Incidental Mutation 'R4886:Apc2'
| ID |
375741 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Apc2
|
| Ensembl Gene |
ENSMUSG00000020135 |
| Gene Name |
APC regulator of WNT signaling pathway 2 |
| Synonyms |
APCL |
| MMRRC Submission |
042492-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R4886 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
80131811-80154097 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 80150047 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 1700
(H1700Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000100996
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020341]
[ENSMUST00000020349]
[ENSMUST00000105359]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020341
|
| SMART Domains |
Protein: ENSMUSP00000020341
Gene: ENSMUSG00000020133
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:UPF0449
|
6 |
103 |
7.5e-40 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000020349
AA Change: H1671Q
PolyPhen 2
Score 0.768 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000020349
Gene: ENSMUSG00000020135
AA Change: H1671Q
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:1DEB|B
|
4 |
57 |
9e-17 |
PDB |
|
Pfam:Suppressor_APC
|
123 |
205 |
1.3e-28 |
PFAM |
|
coiled coil region
|
214 |
236 |
N/A |
INTRINSIC |
|
low complexity region
|
242 |
261 |
N/A |
INTRINSIC |
|
ARM
|
300 |
355 |
2.95e0 |
SMART |
|
ARM
|
417 |
468 |
2.22e-2 |
SMART |
|
ARM
|
470 |
511 |
3.22e0 |
SMART |
|
ARM
|
513 |
555 |
3.56e-1 |
SMART |
|
ARM
|
557 |
602 |
2.1e1 |
SMART |
|
ARM
|
607 |
647 |
1.82e-7 |
SMART |
|
Blast:ARM
|
649 |
689 |
6e-18 |
BLAST |
|
low complexity region
|
772 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
844 |
N/A |
INTRINSIC |
|
low complexity region
|
859 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
971 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1103 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1134 |
1159 |
4.4e-9 |
PFAM |
|
low complexity region
|
1197 |
1208 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1244 |
1269 |
4.1e-8 |
PFAM |
|
Pfam:SAMP
|
1323 |
1343 |
2.1e-10 |
PFAM |
|
Pfam:APC_crr
|
1369 |
1394 |
5.8e-8 |
PFAM |
|
low complexity region
|
1500 |
1516 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1540 |
1565 |
5.7e-8 |
PFAM |
|
Pfam:SAMP
|
1594 |
1613 |
8.8e-11 |
PFAM |
|
low complexity region
|
1673 |
1699 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1757 |
2093 |
1.1e-142 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105359
AA Change: H1700Q
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000100996
Gene: ENSMUSG00000020135
AA Change: H1700Q
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:APC_N_CC
|
30 |
81 |
2.7e-34 |
PFAM |
|
Pfam:Suppressor_APC
|
148 |
228 |
1.4e-27 |
PFAM |
|
coiled coil region
|
238 |
260 |
N/A |
INTRINSIC |
|
low complexity region
|
266 |
285 |
N/A |
INTRINSIC |
|
ARM
|
324 |
379 |
2.95e0 |
SMART |
|
ARM
|
446 |
497 |
2.22e-2 |
SMART |
|
ARM
|
499 |
540 |
3.22e0 |
SMART |
|
ARM
|
542 |
584 |
3.56e-1 |
SMART |
|
ARM
|
586 |
631 |
2.1e1 |
SMART |
|
ARM
|
636 |
676 |
1.82e-7 |
SMART |
|
Blast:ARM
|
678 |
718 |
6e-18 |
BLAST |
|
Pfam:Arm_APC_u3
|
719 |
977 |
1.1e-26 |
PFAM |
|
low complexity region
|
1000 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1086 |
1098 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1132 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1164 |
1187 |
9.3e-8 |
PFAM |
|
low complexity region
|
1226 |
1237 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1274 |
1297 |
7.9e-10 |
PFAM |
|
Pfam:APC_crr
|
1399 |
1423 |
1.3e-9 |
PFAM |
|
low complexity region
|
1529 |
1545 |
