A INTRINSIC
low complexity region 367 377 N/A INTRINSIC
low complexity region 414 432 N/A INTRINSIC
low complexity region 458 482 N/A INTRINSIC
low complexity region 498 511 N/A INTRINSIC
Pfam:TIG 538 618 1.2e-8 PFAM
low complexity region 657 676 N/A INTRINSIC
Blast:ANK 714 747 8e-12 BLAST
SCOP:d1myo__ 715 813 2e-15 SMART
Blast:ANK 759 789 4e-11 BLAST
low complexity region 826 836 N/A INTRINSIC
low complexity region 841 850 N/A INTRINSIC
low complexity region 858 879 N/A INTRINSIC
IQ 1050 1072 2.59e2 SMART
IQ 1073 1095 1.18e1 SMART
IQ 1096 1118 5.42e0 SMART
low complexity region 1130 1147 N/A INTRINSIC
low complexity region 1170 1180 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108541
AA Change: T188A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000104181
Gene: ENSMUSG00000057054
AA Change: T188A

DomainStartEndE-ValueType
Pfam:INCA1 12 187 7.7e-94 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108542
AA Change: T188A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000104182
Gene: ENSMUSG00000057054
AA Change: T188A

DomainStartEndE-ValueType
Pfam:INCA1 12 187 7.7e-94 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108543
AA Change: T153A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000104183
Gene: ENSMUSG00000057054
AA Change: T153A

DomainStartEndE-ValueType
Pfam:INCA1 1 152 1.5e-81 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000126114
AA Change: T188A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000118761
Gene: ENSMUSG00000057054
AA Change: T188A

DomainStartEndE-ValueType
Pfam:INCA1 12 187 8.4e-91 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150224
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125687
Predicted Effect probably benign
Transcript: ENSMUST00000119120
SMART Domains Protein: ENSMUSP00000113847
Gene: ENSMUSG00000040712

DomainStartEndE-ValueType
CG-1 34 150 8.08e-88 SMART
low complexity region 227 238 N/A INTRINSIC
low complexity region 268 286 N/A INTRINSIC
low complexity region 289 300 N/A INTRINSIC
low complexity region 309 324 N/A INTRINSIC
low complexity region 365 375 N/A INTRINSIC
low complexity region 412 430 N/A INTRINSIC
low complexity region 456 480 N/A INTRINSIC
low complexity region 496 509 N/A INTRINSIC
Pfam:TIG 536 616 1.1e-8 PFAM
low complexity region 655 674 N/A INTRINSIC
Blast:ANK 712 745 7e-12 BLAST
SCOP:d1myo__ 713 811 2e-15 SMART
Blast:ANK 757 787 8e-13 BLAST
low complexity region 824 834 N/A INTRINSIC
low complexity region 839 848 N/A INTRINSIC
low complexity region 856 877 N/A INTRINSIC
IQ 1048 1070 2.59e2 SMART
IQ 1071 1093 1.18e1 SMART
IQ 1094 1116 5.42e0 SMART
low complexity region 1128 1145 N/A INTRINSIC
low complexity region 1168 1178 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000145823
SMART Domains Protein: ENSMUSP00000123602
Gene: ENSMUSG00000040712

DomainStartEndE-ValueType
CG-1 34 137 2.55e-44 SMART
low complexity region 146 165 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108545
SMART Domains Protein: ENSMUSP00000104185
Gene: ENSMUSG00000040712

DomainStartEndE-ValueType
CG-1 34 126 3.23e-55 SMART
low complexity region 203 214 N/A INTRINSIC
low complexity region 244 262 N/A INTRINSIC
low complexity region 265 276 N/A INTRINSIC
low complexity region 285 300 N/A INTRINSIC
low complexity region 341 351 N/A INTRINSIC
low complexity region 388 406 N/A INTRINSIC
low complexity region 432 456 N/A INTRINSIC
low complexity region 472 485 N/A INTRINSIC
Pfam:TIG 512 592 1.1e-8 PFAM
low complexity region 631 650 N/A INTRINSIC
Blast:ANK 688 721 7e-12 BLAST
SCOP:d1myo__ 689 787 2e-15 SMART
Blast:ANK 733 763 5e-13 BLAST
low complexity region 800 810 N/A INTRINSIC
low complexity region 815 824 N/A INTRINSIC
low complexity region 832 853 N/A INTRINSIC
IQ 1024 1046 2.59e2 SMART
IQ 1047 1069 1.18e1 SMART
IQ 1070 1092 5.42e0 SMART
low complexity region 1104 1121 N/A INTRINSIC
low complexity region 1144 1154 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000120261
SMART Domains Protein: ENSMUSP00000113667
Gene: ENSMUSG00000040712

