Incidental Mutation 'R4898:Dock3'
| ID |
375923 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock3
|
| Ensembl Gene |
ENSMUSG00000039716 |
| Gene Name |
dedicator of cyto-kinesis 3 |
| Synonyms |
Moca, PBP |
| MMRRC Submission |
042502-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.549)
|
| Stock # |
R4898 (G1)
|
| Quality Score |
219 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
106770024-107109108 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 106807266 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 1354
(F1354L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047652
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044532]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000044532
AA Change: F1354L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000047652
Gene: ENSMUSG00000039716
AA Change: F1354L
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
9 |
66 |
3.85e-9 |
SMART |
|
Pfam:DOCK_N
|
69 |
412 |
1.4e-120 |
PFAM |
|
Pfam:DOCK-C2
|
417 |
608 |
7.7e-56 |
PFAM |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
916 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1121 |
1628 |
9e-133 |
PFAM |
|
low complexity region
|
1679 |
1690 |
N/A |
INTRINSIC |
|
low complexity region
|
1693 |
1704 |
N/A |
INTRINSIC |
|
low complexity region
|
1730 |
1754 |
N/A |
INTRINSIC |
|
low complexity region
|
1880 |
1902 |
N/A |
INTRINSIC |
|
low complexity region
|
1963 |
1977 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000168759
AA Change: F220L
|
| SMART Domains |
Protein: ENSMUSP00000131410
Gene: ENSMUSG00000039716
AA Change: F220L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DHR-2
|
1 |
241 |
4e-48 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal behaviors and muscular weakness associated with axonal dystrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 115 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc6 |
T |
C |
7: 45,639,111 (GRCm39) |
Y944C |
probably damaging |
Het |
| Acacb |
T |
C |
5: 114,370,999 (GRCm39) |
V1747A |
probably benign |
Het |
| Acad8 |
C |
T |
9: 26,889,698 (GRCm39) |
R332H |
probably damaging |
Het |
| Acrbp |
A |
C |
6: 125,027,501 (GRCm39) |
T50P |
probably damaging |
Het |
| Ahctf1 |
G |
T |
1: 179,583,077 (GRCm39) |
N1500K |
probably benign |
Het |
| Aoc1l3 |
A |
G |
6: 48,964,651 (GRCm39) |
T220A |
possibly damaging |
Het |
| Arfgef1 |
A |
G |
1: 10,229,798 (GRCm39) |
I1301T |
possibly damaging |
Het |
| Arhgef15 |
T |
C |
11: 68,842,171 (GRCm39) |
S478G |
probably benign |
Het |
| Armh1 |
T |
C |
4: 117,094,977 (GRCm39) |
D21G |
probably damaging |
Het |
| Atp13a4 |
A |
T |
16: 29,227,779 (GRCm39) |
L1045* |
probably null |
Het |
| Atp2a3 |
T |
A |
11: 72,873,506 (GRCm39) |
L793H |
probably damaging |
Het |
| B4galnt4 |
C |
A |
7: 140,648,173 (GRCm39) |
P563Q |
probably benign |
Het |
| Bcl2a1b |
A |
T |
9: 89,081,713 (GRCm39) |
K94* |
probably null |
Het |
| Bod1 |
T |
A |
11: 31,616,853 (GRCm39) |
Q136L |
possibly damaging |
Het |
| C2cd3 |
A |
G |
7: 100,055,166 (GRCm39) |
K443R |
probably damaging |
Het |
| Cadps |
A |
G |
14: 12,411,588 (GRCm38) |
V1250A |
possibly damaging |
Het |
| Car12 |
T |
A |
9: 66,671,600 (GRCm39) |
Y332* |
probably null |
Het |
| Ccdc186 |
A |
T |
19: 56,790,432 (GRCm39) |
|
probably null |
Het |
| Cdh6 |
T |
C |
15: 13,034,774 (GRCm39) |
T629A |
probably damaging |
Het |
| Cep112 |
T |
A |
11: 108,397,471 (GRCm39) |
D353E |
probably damaging |
Het |
