Incidental Mutation 'R4872:Acad11'
ID 376665
Institutional Source Beutler Lab
Gene Symbol Acad11
Ensembl Gene ENSMUSG00000090150
Gene Name acyl-Coenzyme A dehydrogenase family, member 11
Synonyms 5730439E10Rik
MMRRC Submission 042482-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R4872 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 103940923-104004855 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) G to A at 103963465 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141064 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047799] [ENSMUST00000120854] [ENSMUST00000189998]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000047799
SMART Domains Protein: ENSMUSP00000043424
Gene: ENSMUSG00000090150

DomainStartEndE-ValueType
Pfam:APH 43 307 3.5e-45 PFAM
Pfam:Acyl-CoA_dh_N 376 498 1.5e-13 PFAM
Pfam:Acyl-CoA_dh_M 502 605 1.7e-21 PFAM
Pfam:Acyl-CoA_dh_1 617 768 2.7e-36 PFAM
Pfam:Acyl-CoA_dh_2 632 743 2e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000050139
SMART Domains Protein: ENSMUSP00000062941
Gene: ENSMUSG00000041748

DomainStartEndE-ValueType
transmembrane domain 28 50 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000120854
SMART Domains Protein: ENSMUSP00000112994
Gene: ENSMUSG00000090150

DomainStartEndE-ValueType
Pfam:APH 1 188 1.1e-28 PFAM
Pfam:EcKinase 49 143 4.8e-9 PFAM
Pfam:Acyl-CoA_dh_N 257 380 8.7e-15 PFAM
Pfam:Acyl-CoA_dh_M 385 439 2.4e-19 PFAM
Pfam:Acyl-CoA_dh_1 499 650 1.3e-37 PFAM
Pfam:Acyl-CoA_dh_2 514 632 2.7e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154431
Predicted Effect probably benign
Transcript: ENSMUST00000189998
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.1%
Validation Efficiency 98% (81/83)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd2 C A 15: 91,075,514 (GRCm39) V100L probably benign Het
Actb C T 5: 142,891,307 (GRCm39) probably benign Het
Ano9 G A 7: 140,687,117 (GRCm39) A374V probably damaging Het
Baz2b T C 2: 59,773,103 (GRCm39) probably null Het
Bltp3a G T 17: 28,109,110 (GRCm39) D1110Y probably benign Het
Bpifb9b T A 2: 154,155,551 (GRCm39) L350Q probably damaging Het
Cd27 T A 6: 125,211,281 (GRCm39) probably null Het
Cd72 A G 4: 43,449,563 (GRCm39) probably benign Het
Cdadc1 A T 14: 59,801,973 (GRCm39) S516T probably benign Het
Chst5 T A 8: 112,617,192 (GRCm39) I143F possibly damaging Het
Col20a1 T C 2: 180,639,156 (GRCm39) V452A possibly damaging Het
Cox11 C A 11: 90,535,229 (GRCm39) Q227K probably benign Het
Cpa6 A G 1: 10,665,843 (GRCm39) probably null Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dpm2 T C 2: 32,461,203 (GRCm39) probably benign Het
Dync1h1 C A 12: 110,624,560 (GRCm39) T3700N probably damaging Het
Frem1 A C 4: 82,881,387 (GRCm39) N1273K probably damaging Het
Fry T C 5: 150,317,704 (GRCm39) probably null Het
Gm10306 G T 4: 94,445,069 (GRCm39) probably benign Het
Gm5565 T C 5: 146,094,913 (GRCm39) T278A probably benign Het
Gm8180 A G 14: 44,019,802 (GRCm39) I40T probably benign Het
Iah1 T C 12: 21,367,426 (GRCm39) V44A probably benign Het
Iqgap3 C T 3: 88,020,435 (GRCm39) P360S probably damaging Het
Klhl28 T A 12: 65,003,896 (GRCm39) I206F possibly damaging Het
Krt13 A G 11: 100,012,332 (GRCm39) probably benign Het
Lipo2 T A 19: 33,726,914 (GRCm39) D41V probably benign Het
