Incidental Mutation 'R4900:Vmn2r12'
ID |
376081 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r12
|
Ensembl Gene |
ENSMUSG00000090688 |
Gene Name |
vomeronasal 2, receptor 12 |
Synonyms |
Gm6769 |
MMRRC Submission |
042504-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.070)
|
Stock # |
R4900 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
5 |
Chromosomal Location |
109233715-109245730 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 109240852 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Isoleucine
at position 87
(N87I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000093612
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095922]
|
AlphaFold |
L7N217 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000095922
AA Change: N87I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000093612 Gene: ENSMUSG00000090688 AA Change: N87I
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
76 |
466 |
8.8e-30 |
PFAM |
Pfam:NCD3G
|
505 |
559 |
1.7e-18 |
PFAM |
Pfam:7tm_3
|
591 |
827 |
3.9e-54 |
PFAM |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.1%
|
Validation Efficiency |
100% (84/84) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 77 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930590J08Rik |
T |
C |
6: 91,895,091 (GRCm39) |
V262A |
probably benign |
Het |
Abtb2 |
A |
G |
2: 103,397,349 (GRCm39) |
E93G |
possibly damaging |
Het |
Adam5 |
A |
C |
8: 25,232,172 (GRCm39) |
|
probably null |
Het |
Adam5 |
G |
A |
8: 25,271,619 (GRCm39) |
T596I |
probably damaging |
Het |
Adgrb2 |
T |
A |
4: 129,907,668 (GRCm39) |
Y1001N |
probably damaging |
Het |
Aox1 |
T |
G |
1: 58,344,544 (GRCm39) |
S546A |
probably benign |
Het |
Asic2 |
T |
C |
11: 81,464,280 (GRCm39) |
|
probably benign |
Het |
Bcl11b |
T |
A |
12: 107,955,957 (GRCm39) |
N64I |
probably damaging |
Het |
Cacna1g |
A |
G |
11: 94,350,177 (GRCm39) |
F556S |
possibly damaging |
Het |
Cbl |
A |
G |
9: 44,064,166 (GRCm39) |
V790A |
probably benign |
Het |
Cd300c2 |
A |
T |
11: 114,891,807 (GRCm39) |
C22* |
probably null |
Het |
Cdh11 |
C |
T |
8: 103,374,090 (GRCm39) |
|
probably null |
Het |
Ces2g |
C |
T |
8: 105,693,989 (GRCm39) |
Q442* |
probably null |
Het |
Cps1 |
A |
T |
1: 67,200,063 (GRCm39) |
T404S |
probably damaging |
Het |
Csf2rb2 |
A |
T |
15: 78,170,174 (GRCm39) |
|
probably null |
Het |
Csmd2 |
A |
G |
4: 128,346,318 (GRCm39) |
Y1526C |
probably benign |
Het |
Cyp2a12 |
C |
T |
7: 26,730,640 (GRCm39) |
Q202* |
probably null |
Het |
Cyp2c39 |
G |
A |
19: 39,502,020 (GRCm39) |
M136I |
probably benign |
Het |
Cyp2j13 |
G |
A |
4: 95,947,280 (GRCm39) |
T257I |
probably damaging |
Het |
Dnah8 |
T |
A |
17: 30,965,949 (GRCm39) |
L2427Q |
probably damaging |
Het |
Dop1b |
G |
T |
16: 93,560,318 (GRCm39) |
|
probably null |
Het |
Entrep1 |
A |