| Cep152 |
T |
C |
2: 125,428,301 (GRCm39) |
S777G |
probably benign |
Het |
| Clec4b2 |
A |
C |
6: 123,181,163 (GRCm39) |
K183Q |
probably benign |
Het |
| Cngb3 |
T |
C |
4: 19,395,926 (GRCm39) |
Y323H |
probably benign |
Het |
| Cnp |
G |
T |
11: 100,467,202 (GRCm39) |
E48D |
probably benign |
Het |
| Ctrb1 |
T |
A |
8: 112,413,783 (GRCm39) |
I194F |
probably benign |
Het |
| Cyp2d11 |
T |
A |
15: 82,275,224 (GRCm39) |
D241V |
probably benign |
Het |
| D5Ertd579e |
T |
A |
5: 36,772,285 (GRCm39) |
E703D |
probably damaging |
Het |
| Dlg1 |
T |
C |
16: 31,676,764 (GRCm39) |
V731A |
probably damaging |
Het |
| Dlgap5 |
T |
C |
14: 47,651,276 (GRCm39) |
S86G |
probably benign |
Het |
| Eif3c |
A |
T |
7: 126,156,626 (GRCm39) |
M407K |
probably benign |
Het |
| Eif4a3l1 |
A |
T |
6: 136,305,737 (GRCm39) |
Q66L |
possibly damaging |
Het |
| Epha4 |
T |
A |
1: 77,366,712 (GRCm39) |
K578* |
probably null |
Het |
| Erc2 |
C |
T |
14: 27,375,285 (GRCm39) |
L168F |
probably damaging |
Het |
| Esyt2 |
A |
G |
12: 116,305,708 (GRCm39) |
I313V |
probably benign |
Het |
| Far1 |
T |
A |
7: 113,167,432 (GRCm39) |
Y506N |
probably damaging |
Het |
| Fbxw26 |
T |
A |
9: 109,547,037 (GRCm39) |
N463Y |
possibly damaging |
Het |
| Fgg |
A |
G |
3: 82,915,847 (GRCm39) |
D96G |
probably benign |
Het |
| Gfer |
A |
G |
17: 24,914,274 (GRCm39) |
S130P |
probably damaging |
Het |
| Hdac10 |
A |
T |
15: 89,012,650 (GRCm39) |
M1K |
probably null |
Het |
| Hsd3b1 |
A |
T |
3: 98,760,642 (GRCm39) |
S110R |
probably benign |
Het |
| Ints15 |
A |
G |
5: 143,287,592 (GRCm39) |
S438P |
probably benign |
Het |
| Itga6 |
T |
C |
2: 71,668,717 (GRCm39) |
L552P |
possibly damaging |
Het |
| Klk14 |
G |
A |
7: 43,341,501 (GRCm39) |
C51Y |
probably damaging |
Het |
| Lama2 |
TTTGCGCATT |
TTT |
10: 26,919,639 (GRCm39) |
|
probably null |
Het |
| Llgl1 |
C |
T |
11: 60,600,394 (GRCm39) |
P581L |
probably benign |
Het |
| Lrrc8a |
A |
G |
2: 30,147,214 (GRCm39) |
K676R |
probably benign |
Het |
| Lrrc8b |
A |
T |
5: 105,628,080 (GRCm39) |
Y142F |
probably benign |
Het |
| Lyz2 |
T |
A |
10: 117,114,614 (GRCm39) |
D105V |
possibly damaging |
Het |
| Mamdc4 |
T |
C |
2: 25,460,035 (GRCm39) |
D76G |
probably damaging |
Het |
| Map7d1 |
T |
C |
4: 126,127,018 (GRCm39) |
K731E |
unknown |
Het |
| Mgam |
A |
C |
6: 40,619,988 (GRCm39) |
I26L |
probably benign |
Het |
| Mmp13 |
A |
T |
9: 7,272,953 (GRCm39) |
E104D |
probably benign |
Het |
| Morc2a |
C |
T |
11: 3,626,664 (GRCm39) |
R241* |
probably null |
Het |
| Mtfmt |
C |
A |
9: 65,359,386 (GRCm39) |
H354N |
probably benign |
Het |
| Myh3 |
T |
C |
11: 66,990,233 (GRCm39) |
I1626T |
probably benign |
Het |
| Ndst1 |
A |
T |
18: 60,825,059 (GRCm39) |
V753D |
probably benign |
Het |
| Neurl4 |
A |
G |
11: 69,793,997 (GRCm39) |
D151G |
probably damaging |
Het |
| Nlrx1 |
T |
C |
9: 44,168,194 (GRCm39) |
S568G |
probably benign |
Het |
| Or10g3b |
G |
C |
14: 52,586,999 (GRCm39) |
P168R |
probably damaging |
Het |
| Or2t45 |
T |
C |
11: 58,669,132 (GRCm39) |
Y60H |
possibly damaging |
Het |
| Or2t46 |
T |
G |
11: 58,472,546 (GRCm39) |
L292R |
probably damaging |
Het |
| Or4c52 |
T |
C |
2: 89,845,762 (GRCm39) |
F163L |
probably damaging |
Het |
| Or52s1 |
A |
G |
7: 102,861,747 (GRCm39) |
I216V |
probably damaging |
Het |
| Or6c66 |
A |
T |
10: 129,461,468 (GRCm39) |
I154N |
probably benign |
Het |
| Or8b42 |
A |
T |
9: 38,342,111 (GRCm39) |
M178L |
probably benign |
Het |
| Osbpl7 |
A |
G |