N/A |
INTRINSIC |
|
low complexity region
|
1585 |
1603 |
N/A |
INTRINSIC |
|
Pfam:SAMP
|
1624 |
1642 |
1.3e-11 |
PFAM |
|
low complexity region
|
1702 |
1728 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1786 |
2122 |
1.3e-122 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9430097D07Rik |
A |
T |
2: 32,464,630 (GRCm39) |
|
probably benign |
Het |
| Aagab |
G |
C |
9: 63,543,738 (GRCm39) |
A231P |
possibly damaging |
Het |
| Adgra3 |
C |
T |
5: 50,156,537 (GRCm39) |
D398N |
probably benign |
Het |
| Ap3b1 |
A |
T |
13: 94,609,313 (GRCm39) |
D616V |
possibly damaging |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Atp2b4 |
T |
A |
1: 133,634,518 (GRCm39) |
I1177L |
probably benign |
Het |
| Card6 |
T |
C |
15: 5,134,623 (GRCm39) |
|
probably null |
Het |
| Cdk13 |
A |
G |
13: 17,894,319 (GRCm39) |
S1103P |
probably benign |
Het |
| Cdk6 |
G |
T |
5: 3,394,444 (GRCm39) |
K26N |
possibly damaging |
Het |
| Cfap221 |
T |
C |
1: 119,861,934 (GRCm39) |
T614A |
probably damaging |
Het |
| Cfap221 |
T |
A |
1: 119,912,488 (GRCm39) |
Y133F |
probably damaging |
Het |
| Clcc1 |
A |
G |
3: 108,584,154 (GRCm39) |
T513A |
probably benign |
Het |
| Clec4g |
T |
A |
8: 3,766,419 (GRCm39) |
|
probably benign |
Het |
| Cntln |
A |
C |
4: 84,889,466 (GRCm39) |
E316D |
probably benign |
Het |
| Col6a4 |
A |
G |
9: 105,937,271 (GRCm39) |
I1415T |
probably benign |
Het |
| Cpne2 |
T |
A |
8: 95,290,592 (GRCm39) |
D392E |
probably benign |
Het |
| Cpz |
T |
C |
5: 35,664,048 (GRCm39) |
N496D |
probably damaging |
Het |
| Cyp3a59 |
A |
G |
5: 146,024,197 (GRCm39) |
D61G |
probably damaging |
Het |
| Cyp4a29 |
T |
C |
4: 115,110,078 (GRCm39) |
V440A |
probably benign |
Het |
| Dbn1 |
A |
T |
13: 55,625,355 (GRCm39) |
|
probably benign |
Het |
| Ddx46 |
A |
G |
13: 55,786,012 (GRCm39) |
D64G |
unknown |
Het |
| Dhrs7c |
G |
A |
11: 67,700,620 (GRCm39) |
V56M |
probably damaging |
Het |
| Dnhd1 |
T |
A |
7: 105,364,015 (GRCm39) |
H4122Q |
probably benign |
Het |
| Ecm2 |
A |
T |
13: 49,676,263 (GRCm39) |
I327F |
possibly damaging |
Het |
| Elavl3 |
T |
C |
9: 21,937,614 (GRCm39) |
K189E |
possibly damaging |
Het |
| Enam |
A |
T |
5: 88,636,593 (GRCm39) |
R82* |
probably null |
Het |
| Fat3 |
T |
A |
9: 15,932,626 (GRCm39) |
I1436F |
probably benign |
Het |
| Glt8d2 |
T |
C |
10: 82,487,874 (GRCm39) |
|
probably benign |
Het |
| Grin2c |
T |
C |
11: 115,151,616 (GRCm39) |
T115A |
probably damaging |
Het |
| H6pd |
C |
T |
4: 150,067,235 (GRCm39) |
V384M |
possibly damaging |
Het |
| Hba-x |
A |
G |
11: 32,227,008 (GRCm39) |
E39G |
probably benign |
Het |
| Hcar2 |
G |
A |
5: 124,003,260 (GRCm39) |
T81M |
probably benign |
Het |
| Herpud2 |
G |
A |
9: 25,036,285 (GRCm39) |
P125L |
probably benign |
Het |
| Hnrnpul2 |
C |
T |
19: 8,807,191 (GRCm39) |
P618S |
probably benign |
Het |
| Hpse2 |
T |
C |
19: 43,373,203 (GRCm39) |
Y142C |
probably damaging |
Het |
| Iqcm |
A |
T |
8: 76,615,228 (GRCm39) |
R436S |
possibly damaging |
Het |
| Itih1 |
A |
G |
14: 30,658,658 (GRCm39) |
|
probably null |
Het |
| Kcnk10 |
T |
C |
12: 98,401,418 (GRCm39) |
N405S |
possibly damaging |
Het |
| Klhl14 |
A |
T |
18: 21,691,029 (GRCm39) |
|
probably null |
Het |
| L3mbtl3 |
T |
A |
10: 26,168,668 (GRCm39) |
E587V |
unknown |
Het |
| Leap2 |
A |
T |
11: 53,313,653 (GRCm39) |
F40I |
probably damaging |
Het |
| Leng8 |
T |
A |
7: 4,147,930 (GRCm39) |
|
probably null |
Het |
| Lrrc66 |
A |
G |
5: 73,765,910 (GRCm39) |
F378L |
probably benign |
Het |
| Mansc1 |
T |
C |
6: 134,587,625 (GRCm39) |
H184R |
probably benign |
Het |
| Map10 |
T |
A |
8: 126,397,431 (GRCm39) |
Y275N |
probably damaging |
Het |
| Med23 |
