Incidental Mutation 'R4871:Plekha5'
| ID |
376583 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plekha5
|
| Ensembl Gene |
ENSMUSG00000030231 |
| Gene Name |
pleckstrin homology domain containing, family A member 5 |
| Synonyms |
2810431N21Rik, PEPP2 |
| MMRRC Submission |
042481-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.163)
|
| Stock # |
R4871 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
140369780-140542836 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 140471636 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 20
(Y20C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000145336
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087622]
[ENSMUST00000203517]
[ENSMUST00000203774]
[ENSMUST00000204145]
[ENSMUST00000204876]
|
| AlphaFold |
E9Q6H8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000087622
AA Change: Y129C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000084904
Gene: ENSMUSG00000030231
AA Change: Y129C
| Domain | Start | End | E-Value | Type |
|---|
|
WW
|
12 |
44 |
1.51e-3 |
SMART |
|
WW
|
58 |
90 |
2.17e-4 |
SMART |
|
PH
|
171 |
271 |
1.85e-17 |
SMART |
|
Blast:PH
|
592 |
715 |
7e-39 |
BLAST |
|
coiled coil region
|
747 |
781 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
916 |
N/A |
INTRINSIC |
|
low complexity region
|
924 |
938 |
N/A |
INTRINSIC |
|
low complexity region
|
1206 |
1224 |
N/A |
INTRINSIC |
|
low complexity region
|
1243 |
1258 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000203517
AA Change: Y129C
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000145478
Gene: ENSMUSG00000030231
AA Change: Y129C
| Domain | Start | End | E-Value | Type |
|---|
|
WW
|
12 |
44 |
9e-6 |
SMART |
|
WW
|
58 |
90 |
1.3e-6 |
SMART |
|
PH
|
171 |
271 |
8.6e-20 |
SMART |
|
Blast:PH
|
586 |
697 |
3e-15 |
BLAST |
|
coiled coil region
|
702 |
736 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000203774
AA Change: Y20C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000144832
Gene: ENSMUSG00000030231
AA Change: Y20C
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
62 |
162 |
8.6e-20 |
SMART |
|
Blast:PH
|
477 |
511 |
4e-8 |
BLAST |
|
low complexity region
|
512 |
521 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000203955
AA Change: Y52C
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000204145
AA Change: Y129C
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000145457
Gene: ENSMUSG00000030231
AA Change: Y129C
| Domain | Start | End | E-Value | Type |
|---|
|
WW
|
12 |
44 |
9e-6 |
SMART |
|
WW
|
58 |
90 |
1.3e-6 |
SMART |
|
Blast:PH
|
114 |
151 |
6e-14 |
BLAST |
|
PDB:2DKP|A
|
163 |
196 |
1e-5 |
PDB |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000204876
AA Change: Y20C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000145336
Gene: ENSMUSG00000030231
AA Change: Y20C
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
62 |
162 |
8.6e-20 |
SMART |
|
Blast:PH
|
483 |
517 |
3e-8 |
BLAST |
|
low complexity region
|
518 |
527 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.4611 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.1%
|
| Validation Efficiency |
93% (99/107) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcyap1r1 |
A |
G |
6: 55,457,078 (GRCm39) |
T270A |
probably null |
Het |
| Adgrv1 |
A |
T |
13: 81,681,241 (GRCm39) |
|
probably benign |
Het |
| Aldh1b1 |
A |
T |
4: 45,803,383 (GRCm39) |
D307V |
probably benign |
Het |
| Aldh3a2 |
A |
T |
11: 61,153,065 (GRCm39) |
C220* |
probably null |
Het |
| Ank2 |
T |
C |
3: 126,753,444 (GRCm39) |
Y279C |
probably damaging |
Het |
| Anks1 |
T |
C |
17: 28,210,351 (GRCm39) |
Y444H |
probably benign |
Het |
| Asph |
G |
T |