11: 96,950,976 (GRCm39) |
I608V |
probably damaging |
Het |
| Pard3b |
T |
C |
1: 61,807,159 (GRCm39) |
I58T |
probably damaging |
Het |
| Pcare |
A |
G |
17: 72,058,066 (GRCm39) |
M537T |
probably damaging |
Het |
| Pcdhga1 |
A |
C |
18: 37,795,407 (GRCm39) |
E137A |
possibly damaging |
Het |
| Pde6c |
G |
A |
19: 38,139,072 (GRCm39) |
V301I |
possibly damaging |
Het |
| Pdia5 |
G |
C |
16: 35,230,786 (GRCm39) |
N338K |
possibly damaging |
Het |
| Pex11g |
T |
C |
8: 3,514,042 (GRCm39) |
Y40C |
probably damaging |
Het |
| Plekhg3 |
A |
G |
12: 76,610,899 (GRCm39) |
Y183C |
probably damaging |
Het |
| Pole |
A |
C |
5: 110,438,090 (GRCm39) |
|
probably null |
Het |
| Ppfia1 |
A |
G |
7: 144,045,313 (GRCm39) |
L948P |
probably damaging |
Het |
| Prdm2 |
A |
T |
4: 142,860,761 (GRCm39) |
V843E |
probably damaging |
Het |
| Prss56 |
C |
A |
1: 87,115,708 (GRCm39) |
F527L |
probably damaging |
Het |
| Psmd11 |
T |
C |
11: 80,329,146 (GRCm39) |
L88P |
probably damaging |
Het |
| Ptx3 |
G |
C |
3: 66,132,412 (GRCm39) |
G311A |
probably damaging |
Het |
| Rars1 |
A |
T |
11: 35,699,385 (GRCm39) |
L636H |
probably damaging |
Het |
| Rnft2 |
A |
G |
5: 118,375,507 (GRCm39) |
S81P |
probably benign |
Het |
| Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
| Rxra |
T |
A |
2: 27,631,195 (GRCm39) |
I142N |
probably damaging |
Het |
| Scin |
T |
C |
12: 40,154,931 (GRCm39) |
M221V |
probably benign |
Het |
| Sfmbt2 |
G |
A |
2: 10,584,069 (GRCm39) |
V809I |
possibly damaging |
Het |
| Sirt1 |
T |
A |
10: 63,157,783 (GRCm39) |
I505F |
probably benign |
Het |
| Six5 |
T |
C |
7: 18,829,096 (GRCm39) |
Y179H |
probably damaging |
Het |
| Slc12a4 |
A |
C |
8: 106,671,241 (GRCm39) |
M982R |
probably damaging |
Het |
| Slco4c1 |
T |
A |
1: 96,765,237 (GRCm39) |
L404F |
probably damaging |
Het |
| Smn1 |
T |
C |
13: 100,268,931 (GRCm39) |
L259P |
probably damaging |
Het |
| Sorl1 |
T |
G |
9: 41,952,935 (GRCm39) |
D702A |
probably damaging |
Het |
| Spta1 |
A |
G |
1: 174,065,400 (GRCm39) |
E1983G |
possibly damaging |
Het |
| Srsf1 |
T |
A |
11: 87,940,788 (GRCm39) |
|
probably null |
Het |
| Stard9 |
C |
T |
2: 120,536,900 (GRCm39) |
R4224* |
probably null |
Het |
| Sybu |
T |
G |
15: 44,538,895 (GRCm39) |
M383L |
probably benign |
Het |
| Tbx15 |
A |
C |
3: 99,259,583 (GRCm39) |
N485H |
possibly damaging |
Het |
| Tcerg1l |
A |
T |
7: 137,819,786 (GRCm39) |
F485I |
probably damaging |
Het |
| Tdrd7 |
C |
A |
4: 46,005,616 (GRCm39) |
T474N |
possibly damaging |
Het |
| Thada |
A |
T |
17: 84,755,470 (GRCm39) |
|
probably null |
Het |
| Tnik |
A |
T |
3: 28,704,235 (GRCm39) |
I1020F |
probably damaging |
Het |
| Tnxb |
A |
G |
17: 34,914,566 (GRCm39) |
D1884G |
possibly damaging |
Het |
| Tprn |
T |
C |
2: 25,158,845 (GRCm39) |
M623T |
probably damaging |
Het |
| Trdn |
T |
A |
10: 33,350,413 (GRCm39) |
Y661N |
probably damaging |
Het |
| Ttc41 |
T |
C |
10: 86,612,056 (GRCm39) |
S1110P |
possibly damaging |
Het |
| Ttc6 |
A |
C |
12: 57,707,026 (GRCm39) |
R644S |
probably benign |
Het |
| Ttyh1 |
A |
T |
7: 4,136,735 (GRCm39) |
M448L |
probably benign |
Het |
| Unc79 |
G |
T |
12: 103,128,079 (GRCm39) |
C2250F |
probably damaging |
Het |
| Ush2a |
A |
G |
1: 188,358,805 (GRCm39) |
I2110M |
probably benign |
Het |
| Uvssa |
G |
T |
5: 33,571,257 (GRCm39) |
E634* |
probably null |
Het |
| Vac14 |
A |
C |
8: 111,372,440 (GRCm39) |
T384P |
probably benign |
Het |
| Wdr11 |
A |
G |
7: 129,235,445 (GRCm39) |
E1169G |
