Incidental Mutation 'R4894:Zfp442'
ID 377473
Institutional Source Beutler Lab
Gene Symbol Zfp442
Ensembl Gene ENSMUSG00000068130
Gene Name zinc finger protein 442
Synonyms OTTMUSG00000015730
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R4894 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 150249061-150293406 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 150253130 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140098 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109916] [ENSMUST00000185796]
AlphaFold A2AQA0
Predicted Effect probably null
Transcript: ENSMUST00000109916
SMART Domains Protein: ENSMUSP00000105542
Gene: ENSMUSG00000068130

DomainStartEndE-ValueType
KRAB 4 66 3.27e-19 SMART
ZnF_C2H2 159 181 8.34e-3 SMART
ZnF_C2H2 211 233 9.58e-3 SMART
ZnF_C2H2 239 261 2.43e-4 SMART
ZnF_C2H2 267 289 1.38e-3 SMART
ZnF_C2H2 295 317 4.17e-3 SMART
ZnF_C2H2 323 345 3.16e-3 SMART
ZnF_C2H2 351 373 1.58e-3 SMART
ZnF_C2H2 379 401 9.58e-3 SMART
ZnF_C2H2 407 429 2.09e-3 SMART
ZnF_C2H2 435 457 2.2e-2 SMART
ZnF_C2H2 463 485 1.6e-4 SMART
ZnF_C2H2 491 513 1.82e-3 SMART
ZnF_C2H2 519 541 4.47e-3 SMART
ZnF_C2H2 547 569 3.63e-3 SMART
ZnF_C2H2 575 597 4.79e-3 SMART
ZnF_C2H2 603 625 8.47e-4 SMART
ZnF_C2H2 631 654 3.11e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000185796
SMART Domains Protein: ENSMUSP00000140098
Gene: ENSMUSG00000068130

DomainStartEndE-ValueType
KRAB 3 65 1.4e-21 SMART
ZnF_C2H2 158 180 3.4e-5 SMART
ZnF_C2H2 210 232 3.9e-5 SMART
ZnF_C2H2 238 260 1e-6 SMART
ZnF_C2H2 266 288 5.6e-6 SMART
ZnF_C2H2 294 316 1.8e-5 SMART
ZnF_C2H2 322 344 1.3e-5 SMART
ZnF_C2H2 350 372 6.7e-6 SMART
ZnF_C2H2 378 400 9.6e-5 SMART
ZnF_C2H2 406 428 6.9e-7 SMART
ZnF_C2H2 434 456 7.7e-6 SMART
ZnF_C2H2 462 484 1.9e-5 SMART
ZnF_C2H2 490 512 1.5e-5 SMART
ZnF_C2H2 518 540 2e-5 SMART
ZnF_C2H2 546 568 3.5e-6 SMART
ZnF_C2H2 574 597 1.3e-4 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf1 C A 17: 43,609,975 (GRCm39) Y176* probably null Het
Akap13 T A 7: 75,375,068 (GRCm39) M1900K possibly damaging Het
Ankrd36 A G 11: 5,585,332 (GRCm39) E381G probably damaging Het
Ap3s1 T C 18: 46,891,183 (GRCm39) probably null Het
Cacna1e G T 1: 154,364,551 (GRCm39) S341* probably null Het
Camk1d G A 2: 5,359,539 (GRCm39) S161L probably damaging Het
Cdh23 G T 10: 60,173,630 (GRCm39) H1619Q probably benign Het
Chd7 T A 4: 8,838,629 (GRCm39) I1276N probably damaging Het
Clca3a1 A G 3: 144,719,662 (GRCm39) V436A probably damaging Het
Ctcfl G A 2: 172,959,196 (GRCm39) P177S probably benign Het
Dab2ip A G 2: 35,620,539 (GRCm39) probably benign Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Epc1 A T 18: 6,449,011 (GRCm39) S495R probably benign Het
Espl1 A G 15: 102,230,758 (GRCm39) probably null Het
Eya4 T C 10: 22,985,753 (GRCm39) E583G possibly damaging Het
Fam111a C G 19: 12,565,913 (GRCm39) T554R probably benign Het
Fbh1 A T 2: 11,767,771 (GRCm39) I359N probably damaging Het
Fer1l6 T C 15: 58,490,751 (GRCm39) C1023R probably damaging Het
Helz2 G C 2: 180,877,940 (GRCm39) P953A probably benign Het
Ifi204 G T 1: 173,587,808 (GRCm39) S117Y probably damaging Het
Ift70a1 T C 2: 75,810,088 (GRCm39) *665W probably null Het
Igfn1 G A 1: 135,882,520 (GRCm39) T2775M probably damaging Het
Igsf9 A G 1: 172,325,634 (GRCm39) T1101A probably benign Het
