Incidental Mutation 'R4869:Tns1'
| ID |
376376 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tns1
|
| Ensembl Gene |
ENSMUSG00000055322 |
| Gene Name |
tensin 1 |
| Synonyms |
E030018G17Rik, 1110018I21Rik, E030037J05Rik, 1200014E20Rik, Tns |
| MMRRC Submission |
042479-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.528)
|
| Stock # |
R4869 (G1)
|
| Quality Score |
200 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
73949390-74163608 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 73991774 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Arginine
at position 968
(H968R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148638
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169786]
[ENSMUST00000187584]
[ENSMUST00000191104]
[ENSMUST00000191367]
[ENSMUST00000212888]
|
| AlphaFold |
E9Q0S6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169786
AA Change: H968R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000127715
Gene: ENSMUSG00000055322
AA Change: H968R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
33 |
N/A |
INTRINSIC |
|
C1
|
62 |
108 |
1.77e-2 |
SMART |
|
low complexity region
|
154 |
167 |
N/A |
INTRINSIC |
|
SCOP:d1d5ra2
|
176 |
348 |
3e-32 |
SMART |
|
PTEN_C2
|
350 |
477 |
1.12e-51 |
SMART |
|
low complexity region
|
822 |
833 |
N/A |
INTRINSIC |
|
low complexity region
|
905 |
922 |
N/A |
INTRINSIC |
|
low complexity region
|
1227 |
1239 |
N/A |
INTRINSIC |
|
low complexity region
|
1284 |
1300 |
N/A |
INTRINSIC |
|
low complexity region
|
1459 |
1470 |
N/A |
INTRINSIC |
|
low complexity region
|
1518 |
1530 |
N/A |
INTRINSIC |
|
SH2
|
1614 |
1716 |
6.85e-17 |
SMART |
|
PTB
|
1747 |
1888 |
1.69e-29 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000185331
AA Change: H798R
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000185702
AA Change: H798R
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187584
AA Change: H924R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000140254
Gene: ENSMUSG00000055322
AA Change: H924R
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
21 |
67 |
8.6e-5 |
SMART |
|
low complexity region
|
113 |
124 |
N/A |
INTRINSIC |
|
PTPc_DSPc
|
197 |
319 |
9.9e-6 |
SMART |
|
PTEN_C2
|
306 |
433 |
5.6e-56 |
SMART |
|
low complexity region
|
778 |
789 |
N/A |
INTRINSIC |
|
low complexity region
|
861 |
878 |
N/A |
INTRINSIC |
|
low complexity region
|
1162 |
1174 |
N/A |
INTRINSIC |
|
low complexity region
|
1219 |
1235 |
N/A |
INTRINSIC |
|
low complexity region
|
1394 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1453 |
1465 |
N/A |
INTRINSIC |
|
SH2
|
1549 |
1651 |
4.3e-19 |
SMART |
|
PTB
|
1682 |
1823 |
9e-32 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000191104
AA Change: H968R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000140317
Gene: ENSMUSG00000055322
AA Change: H968R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
33 |
N/A |
INTRINSIC |
|
C1
|
62 |
108 |
8.6e-5 |
SMART |
|
low complexity region
|
154 |
167 |
N/A |
INTRINSIC |
|
PTPc_DSPc
|
241 |
363 |
9.9e-6 |
SMART |
|
PTEN_C2
|
350 |
477 |
5.6e-56 |
SMART |
|
low complexity region
|
822 |
833 |
N/A |
INTRINSIC |
|
low complexity region
|
905 |
922 |
N/A |
INTRINSIC |
|
low complexity region
|
1206 |
1218 |
N/A |
INTRINSIC |
|
low complexity region
|
1263 |
1279 |
N/A |
INTRINSIC |
|
low complexity region
|
1438 |
1449 |
N/A |
INTRINSIC |
|
low complexity region
|
1497 |
1509 |
N/A |
INTRINSIC |
|
SH2
|
1593 |
1695 |
4.3e-19 |
SMART |
|
PTB
|
1726 |
1867 |
9e-32 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000191367