T |
C |
10: 24,750,581 (GRCm39) |
|
probably null |
Het |
| Mpp3 |
A |
G |
11: 101,915,962 (GRCm39) |
Y55H |
probably benign |
Het |
| Mrpl17 |
T |
C |
7: 105,459,260 (GRCm39) |
N112S |
probably benign |
Het |
| Nectin4 |
T |
C |
1: 171,212,383 (GRCm39) |
V327A |
possibly damaging |
Het |
| Nlrp14 |
A |
T |
7: 106,781,862 (GRCm39) |
H353L |
probably benign |
Het |
| Notch2 |
A |
T |
3: 98,009,735 (GRCm39) |
Y554F |
probably damaging |
Het |
| Nphp3 |
T |
C |
9: 103,880,193 (GRCm39) |
S72P |
probably damaging |
Het |
| Nrsn2 |
T |
C |
2: 152,211,531 (GRCm39) |
K167E |
probably benign |
Het |
| Or14j8 |
A |
T |
17: 38,262,962 (GRCm39) |
S318T |
probably benign |
Het |
| Or5b117 |
T |
C |
19: 13,431,885 (GRCm39) |
|
probably null |
Het |
| Or8g30 |
T |
C |
9: 39,230,881 (GRCm39) |
T10A |
probably benign |
Het |
| Or9i2 |
T |
A |
19: 13,815,643 (GRCm39) |
E298V |
probably damaging |
Het |
| Osbpl9 |
T |
C |
4: 108,925,564 (GRCm39) |
N485S |
probably benign |
Het |
| Pbk |
T |
A |
14: 66,052,650 (GRCm39) |
H164Q |
probably damaging |
Het |
| Pfn2 |
G |
T |
3: 57,754,874 (GRCm39) |
N10K |
probably damaging |
Het |
| Pi4ka |
A |
G |
16: 17,176,225 (GRCm39) |
S405P |
|
Het |
| Pik3ca |
A |
G |
3: 32,491,312 (GRCm39) |
D133G |
probably damaging |
Het |
| Pramel27 |
G |
T |
4: 143,579,873 (GRCm39) |
R486L |
probably benign |
Het |
| Prkar2a |
G |
A |
9: 108,622,823 (GRCm39) |
|
probably null |
Het |
| Prl6a1 |
A |
T |
13: 27,502,983 (GRCm39) |
D193V |
probably damaging |
Het |
| Psg25 |
A |
T |
7: 18,258,838 (GRCm39) |
D279E |
probably benign |
Het |
| Rad21 |
G |
T |
15: 51,831,896 (GRCm39) |
P395Q |
probably damaging |
Het |
| Rnf168 |
C |
A |
16: 32,118,014 (GRCm39) |
T525K |
probably benign |
Het |
| Rpn2 |
T |
C |
2: 157,159,964 (GRCm39) |
|
probably null |
Het |
| Rreb1 |
G |
A |
13: 38,115,034 (GRCm39) |
V798M |
possibly damaging |
Het |
| Scgb3a2 |
C |
T |
18: 43,899,819 (GRCm39) |
P36S |
probably damaging |
Het |
| Scn3a |
T |
C |
2: 65,291,376 (GRCm39) |
D1790G |
probably damaging |
Het |
| Sec24b |
A |
T |
3: 129,777,619 (GRCm39) |
H1226Q |
probably benign |
Het |
| Sec63 |
T |
A |
10: 42,665,389 (GRCm39) |
Y106* |
probably null |
Het |
| Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
| Slc12a3 |
G |
A |
8: 95,078,438 (GRCm39) |
|
probably null |
Het |
| Slc6a1 |
T |
A |
6: 114,279,494 (GRCm39) |
I91N |
possibly damaging |
Het |
| Slitrk6 |
T |
C |
14: 110,989,315 (GRCm39) |
T131A |
probably damaging |
Het |
| Spata1 |
C |
G |
3: 146,175,529 (GRCm39) |
D326H |
probably damaging |
Het |
| St8sia1 |
G |
A |
6: 142,859,860 (GRCm39) |
L90F |
probably damaging |
Het |
| Thsd4 |
T |
A |
9: 59,896,313 (GRCm39) |
Y657F |
probably benign |
Het |
| Thsd7a |
A |
T |
6: 12,327,659 (GRCm39) |
C1404* |
probably null |
Het |
| Tma16 |
A |
C |
8: 66,934,129 (GRCm39) |
C75W |
probably damaging |
Het |
| Trgv4 |
T |
C |
13: 19,369,236 (GRCm39) |
V29A |
probably benign |
Het |
| Trim3 |
T |
A |
7: 105,267,047 (GRCm39) |
H444L |
probably damaging |
Het |
| Trmt10a |
A |
T |
3: 137,854,146 (GRCm39) |
K75* |
probably null |
Het |
| Ttn |
T |
C |
2: 76,561,644 (GRCm39) |
D28954G |
probably damaging |
Het |
| Uggt2 |
A |
G |
14: 119,273,376 (GRCm39) |
|
probably null |
Het |
| Vars1 |
T |
A |
17: 35,234,702 (GRCm39) |
V1177E |
probably benign |
Het |
| Vmn2r114 |
G |
T |
17: 23,527,008 (GRCm39) |
A508E |
probably benign |
Het |
| Vmn2r19 |
G |
T |
6: 123,286,800 (GRCm39) |
K144N |
probably benign |
Het |
| Wdr41 |
C |
T |
13: 95,151,682 (GRCm39) |
Q281* |
probably null |
Het |
| Zfp938 |
T |
A |
10: 82,061,957 (GRCm39) |
Q221L |
probably benign |
Het |
|