G |
19: 23,952,790 (GRCm39) |
S507P |
possibly damaging |
Het |
Epcam |
T |
C |
17: 87,951,049 (GRCm39) |
V212A |
possibly damaging |
Het |
Flt1 |
C |
A |
5: 147,620,749 (GRCm39) |
A132S |
probably benign |
Het |
Flvcr2 |
T |
A |
12: 85,829,756 (GRCm39) |
V255D |
probably damaging |
Het |
Galc |
G |
T |
12: 98,197,731 (GRCm39) |
T326K |
probably damaging |
Het |
Gas2l3 |
CACTCGTCATACT |
CACT |
10: 89,266,820 (GRCm39) |
|
probably benign |
Het |
Gen1 |
A |
T |
12: 11,291,561 (GRCm39) |
Y808N |
probably benign |
Het |
Glis1 |
C |
T |
4: 107,476,761 (GRCm39) |
A306V |
probably damaging |
Het |
Gm10638 |
A |
G |
8: 87,473,028 (GRCm39) |
|
probably benign |
Het |
Gm12789 |
G |
A |
4: 101,846,182 (GRCm39) |
|
probably benign |
Het |
Gm27048 |
C |
T |
8: 81,661,228 (GRCm39) |
|
noncoding transcript |
Het |
Gm4204 |
T |
C |
1: 135,160,556 (GRCm39) |
|
noncoding transcript |
Het |
Gm904 |
A |
T |
13: 50,799,325 (GRCm39) |
I95F |
possibly damaging |
Het |
Gvin3 |
T |
G |
7: 106,197,793 (GRCm39) |
|
noncoding transcript |
Het |
Hjurp |
GT |
GTT |
1: 88,194,246 (GRCm39) |
|
probably null |
Het |
Ints11 |
G |
A |
4: 155,972,887 (GRCm39) |
D526N |
probably benign |
Het |
Itfg2 |
A |
G |
6: 128,393,279 (GRCm39) |
|
probably benign |
Het |
Jund |
T |
C |
8: 71,152,254 (GRCm39) |
V183A |
probably damaging |
Het |
Kcnj8 |
A |
G |
6: 142,512,221 (GRCm39) |
S129P |
probably damaging |
Het |
Kcnq3 |
A |
G |
15: 65,867,259 (GRCm39) |
S795P |
probably damaging |
Het |
Lhx8 |
G |
T |
3: 154,035,925 (GRCm39) |
A22E |
probably benign |
Het |
Lrp8 |
A |
G |
4: 107,664,006 (GRCm39) |
|
probably benign |
Het |
Lvrn |
G |
T |
18: 47,026,768 (GRCm39) |
A789S |
probably damaging |
Het |
Lvrn |
T |
C |
18: 47,014,479 (GRCm39) |
S526P |
probably damaging |
Het |
Mga |
T |
A |
2: 119,794,535 (GRCm39) |
C2622S |
possibly damaging |
Het |
Mroh8 |
T |
C |
2: 157,070,647 (GRCm39) |
E568G |
probably benign |
Het |
Ms4a4b |
C |
A |
19: 11,440,503 (GRCm39) |
|
probably benign |
Het |
Muc2 |
T |
C |
7: 141,303,280 (GRCm39) |
F99S |
probably benign |
Het |
Myo5c |
T |
A |
9: 75,180,825 (GRCm39) |
I738N |
probably damaging |
Het |
Naip6 |
A |
C |
13: 100,433,477 (GRCm39) |
V1120G |
probably damaging |
Het |
Ncl |
T |
C |
1: 86,283,901 (GRCm39) |
T307A |
probably benign |
Het |
Npr1 |
A |
T |
3: 90,363,272 (GRCm39) |
D869E |
possibly damaging |
Het |
Nup93 |
A |
G |
8: 95,013,231 (GRCm39) |
T36A |
probably benign |
Het |
Olfml2b |
C |
A |
1: 170,489,947 (GRCm39) |
T189N |
probably damaging |
Het |
Or4c12b |
A |
G |
2: 89,647,312 (GRCm39) |
N208S |
possibly damaging |
Het |
Or8b9 |
T |
C |
9: 37,766,608 (GRCm39) |
F165L |
probably benign |
Het |
P4htm |
A |
C |
9: 108,456,427 (GRCm39) |
W458G |
probably damaging |
Het |
Pdzrn4 |
G |
T |
15: 92,668,638 (GRCm39) |
R930L |
probably damaging |
Het |