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000212888
AA Change: H968R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Meta Mutation Damage Score |
0.0594 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.3%
|
| Validation Efficiency |
99% (102/103) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced female fertility, and develop kidney cysts and progressive kidney degeneration that may lead to death from renal failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017B05Rik |
C |
A |
9: 57,161,488 (GRCm39) |
K943N |
probably damaging |
Het |
| Abca13 |
G |
A |
11: 9,265,434 (GRCm39) |
|
probably null |
Het |
| Ankub1 |
A |
G |
3: 57,597,751 (GRCm39) |
L73P |
probably damaging |
Het |
| Birc6 |
A |
G |
17: 74,893,007 (GRCm39) |
I982V |
probably benign |
Het |
| Cabyr |
G |
T |
18: 12,884,875 (GRCm39) |
*454L |
probably null |
Het |
| Ccdc57 |
C |
T |
11: 120,794,344 (GRCm39) |
|
probably null |
Het |
| Cd209c |
A |
G |
8: 3,994,077 (GRCm39) |
F128L |
probably benign |
Het |
| Cdh23 |
A |
T |
10: 60,212,713 (GRCm39) |
I1566N |
probably damaging |
Het |
| Cdon |
T |
C |
9: 35,364,200 (GRCm39) |
V106A |
possibly damaging |
Het |
| Cebpa |
G |
T |
7: 34,819,246 (GRCm39) |
G135C |
probably damaging |
Het |
| Cfap65 |
A |
G |
1: 74,958,420 (GRCm39) |
S896P |
probably benign |
Het |
| Ciz1 |
T |
C |
2: 32,254,247 (GRCm39) |
S63P |
probably damaging |
Het |
| Clybl |
G |
A |
14: 122,621,618 (GRCm39) |
V269M |
probably damaging |
Het |
| Ctnnb1 |
G |
T |
9: 120,782,060 (GRCm39) |
V358L |
possibly damaging |
Het |
| Cwh43 |
G |
T |
5: 73,586,016 (GRCm39) |
|
probably null |
Het |
| Cyp2d10 |
G |
A |
15: 82,287,967 (GRCm39) |
R379C |
probably benign |
Het |
| Dab2ip |
C |
A |
2: 35,610,049 (GRCm39) |
R727S |
probably damaging |
Het |
| Dmrt1 |
T |
A |
19: 25,483,219 (GRCm39) |
M1K |
probably null |
Het |
| Dock1 |
A |
T |
7: 134,335,800 (GRCm39) |
I65F |
probably damaging |
Het |
| Ercc2 |
T |
C |
7: 19,120,732 (GRCm39) |
V155A |
probably damaging |
Het |
| Exph5 |
A |
C |
9: 53,287,539 (GRCm39) |
D1540A |
possibly damaging |
Het |
| Fat3 |
T |
A |
9: 16,288,773 (GRCm39) |
H250L |
probably damaging |
Het |
| Fbxw10 |
C |
A |
11: 62,753,557 (GRCm39) |
A517E |
probably damaging |
Het |
| Furin |
A |
T |
7: 80,046,727 (GRCm39) |
N176K |
probably damaging |
Het |
| Gabrb3 |
A |
G |
7: 57,442,207 (GRCm39) |
|
probably benign |
Het |
| Gabrg2 |
A |
T |
11: 41,811,231 (GRCm39) |
S305T |
probably damaging |
Het |
| Gas6 |
G |
T |
8: 13,525,086 (GRCm39) |
S299R |
possibly damaging |
Het |
| Gga3 |
G |
T |
11: 115,477,111 (GRCm39) |
|
probably benign |
Het |
| Gle1 |
A |
G |
2: 29,826,032 (GRCm39) |
E37G |
possibly damaging |
Het |
| Gm7964 |
A |
G |
7: 83,405,350 (GRCm39) |
D80G |
possibly damaging |
Het |
| Gne |
C |
T |
4: 44,055,204 (GRCm39) |
|
probably null |
Het |
| Grid2 |
G |
T |
6: 64,406,724 (GRCm39) |
G695W |
probably damaging |
Het |
| H2-M10.6 |
A |
T |
17: 37,123,425 (GRCm39) |
M40L |
probably benign |
Het |
| Hectd4 |
G |
T |
5: 121,460,735 (GRCm39) |
V905L |
possibly damaging |
Het |
| Isyna1 |
C |
A |
8: 71,049,412 (GRCm39) |
S441R |
possibly damaging |
Het |
| Kcnh3 |
C |
T |
15: 99,139,913 (GRCm39) |
S933L |
probably benign |
Het |
| Knl1 |
T |
C |
2: 118,902,832 (GRCm39) |
I1511T |
possibly damaging |
Het |
| Krt73 |
T |
C |
15: 101,704,833 (GRCm39) |
E351G |
probably damaging |
Het |
| Lipo4 |
C |
T |
19: 33,478,953 (GRCm39) |
|
probably null |
Het |
| Llgl1 |
T |
A |
11: 60,598,036 (GRCm39) |
L360* |
probably null |