| Other mutations in Apc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01069:Apc2
|
APN |
10 |
80,147,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01154:Apc2
|
APN |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01411:Apc2
|
APN |
10 |
80,150,912 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01598:Apc2
|
APN |
10 |
80,148,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01621:Apc2
|
APN |
10 |
80,142,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01720:Apc2
|
APN |
10 |
80,150,333 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01837:Apc2
|
APN |
10 |
80,150,492 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01933:Apc2
|
APN |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02243:Apc2
|
APN |
10 |
80,138,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02292:Apc2
|
APN |
10 |
80,138,258 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02956:Apc2
|
APN |
10 |
80,142,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03081:Apc2
|
APN |
10 |
80,148,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Apc2
|
APN |
10 |
80,149,220 (GRCm39) |
missense |
probably damaging |
0.98 |
|
LCD18:Apc2
|
UTSW |
10 |
80,135,808 (GRCm39) |
intron |
probably benign |
|
|
R0278:Apc2
|
UTSW |
10 |
80,148,647 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0501:Apc2
|
UTSW |
10 |
80,150,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0594:Apc2
|
UTSW |
10 |
80,142,090 (GRCm39) |
nonsense |
probably null |
|
|
R0607:Apc2
|
UTSW |
10 |
80,149,935 (GRCm39) |
missense |
probably benign |
|
|
R0624:Apc2
|
UTSW |
10 |
80,150,417 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0633:Apc2
|
UTSW |
10 |
80,143,289 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0638:Apc2
|
UTSW |
10 |
80,140,801 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0647:Apc2
|
UTSW |
10 |
80,140,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0830:Apc2
|
UTSW |
10 |
80,151,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1071:Apc2
|
UTSW |
10 |
80,147,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1221:Apc2
|
UTSW |
10 |
80,142,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1432:Apc2
|
UTSW |
10 |
80,148,183 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1579:Apc2
|
UTSW |
10 |
80,147,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Apc2
|
UTSW |
10 |
80,137,676 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1700:Apc2
|
UTSW |
10 |
80,148,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Apc2
|
UTSW |
10 |
80,144,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Apc2
|
UTSW |
10 |
80,149,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Apc2
|
UTSW |
10 |
80,150,678 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1915:Apc2
|
UTSW |
10 |
80,151,701 (GRCm39) |
missense |
probably benign |
|
|
R1999:Apc2
|
UTSW |
10 |
80,144,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Apc2
|
UTSW |
10 |
80,143,443 (GRCm39) |
splice site |
probably null |
|
|
R2219:Apc2
|
UTSW |
10 |
80,144,943 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2393:Apc2
|
UTSW |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3862:Apc2
|
UTSW |
10 |
80,143,393 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3900:Apc2
|
UTSW |
10 |
80,131,806 (GRCm39) |
splice site |
probably null |
|
|
R3901:Apc2
|
UTSW |
10 |
80,150,922 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3952:Apc2
|
UTSW |
10 |
80,150,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4009:Apc2
|
UTSW |
10 |
80,149,426 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4090:Apc2
|
UTSW |
10 |
80,141,378 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4695:Apc2
|
UTSW |