probably benign |
Het |
| Zfp36l1 |
T |
A |
12: 80,157,298 (GRCm39) |
T28S |
probably benign |
Het |
| Zfp715 |
A |
T |
7: 42,949,106 (GRCm39) |
Y285N |
possibly damaging |
Het |
| Zfp91 |
A |
T |
19: 12,747,424 (GRCm39) |
D566E |
probably damaging |
Het |
| Zgrf1 |
G |
A |
3: 127,396,085 (GRCm39) |
V544M |
probably damaging |
Het |
|
| Other mutations in Dock3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00940:Dock3
|
APN |
9 |
106,788,576 (GRCm39) |
splice site |
probably benign |
|
|
IGL01067:Dock3
|
APN |
9 |
106,959,572 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01160:Dock3
|
APN |
9 |
106,783,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01290:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01291:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01391:Dock3
|
APN |
9 |
106,784,433 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL01399:Dock3
|
APN |
9 |
106,870,670 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01660:Dock3
|
APN |
9 |
106,909,563 (GRCm39) |
splice site |
probably benign |
|
|
IGL01752:Dock3
|
APN |
9 |
106,902,512 (GRCm39) |
splice site |
probably benign |
|
|
IGL01820:Dock3
|
APN |
9 |
106,773,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01908:Dock3
|
APN |
9 |
106,783,861 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02191:Dock3
|
APN |
9 |
106,815,340 (GRCm39) |
missense |
probably benign |
|
|
IGL02227:Dock3
|
APN |
9 |
106,939,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02309:Dock3
|
APN |
9 |
106,790,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Dock3
|
APN |
9 |
106,790,298 (GRCm39) |
splice site |
probably benign |
|
|
IGL02469:Dock3
|
APN |
9 |
106,863,215 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02545:Dock3
|
APN |
9 |
106,939,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02894:Dock3
|
APN |
9 |
106,807,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02934:Dock3
|
APN |
9 |
106,900,944 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03027:Dock3
|
APN |
9 |
106,870,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03068:Dock3
|
APN |
9 |
106,841,958 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03128:Dock3
|
APN |
9 |
106,909,491 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03161:Dock3
|
APN |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03263:Dock3
|
APN |
9 |
106,807,330 (GRCm39) |
splice site |
probably benign |
|
|
IGL03279:Dock3
|
APN |
9 |
106,788,447 (GRCm39) |
splice site |
probably benign |
|
|
IGL03366:Dock3
|
APN |
9 |
106,882,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
Implosion
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
Squeeze
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Tight
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
ANU05:Dock3
|
UTSW |
9 |
106,772,862 (GRCm39) |
missense |
probably benign |
|
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0030:Dock3
|
UTSW |
9 |
106,789,512 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0206:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0208:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0384:Dock3
|
UTSW |
9 |
106,779,094 (GRCm39) |
splice site |
probably benign |
|
|
R0610:Dock3
|
UTSW |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0731:Dock3
|
UTSW |
9 |
106,847,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dock3
|
UTSW |
9 |
106,846,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1350:Dock3
|
UTSW |
