Mutagenetix > Incidental Mutation

Incidental Mutation 'R4872:Or10al7'

376699

Institutional Source

Beutler Lab

Gene Symbol

Or10al7

Ensembl Gene

ENSMUSG00000081724

Gene Name

olfactory receptor family 10 subfamily AL member 7

Synonyms

MOR263-9, GA_x6K02T2PSCP-2503741-2502776, Olfr129

MMRRC Submission

042482-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.123) question?

Stock #

R4872 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

38365490-38370675 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 38366467 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Phenylalanine at position 6 (V6F)

Ref Sequence

ENSEMBL: ENSMUSP00000113564 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000122318] [ENSMUST00000174675] [ENSMUST00000216476]

AlphaFold

Q8VEY1

Predicted Effect

probably benign
Transcript: ENSMUST00000122318
AA Change: V6F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000113564
Gene: ENSMUSG00000081724
AA Change: V6F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	46	323	4.6e-56	PFAM
Pfam:7TM_GPCR_Srsx	50	319	1.1e-5	PFAM
Pfam:7tm_1	56	305	3.2e-21	PFAM

Predicted Effect

SMART Domains

Protein: ENSMUSP00000133865
Gene: ENSMUSG00000060017

Domain	Start	End	E-Value	Type
transmembrane domain	33	55	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000216476

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.1%

Validation Efficiency

98% (81/83)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcd2	C	A	15: 91,075,514 (GRCm39)	V100L	probably benign	Het
Acad11	G	A	9: 103,963,465 (GRCm39)		probably benign	Het
Actb	C	T	5: 142,891,307 (GRCm39)		probably benign	Het
Ano9	G	A	7: 140,687,117 (GRCm39)	A374V	probably damaging	Het
Baz2b	T	C	2: 59,773,103 (GRCm39)		probably null	Het
Bltp3a	G	T	17: 28,109,110 (GRCm39)	D1110Y	probably benign	Het
Bpifb9b	T	A	2: 154,155,551 (GRCm39)	L350Q	probably damaging	Het
Cd27	T	A	6: 125,211,281 (GRCm39)		probably null	Het
Cd72	A	G	4: 43,449,563 (GRCm39)		probably benign	Het
Cdadc1	A	T	14: 59,801,973 (GRCm39)	S516T	probably benign	Het
Chst5	T	A	8: 112,617,192 (GRCm39)	I143F	possibly damaging	Het
Col20a1	T	C	2: 180,639,156 (GRCm39)	V452A	possibly damaging	Het
Cox11	C	A	11: 90,535,229 (GRCm39)	Q227K	probably benign	Het
Cpa6	A	G	1: 10,665,843 (GRCm39)		probably null	Het
Dnase1l1	C	T	X: 73,320,644 (GRCm39)		probably null	Het
Dpm2	T	C	2: 32,461,203 (GRCm39)		probably benign	Het
Dync1h1	C	A	12: 110,624,560 (GRCm39)	T3700N	probably damaging	Het
Frem1	A	C	4: 82,881,387 (GRCm39)	N1273K	probably damaging	Het
Fry	T	C	5: 150,317,704 (GRCm39)		probably null	Het
Gm10306	G	T	4: 94,445,069 (GRCm39)		probably benign	Het
Gm5565	T	C	5: 146,094,913 (GRCm39)	T278A	probably benign	Het
Gm8180	A	G	14: 44,019,802 (GRCm39)	I40T	probably benign	Het
Iah1	T	C	12: 21,367,426 (GRCm39)	V44A	probably benign	Het
Iqgap3	C	T	3: 88,020,435 (GRCm39)	P360S	probably damaging	Het
Klhl28	T	A	12: 65,003,896 (GRCm39)	I206F	possibly damaging	Het
Krt13	A	G	11: 100,012,332 (GRCm39)		probably benign	Het
Lipo2	T	A	19: 33,726,914 (GRCm39)	D41V	probably benign	Het
Lrig2	C	G	3: 104,398,842 (GRCm39)	V229L	possibly damaging	Het
Lrrc32	C	T	7: 98,147,727 (GRCm39)	T169I	probably damaging	Het
Lrriq1	T	C	10: 103,014,649 (GRCm39)	N1053S	possibly damaging	Het
Mfng	C	T	15: 78,648,588 (GRCm39)	R163H	probably benign	Het
Mgat4c	G	C	10: 102,224,599 (GRCm39)	R271P	probably damaging	Het
Mylk	A	G	16: 34,735,360 (GRCm39)	N780S	possibly damaging	Het
N4bp1	T	C	8: 87,587,676 (GRCm39)	T421A	probably benign	Het
Nat8f1	T	C	6: 85,887,295 (GRCm39)	T222A	probably benign	Het
Nsun2	T	C	13: 69,691,992 (GRCm39)		probably benign	Het
Oas2	T	A	5: 120,876,599 (GRCm39)	D448V	probably damaging	Het
Or2l13b	A	T	16: 19,349,383 (GRCm39)	C96S	probably damaging	Het
Or5ak22	T	C	2: 85,230,772 (GRCm39)	Y35C	probably damaging	Het
Pgm2l1	T	A	7: 99,877,204 (GRCm39)	L25Q	probably damaging	Het
Pigp	A	T	16: 94,166,309 (GRCm39)	V133D	probably benign	Het
Pnkp	C	T	7: 44,511,827 (GRCm39)	S113L	probably damaging	Het
Pomt2	C	T	12: 87,156,881 (GRCm39)	D752N	possibly damaging	Het
Ppat	T	C	5: 77,074,640 (GRCm39)	K65E	probably damaging	Het
Ptprn2	T	C	12: 117,125,314 (GRCm39)	L616P	probably damaging	Het
Rad54l2	A	G	9: 106,595,091 (GRCm39)	S289P	probably damaging	Het
Rbm39	G	A	2: 156,019,266 (GRCm39)	R31C	possibly damaging	Het
Rhbdf2	C	A	11: 116,492,771 (GRCm39)	V417L	probably benign	Het
Rnf157	T	A	11: 116,246,298 (GRCm39)	E255D	possibly damaging	Het
Rpl6l	A	T	10: 110,962,304 (GRCm39)		noncoding transcript	Het
Sec24c	A	G	14: 20,743,813 (GRCm39)	D1006G	probably damaging	Het
Sh3bp1	G	T	15: 78,792,237 (GRCm39)	A401S	probably benign	Het
Slc17a8	A	T	10: 89,412,367 (GRCm39)	D539E	probably benign	Het
Slc38a9	T	A	13: 112,826,098 (GRCm39)	S136R	probably damaging	Het
Smoc2	A	C	17: 14,589,295 (GRCm39)	T255P	probably benign	Het
Smyd2	T	C	1: 189,628,847 (GRCm39)	D152G	probably damaging	Het
Stab1	A	G	14: 30,862,350 (GRCm39)	V2328A	probably damaging	Het
Taar2	A	G	10: 23,816,591 (GRCm39)	I44V	probably benign	Het
Tbc1d4	T	C	14: 101,682,144 (GRCm39)	K1251E	probably benign	Het
Thada	G	A	17: 84,754,027 (GRCm39)	L315F	probably damaging	Het
Trbv14	T	C	6: 41,112,259 (GRCm39)	S19P	probably benign	Het
Ttc39c	T	C	18: 12,820,173 (GRCm39)		probably benign	Het
Ttc39d	A	G	17: 80,524,527 (GRCm39)	I395M	probably benign	Het
Ttn	T	C	2: 76,548,728 (GRCm39)	E31891G	probably damaging	Het
Ubr3	T	C	2: 69,800,527 (GRCm39)	V950A	probably damaging	Het
Usp9y	T	A	Y: 1,307,920 (GRCm39)	K2305N	probably damaging	Het
Vmn1r158	G	A	7: 22,490,179 (GRCm39)	T10I	possibly damaging	Het
Vmn2r129	G	T	4: 156,686,692 (GRCm39)		noncoding transcript	Het
Vmn2r78	T	A	7: 86,603,916 (GRCm39)	I698K	possibly damaging	Het
Vmn2r86	G	T	10: 130,289,460 (GRCm39)	T145K	probably damaging	Het
Zfp51	T	C	17: 21,684,933 (GRCm39)	V516A	probably benign	Het
Zfp654	A	T	16: 64,606,145 (GRCm39)	S686T	probably benign	Het
Zfp846	T	A	9: 20,502,111 (GRCm39)	C55S	probably benign	Het

