Incidental Mutation 'R4901:Vmn2r74'
| ID |
376159 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r74
|
| Ensembl Gene |
ENSMUSG00000090774 |
| Gene Name |
vomeronasal 2, receptor 74 |
| Synonyms |
EG546980 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.110)
|
| Stock # |
R4901 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
85601075-85610690 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to T
at 85605199 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Stop codon
at position 483
(S483*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126917
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166355]
|
| AlphaFold |
E9PW21 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000166355
AA Change: S483*
|
| SMART Domains |
Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: S483*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
467 |
7.3e-28 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
4.7e-20 |
PFAM |
|
Pfam:7tm_3
|
592 |
830 |
1.3e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.4%
- 20x: 92.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcg4 |
C |
T |
9: 44,188,954 (GRCm39) |
|
probably null |
Het |
| Arg2 |
T |
C |
12: 79,194,485 (GRCm39) |
V103A |
probably damaging |
Het |
| Bicra |
T |
A |
7: 15,721,526 (GRCm39) |
T664S |
possibly damaging |
Het |
| Bptf |
A |
T |
11: 107,001,686 (GRCm39) |
Y475* |
probably null |
Het |
| Calcrl |
T |
C |
2: 84,163,857 (GRCm39) |
I445V |
probably benign |
Het |
| Ccdc110 |
G |
A |
8: 46,396,437 (GRCm39) |
R776Q |
probably benign |
Het |
| Ccnc |
A |
G |
4: 21,727,894 (GRCm39) |
N4S |
probably damaging |
Het |
| Ccni |
G |
A |
5: 93,331,003 (GRCm39) |
R323W |
probably damaging |
Het |
| Celsr2 |
T |
A |
3: 108,314,303 (GRCm39) |
M1241L |
possibly damaging |
Het |
| Cpd |
T |
C |
11: 76,681,707 (GRCm39) |
I1145M |
probably damaging |
Het |
| Cybb |
C |
G |
X: 9,316,989 (GRCm39) |
D246H |
probably benign |
Het |
| Cyp2j8 |
T |
A |
4: 96,367,323 (GRCm39) |
D265V |
probably benign |
Het |
| Dennd2a |
T |
C |
6: 39,499,621 (GRCm39) |
T315A |
probably benign |
Het |
| Dgkz |
T |
A |
2: 91,767,076 (GRCm39) |
Q905L |
probably benign |
Het |
| Dnah8 |
G |
A |
17: 31,059,688 (GRCm39) |
|
probably null |
Het |
| Elp2 |
A |
G |
18: 24,752,542 (GRCm39) |
H365R |
probably damaging |
Het |
| Gm136 |
G |
A |
4: 34,746,580 (GRCm39) |
Q144* |
probably null |
Het |
| Gon4l |
T |
C |
3: 88,815,458 (GRCm39) |
V2008A |
possibly damaging |
Het |
| Hjurp |
GT |
GTT |
1: 88,194,246 (GRCm39) |
|
probably null |
Het |
| Isyna1 |
A |
T |
8: 71,049,246 (GRCm39) |
H414L |
probably damaging |
Het |
| Kif20b |
A |
G |
19: 34,911,836 (GRCm39) |
Y233C |
probably benign |
Het |
| Klk1 |
A |
T |
7: 43,878,139 (GRCm39) |
I132F |
probably damaging |
Het |
| Klre1 |
A |
T |
6: 129,561,188 (GRCm39) |
H183L |
probably benign |
Het |
| Lrp1b |
T |
C |
2: 40,711,657 (GRCm39) |
T3188A |
probably damaging |
Het |
| Mapk12 |
A |
T |
15: 89,018,841 (GRCm39) |
L198* |
probably null |
Het |
| Mt4 |
A |
C |
8: 94,864,912 (GRCm39) |
T29P |
possibly damaging |
Het |
| Myh14 |
C |
T |
7: 44,310,464 (GRCm39) |
V140I |
probably damaging |
Het |
| Nr1h4 |
T |
C |
10: 89,314,659 (GRCm39) |
Q269R |
possibly damaging |
Het |
| Or4p23 |
C |
G |
2: 88,577,231 (GRCm39) |
|
probably null |
Het |
| Or51e1 |
A |
G |
7: 102,359,405 (GRCm39) |
H313R |
probably benign |
Het |
| Pde1b |
A |
G |
15: 103,435,112 (GRCm39) |
I421V |
probably null |
Het |
| Pde3b |
A |
T |
7: 114,107,425 (GRCm39) |
T519S |
probably damaging |
Het |
| Phf21a |
T |
A |
2: 92,187,346 (GRCm39) |
C178* |
probably null |
Het |
| Phtf2 |
A |
G |
5: 21,010,722 (GRCm39) |
S88P |
possibly damaging |
Het |
| Pik3c3 |
A |
G |
18: 30,435,982 (GRCm39) |
M394V |
possibly damaging |
Het |
| Plxnb1 |
C |
T |
9: 108,934,027 (GRCm39) |
P752S |
probably benign |
Het |
| Pp2d1 |
C |
A |
17: 53,822,037 (GRCm39) |
G343V |