Het |
| Map2k5 |
G |
A |
9: 63,229,525 (GRCm39) |
R169* |
probably null |
Het |
| Muc19 |
A |
T |
15: 91,781,910 (GRCm39) |
|
noncoding transcript |
Het |
| Muc4 |
G |
A |
16: 32,754,836 (GRCm38) |
|
probably benign |
Het |
| Myh4 |
A |
G |
11: 67,143,490 (GRCm39) |
E1074G |
probably damaging |
Het |
| Naip5 |
C |
T |
13: 100,381,639 (GRCm39) |
G210E |
probably damaging |
Het |
| Nalcn |
A |
G |
14: 123,837,296 (GRCm39) |
S23P |
probably benign |
Het |
| Nepro |
T |
A |
16: 44,550,536 (GRCm39) |
M176K |
probably damaging |
Het |
| Nlrp6 |
G |
A |
7: 140,504,006 (GRCm39) |
C704Y |
probably damaging |
Het |
| Notch1 |
A |
G |
2: 26,361,191 (GRCm39) |
S1100P |
probably benign |
Het |
| Nrxn3 |
A |
G |
12: 88,762,352 (GRCm39) |
E133G |
possibly damaging |
Het |
| Obi1 |
A |
G |
14: 104,716,252 (GRCm39) |
I707T |
probably damaging |
Het |
| Parp9 |
T |
C |
16: 35,777,274 (GRCm39) |
L406S |
probably damaging |
Het |
| Peak1 |
G |
T |
9: 56,134,876 (GRCm39) |
A155D |
probably benign |
Het |
| Piezo1 |
G |
A |
8: 123,214,284 (GRCm39) |
H1628Y |
probably benign |
Het |
| Piwil2 |
A |
G |
14: 70,632,811 (GRCm39) |
V587A |
probably benign |
Het |
| Pkn2 |
A |
G |
3: 142,509,379 (GRCm39) |
Y722H |
probably damaging |
Het |
| Plch2 |
A |
T |
4: 155,073,885 (GRCm39) |
I834K |
probably benign |
Het |
| Pld1 |
A |
G |
3: 28,163,951 (GRCm39) |
T795A |
possibly damaging |
Het |
| Plekhh1 |
A |
G |
12: 79,097,160 (GRCm39) |
S103G |
probably benign |
Het |
| Ppl |
T |
C |
16: 4,922,753 (GRCm39) |
Y246C |
probably damaging |
Het |
| Prpf40b |
G |
A |
15: 99,207,726 (GRCm39) |
|
probably benign |
Het |
| Prr14l |
A |
G |
5: 32,986,177 (GRCm39) |
L1106P |
probably damaging |
Het |
| Ptbp3 |
T |
A |
4: 59,524,443 (GRCm39) |
I28F |
possibly damaging |
Het |
| Ptrh2 |
A |
T |
11: 86,580,631 (GRCm39) |
K83* |
probably null |
Het |
| Rai1 |
T |
C |
11: 60,077,588 (GRCm39) |
S551P |
probably damaging |
Het |
| Rapgefl1 |
A |
T |
11: 98,741,935 (GRCm39) |
Q633L |
probably damaging |
Het |
| Rb1cc1 |
T |
C |
1: 6,285,245 (GRCm39) |
|
probably benign |
Het |
| Rif1 |
T |
A |
2: 51,983,623 (GRCm39) |
|
probably benign |
Het |
| Rnf141 |
A |
G |
7: 110,424,557 (GRCm39) |
Y101H |
probably damaging |
Het |
| Rttn |
T |
A |
18: 89,061,138 (GRCm39) |
L1102* |
probably null |
Het |
| Sall4 |
G |
A |
2: 168,597,637 (GRCm39) |
S401F |
probably damaging |
Het |
| Saxo5 |
G |
A |
8: 3,537,148 (GRCm39) |
S498N |
probably damaging |
Het |
| Sec11c |
T |
C |
18: 65,934,541 (GRCm39) |
I36T |
probably benign |
Het |
| Sel1l |
A |
G |
12: 91,780,828 (GRCm39) |
|
probably benign |
Het |
| Setd1a |
T |
C |
7: 127,396,776 (GRCm39) |
|
probably benign |
Het |
| Sez6l2 |
C |
T |
7: 126,561,014 (GRCm39) |
P433L |
probably benign |
Het |
| Sgf29 |
T |
C |
7: 126,248,547 (GRCm39) |
|
probably benign |
Het |
| Slc47a1 |
A |
G |
11: 61,253,520 (GRCm39) |
V305A |
probably benign |
Het |
| Slco1a8 |
T |
C |
6: 141,933,492 (GRCm39) |
D431G |
probably damaging |
Het |
| Sun2 |
T |
C |
15: 79,612,587 (GRCm39) |
|
probably benign |
Het |
| Tecta |
T |
C |
9: 42,286,830 (GRCm39) |
S609G |
probably benign |
Het |
| Tmprss6 |
T |
A |
15: 78,327,880 (GRCm39) |
|
probably null |
Het |
| Tomm34 |
G |
A |
2: 163,896,637 (GRCm39) |
A270V |
probably damaging |
Het |
| Tpo |
T |
C |
12: 30,153,364 (GRCm39) |
K330R |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,542,837 (GRCm39) |
Y33383F |
probably damaging |
Het |
| Unc13c |
G |
T |
9: 73,587,716 (GRCm39) |
A1439D |
probably benign |
Het |
| Vcp |
C |
T |
4: 42,993,691 (GRCm39) |