4: 9,531,968 (GRCm39) |
T383K |
probably benign |
Het |
| Asphd1 |
G |
T |
7: 126,547,747 (GRCm39) |
S185R |
possibly damaging |
Het |
| Bcl2a1d |
T |
A |
9: 88,613,748 (GRCm39) |
I9F |
probably damaging |
Het |
| Bcl2l11 |
T |
C |
2: 127,970,961 (GRCm39) |
|
probably benign |
Het |
| C2cd3 |
T |
G |
7: 100,062,581 (GRCm39) |
S656A |
possibly damaging |
Het |
| Cd5l |
T |
C |
3: 87,274,929 (GRCm39) |
V156A |
probably damaging |
Het |
| Cdh8 |
G |
C |
8: 99,757,536 (GRCm39) |
N687K |
probably damaging |
Het |
| Cdk19 |
A |
G |
10: 40,352,232 (GRCm39) |
D338G |
probably benign |
Het |
| Cenpf |
A |
G |
1: 189,390,728 (GRCm39) |
C1035R |
probably damaging |
Het |
| Cep290 |
A |
G |
10: 100,384,776 (GRCm39) |
R1845G |
probably benign |
Het |
| Cep295nl |
G |
T |
11: 118,224,650 (GRCm39) |
Q65K |
probably damaging |
Het |
| Ciz1 |
T |
C |
2: 32,262,300 (GRCm39) |
|
probably benign |
Het |
| Clasrp |
T |
C |
7: 19,324,173 (GRCm39) |
D234G |
possibly damaging |
Het |
| Dctd |
C |
T |
8: 48,590,449 (GRCm39) |
|
probably benign |
Het |
| Ddr2 |
A |
G |
1: 169,832,340 (GRCm39) |
V150A |
probably benign |
Het |
| Dennd10 |
A |
G |
19: 60,819,252 (GRCm39) |
E120G |
probably damaging |
Het |
| Dnah7b |
T |
C |
1: 46,120,604 (GRCm39) |
S74P |
probably benign |
Het |
| Dnttip2 |
C |
A |
3: 122,078,750 (GRCm39) |
A743E |
probably damaging |
Het |
| Dysf |
A |
T |
6: 84,044,005 (GRCm39) |
Q281L |
possibly damaging |
Het |
| Ece2 |
A |
G |
16: 20,462,905 (GRCm39) |
E610G |
probably damaging |
Het |
| Edem3 |
T |
G |
1: 151,679,982 (GRCm39) |
|
probably null |
Het |
| Ext1 |
G |
T |
15: 52,955,773 (GRCm39) |
N441K |
probably benign |
Het |
| Fam118a |
A |
G |
15: 84,942,969 (GRCm39) |
R333G |
probably damaging |
Het |
| Fat4 |
C |
T |
3: 38,945,754 (GRCm39) |
T1549I |
probably damaging |
Het |
| Fbxo4 |
A |
G |
15: 4,005,394 (GRCm39) |
V162A |
probably damaging |
Het |
| Fgd2 |
A |
G |
17: 29,592,223 (GRCm39) |
H385R |
possibly damaging |
Het |
| Garnl3 |
A |
T |
2: 32,977,100 (GRCm39) |
M1K |
probably null |
Het |
| Gm37267 |
T |
G |
1: 180,338,083 (GRCm39) |
|
noncoding transcript |
Het |
| Gpbar1 |
C |
T |
1: 74,318,702 (GRCm39) |
A315V |
probably damaging |
Het |
| Grm2 |
T |
C |
9: 106,524,844 (GRCm39) |
I624V |
probably benign |
Het |
| Hmcn1 |
T |
C |
1: 150,468,836 (GRCm39) |
I5042V |
probably benign |
Het |
| Hnf4g |
T |
C |
3: 3,716,448 (GRCm39) |
Y291H |
possibly damaging |
Het |
| Ighm |
A |
G |
12: 113,385,241 (GRCm39) |
S240P |
unknown |
Het |
| Igkv4-91 |
A |
G |
6: 68,745,604 (GRCm39) |
I98T |
probably damaging |
Het |
| Krt72 |
T |
C |
15: 101,694,469 (GRCm39) |
N142S |
probably damaging |
Het |
| Kynu |
T |
A |
2: 43,569,830 (GRCm39) |
Y371N |
possibly damaging |
Het |
| Ly9 |
G |
T |
1: 171,434,898 (GRCm39) |
|
probably benign |
Het |
| Man1a2 |
C |
A |
3: 100,524,372 (GRCm39) |
V359F |
probably damaging |
Het |
| Mast1 |
T |
C |
8: 85,647,287 (GRCm39) |
I623M |
probably damaging |
Het |
| Mb |
A |
G |
15: 76,906,687 (GRCm39) |
|
probably null |
Het |
| Mcm4 |
A |
C |
16: 15,452,374 (GRCm39) |
L113* |
probably null |
Het |
| Mcub |
C |
T |
3: 129,710,685 (GRCm39) |
W249* |
probably null |
Het |
| Mme |
T |
A |
3: 63,247,453 (GRCm39) |
V246E |
probably benign |
Het |
| Mplkipl1 |
C |
T |
19: 61,164,364 (GRCm39) |
G24R |
unknown |
Het |
| Mrpl38 |
A |
G |
11: 116,025,098 (GRCm39) |
Y232H |
probably damaging |
Het |
| Myh7b |
T |
A |
2: 155,455,420 (GRCm39) |
M89K |
probably benign |
Het |
| Notch4 |
A |
G |
17: 34,796,536 (GRCm39) |
S892G |
possibly damaging |
Het |
| Nt5dc3 |
A |
G |
10: 86,652,941 (GRCm39) |
Y245C |
probably damaging |
Het |
| Ntn1 |
CCTTCTTCT |
CCTTCT |
11: 68,103,852 (GRCm39) |
|
probably benign |