Pgam5 |
G |
A |
5: 110,408,301 (GRCm39) |
A240V |
probably damaging |
Het |
Prex2 |
T |
C |
1: 11,220,129 (GRCm39) |
|
probably benign |
Het |
Ptpru |
T |
G |
4: 131,515,693 (GRCm39) |
E897A |
probably damaging |
Het |
Rapgef2 |
A |
T |
3: 78,981,670 (GRCm39) |
N1256K |
probably benign |
Het |
Rhbdl3 |
A |
G |
11: 80,210,439 (GRCm39) |
E64G |
probably benign |
Het |
Sel1l3 |
A |
T |
5: 53,289,184 (GRCm39) |
L879Q |
probably damaging |
Het |
Siah1a |
G |
T |
8: 87,451,703 (GRCm39) |
D260E |
probably benign |
Het |
Skint6 |
T |
C |
4: 112,924,667 (GRCm39) |
I522V |
probably benign |
Het |
Slco4c1 |
G |
A |
1: 96,768,953 (GRCm39) |
P303L |
probably damaging |
Het |
Smok3c |
T |
C |
5: 138,062,813 (GRCm39) |
I100T |
probably damaging |
Het |
Snx24 |
C |
A |
18: 53,518,295 (GRCm39) |
Y141* |
probably null |
Het |
Tigit |
A |
G |
16: 43,469,594 (GRCm39) |
S166P |
probably damaging |
Het |
Tmem183a |
C |
T |
1: 134,275,904 (GRCm39) |
R324Q |
probably benign |
Het |
Tmie |
T |
C |
9: 110,696,001 (GRCm39) |
D130G |
possibly damaging |
Het |
Uggt1 |
G |
A |
1: 36,241,936 (GRCm39) |
R333* |
probably null |
Het |
Vmn2r111 |
T |
C |
17: 22,767,637 (GRCm39) |
N620S |
possibly damaging |
Het |
Vmn2r92 |
A |
G |
17: 18,404,605 (GRCm39) |
D583G |
probably benign |
Het |
Zdhhc17 |
T |
C |
10: 110,821,819 (GRCm39) |
D60G |
possibly damaging |
Het |
|
Other mutations in Vmn2r12 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00948:Vmn2r12
|
APN |
5 |
109,245,541 (GRCm39) |
missense |
possibly damaging |
0.47 |
IGL01096:Vmn2r12
|
APN |
5 |
109,234,125 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01538:Vmn2r12
|
APN |
5 |
109,239,716 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01548:Vmn2r12
|
APN |
5 |
109,240,893 (GRCm39) |
nonsense |
probably null |
|
IGL01762:Vmn2r12
|
APN |
5 |
109,234,430 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01860:Vmn2r12
|
APN |
5 |
109,240,025 (GRCm39) |
missense |
probably benign |
0.10 |
IGL02269:Vmn2r12
|
APN |
5 |
109,234,343 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02530:Vmn2r12
|
APN |
5 |
109,233,858 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02887:Vmn2r12
|
APN |
5 |
109,238,351 (GRCm39) |
missense |
probably benign |
0.03 |
IGL03265:Vmn2r12
|
APN |
5 |
109,239,936 (GRCm39) |
missense |
probably benign |
0.05 |
R0396:Vmn2r12
|
UTSW |
5 |
109,240,765 (GRCm39) |
missense |
probably benign |
0.00 |
R0497:Vmn2r12
|
UTSW |
5 |
109,239,755 (GRCm39) |
nonsense |
probably null |
|
R0529:Vmn2r12
|
UTSW |
5 |
109,240,714 (GRCm39) |
missense |
probably benign |
|
R0715:Vmn2r12
|
UTSW |
5 |
109,238,373 (GRCm39) |
missense |
probably benign |
0.10 |
R0742:Vmn2r12
|
UTSW |
5 |
109,234,281 (GRCm39) |
missense |
possibly damaging |
0.55 |
R0894:Vmn2r12
|
UTSW |
5 |
109,235,716 (GRCm39) |
critical splice donor site |