R147H |
probably benign |
Het |
| Vps13d |
A |
G |
4: 144,854,612 (GRCm39) |
L2272P |
probably damaging |
Het |
| Wdfy3 |
A |
G |
5: 102,042,787 (GRCm39) |
L1988P |
probably damaging |
Het |
| Wwc2 |
A |
G |
8: 48,373,713 (GRCm39) |
F51S |
probably damaging |
Het |
| Zfp454 |
C |
T |
11: 50,763,980 (GRCm39) |
C373Y |
probably damaging |
Het |
| Zfp853 |
A |
T |
5: 143,274,048 (GRCm39) |
V473E |
probably damaging |
Het |
| Zfp959 |
A |
T |
17: 56,204,228 (GRCm39) |
R85S |
possibly damaging |
Het |
|
| Other mutations in Tns1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Tns1
|
APN |
1 |
73,964,128 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01288:Tns1
|
APN |
1 |
73,992,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01536:Tns1
|
APN |
1 |
73,958,807 (GRCm39) |
splice site |
probably benign |
|
|
IGL01568:Tns1
|
APN |
1 |
73,992,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01683:Tns1
|
APN |
1 |
73,992,428 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02267:Tns1
|
APN |
1 |
74,031,290 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02597:Tns1
|
APN |
1 |
74,025,032 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02819:Tns1
|
APN |
1 |
73,976,407 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03370:Tns1
|
APN |
1 |
74,025,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0087:Tns1
|
UTSW |
1 |
73,956,076 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0207:Tns1
|
UTSW |
1 |
73,976,477 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0411:Tns1
|
UTSW |
1 |
73,964,920 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0543:Tns1
|
UTSW |
1 |
73,991,856 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0552:Tns1
|
UTSW |
1 |
73,959,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0720:Tns1
|
UTSW |
1 |
73,964,740 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0828:Tns1
|
UTSW |
1 |
73,958,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1034:Tns1
|
UTSW |
1 |
73,981,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1061:Tns1
|
UTSW |
1 |
73,956,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1819:Tns1
|
UTSW |
1 |
73,955,635 (GRCm39) |
splice site |
probably benign |
|
|
R1826:Tns1
|
UTSW |
1 |
73,992,793 (GRCm39) |
start codon destroyed |
probably null |
0.91 |
|
R2208:Tns1
|
UTSW |
1 |
74,118,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3723:Tns1
|
UTSW |
1 |
73,964,099 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4079:Tns1
|
UTSW |
1 |
74,034,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4111:Tns1
|
UTSW |
1 |
73,981,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4155:Tns1
|
UTSW |
1 |
73,953,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4156:Tns1
|
UTSW |
1 |
73,953,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4157:Tns1
|
UTSW |
1 |
73,953,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4274:Tns1
|
UTSW |
1 |
73,967,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4426:Tns1
|
UTSW |
1 |
74,024,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4649:Tns1
|
UTSW |
1 |
73,992,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4742:Tns1
|
UTSW |
1 |
74,163,449 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4961:Tns1
|
UTSW |
1 |
73,975,074 (GRCm39) |
missense |
probably benign |
0.35 |
|
R5025:Tns1
|
UTSW |
1 |
73,964,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5035:Tns1
|
UTSW |
1 |
73,992,979 (GRCm39) |
start gained |
probably benign |
|
|
R5062:Tns1
|
UTSW |
1 |
73,992,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5080:Tns1