9 |
106,791,831 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1393:Dock3
|
UTSW |
9 |
106,788,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1424:Dock3
|
UTSW |
9 |
106,790,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1539:Dock3
|
UTSW |
9 |
106,874,112 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1539:Dock3
|
UTSW |
9 |
106,829,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1571:Dock3
|
UTSW |
9 |
106,815,158 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1682:Dock3
|
UTSW |
9 |
106,851,040 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1795:Dock3
|
UTSW |
9 |
106,902,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1987:Dock3
|
UTSW |
9 |
106,985,620 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2000:Dock3
|
UTSW |
9 |
106,870,160 (GRCm39) |
splice site |
probably benign |
|
|
R2074:Dock3
|
UTSW |
9 |
106,870,662 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2114:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2265:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2370:Dock3
|
UTSW |
9 |
106,829,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2377:Dock3
|
UTSW |
9 |
106,773,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2385:Dock3
|
UTSW |
9 |
106,868,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Dock3
|
UTSW |
9 |
106,791,740 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R3076:Dock3
|
UTSW |
9 |
106,818,725 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3122:Dock3
|
UTSW |
9 |
106,788,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4052:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4294:Dock3
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4623:Dock3
|
UTSW |
9 |
106,939,244 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4664:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4705:Dock3
|
UTSW |
9 |
106,902,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Dock3
|
UTSW |
9 |
106,829,557 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4898:Dock3
|
UTSW |
9 |
106,870,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4948:Dock3
|
UTSW |
9 |
106,868,354 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4961:Dock3
|
UTSW |
9 |
106,818,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4986:Dock3
|
UTSW |
9 |
106,809,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5054:Dock3
|
UTSW |
9 |
106,815,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5065:Dock3
|
UTSW |
9 |
106,832,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5081:Dock3
|
UTSW |
9 |
106,868,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5101:Dock3
|
UTSW |
9 |
106,846,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Dock3
|
UTSW |
9 |
106,810,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5227:Dock3
|
UTSW |
9 |
106,863,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5257:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5258:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5273:Dock3
|
UTSW |
9 |
106,777,904 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5322:Dock3
|
UTSW |
9 |
106,779,028 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5482:Dock3
|
UTSW |
9 |
106,855,937 (GRCm39) |
nonsense |
probably null |
|
|
R5553:Dock3
|
UTSW |
9 |
106,868,309 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5631:Dock3
|
UTSW |
9 |
106,832,898 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5739:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5838:Dock3