Het |
| Or12d12 |
T |
A |
17: 37,611,095 (GRCm39) |
T73S |
probably benign |
Het |
| Or12d14-ps1 |
A |
T |
17: 37,673,337 (GRCm39) |
I107L |
probably benign |
Het |
| Or14a259 |
A |
T |
7: 86,012,692 (GRCm39) |
N284K |
probably damaging |
Het |
| Or5m12 |
T |
A |
2: 85,734,715 (GRCm39) |
I228F |
probably benign |
Het |
| Or8b36 |
G |
T |
9: 37,937,822 (GRCm39) |
C240F |
probably damaging |
Het |
| Or8k28 |
A |
T |
2: 86,286,153 (GRCm39) |
I154N |
possibly damaging |
Het |
| Palld |
A |
T |
8: 62,002,815 (GRCm39) |
|
probably benign |
Het |
| Pcdhga10 |
T |
C |
18: 37,881,253 (GRCm39) |
V338A |
probably damaging |
Het |
| Pcdhga11 |
A |
G |
18: 37,890,459 (GRCm39) |
Y489C |
probably damaging |
Het |
| Pgm2 |
T |
C |
5: 64,261,237 (GRCm39) |
Y244H |
probably benign |
Het |
| Phactr4 |
A |
T |
4: 132,105,759 (GRCm39) |
S102R |
probably damaging |
Het |
| Rdh19 |
A |
G |
10: 127,696,013 (GRCm39) |
D255G |
probably benign |
Het |
| Rgs3 |
T |
C |
4: 62,549,532 (GRCm39) |
V438A |
probably benign |
Het |
| Rnf186 |
A |
G |
4: 138,695,254 (GRCm39) |
T265A |
probably benign |
Het |
| Ror1 |
T |
C |
4: 100,283,195 (GRCm39) |
F420S |
probably benign |
Het |
| Rtkn2 |
A |
G |
10: 67,841,463 (GRCm39) |
K204E |
probably damaging |
Het |
| Rundc1 |
A |
G |
11: 101,324,874 (GRCm39) |
T527A |
probably benign |
Het |
| Samd4 |
T |
C |
14: 47,303,920 (GRCm39) |
S301P |
probably damaging |
Het |
| Scaf1 |
G |
A |
7: 44,655,303 (GRCm39) |
|
probably benign |
Het |
| Srgap2 |
A |
G |
1: 131,217,210 (GRCm39) |
V1034A |
probably benign |
Het |
| Stab2 |
T |
C |
10: 86,778,099 (GRCm39) |
D743G |
probably damaging |
Het |
| Stim1 |
A |
T |
7: 102,003,779 (GRCm39) |
I71F |
probably damaging |
Het |
| Stk17b |
T |
C |
1: 53,796,693 (GRCm39) |
D358G |
probably benign |
Het |
| Sun2 |
A |
G |
15: 79,611,765 (GRCm39) |
Y551H |
probably damaging |
Het |
| Tas2r110 |
A |
T |
6: 132,845,091 (GRCm39) |
T41S |
probably benign |
Het |
| Tead3 |
T |
A |
17: 28,552,589 (GRCm39) |
E268V |
probably damaging |
Het |
| Tead3 |
A |
G |
17: 28,553,962 (GRCm39) |
S131P |
probably benign |
Het |
| Tepsin |
A |
T |
11: 119,982,351 (GRCm39) |
M505K |
possibly damaging |
Het |
| Trbv28 |
A |
G |
6: 41,248,668 (GRCm39) |
Y66C |
possibly damaging |
Het |
| Ttc6 |
A |
G |
12: 57,749,142 (GRCm39) |
Q1358R |
probably damaging |
Het |
| Ttll2 |
C |
T |
17: 7,618,998 (GRCm39) |
V310I |
probably benign |
Het |
| Uaca |
T |
C |
9: 60,753,283 (GRCm39) |
V76A |
probably damaging |
Het |
| Vwf |
A |
T |
6: 125,663,425 (GRCm39) |
T2789S |
probably benign |
Het |
| Yipf4 |
T |
C |
17: 74,801,089 (GRCm39) |
F136L |
probably benign |
Het |
| Zdhhc1 |
CGGGGG |
CGGGGGG |
8: 106,210,376 (GRCm39) |
|
probably null |
Het |
| Zfp804b |
A |
T |
5: 6,926,479 (GRCm39) |
D51E |
probably damaging |
Het |
| Zfyve9 |
C |
T |
4: 108,538,183 (GRCm39) |
G969R |
probably damaging |
Het |
|
| Other mutations in Plekha5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00577:Plekha5
|
APN |
6 |
140,515,822 (GRCm39) |
splice site |
probably benign |
|
|
IGL00908:Plekha5
|
APN |
6 |
140,496,656 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01346:Plekha5
|
APN |
6 |
140,480,292 (GRCm39) |
splice site |
probably benign |
|
|
IGL01380:Plekha5
|
APN |
6 |
140,516,042 (GRCm39) |
splice site |
probably benign |
|
|
IGL01406:Plekha5
|
APN |
6 |
140,518,676 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01408:Plekha5
|
APN |
6 |
140,516,042 (GRCm39) |
splice site |
probably benign |
|
|
IGL01688:Plekha5
|
APN |
6 |
140,515,115 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01719:Plekha5
|
APN |
6 |
140,515,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01926:Plekha5
|
APN |