DomainStartEndE-ValueType
CG-1 34 126 3.23e-55 SMART
low complexity region 203 214 N/A INTRINSIC
low complexity region 244 262 N/A INTRINSIC
low complexity region 265 276 N/A INTRINSIC
low complexity region 285 300 N/A INTRINSIC
low complexity region 341 351 N/A INTRINSIC
low complexity region 388 406 N/A INTRINSIC
low complexity region 432 456 N/A INTRINSIC
low complexity region 472 485 N/A INTRINSIC
Pfam:TIG 512 592 1e-8 PFAM
low complexity region 631 650 N/A INTRINSIC
Blast:ANK 688 721 7e-12 BLAST
SCOP:d1myo__ 689 787 2e-15 SMART
Blast:ANK 733 763 7e-13 BLAST
low complexity region 800 810 N/A INTRINSIC
low complexity region 815 824 N/A INTRINSIC
low complexity region 832 853 N/A INTRINSIC
IQ 1024 1046 2.59e2 SMART
IQ 1047 1063 2.38e2 SMART
IQ 1077 1099 5.42e0 SMART
low complexity region 1111 1128 N/A INTRINSIC
low complexity region 1151 1161 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108544
SMART Domains Protein: ENSMUSP00000104184
Gene: ENSMUSG00000040712