probably null |
|
R1173:Vmn2r12
|
UTSW |
5 |
109,240,720 (GRCm39) |
missense |
probably benign |
0.00 |
R1174:Vmn2r12
|
UTSW |
5 |
109,240,720 (GRCm39) |
missense |
probably benign |
0.00 |
R1259:Vmn2r12
|
UTSW |
5 |
109,239,763 (GRCm39) |
missense |
probably damaging |
0.97 |
R1349:Vmn2r12
|
UTSW |
5 |
109,234,452 (GRCm39) |
missense |
probably benign |
0.00 |
R1388:Vmn2r12
|
UTSW |
5 |
109,240,840 (GRCm39) |
missense |
possibly damaging |
0.56 |
R1549:Vmn2r12
|
UTSW |
5 |
109,240,696 (GRCm39) |
missense |
probably benign |
0.06 |
R1766:Vmn2r12
|
UTSW |
5 |
109,239,910 (GRCm39) |
missense |
probably damaging |
1.00 |
R1781:Vmn2r12
|
UTSW |
5 |
109,239,594 (GRCm39) |
missense |
probably benign |
0.00 |
R1885:Vmn2r12
|
UTSW |
5 |
109,239,942 (GRCm39) |
missense |
probably damaging |
1.00 |
R2159:Vmn2r12
|
UTSW |
5 |
109,239,340 (GRCm39) |
missense |
probably benign |
0.02 |
R2420:Vmn2r12
|
UTSW |
5 |
109,234,398 (GRCm39) |
missense |
probably benign |
0.39 |
R2421:Vmn2r12
|
UTSW |
5 |
109,234,398 (GRCm39) |
missense |
probably benign |
0.39 |
R2422:Vmn2r12
|
UTSW |
5 |
109,234,398 (GRCm39) |
missense |
probably benign |
0.39 |
R2937:Vmn2r12
|
UTSW |
5 |
109,239,397 (GRCm39) |
missense |
probably damaging |
1.00 |
R2938:Vmn2r12
|
UTSW |
5 |
109,239,397 (GRCm39) |
missense |
probably damaging |
1.00 |
R3898:Vmn2r12
|
UTSW |
5 |
109,238,370 (GRCm39) |
missense |
probably benign |
0.02 |
R4061:Vmn2r12
|
UTSW |
5 |
109,240,058 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4063:Vmn2r12
|
UTSW |
5 |
109,240,058 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4090:Vmn2r12
|
UTSW |
5 |
109,239,412 (GRCm39) |
missense |
probably benign |
0.06 |
R4297:Vmn2r12
|
UTSW |
5 |
109,239,830 (GRCm39) |
missense |
probably benign |
0.12 |
R4298:Vmn2r12
|
UTSW |
5 |
109,239,830 (GRCm39) |
missense |
probably benign |
0.12 |
R4299:Vmn2r12
|
UTSW |
5 |
109,239,830 (GRCm39) |
missense |
probably benign |
0.12 |
R4304:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
R4306:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
R4307:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
R4308:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
R4594:Vmn2r12
|
UTSW |
5 |
109,234,301 (GRCm39) |
missense |
probably damaging |
1.00 |
R4783:Vmn2r12
|
UTSW |
5 |
109,234,379 (GRCm39) |
missense |
probably damaging |
1.00 |
R4929:Vmn2r12
|
UTSW |
5 |
109,239,544 (GRCm39) |
missense |
probably damaging |
1.00 |
R4974:Vmn2r12
|
UTSW |
5 |
109,239,372 (GRCm39) |
missense |
probably damaging |
1.00 |
R5389:Vmn2r12
|
UTSW |
5 |
109,238,261 (GRCm39) |
missense |
probably benign |
0.00 |
R5431:Vmn2r12
|
UTSW |
5 |
109,239,684 (GRCm39) |
missense |
probably damaging |
0.99 |
R5527:Vmn2r12
|
UTSW |
5 |
109,234,483 (GRCm39) |
nonsense |
probably null |
|
R5639:Vmn2r12