6 |
140,471,642 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01936:Plekha5
|
APN |
6 |
140,470,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02326:Plekha5
|
APN |
6 |
140,529,576 (GRCm39) |
nonsense |
probably null |
|
|
IGL02544:Plekha5
|
APN |
6 |
140,535,454 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02573:Plekha5
|
APN |
6 |
140,527,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02704:Plekha5
|
APN |
6 |
140,489,592 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02959:Plekha5
|
APN |
6 |
140,489,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Doubletime
|
UTSW |
6 |
140,471,655 (GRCm39) |
nonsense |
probably null |
|
|
R0067:Plekha5
|
UTSW |
6 |
140,470,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0067:Plekha5
|
UTSW |
6 |
140,470,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0095:Plekha5
|
UTSW |
6 |
140,474,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0095:Plekha5
|
UTSW |
6 |
140,474,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Plekha5
|
UTSW |
6 |
140,537,473 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0107:Plekha5
|
UTSW |
6 |
140,537,473 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0359:Plekha5
|
UTSW |
6 |
140,537,473 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0360:Plekha5
|
UTSW |
6 |
140,537,473 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0362:Plekha5
|
UTSW |
6 |
140,537,473 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0363:Plekha5
|
UTSW |
6 |
140,537,473 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0364:Plekha5
|
UTSW |
6 |
140,537,473 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0365:Plekha5
|
UTSW |
6 |
140,537,473 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0833:Plekha5
|
UTSW |
6 |
140,535,360 (GRCm39) |
splice site |
probably benign |
|
|
R0835:Plekha5
|
UTSW |
6 |
140,514,576 (GRCm39) |
nonsense |
probably null |
|
|
R0836:Plekha5
|
UTSW |
6 |
140,535,360 (GRCm39) |
splice site |
probably benign |
|
|
R0944:Plekha5
|
UTSW |
6 |
140,515,922 (GRCm39) |
splice site |
probably benign |
|
|
R2015:Plekha5
|
UTSW |
6 |
140,480,290 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2043:Plekha5
|
UTSW |
6 |
140,498,530 (GRCm39) |
splice site |
probably benign |
|
|
R2086:Plekha5
|
UTSW |
6 |
140,516,044 (GRCm39) |
splice site |
probably null |
|
|
R2102:Plekha5
|
UTSW |
6 |
140,518,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Plekha5
|
UTSW |
6 |
140,369,942 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2135:Plekha5
|
UTSW |
6 |
140,526,225 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2150:Plekha5
|
UTSW |
6 |
140,516,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2211:Plekha5
|
UTSW |
6 |
140,471,587 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2414:Plekha5
|
UTSW |
6 |
140,496,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2915:Plekha5
|
UTSW |
6 |
140,534,925 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3120:Plekha5
|
UTSW |
6 |
140,537,367 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3924:Plekha5
|
UTSW |
6 |
140,516,105 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R4049:Plekha5
|
UTSW |
6 |
140,529,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4056:Plekha5
|
UTSW |
6 |
140,534,958 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4077:Plekha5
|
UTSW |
6 |
140,501,647 (GRCm39) |
splice site |
probably null |
|
|
R4320:Plekha5
|
UTSW |
6 |
140,489,543 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4343:Plekha5
|
UTSW |
6 |
140,501,780 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4359:Plekha5
|
UTSW |
6 |
140,537,414 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4377:Plekha5
