Incidental Mutation 'R4897:Or4c10b'
ID 375792
Institutional Source Beutler Lab
Gene Symbol Or4c10b
Ensembl Gene ENSMUSG00000049057
Gene Name olfactory receptor family 4 subfamily C member 10B
Synonyms MOR232-1, Olfr1257, GA_x6K02T2Q125-51319458-51320387
MMRRC Submission 042501-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R4897 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 89709708-89712147 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 89711476 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 102 (E102G)
Ref Sequence ENSEMBL: ENSMUSP00000107144 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060795] [ENSMUST00000111519]
AlphaFold Q8VGP0
Predicted Effect probably benign
Transcript: ENSMUST00000060795
AA Change: E102G

PolyPhen 2 Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000056439
Gene: ENSMUSG00000049057
AA Change: E102G

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 2.6e-31 PFAM
Pfam:7tm_4 137 278 8e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111519
AA Change: E102G

PolyPhen 2 Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000107144
Gene: ENSMUSG00000049057
AA Change: E102G

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.5e-49 PFAM
Pfam:7tm_1 39 285 3.9e-18 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.1%
Validation Efficiency 100% (79/79)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402F06Rik C A 2: 35,266,309 (GRCm39) M120I probably damaging Het
4933427D14Rik A T 11: 72,082,342 (GRCm39) L328Q probably damaging Het
Adgrv1 A C 13: 81,709,704 (GRCm39) probably null Het
Ankrd46 A T 15: 36,484,279 (GRCm39) probably benign Het
Arhgef18 A T 8: 3,494,979 (GRCm39) M413L probably benign Het
Atp6v1e1 G A 6: 120,781,044 (GRCm39) T87M probably null Het
Bap1 T C 14: 30,980,402 (GRCm39) probably benign Het
Brf1 A G 12: 112,929,507 (GRCm39) L385P probably benign Het
C1qtnf1 A T 11: 118,338,938 (GRCm39) N203Y probably damaging Het
Catsperb A T 12: 101,569,025 (GRCm39) N899I probably damaging Het
Ccnjl A C 11: 43,470,718 (GRCm39) D162A probably damaging Het
Cd248 A C 19: 5,119,195 (GRCm39) I348L probably benign Het
Cdc20 T C 4: 118,293,029 (GRCm39) T265A probably benign Het
Cdca5 T A 19: 6,140,427 (GRCm39) L196* probably null Het
Cdk4 T A 10: 126,900,444 (GRCm39) probably benign Het
Cldn10 G A 14: 119,025,725 (GRCm39) G53S possibly damaging Het
Clec4b2 G T 6: 123,177,999 (GRCm39) E105* probably null Het
Dapk1 T A 13: 60,909,600 (GRCm39) D1404E probably benign Het
Dnah1 T C 14: 30,989,496 (GRCm39) Y3308C probably damaging Het
Dnah17 A C 11: 117,969,419 (GRCm39) Y2260D probably damaging Het
Dock8 T G 19: 25,159,001 (GRCm39) S1720A probably benign Het
Erc1 A G 6: 119,754,947 (GRCm39) probably null Het
Ergic1 A G 17: 26,848,597 (GRCm39) I66V probably benign Het
Fam186a T C 15: 99,843,158 (GRCm39) T1029A possibly damaging Het
Fat4 A T 3: 39,034,781 (GRCm39) Y2811F probably damaging Het
Flt3 A G 5: 147,306,110 (GRCm39) M310T probably damaging Het
Ganab T A 19: 8,892,355 (GRCm39) C844S probably benign Het
Gas2l2 C A 11: 83,320,041 (GRCm39) V72F probably damaging Het
Gm14401 T A 2: 176,778,573 (GRCm39) C220S probably damaging Het
Hmmr A T 11: 40,619,261 (GRCm39) V73E probably benign Het
Idi2l T G 13: 8,990,637 (GRCm39) probably benign Het
Ifih1 G T 2: 62,465,358 (GRCm39) probably benign Het
Jak3 A G 8: 72,138,048 (GRCm39) E833G probably damaging Het
Lama2 TTTGCGCATT TTT 10: 26,919,639 (GRCm39) probably null Het
Ldb1 G A 19: 46,023,132 (GRCm39) A217V probably benign Het
Lrrc8c A G 5: 105,755,955 (GRCm39) T577A probably benign Het
Mfn1 T A 3: 32,600,711 (GRCm39) probably benign Het
Mki67 G A 7: 135,298,474 (GRCm39) P2187S probably damaging Het
Mrc1 T A 2: 14,323,952 (GRCm39) D1096E probably benign Het
Msi1 A G 5: 115,573,654 (GRCm39) probably benign Het
Msto1 T A 3: 88,819,559 (GRCm39) I152F probably benign Het
Myo9a A G 9: 59,803,800 (GRCm39) R2060G probably benign Het
Nnt A T 13: 119,541,107 (GRCm39) C44* probably null Het
Nup210l A G 3: 90,100,378 (GRCm39) D1468G probably damaging Het
Or1j16 T C 2: 36,530,906 (GRCm39) L285P probably damaging Het
Or5d46 C A 2: 88,174,686 (GRCm39) C129F possibly damaging Het
