Incidental Mutation 'R4873:Vmn2r87'
ID 376830
Institutional Source Beutler Lab
Gene Symbol Vmn2r87
Ensembl Gene ENSMUSG00000091511
Gene Name vomeronasal 2, receptor 87
Synonyms EG625131
MMRRC Submission 042483-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R4873 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 130307690-130333248 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 130308367 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 624 (I624V)
Ref Sequence ENSEMBL: ENSMUSP00000129215 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164227]
AlphaFold E9PZX4
Predicted Effect probably damaging
Transcript: ENSMUST00000164227
AA Change: I624V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000129215
Gene: ENSMUSG00000091511
AA Change: I624V

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 77 422 1.8e-27 PFAM
Pfam:NCD3G 508 562 1.8e-19 PFAM
Pfam:7tm_3 595 829 8.8e-55 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218030
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.9%
Validation Efficiency 98% (40/41)
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ak1 A T 2: 32,521,189 (GRCm39) E119D probably benign Het
Alox5 A T 6: 116,390,811 (GRCm39) probably null Het
Atad5 T C 11: 80,011,515 (GRCm39) V1294A probably damaging Het
BB019430 A G 10: 58,539,865 (GRCm39) noncoding transcript Het
Bbs9 T C 9: 22,490,011 (GRCm39) F261L probably benign Het
Catsperb A T 12: 101,554,244 (GRCm39) N646I possibly damaging Het
Ccdc112 A G 18: 46,429,356 (GRCm39) I114T probably damaging Het
Cecr2 T C 6: 120,727,877 (GRCm39) L340P probably damaging Het
Ces2e T A 8: 105,653,817 (GRCm39) V85E probably damaging Het
Cnpy2 C A 10: 128,161,964 (GRCm39) T79K probably damaging Het
Cntn4 G A 6: 106,414,874 (GRCm39) R135H possibly damaging Het
Cyp3a16 C A 5: 145,389,659 (GRCm39) M235I probably benign Het
Dll3 A G 7: 27,995,860 (GRCm39) C314R probably damaging Het
Dnah7c A G 1: 46,728,085 (GRCm39) N2928D probably benign Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dqx1 C A 6: 83,037,993 (GRCm39) D460E probably benign Het
Dync1h1 C A 12: 110,624,560 (GRCm39) T3700N probably damaging Het
Ehbp1 A G 11: 22,051,164 (GRCm39) C438R probably damaging Het
Ehd3 T G 17: 74,112,299 (GRCm39) V21G probably damaging Het
Ero1b G A 13: 12,619,325 (GRCm39) V440I probably damaging Het
Fpgt G A 3: 154,793,550 (GRCm39) A159V probably damaging Het
Gcn1 T C 5: 115,714,229 (GRCm39) L123P possibly damaging Het
Gm14496 A T 2: 181,639,226 (GRCm39) R439W probably damaging Het
Gm4353 G C 7: 115,683,648 (GRCm39) P49R probably damaging Het
Gsdmc2 C T 15: 63,700,101 (GRCm39) A224T probably benign Het
Hnf1a T C 5: 115,108,732 (GRCm39) T58A probably benign Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Kcns1 T C 2: 164,010,021 (GRCm39) Y246C probably damaging Het