10 |
80,146,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Apc2
|
UTSW |
10 |
80,150,192 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4807:Apc2
|
UTSW |
10 |
80,150,196 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4964:Apc2
|
UTSW |
10 |
80,149,841 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5056:Apc2
|
UTSW |
10 |
80,137,148 (GRCm39) |
missense |
probably benign |
|
|
R5057:Apc2
|
UTSW |
10 |
80,144,903 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5165:Apc2
|
UTSW |
10 |
80,151,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5241:Apc2
|
UTSW |
10 |
80,148,068 (GRCm39) |
missense |
probably benign |
|
|
R5649:Apc2
|
UTSW |
10 |
80,149,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5924:Apc2
|
UTSW |
10 |
80,147,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6124:Apc2
|
UTSW |
10 |
80,142,185 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6218:Apc2
|
UTSW |
10 |
80,142,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6376:Apc2
|
UTSW |
10 |
80,148,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6490:Apc2
|
UTSW |
10 |
80,149,757 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6572:Apc2
|
UTSW |
10 |
80,147,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Apc2
|
UTSW |
10 |
80,149,401 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7171:Apc2
|
UTSW |
10 |
80,151,170 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7180:Apc2
|
UTSW |
10 |
80,146,990 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7326:Apc2
|
UTSW |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7340:Apc2
|
UTSW |
10 |
80,149,316 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7378:Apc2
|
UTSW |
10 |
80,147,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7384:Apc2
|
UTSW |
10 |
80,148,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Apc2
|
UTSW |
10 |
80,138,017 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7543:Apc2
|
UTSW |
10 |
80,150,720 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7743:Apc2
|
UTSW |
10 |
80,140,749 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7759:Apc2
|
UTSW |
10 |
80,147,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8244:Apc2
|
UTSW |
10 |
80,151,166 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8327:Apc2
|
UTSW |
10 |
80,137,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8489:Apc2
|
UTSW |
10 |
80,143,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8494:Apc2
|
UTSW |
10 |
80,150,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8669:Apc2
|
UTSW |
10 |
80,149,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8773:Apc2
|
UTSW |
10 |
80,142,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8920:Apc2
|
UTSW |
10 |
80,149,934 (GRCm39) |
missense |
probably benign |
|
|
R9178:Apc2
|
UTSW |
10 |
80,150,235 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9224:Apc2
|
UTSW |
10 |
80,150,111 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9357:Apc2
|
UTSW |
10 |
80,146,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9394:Apc2
|
UTSW |
10 |
80,145,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Apc2
|
UTSW |
10 |
80,147,183 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R9689:Apc2
|
UTSW |
10 |
80,150,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0018:Apc2
|
UTSW |
10 |
80,148,098 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1177:Apc2
|
UTSW |
10 |
80,147,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGAGATGTATCAGCTTGGCC -3'
(R):5'- GATCTTAGTGGAAGTTGTGCCCC -3'
Sequencing Primer
(F):5'- CCGGACCCAGGTGCCTG -3'
(R):5'- GAAGTTGTGCCCCGTTTCTCAG -3'
|
| Posted On |
2016-03-17 |
Incidental Mutation