|
UTSW |
1 |
73,992,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5213:Tns1
|
UTSW |
1 |
73,992,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Tns1
|
UTSW |
1 |
74,034,585 (GRCm39) |
intron |
probably benign |
|
|
R5368:Tns1
|
UTSW |
1 |
73,980,176 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5391:Tns1
|
UTSW |
1 |
74,029,568 (GRCm39) |
splice site |
probably null |
|
|
R5587:Tns1
|
UTSW |
1 |
73,959,755 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5735:Tns1
|
UTSW |
1 |
73,967,138 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5855:Tns1
|
UTSW |
1 |
73,957,192 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5999:Tns1
|
UTSW |
1 |
73,967,256 (GRCm39) |
nonsense |
probably null |
|
|
R6122:Tns1
|
UTSW |
1 |
73,991,578 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6148:Tns1
|
UTSW |
1 |
73,992,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6457:Tns1
|
UTSW |
1 |
73,957,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6525:Tns1
|
UTSW |
1 |
73,992,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6712:Tns1
|
UTSW |
1 |
74,118,460 (GRCm39) |
nonsense |
probably null |
|
|
R6773:Tns1
|
UTSW |
1 |
73,958,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6825:Tns1
|
UTSW |
1 |
74,041,482 (GRCm39) |
nonsense |
probably null |
|
|
R7085:Tns1
|
UTSW |
1 |
73,964,621 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7128:Tns1
|
UTSW |
1 |
74,034,463 (GRCm39) |
missense |
|
|
|
R7209:Tns1
|
UTSW |
1 |
73,993,074 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7348:Tns1
|
UTSW |
1 |
73,956,076 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7570:Tns1
|
UTSW |
1 |
73,992,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7670:Tns1
|
UTSW |
1 |
73,991,636 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7769:Tns1
|
UTSW |
1 |
73,992,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7833:Tns1
|
UTSW |
1 |
74,130,490 (GRCm39) |
intron |
probably benign |
|
|
R8052:Tns1
|
UTSW |
1 |
73,992,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8225:Tns1
|
UTSW |
1 |
74,025,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8244:Tns1
|
UTSW |
1 |
73,976,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8321:Tns1
|
UTSW |
1 |
74,024,939 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8344:Tns1
|
UTSW |
1 |
74,024,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8378:Tns1
|
UTSW |
1 |
73,976,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8434:Tns1
|
UTSW |
1 |
73,964,765 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8773:Tns1
|
UTSW |
1 |
73,976,407 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9211:Tns1
|
UTSW |
1 |
73,956,948 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9251:Tns1
|
UTSW |
1 |
74,030,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9315:Tns1
|
UTSW |
1 |
73,980,141 (GRCm39) |
missense |
|
|
|
R9411:Tns1
|
UTSW |
1 |
73,992,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9592:Tns1
|
UTSW |
1 |
74,029,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9658:Tns1
|
UTSW |
1 |
73,981,183 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9658:Tns1
|
UTSW |
1 |
73,981,182 (GRCm39) |
missense |
probably benign |
0.14 |
|
Z1177:Tns1
|
UTSW |
1 |
74,041,466 (GRCm39) |
missense |
probably benign |
0.12 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTACCTGCTACCCGATGG -3'
(R):5'- TCATAAGTCCCAGAGTGTCCCTG -3'
Sequencing Primer
(F):5'- GCTGAGCGATGAGACCA -3'
(R):5'- AGAGTGTCCCTGGGGCC -3'
|
| Posted On |
2016-03-17 |
Incidental Mutation