probably benign |
Het |
| Ppp6r2 |
A |
G |
15: 89,143,272 (GRCm39) |
I140V |
possibly damaging |
Het |
| Ppp6r3 |
C |
A |
19: 3,517,229 (GRCm39) |
V75L |
probably damaging |
Het |
| Ptprq |
T |
A |
10: 107,524,275 (GRCm39) |
H486L |
probably benign |
Het |
| Rasgrf1 |
C |
T |
9: 89,877,056 (GRCm39) |
T807M |
probably benign |
Het |
| Rasgrp3 |
C |
A |
17: 75,821,111 (GRCm39) |
Y439* |
probably null |
Het |
| Rbm44 |
A |
G |
1: 91,081,050 (GRCm39) |
T413A |
probably benign |
Het |
| Rnf135 |
T |
C |
11: 80,089,662 (GRCm39) |
C333R |
probably damaging |
Het |
| Scfd2 |
A |
G |
5: 74,680,226 (GRCm39) |
V309A |
probably damaging |
Het |
| Semp2l1 |
T |
C |
1: 32,585,701 (GRCm39) |
S70G |
probably benign |
Het |
| Serpina3m |
A |
T |
12: 104,355,908 (GRCm39) |
K192* |
probably null |
Het |
| Sft2d1rt |
A |
G |
11: 45,942,656 (GRCm39) |
S156P |
probably damaging |
Het |
| Sh3tc2 |
A |
G |
18: 62,123,506 (GRCm39) |
I756V |
probably benign |
Het |
| Slc27a4 |
T |
C |
2: 29,702,648 (GRCm39) |
V516A |
probably damaging |
Het |
| Sult2a5 |
T |
A |
7: 13,359,188 (GRCm39) |
C55S |
probably benign |
Het |
| Tars3 |
C |
T |
7: 65,341,042 (GRCm39) |
T783M |
probably benign |
Het |
| Tet2 |
A |
T |
3: 133,172,805 (GRCm39) |
I1819N |
possibly damaging |
Het |
| Timeless |
T |
C |
10: 128,086,631 (GRCm39) |
F1057L |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,628,418 (GRCm39) |
I12835F |
probably damaging |
Het |
| Uhrf1 |
T |
A |
17: 56,617,834 (GRCm39) |
D185E |
probably benign |
Het |
| Xpo1 |
A |
T |
11: 23,231,327 (GRCm39) |
I304F |
possibly damaging |
Het |
| Zc3h11a |
A |
G |
1: 133,552,449 (GRCm39) |
S553P |
probably benign |
Het |
| Zdhhc1 |
A |
G |
8: 106,199,484 (GRCm39) |
S402P |
probably benign |
Het |
| Zwilch |
T |
C |
9: 64,070,028 (GRCm39) |
Y101C |
probably damaging |
Het |
|
| Other mutations in Vmn2r74 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00899:Vmn2r74
|
APN |
7 |
85,606,338 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00904:Vmn2r74
|
APN |
7 |
85,606,788 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01285:Vmn2r74
|
APN |
7 |
85,606,692 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01300:Vmn2r74
|
APN |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01410:Vmn2r74
|
APN |
7 |
85,610,500 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01827:Vmn2r74
|
APN |
7 |
85,606,800 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02094:Vmn2r74
|
APN |
7 |
85,610,669 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02252:Vmn2r74
|
APN |
7 |
85,606,531 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02349:Vmn2r74
|
APN |
7 |
85,601,724 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02438:Vmn2r74
|
APN |
7 |
85,601,824 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02554:Vmn2r74
|
APN |
7 |
85,606,581 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03036:Vmn2r74
|
APN |
7 |
85,601,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL03370:Vmn2r74
|
APN |
7 |
85,607,265 (GRCm39) |
missense |
probably benign |
|
|
R0115:Vmn2r74
|
UTSW |
7 |
85,606,564 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0333:Vmn2r74
|
UTSW |
7 |
85,601,491 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0415:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Vmn2r74
|
UTSW |
7 |
85,601,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0626:Vmn2r74
|
UTSW |
7 |
85,610,517 (GRCm39) |
nonsense |
probably null |
|
|
R0659:Vmn2r74
|
UTSW |
7 |
85,605,122 (GRCm39) |
splice site |
probably benign |
|
|
R1202:Vmn2r74
|
UTSW |
7 |
85,610,545 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1473:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Vmn2r74
|
UTSW |
7 |
85,601,650 (GRCm39) |
missense |
probably benign |
|
|
R2079:Vmn2r74
|
UTSW |
7 |
85,606,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2368:Vmn2r74
|
UTSW |
7 |
85,610,522 (GRCm39) |
missense |