DomainStartEndE-ValueType
CG-1 34 150 8.08e-88 SMART
low complexity region 227 238 N/A INTRINSIC
low complexity region 268 286 N/A INTRINSIC
low complexity region 289 300 N/A INTRINSIC
low complexity region 309 324 N/A INTRINSIC
low complexity region 365 375 N/A INTRINSIC
low complexity region 412 430 N/A INTRINSIC
low complexity region 456 480 N/A INTRINSIC
low complexity region 496 509 N/A INTRINSIC
Pfam:TIG 536 616 1.2e-8 PFAM
low complexity region 655 674 N/A INTRINSIC
Blast:ANK 712 745 7e-12 BLAST
SCOP:d1myo__ 713 811 2e-15 SMART
Blast:ANK 757 787 4e-11 BLAST
low complexity region 824 834 N/A INTRINSIC
low complexity region 839 848 N/A INTRINSIC
low complexity region 856 877 N/A INTRINSIC
IQ 1048 1070 2.59e2 SMART
IQ 1071 1087 2.38e2 SMART
IQ 1101 1123 5.42e0 SMART
low complexity region 1135 1152 N/A INTRINSIC
low complexity region 1175 1185 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.9%
Validation Efficiency 98% (59/60)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased cell proliferation in mouse embryonic fibroblasts and older mice exhibit abnormal spleen architecture, particularly in the white pulp, and extramedullary hematopoiesis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap3 A G 4: 155,990,112 (GRCm39) D764G probably damaging Het
Adgrg6 T A 10: 14,310,081 (GRCm39) I775F possibly damaging Het
Ahnak T A 19: 8,983,261 (GRCm39) M1515K probably damaging Het
Aqp4 A G 18: 15,531,311 (GRCm39) V150A possibly damaging Het
Axdnd1 A T 1: 156,223,129 (GRCm39) probably null Het
Bap1 C T 14: 30,973,678 (GRCm39) probably benign Het
BB014433 A G 8: 15,092,016 (GRCm39) V279A probably benign Het
Cacng8 T C 7: 3,460,669 (GRCm39) Y151H probably damaging Het
Caskin1 T C 17: 24,723,389 (GRCm39) S726P probably damaging Het
Cd200 T C 16: 45,217,380 (GRCm39) T104A probably benign Het
Cdk12 C T 11: 98,101,272 (GRCm39) R377C unknown Het
Ceacam13 A G 7: 17,746,997 (GRCm39) H150R probably benign Het
Cebpzos T C 17: 79,227,220 (GRCm39) Y65H probably benign Het
Cgnl1 T A 9: 71,624,683 (GRCm39) M630L probably benign Het
Dop1b G T 16: 93,549,802 (GRCm39) R247L possibly damaging Het
Dqx1 A G 6: 83,043,069 (GRCm39) probably null Het
Etaa1 T C 11: 17,896,174 (GRCm39) S648G probably benign Het
Flnb A G 14: 7,929,936 (GRCm38) D2022G possibly damaging Het
Gpr158 T A 2: 21,830,059 (GRCm39) N701K probably damaging Het
H2-Eb2 C T 17: 34,553,230 (GRCm39) H139Y probably benign Het
Hbb-bh2 A T 7: 103,488,455 (GRCm39) V114E probably damaging Het
Ifna9 T A 4: 88,510,540 (GRCm39) Q28L probably benign Het
Irf9 G T 14: 55,846,496 (GRCm39) probably benign Het
Kdm1b T A 13: 47,214,369 (GRCm39) H238Q probably benign Het
Lpin1 G C 12: 16,588,537 (GRCm39) F851L probably damaging Het
Map3k9 C T 12: 81,770,936 (GRCm39) R884Q probably damaging Het
Mcm3ap C T 10: 76,320,495 (GRCm39) Q818* probably null Het
Mcm7 A T 5: 138,164,173 (GRCm39) probably null Het
Npdc1 G A 2: 25,298,957 (GRCm39) D284N probably damaging Het
Nppa G T 4: 148,085,544 (GRCm39) M50I probably benign Het
Opcml G A 9: 28,812,886 (GRCm39) E193K probably damaging Het
Phf14 T A 6: 11,988,756 (GRCm39) N665K possibly damaging Het
Plekhh3 G A 11: 101,056,009 (GRCm39) A47V probably damaging Het
Plekhh3 T A 11: 101,058,764 (GRCm39) E156V probably null Het
Prpf19 T C 19: 10,876,323 (GRCm39) probably benign Het
Rev3l T A 10: 39,697,456 (GRCm39) V651E possibly damaging Het
Sgpl1 T C 10: 60,948,044 (GRCm39) N171S probably damaging Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Slx4 T C 16: 3,798,860 (GRCm39) probably null Het
Smchd1 T A 17: 71,665,234 (GRCm39) probably benign Het
Snca A G 6: 60,792,719 (GRCm39) V63A probably benign Het
Taok3 A T 5: 117,390,695 (GRCm39) Q92L probably damaging Het
Uhrf1 T C 17: 56,616,401 (GRCm39) V73A probably damaging Het
Usp38 G A 8: 81,708,606 (GRCm39) Q991* probably null Het
Vmn2r96 T A 17: 18,817,866 (GRCm39) V673E probably damaging Het
Zan A G 5: 137,436,710 (GRCm39) Y2048H unknown Het
Zfp759 T A 13: 67,287,354 (GRCm39) Y302N probably damaging Het
Other mutations in Inca1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0505:Inca1 UTSW 11 70,581,025 (GRCm39) missense probably damaging 0.99
R5395:Inca1 UTSW 11 70,581,264 (GRCm39) critical splice donor site probably null
R5838:Inca1 UTSW 11 70,580,707 (GRCm39) missense probably damaging 1.00
R5878:Inca1 UTSW 11 70,586,808 (GRCm39) unclassified probably benign
R6532:Inca1 UTSW 11 70,586,733 (GRCm39) start codon destroyed probably null 0.77
R9158:Inca1 UTSW 11 70,581,376 (GRCm39) missense probably damaging 0.99
R9174:Inca1 UTSW 11 70,580,732 (GRCm39) missense possibly damaging 0.86
R9688:Inca1 UTSW 11 70,579,810 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- AACATCCGCTCTGAAGCCAG -3'
(R):5'- TCATAATCAAATGGGGATGTGGC -3'

Sequencing Primer
(F):5'- TCTGAAGCCAGCACTAGGG -3'
(R):5'- CAGAAGCCAAGAGCCAGGTAG -3'
Posted On 2016-03-17