|
UTSW |
9 |
106,772,687 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R5888:Dock3
|
UTSW |
9 |
106,901,002 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5960:Dock3
|
UTSW |
9 |
106,788,554 (GRCm39) |
nonsense |
probably null |
|
|
R5974:Dock3
|
UTSW |
9 |
106,871,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6116:Dock3
|
UTSW |
9 |
106,809,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6162:Dock3
|
UTSW |
9 |
106,841,998 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6176:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6219:Dock3
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6238:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6266:Dock3
|
UTSW |
9 |
106,841,952 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Dock3
|
UTSW |
9 |
106,785,631 (GRCm39) |
missense |
probably benign |
|
|
R6531:Dock3
|
UTSW |
9 |
106,844,415 (GRCm39) |
missense |
probably benign |
|
|
R6567:Dock3
|
UTSW |
9 |
106,773,946 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6572:Dock3
|
UTSW |
9 |
106,866,674 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6620:Dock3
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6726:Dock3
|
UTSW |
9 |
107,036,651 (GRCm39) |
nonsense |
probably null |
|
|
R7085:Dock3
|
UTSW |
9 |
106,779,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7151:Dock3
|
UTSW |
9 |
106,841,916 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7320:Dock3
|
UTSW |
9 |
106,772,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7357:Dock3
|
UTSW |
9 |
106,882,568 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7423:Dock3
|
UTSW |
9 |
106,844,370 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7426:Dock3
|
UTSW |
9 |
106,772,782 (GRCm39) |
missense |
probably benign |
|
|
R7439:Dock3
|
UTSW |
9 |
106,900,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Dock3
|
UTSW |
9 |
106,866,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7470:Dock3
|
UTSW |
9 |
106,882,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7879:Dock3
|
UTSW |
9 |
106,785,700 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8047:Dock3
|
UTSW |
9 |
106,870,208 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8308:Dock3
|
UTSW |
9 |
106,790,371 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8837:Dock3
|
UTSW |
9 |
106,774,539 (GRCm39) |
missense |
probably benign |
|
|
R8862:Dock3
|
UTSW |
9 |
106,855,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8952:Dock3
|
UTSW |
9 |
106,850,958 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9230:Dock3
|
UTSW |
9 |
106,807,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9269:Dock3
|
UTSW |
9 |
106,818,522 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9272:Dock3
|
UTSW |
9 |
106,774,569 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9344:Dock3
|
UTSW |
9 |
106,870,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Dock3
|
UTSW |
9 |
106,901,035 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9764:Dock3
|
UTSW |
9 |
106,959,713 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9766:Dock3
|
UTSW |
9 |
106,788,483 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0023:Dock3
|
UTSW |
9 |
106,863,197 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACTTTGTGTGCGGAAATGTGC -3'
(R):5'- AAAGGAGGGCTTTCTTCTCTTCC -3'
Sequencing Primer
(F):5'- TGCGGAAATGTGCACATACC -3'
(R):5'- TCCATAATGCACTTCCTGGAGAGAG -3'
|
| Posted On |
2016-03-17 |
Incidental Mutation