Kif26b A G 1: 178,742,892 (GRCm39) E549G probably benign Het
Krt9 T C 11: 100,080,863 (GRCm39) I330V probably benign Het
Lair1 A T 7: 4,032,033 (GRCm39) S25T probably benign Het
Lhx4 T C 1: 155,581,013 (GRCm39) T171A possibly damaging Het
Luzp2 A G 7: 54,816,996 (GRCm39) I149V possibly damaging Het
Mcoln1 T A 8: 3,557,422 (GRCm39) S143T probably benign Het
Mcph1 A G 8: 18,675,574 (GRCm39) probably null Het
Mgat5 G A 1: 127,396,986 (GRCm39) V578M probably damaging Het
Mis18bp1 G A 12: 65,208,209 (GRCm39) T168M probably benign Het
Mroh2a G T 1: 88,182,657 (GRCm39) R1195L possibly damaging Het
Myom1 T C 17: 71,379,114 (GRCm39) V626A probably damaging Het
Naa80 C T 9: 107,460,818 (GRCm39) R238C probably damaging Het
Ncam1 T C 9: 49,418,921 (GRCm39) probably benign Het
Nlrp2 A T 7: 5,301,858 (GRCm39) F211L probably benign Het
Or10a49 A T 7: 108,467,993 (GRCm39) F123I probably damaging Het
Or10q12 T A 19: 13,746,126 (GRCm39) M140K probably damaging Het
Or2ad1 T A 13: 21,326,450 (GRCm39) Y259F probably damaging Het
Osbpl11 G A 16: 33,054,863 (GRCm39) V649I probably benign Het
Oscar A T 7: 3,619,016 (GRCm39) probably null Het
Pax8 T A 2: 24,331,652 (GRCm39) M144L probably benign Het
Pcnt T C 10: 76,205,688 (GRCm39) T2555A probably benign Het
Plat T A 8: 23,258,466 (GRCm39) I23K probably benign Het
Plpp2 G A 10: 79,366,763 (GRCm39) T51M probably damaging Het
Pnkp C T 7: 44,511,827 (GRCm39) S113L probably damaging Het
Prl7c1 T C 13: 27,957,742 (GRCm39) M233V probably benign Het
Prox1 A C 1: 189,894,319 (GRCm39) F42C probably damaging Het
Pwwp2b A T 7: 138,835,978 (GRCm39) Q473L possibly damaging Het
Rims4 A T 2: 163,707,443 (GRCm39) N127K probably null Het
Scn1a T C 2: 66,158,820 (GRCm39) T367A possibly damaging Het
Slc23a2 A G 2: 131,898,800 (GRCm39) I579T possibly damaging Het
Sp9 T C 2: 73,103,962 (GRCm39) V172A possibly damaging Het
Spta1 T A 1: 174,003,396 (GRCm39) L109Q probably damaging Het
Synj2 A T 17: 6,038,343 (GRCm39) probably benign Het
Tcstv2c T C 13: 120,616,206 (GRCm39) V15A probably damaging Het
Tnrc18 A T 5: 142,750,932 (GRCm39) M1216K unknown Het
Tpst2 T A 5: 112,457,687 (GRCm39) Y69* probably null Het
Tpx2 C A 2: 152,735,535 (GRCm39) A721E probably benign Het
Trmt1l A G 1: 151,330,755 (GRCm39) T591A probably benign Het
Tubgcp4 T A 2: 121,015,330 (GRCm39) probably benign Het
Ubiad1 T C 4: 148,528,556 (GRCm39) T118A possibly damaging Het
Unc13c T C 9: 73,424,566 (GRCm39) T2017A probably damaging Het
Vmn1r59 G T 7: 5,457,108 (GRCm39) N217K probably benign Het
Wdr4 A G 17: 31,718,129 (GRCm39) V315A probably benign Het
Xpo7 T C 14: 70,914,256 (GRCm39) probably null Het
Zfp827 T A 8: 79,787,403 (GRCm39) W190R probably damaging Het
Zfp971 A G 2: 177,674,940 (GRCm39) T180A probably benign Het
Zfp980 G A 4: 145,428,653 (GRCm39) G461S probably benign Het