probably benign |
0.39 |
|
R3782:Vmn2r74
|
UTSW |
7 |
85,605,322 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3824:Vmn2r74
|
UTSW |
7 |
85,607,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3977:Vmn2r74
|
UTSW |
7 |
85,607,345 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4182:Vmn2r74
|
UTSW |
7 |
85,606,395 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4289:Vmn2r74
|
UTSW |
7 |
85,606,562 (GRCm39) |
missense |
probably benign |
|
|
R4294:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4645:Vmn2r74
|
UTSW |
7 |
85,606,317 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r74
|
UTSW |
7 |
85,606,782 (GRCm39) |
missense |
probably benign |
0.42 |
|
R4655:Vmn2r74
|
UTSW |
7 |
85,610,555 (GRCm39) |
missense |
probably benign |
|
|
R5532:Vmn2r74
|
UTSW |
7 |
85,601,197 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5642:Vmn2r74
|
UTSW |
7 |
85,606,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5913:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6170:Vmn2r74
|
UTSW |
7 |
85,606,348 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6232:Vmn2r74
|
UTSW |
7 |
85,607,498 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6238:Vmn2r74
|
UTSW |
7 |
85,601,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6255:Vmn2r74
|
UTSW |
7 |
85,601,659 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6468:Vmn2r74
|
UTSW |
7 |
85,610,599 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6732:Vmn2r74
|
UTSW |
7 |
85,606,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Vmn2r74
|
UTSW |
7 |
85,610,621 (GRCm39) |
nonsense |
probably null |
|
|
R6836:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6995:Vmn2r74
|
UTSW |
7 |
85,606,860 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6995:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7186:Vmn2r74
|
UTSW |
7 |
85,601,150 (GRCm39) |
nonsense |
probably null |
|
|
R7246:Vmn2r74
|
UTSW |
7 |
85,605,173 (GRCm39) |
missense |
probably benign |
|
|
R7374:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7505:Vmn2r74
|
UTSW |
7 |
85,606,279 (GRCm39) |
nonsense |
probably null |
|
|
R7525:Vmn2r74
|
UTSW |
7 |
85,610,510 (GRCm39) |
missense |
probably benign |
|
|
R7569:Vmn2r74
|
UTSW |
7 |
85,601,544 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r74
|
UTSW |
7 |
85,606,746 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7956:Vmn2r74
|
UTSW |
7 |
85,605,166 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8119:Vmn2r74
|
UTSW |
7 |
85,610,690 (GRCm39) |
start codon destroyed |
probably null |
0.08 |
|
R8131:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8147:Vmn2r74
|
UTSW |
7 |
85,605,227 (GRCm39) |
nonsense |
probably null |
|
|
R8181:Vmn2r74
|
UTSW |
7 |
85,605,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8184:Vmn2r74
|
UTSW |
7 |
85,601,454 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8375:Vmn2r74
|
UTSW |
7 |
85,601,914 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8948:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8950:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9033:Vmn2r74
|
UTSW |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
|
|
R9342:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9578:Vmn2r74
|
UTSW |
7 |
85,606,101 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9607:Vmn2r74
|
UTSW |
7 |
85,610,619 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9776:Vmn2r74
|
UTSW |
7 |
85,605,212 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Z1176:Vmn2r74
|
UTSW |
7 |
85,604,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z31818:Vmn2r74
|
UTSW |
7 |
85,604,729 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATCTAGGGCAGTGTAAAGTAAGTC -3'
(R):5'- GTTTTAAAGCACCAAGTCCAGAAAG -3'
Sequencing Primer
(F):5'- AGTCAATAAATGAAGAAATACCGAGC -3'
(R):5'- TTCTATTCTATTGTGTAAGCCAGTTG -3'
|
| Posted On |
2016-03-17 |
Incidental Mutation