|
UTSW |
5 |
109,240,666 (GRCm39) |
missense |
probably benign |
0.06 |
R5753:Vmn2r12
|
UTSW |
5 |
109,239,670 (GRCm39) |
missense |
probably damaging |
1.00 |
R5797:Vmn2r12
|
UTSW |
5 |
109,233,736 (GRCm39) |
nonsense |
probably null |
|
R6142:Vmn2r12
|
UTSW |
5 |
109,240,763 (GRCm39) |
missense |
probably benign |
|
R6162:Vmn2r12
|
UTSW |
5 |
109,234,430 (GRCm39) |
missense |
probably damaging |
0.99 |
R6176:Vmn2r12
|
UTSW |
5 |
109,233,866 (GRCm39) |
missense |
probably benign |
0.43 |
R6853:Vmn2r12
|
UTSW |
5 |
109,240,771 (GRCm39) |
missense |
probably damaging |
1.00 |
R7238:Vmn2r12
|
UTSW |
5 |
109,245,655 (GRCm39) |
missense |
possibly damaging |
0.81 |
R7341:Vmn2r12
|
UTSW |
5 |
109,239,811 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7341:Vmn2r12
|
UTSW |
5 |
109,234,113 (GRCm39) |
missense |
possibly damaging |
0.74 |
R7383:Vmn2r12
|
UTSW |
5 |
109,240,684 (GRCm39) |
missense |
probably benign |
0.19 |
R7740:Vmn2r12
|
UTSW |
5 |
109,239,615 (GRCm39) |
missense |
probably damaging |
1.00 |
R7749:Vmn2r12
|
UTSW |
5 |
109,233,920 (GRCm39) |
missense |
probably damaging |
0.99 |
R7861:Vmn2r12
|
UTSW |
5 |
109,235,829 (GRCm39) |
missense |
probably benign |
0.00 |
R7908:Vmn2r12
|
UTSW |
5 |
109,234,307 (GRCm39) |
missense |
probably damaging |
1.00 |
R8128:Vmn2r12
|
UTSW |
5 |
109,239,747 (GRCm39) |
missense |
possibly damaging |
0.81 |
R8175:Vmn2r12
|
UTSW |
5 |
109,238,349 (GRCm39) |
missense |
probably damaging |
0.97 |
R8234:Vmn2r12
|
UTSW |
5 |
109,234,074 (GRCm39) |
missense |
probably benign |
0.01 |
R8771:Vmn2r12
|
UTSW |
5 |
109,239,952 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8947:Vmn2r12
|
UTSW |
5 |
109,234,522 (GRCm39) |
missense |
possibly damaging |
0.64 |
R8991:Vmn2r12
|
UTSW |
5 |
109,234,033 (GRCm39) |
nonsense |
probably null |
|
R9116:Vmn2r12
|
UTSW |
5 |
109,233,885 (GRCm39) |
missense |
probably damaging |
1.00 |
R9122:Vmn2r12
|
UTSW |
5 |
109,240,910 (GRCm39) |
missense |
probably benign |
0.00 |
R9153:Vmn2r12
|
UTSW |
5 |
109,234,203 (GRCm39) |
missense |
probably damaging |
1.00 |
R9371:Vmn2r12
|
UTSW |
5 |
109,234,452 (GRCm39) |
missense |
probably benign |
0.00 |
R9375:Vmn2r12
|
UTSW |
5 |
109,233,986 (GRCm39) |
missense |
probably damaging |
1.00 |
R9524:Vmn2r12
|
UTSW |
5 |
109,239,823 (GRCm39) |
missense |
probably damaging |
1.00 |
R9587:Vmn2r12
|
UTSW |
5 |
109,239,322 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1088:Vmn2r12
|
UTSW |
5 |
109,240,646 (GRCm39) |
missense |
probably benign |
|
Z1176:Vmn2r12
|
UTSW |
5 |
109,239,303 (GRCm39) |
missense |
probably benign |
0.01 |
|
Predicted Primers |
PCR Primer
(F):5'- CAGATGTTTTCCATGATGGTCC -3'
(R):5'- CCAAACTTTTCAAATCATAGTGCCC -3'
Sequencing Primer
(F):5'- TTCCATGATGGTCCTATAAGGC -3'
(R):5'- AGTGCCCTATGTCTATGAA -3'
|
Posted On |
2016-03-17 |