Other mutations in Vmn2r87
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01090:Vmn2r87 APN 10 130,333,247 (GRCm39) start codon destroyed probably null 1.00
IGL01295:Vmn2r87 APN 10 130,307,878 (GRCm39) missense probably damaging 1.00
IGL01411:Vmn2r87 APN 10 130,308,429 (GRCm39) missense probably benign 0.03
IGL01680:Vmn2r87 APN 10 130,315,586 (GRCm39) nonsense probably null
IGL01822:Vmn2r87 APN 10 130,307,991 (GRCm39) missense probably damaging 1.00
IGL01835:Vmn2r87 APN 10 130,314,978 (GRCm39) missense probably damaging 1.00
IGL01965:Vmn2r87 APN 10 130,314,924 (GRCm39) missense possibly damaging 0.49
IGL02562:Vmn2r87 APN 10 130,314,513 (GRCm39) missense probably damaging 1.00
IGL02665:Vmn2r87 APN 10 130,333,049 (GRCm39) missense probably benign 0.16
IGL03202:Vmn2r87 APN 10 130,333,091 (GRCm39) missense probably benign
FR4304:Vmn2r87 UTSW 10 130,314,583 (GRCm39) missense probably benign 0.01
FR4340:Vmn2r87 UTSW 10 130,314,583 (GRCm39) missense probably benign 0.01
FR4342:Vmn2r87 UTSW 10 130,314,583 (GRCm39) missense probably benign 0.01
FR4589:Vmn2r87 UTSW 10 130,314,583 (GRCm39) missense probably benign 0.01
LCD18:Vmn2r87 UTSW 10 130,314,583 (GRCm39) missense probably benign 0.01
R0344:Vmn2r87 UTSW 10 130,315,806 (GRCm39) missense probably damaging 1.00
R0374:Vmn2r87 UTSW 10 130,307,848 (GRCm39) missense probably damaging 1.00
R0384:Vmn2r87 UTSW 10 130,307,712 (GRCm39) missense probably benign
R1144:Vmn2r87 UTSW 10 130,312,098 (GRCm39) splice site probably benign
R1172:Vmn2r87 UTSW 10 130,313,453 (GRCm39) missense probably benign 0.03
R1860:Vmn2r87 UTSW 10 130,315,755 (GRCm39) missense probably benign 0.00
R1866:Vmn2r87 UTSW 10 130,308,441 (GRCm39) missense possibly damaging 0.88
R1897:Vmn2r87 UTSW 10 130,307,829 (GRCm39) missense probably damaging 1.00
R2360:Vmn2r87 UTSW 10 130,315,631 (GRCm39) missense probably damaging 0.99
R2909:Vmn2r87 UTSW 10 130,314,865 (GRCm39) missense probably damaging 0.99
R3874:Vmn2r87 UTSW 10 130,315,856 (GRCm39) missense possibly damaging 0.62
R4113:Vmn2r87 UTSW 10 130,315,691 (GRCm39) missense probably benign
R4190:Vmn2r87 UTSW 10 130,308,556 (GRCm39) missense probably damaging 1.00
R4197:Vmn2r87 UTSW 10 130,315,779 (GRCm39) missense possibly damaging 0.55
R4201:Vmn2r87 UTSW 10 130,308,448 (GRCm39) missense probably benign 0.03
R4202:Vmn2r87 UTSW 10 130,308,448 (GRCm39) missense probably benign 0.03
R4368:Vmn2r87 UTSW 10 130,315,676 (GRCm39) missense probably benign 0.44
R4485:Vmn2r87 UTSW 10 130,315,678 (GRCm39) nonsense probably null
R4537:Vmn2r87 UTSW 10 130,308,054 (GRCm39) missense probably benign 0.12
R4590:Vmn2r87 UTSW 10 130,315,014 (GRCm39) missense possibly damaging 0.69
R4752:Vmn2r87 UTSW 10 130,314,336 (GRCm39) nonsense probably null
R4875:Vmn2r87 UTSW 10 130,308,367 (GRCm39) missense probably damaging 1.00