Lrig2 C G 3: 104,398,842 (GRCm39) V229L possibly damaging Het
Lrrc32 C T 7: 98,147,727 (GRCm39) T169I probably damaging Het
Lrriq1 T C 10: 103,014,649 (GRCm39) N1053S possibly damaging Het
Mfng C T 15: 78,648,588 (GRCm39) R163H probably benign Het
Mgat4c G C 10: 102,224,599 (GRCm39) R271P probably damaging Het
Mylk A G 16: 34,735,360 (GRCm39) N780S possibly damaging Het
N4bp1 T C 8: 87,587,676 (GRCm39) T421A probably benign Het
Nat8f1 T C 6: 85,887,295 (GRCm39) T222A probably benign Het
Nsun2 T C 13: 69,691,992 (GRCm39) probably benign Het
Oas2 T A 5: 120,876,599 (GRCm39) D448V probably damaging Het
Or10al7 C A 17: 38,366,467 (GRCm39) V6F probably benign Het
Or2l13b A T 16: 19,349,383 (GRCm39) C96S probably damaging Het
Or5ak22 T C 2: 85,230,772 (GRCm39) Y35C probably damaging Het
Pgm2l1 T A 7: 99,877,204 (GRCm39) L25Q probably damaging Het
Pigp A T 16: 94,166,309 (GRCm39) V133D probably benign Het
Pnkp C T 7: 44,511,827 (GRCm39) S113L probably damaging Het
Pomt2 C T 12: 87,156,881 (GRCm39) D752N possibly damaging Het
Ppat T C 5: 77,074,640 (GRCm39) K65E probably damaging Het
Ptprn2 T C 12: 117,125,314 (GRCm39) L616P probably damaging Het
Rad54l2 A G 9: 106,595,091 (GRCm39) S289P probably damaging Het
Rbm39 G A 2: 156,019,266 (GRCm39) R31C possibly damaging Het
Rhbdf2 C A 11: 116,492,771 (GRCm39) V417L probably benign Het
Rnf157 T A 11: 116,246,298 (GRCm39) E255D possibly damaging Het
Rpl6l A T 10: 110,962,304 (GRCm39) noncoding transcript Het
Sec24c A G 14: 20,743,813 (GRCm39) D1006G probably damaging Het
Sh3bp1 G T 15: 78,792,237 (GRCm39) A401S probably benign Het
Slc17a8 A T 10: 89,412,367 (GRCm39) D539E probably benign Het
Slc38a9 T A 13: 112,826,098 (GRCm39) S136R probably damaging Het
Smoc2 A C 17: 14,589,295 (GRCm39) T255P probably benign Het
Smyd2 T C 1: 189,628,847 (GRCm39) D152G probably damaging Het
Stab1 A G 14: 30,862,350 (GRCm39) V2328A probably damaging Het
Taar2 A G 10: 23,816,591 (GRCm39) I44V probably benign Het
Tbc1d4 T C 14: 101,682,144 (GRCm39) K1251E probably benign Het
Thada G A 17: 84,754,027 (GRCm39) L315F probably damaging Het
Trbv14 T C 6: 41,112,259 (GRCm39) S19P probably benign Het
Ttc39c T C 18: 12,820,173 (GRCm39) probably benign Het
Ttc39d A G 17: 80,524,527 (GRCm39) I395M probably benign Het
Ttn T C 2: 76,548,728 (GRCm39) E31891G probably damaging Het
Ubr3 T C 2: 69,800,527 (GRCm39) V950A probably damaging Het
Usp9y T A Y: 1,307,920 (GRCm39) K2305N probably damaging Het
Vmn1r158 G A 7: 22,490,179 (GRCm39) T10I possibly damaging Het
Vmn2r129 G T 4: 156,686,692 (GRCm39) noncoding transcript Het
Vmn2r78 T A 7: 86,603,916 (GRCm39) I698K possibly damaging Het
Vmn2r86 G T 10: 130,289,460 (GRCm39) T145K probably damaging Het
Zfp51 T C 17: 21,684,933 (GRCm39) V516A probably benign Het
Zfp654 A T 16: 64,606,145 (GRCm39) S686T probably benign Het
Zfp846 T A 9: 20,502,111 (GRCm39) C55S probably benign Het
Other mutations in Acad11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00966:Acad11 APN 9 104,003,855 (GRCm39) missense probably damaging 1.00
IGL01100:Acad11 APN 9 103,953,607 (GRCm39) missense probably damaging 0.98
IGL01920:Acad11 APN 9 103,941,104 (GRCm39) critical splice donor site probably null