|
UTSW |
6 |
140,525,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4480:Plekha5
|
UTSW |
6 |
140,472,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4533:Plekha5
|
UTSW |
6 |
140,516,057 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4623:Plekha5
|
UTSW |
6 |
140,496,912 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4672:Plekha5
|
UTSW |
6 |
140,470,655 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4903:Plekha5
|
UTSW |
6 |
140,532,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5121:Plekha5
|
UTSW |
6 |
140,525,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5156:Plekha5
|
UTSW |
6 |
140,372,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5376:Plekha5
|
UTSW |
6 |
140,496,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5445:Plekha5
|
UTSW |
6 |
140,498,459 (GRCm39) |
nonsense |
probably null |
|
|
R5753:Plekha5
|
UTSW |
6 |
140,482,730 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5836:Plekha5
|
UTSW |
6 |
140,372,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5972:Plekha5
|
UTSW |
6 |
140,518,639 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6196:Plekha5
|
UTSW |
6 |
140,525,179 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6254:Plekha5
|
UTSW |
6 |
140,532,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6501:Plekha5
|
UTSW |
6 |
140,471,655 (GRCm39) |
nonsense |
probably null |
|
|
R6620:Plekha5
|
UTSW |
6 |
140,518,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6663:Plekha5
|
UTSW |
6 |
140,523,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6823:Plekha5
|
UTSW |
6 |
140,471,584 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6992:Plekha5
|
UTSW |
6 |
140,489,634 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7196:Plekha5
|
UTSW |
6 |
140,489,648 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7487:Plekha5
|
UTSW |
6 |
140,516,059 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7493:Plekha5
|
UTSW |
6 |
140,526,161 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7557:Plekha5
|
UTSW |
6 |
140,372,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7743:Plekha5
|
UTSW |
6 |
140,501,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7792:Plekha5
|
UTSW |
6 |
140,534,950 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7808:Plekha5
|
UTSW |
6 |
140,529,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7910:Plekha5
|
UTSW |
6 |
140,472,184 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7944:Plekha5
|
UTSW |
6 |
140,526,201 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7945:Plekha5
|
UTSW |
6 |
140,526,201 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7992:Plekha5
|
UTSW |
6 |
140,472,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8979:Plekha5
|
UTSW |
6 |
140,496,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9024:Plekha5
|
UTSW |
6 |
140,370,176 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9135:Plekha5
|
UTSW |
6 |
140,480,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9215:Plekha5
|
UTSW |
6 |
140,501,733 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9241:Plekha5
|
UTSW |
6 |
140,525,204 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9447:Plekha5
|
UTSW |
6 |
140,525,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9625:Plekha5
|
UTSW |
6 |
140,372,253 (GRCm39) |
missense |
probably benign |
0.24 |
|
X0027:Plekha5
|
UTSW |
6 |
140,370,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTCACTCATGTTAGGCTAGAATTAG -3'
(R):5'- GCTGATTCAACAGAATACCCATTC -3'
Sequencing Primer
(F):5'- GGCAACAGCATTAAAGTATTATTACC -3'
(R):5'- TCAACAGAATACCCATTCCCTCATAC -3'
|
| Posted On |
2016-03-17 |
Incidental Mutation