R4923:Vmn2r87 UTSW 10 130,314,435 (GRCm39) missense probably damaging 0.99
R4970:Vmn2r87 UTSW 10 130,314,422 (GRCm39) missense probably damaging 1.00
R5049:Vmn2r87 UTSW 10 130,308,298 (GRCm39) missense probably damaging 0.96
R5112:Vmn2r87 UTSW 10 130,314,422 (GRCm39) missense probably damaging 1.00
R5187:Vmn2r87 UTSW 10 130,333,208 (GRCm39) missense probably null 0.99
R5618:Vmn2r87 UTSW 10 130,315,817 (GRCm39) missense probably damaging 1.00
R6057:Vmn2r87 UTSW 10 130,308,226 (GRCm39) missense probably benign 0.02
R6220:Vmn2r87 UTSW 10 130,315,807 (GRCm39) missense probably benign 0.01
R6287:Vmn2r87 UTSW 10 130,314,291 (GRCm39) critical splice donor site probably null
R6383:Vmn2r87 UTSW 10 130,314,869 (GRCm39) missense probably damaging 1.00
R6576:Vmn2r87 UTSW 10 130,314,654 (GRCm39) missense probably benign 0.05
R6742:Vmn2r87 UTSW 10 130,308,396 (GRCm39) missense probably damaging 1.00
R7086:Vmn2r87 UTSW 10 130,333,178 (GRCm39) missense probably benign 0.00
R7162:Vmn2r87 UTSW 10 130,313,416 (GRCm39) missense probably benign 0.08
R7419:Vmn2r87 UTSW 10 130,307,992 (GRCm39) missense probably damaging 1.00
R7425:Vmn2r87 UTSW 10 130,314,761 (GRCm39) missense probably damaging 1.00
R7443:Vmn2r87 UTSW 10 130,308,588 (GRCm39) missense probably damaging 1.00
R7571:Vmn2r87 UTSW 10 130,314,940 (GRCm39) missense probably damaging 0.99
R7663:Vmn2r87 UTSW 10 130,308,054 (GRCm39) missense probably damaging 0.97
R7716:Vmn2r87 UTSW 10 130,308,018 (GRCm39) missense probably benign 0.09
R7793:Vmn2r87 UTSW 10 130,313,413 (GRCm39) missense probably benign 0.05
R7806:Vmn2r87 UTSW 10 130,315,679 (GRCm39) missense probably benign
R7841:Vmn2r87 UTSW 10 130,333,095 (GRCm39) missense probably benign 0.31
R8326:Vmn2r87 UTSW 10 130,308,180 (GRCm39) missense possibly damaging 0.67
R8411:Vmn2r87 UTSW 10 130,308,126 (GRCm39) missense probably damaging 0.99
R8445:Vmn2r87 UTSW 10 130,313,335 (GRCm39) missense probably damaging 1.00
R8540:Vmn2r87 UTSW 10 130,314,762 (GRCm39) missense possibly damaging 0.74
R8892:Vmn2r87 UTSW 10 130,308,105 (GRCm39) missense probably damaging 0.99
R9093:Vmn2r87 UTSW 10 130,308,165 (GRCm39) missense probably benign 0.08
R9623:Vmn2r87 UTSW 10 130,315,794 (GRCm39) missense probably damaging 1.00
R9667:Vmn2r87 UTSW 10 130,314,776 (GRCm39) missense probably damaging 1.00
R9797:Vmn2r87 UTSW 10 130,312,064 (GRCm39) missense probably benign 0.44
R9797:Vmn2r87 UTSW 10 130,308,138 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r87 UTSW 10 130,308,183 (GRCm39) missense probably damaging 0.98
Z1176:Vmn2r87 UTSW 10 130,307,713 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- ATGACCAACTTAGGTGCCCC -3'
(R):5'- TTAGAGCAATCCCACTGCC -3'

Sequencing Primer
(F):5'- CATCCTTTTTCCTGGAGTAGTGAGC -3'
(R):5'- TGCCTCCAAAGAACTGTGTC -3'
Posted On 2016-03-17