Or7a40 T C 16: 16,491,482 (GRCm39) D121G probably damaging Het
P2rx3 G A 2: 84,855,270 (GRCm39) T62I probably damaging Het
Pabpc4l G T 3: 46,401,578 (GRCm39) T22K probably damaging Het
Pcdha7 A G 18: 37,108,646 (GRCm39) D557G probably damaging Het
Pcdhb20 A G 18: 37,639,298 (GRCm39) K608R possibly damaging Het
Pcnx1 A G 12: 81,964,939 (GRCm39) S369G probably damaging Het
Plod1 T C 4: 148,004,736 (GRCm39) I455V probably benign Het
Prune2 A T 19: 17,099,219 (GRCm39) E1574D probably benign Het
Ptar1 T A 19: 23,680,472 (GRCm39) L96H probably damaging Het
Rabgap1 T C 2: 37,450,583 (GRCm39) S904P probably benign Het
Rps6ka4 C T 19: 6,815,467 (GRCm39) V176I probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Runx1t1 T A 4: 13,771,459 (GRCm39) M1K probably null Het
Serinc4 T A 2: 121,282,905 (GRCm39) Y419F probably damaging Het
Serpina12 A T 12: 104,004,056 (GRCm39) M192K possibly damaging Het
Spata21 T A 4: 140,832,261 (GRCm39) M474K probably damaging Het
Stpg1 T C 4: 135,246,676 (GRCm39) S135P possibly damaging Het
Tdrkh A G 3: 94,336,671 (GRCm39) D481G probably damaging Het
Ube2e1 A C 14: 18,285,268 (GRCm38) S68R probably damaging Het
Vcpip1 A C 1: 9,817,572 (GRCm39) N270K probably damaging Het
Vmn2r79 T C 7: 86,650,675 (GRCm39) F154L probably benign Het
Vwa3b A G 1: 37,153,684 (GRCm39) probably benign Het
Xdh C A 17: 74,207,703 (GRCm39) V885L probably benign Het
Zfp141 A T 7: 42,125,629 (GRCm39) V281D probably benign Het
Zfp317 T A 9: 19,558,143 (GRCm39) I119N probably benign Het
Zfp345 G A 2: 150,314,608 (GRCm39) R310C probably benign Het
Zfp760 G A 17: 21,942,229 (GRCm39) C468Y probably benign Het
Other mutations in Or4c10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01600:Or4c10b APN 2 89,712,006 (GRCm39) missense probably benign 0.02
IGL01641:Or4c10b APN 2 89,711,952 (GRCm39) missense probably benign 0.01
IGL01668:Or4c10b APN 2 89,711,443 (GRCm39) missense probably benign 0.01
IGL01901:Or4c10b APN 2 89,711,826 (GRCm39) missense probably damaging 1.00
IGL02401:Or4c10b APN 2 89,711,797 (GRCm39) missense probably damaging 1.00
IGL02472:Or4c10b APN 2 89,711,755 (GRCm39) missense probably benign 0.44
IGL02631:Or4c10b APN 2 89,711,599 (GRCm39) missense possibly damaging 0.95
PIT4354001:Or4c10b UTSW 2 89,711,852 (GRCm39) missense probably benign 0.04
R0552:Or4c10b UTSW 2 89,711,235 (GRCm39) nonsense probably null
R0616:Or4c10b UTSW 2 89,711,935 (GRCm39) missense probably benign 0.07
R0943:Or4c10b UTSW 2 89,711,305 (GRCm39) missense probably benign 0.11
R1146:Or4c10b UTSW 2 89,711,550 (GRCm39) missense probably damaging 1.00
R1146:Or4c10b UTSW 2 89,711,550 (GRCm39) missense probably damaging 1.00
R1314:Or4c10b UTSW 2 89,711,221 (GRCm39) missense probably benign 0.35
R1641:Or4c10b UTSW 2 89,711,745 (GRCm39) missense probably benign 0.07
R1763:Or4c10b UTSW 2 89,711,473 (GRCm39) missense probably damaging 0.99
R1836:Or4c10b UTSW 2 89,711,629 (GRCm39) missense probably damaging 1.00
R2125:Or4c10b UTSW 2 89,711,982 (GRCm39) missense probably benign
R4322:Or4c10b UTSW 2 89,712,078 (GRCm39) missense probably benign 0.07
R5446:Or4c10b UTSW 2 89,711,893 (GRCm39) missense probably damaging 1.00
R5456:Or4c10b UTSW 2 89,711,602 (GRCm39) missense probably damaging 0.97
R6415:Or4c10b UTSW 2 89,711,206 (GRCm39) missense probably damaging 1.00
R6905:Or4c10b UTSW 2 89,712,052 (GRCm39) missense probably benign 0.05
R7170:Or4c10b UTSW 2 89,711,397 (GRCm39) missense possibly damaging 0.70
R7170:Or4c10b UTSW 2 89,711,185 (GRCm39) missense probably benign 0.12
R7411:Or4c10b UTSW 2 89,711,605 (GRCm39) missense probably damaging 0.98
R8171:Or4c10b UTSW 2 89,711,409 (GRCm39) missense probably benign 0.05
R8490:Or4c10b UTSW 2 89,711,511 (GRCm39) missense probably damaging 1.00
R9176:Or4c10b UTSW 2 89,711,515 (GRCm39) missense probably benign 0.05
R9204:Or4c10b UTSW 2 89,711,482 (GRCm39) missense probably damaging 1.00
R9751:Or4c10b UTSW 2 89,711,956 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- AATGTGCTCATTGTGGTCACC -3'
(R):5'- CTATGATGTTAGGGCCACAGAAG -3'

Sequencing Primer
(F):5'- ATGTGCTCATTGTGGTCACCATAAC -3'
(R):5'- TTGGAAAATGAACAGGATCTGTATG -3'
Posted On 2016-03-17