IGL02019:Acad11 APN 9 103,992,544 (GRCm39) missense probably damaging 1.00
IGL02506:Acad11 APN 9 103,968,931 (GRCm39) critical splice donor site probably null
IGL02742:Acad11 APN 9 103,972,824 (GRCm39) missense probably damaging 1.00
IGL02830:Acad11 APN 9 103,953,118 (GRCm39) missense probably damaging 1.00
IGL02936:Acad11 APN 9 103,990,711 (GRCm39) missense probably benign 0.31
R0092:Acad11 UTSW 9 103,967,540 (GRCm39) splice site probably benign
R0277:Acad11 UTSW 9 104,001,224 (GRCm39) missense probably damaging 1.00
R0377:Acad11 UTSW 9 103,958,891 (GRCm39) splice site probably benign
R0411:Acad11 UTSW 9 103,993,495 (GRCm39) missense probably damaging 1.00
R0556:Acad11 UTSW 9 103,992,501 (GRCm39) missense probably damaging 1.00
R0594:Acad11 UTSW 9 103,972,762 (GRCm39) missense probably benign 0.09
R0688:Acad11 UTSW 9 104,001,299 (GRCm39) missense probably damaging 1.00
R1416:Acad11 UTSW 9 103,950,822 (GRCm39) missense probably damaging 0.96
R1551:Acad11 UTSW 9 104,003,785 (GRCm39) missense probably damaging 0.99
R1730:Acad11 UTSW 9 103,941,081 (GRCm39) missense probably benign 0.02
R1819:Acad11 UTSW 9 103,991,738 (GRCm39) critical splice donor site probably null
R1884:Acad11 UTSW 9 103,991,684 (GRCm39) missense probably benign 0.13
R2411:Acad11 UTSW 9 103,963,222 (GRCm39) intron probably benign
R3055:Acad11 UTSW 9 103,953,535 (GRCm39) missense probably damaging 0.98
R3683:Acad11 UTSW 9 103,992,543 (GRCm39) missense probably damaging 1.00
R3954:Acad11 UTSW 9 103,963,351 (GRCm39) intron probably benign
R3956:Acad11 UTSW 9 103,963,351 (GRCm39) intron probably benign
R4425:Acad11 UTSW 9 103,950,844 (GRCm39) missense probably damaging 1.00
R4557:Acad11 UTSW 9 103,960,038 (GRCm39) missense probably benign 0.00
R4701:Acad11 UTSW 9 103,972,764 (GRCm39) nonsense probably null
R4764:Acad11 UTSW 9 103,953,076 (GRCm39) missense probably damaging 0.99
R5132:Acad11 UTSW 9 104,003,791 (GRCm39) missense probably benign 0.03
R5161:Acad11 UTSW 9 104,001,227 (GRCm39) missense probably benign 0.19
R5222:Acad11 UTSW 9 103,974,576 (GRCm39) missense probably damaging 1.00
R5587:Acad11 UTSW 9 103,940,966 (GRCm39) missense probably benign
R5683:Acad11 UTSW 9 103,961,482 (GRCm39) missense probably damaging 1.00
R6512:Acad11 UTSW 9 103,972,758 (GRCm39) nonsense probably null
R6815:Acad11 UTSW 9 103,958,526 (GRCm39) missense probably benign 0.01
R7035:Acad11 UTSW 9 103,990,694 (GRCm39) missense probably damaging 1.00
R7318:Acad11 UTSW 9 103,958,466 (GRCm39) missense probably damaging 1.00
R7564:Acad11 UTSW 9 104,000,288 (GRCm39) missense possibly damaging 0.94
R7673:Acad11 UTSW 9 103,941,105 (GRCm39) splice site probably null
R7812:Acad11 UTSW 9 103,972,747 (GRCm39) missense probably benign 0.41
R7850:Acad11 UTSW 9 103,991,728 (GRCm39) missense probably damaging 1.00
R8037:Acad11 UTSW 9 103,953,035 (GRCm39) missense possibly damaging 0.93
R8251:Acad11 UTSW 9 103,968,906 (GRCm39) missense possibly damaging 0.88
R9021:Acad11 UTSW 9 104,003,864 (GRCm39) missense possibly damaging 0.88
R9657:Acad11 UTSW 9 103,953,035 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- TCAGAGTGAGGTTGCAGTGC -3'
(R):5'- TTCTAGACACGCCCATTTTGG -3'

Sequencing Primer
(F):5'- CCACTCAGCTGTTAAAATATGTGCG -3'
(R):5'- GGTTTGGCACCTCAGTTGTAATAAC -3'
Posted On 2016-03-17