Other mutations in Or10al7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02140:Or10al7	APN	17	38,366,481 (GRCm39)	start codon destroyed	probably null	0.15
IGL02163:Or10al7	APN	17	38,365,641 (GRCm39)	missense	probably benign	0.06
IGL02374:Or10al7	APN	17	38,366,412 (GRCm39)	missense	probably damaging	1.00
R0840:Or10al7	UTSW	17	38,366,463 (GRCm39)	missense	probably benign	0.00
R1774:Or10al7	UTSW	17	38,366,328 (GRCm39)	missense	probably benign	0.00
R3720:Or10al7	UTSW	17	38,366,259 (GRCm39)	missense	probably damaging	1.00
R3794:Or10al7	UTSW	17	38,365,786 (GRCm39)	missense	probably damaging	1.00
R3840:Or10al7	UTSW	17	38,366,239 (GRCm39)	missense	probably damaging	1.00
R4002:Or10al7	UTSW	17	38,365,879 (GRCm39)	missense	probably damaging	1.00
R4273:Or10al7	UTSW	17	38,366,163 (GRCm39)	missense	probably damaging	1.00
R5606:Or10al7	UTSW	17	38,365,693 (GRCm39)	missense	probably damaging	0.98
R6309:Or10al7	UTSW	17	38,366,043 (GRCm39)	missense	probably damaging	1.00
R7269:Or10al7	UTSW	17	38,366,442 (GRCm39)	missense	probably damaging	1.00
R7450:Or10al7	UTSW	17	38,366,000 (GRCm39)	missense	probably benign	0.00
R7829:Or10al7	UTSW	17	38,366,220 (GRCm39)	missense	possibly damaging	0.64
R8103:Or10al7	UTSW	17	38,365,903 (GRCm39)	missense	probably damaging	1.00
R8994:Or10al7	UTSW	17	38,366,220 (GRCm39)	missense	possibly damaging	0.64
R9388:Or10al7	UTSW	17	38,366,148 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CAAGGGTTATGAGTGCATTTCCTG -3'
(R):5'- CCAGGACTGCAAGTTTCCAC -3'

Sequencing Primer
(F):5'- AGTGCATTTCCTGTCAGTGATAC -3'
(R):5'- GGTCAGTACACTTTGGAAAATCCC -3'

Posted On

2016-03-17