Ipo13 A C 4: 117,760,638 (GRCm39) I614S probably damaging Het
Ipo13 A G 4: 117,761,687 (GRCm39) I476T possibly damaging Het
Kdm2b C A 5: 123,079,030 (GRCm39) E308* probably null Het
Klhl20 A T 1: 160,937,102 (GRCm39) M91K possibly damaging Het
Klrb1f T C 6: 129,030,151 (GRCm39) F64L probably benign Het
Ldlrad3 C T 2: 101,888,293 (GRCm39) C106Y probably damaging Het
Lilra6 T C 7: 3,915,530 (GRCm39) T161A probably benign Het
Lrriq1 A T 10: 102,997,613 (GRCm39) M1334K possibly damaging Het
Mepe C G 5: 104,473,268 (GRCm39) P3R probably damaging Het
Mgat4e A G 1: 134,468,856 (GRCm39) V396A probably benign Het
Nfx1 T G 4: 40,996,877 (GRCm39) S651A probably damaging Het
Or10ak13 A T 4: 118,639,483 (GRCm39) C100S probably damaging Het
Or2w6 T C 13: 21,843,352 (GRCm39) N47S probably damaging Het
Or4c109 T C 2: 88,817,783 (GRCm39) I254M possibly damaging Het
Rag2 T C 2: 101,460,022 (GRCm39) S111P probably damaging Het
Rai1 T A 11: 60,077,572 (GRCm39) D545E probably damaging Het
Ralgps1 A G 2: 33,033,115 (GRCm39) V498A possibly damaging Het
Rasal2 G A 1: 157,020,374 (GRCm39) S205L probably damaging Het
Rec8 T C 14: 55,862,787 (GRCm39) L582P probably damaging Het
Retn G A 8: 3,707,358 (GRCm39) R106H probably damaging Het
Rnf112 A G 11: 61,343,488 (GRCm39) L116P probably damaging Het
Rnf213 T C 11: 119,372,066 (GRCm39) Y4885H probably damaging Het
Sacm1l A G 9: 123,411,409 (GRCm39) I399M probably benign Het
Sez6 G T 11: 77,866,086 (GRCm39) G738V probably damaging Het
Spata17 A G 1: 186,872,643 (GRCm39) V56A probably benign Het
Spata31d1a A T 13: 59,849,542 (GRCm39) V862D probably damaging Het
Sptb A G 12: 76,671,768 (GRCm39) probably null Het
Srpk2 C A 5: 23,750,527 (GRCm39) G59W probably damaging Het
Tyro3 T C 2: 119,632,779 (GRCm39) S96P probably damaging Het
Ube2v1 A G 2: 167,452,280 (GRCm39) S108P probably damaging Het
Usp2 C T 9: 43,987,125 (GRCm39) S141L probably benign Het
Vamp5 T C 6: 72,347,181 (GRCm39) D46G possibly damaging Het
Vmn1r23 T A 6: 57,903,310 (GRCm39) Q156L probably benign Het
Vmn2r6 C T 3: 64,454,829 (GRCm39) S490N probably benign Het
Vps39 A T 2: 120,183,440 (GRCm39) I10N probably damaging Het
Vwf C T 6: 125,622,897 (GRCm39) Q1755* probably null Het
Wdfy4 A T 14: 32,877,717 (GRCm39) H82Q probably benign Het
Wdr24 T C 17: 26,045,101 (GRCm39) Y279H probably damaging Het
Wdr72 A G 9: 74,117,843 (GRCm39) T852A probably benign Het
Zfp1 T A 8: 112,396,355 (GRCm39) C92* probably null Het
Zfp1004 T A 2: 150,033,899 (GRCm39) C104* probably null Het
Zfp426 A T 9: 20,386,369 (GRCm39) probably benign Het
Zfp74 T C 7: 29,635,470 (GRCm39) probably benign Het
Other mutations in Zfp442
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01081:Zfp442 APN 2 150,251,267 (GRCm39) nonsense probably null
IGL02566:Zfp442 APN 2 150,251,711 (GRCm39) critical splice acceptor site probably null
IGL03217:Zfp442 APN 2 150,251,714 (GRCm39) splice site probably benign
LCD18:Zfp442 UTSW 2 150,261,768 (GRCm39) intron probably benign
PIT4812001:Zfp442 UTSW 2 150,251,661 (GRCm39) nonsense probably null
R0219:Zfp442 UTSW 2 150,253,160 (GRCm39) missense probably damaging 0.99
R0521:Zfp442 UTSW 2 150,253,169 (GRCm39) missense possibly damaging 0.92
R1633:Zfp442 UTSW 2 150,250,260 (GRCm39) nonsense probably null
R1702:Zfp442 UTSW 2 150,251,100 (GRCm39) nonsense probably null
R1829:Zfp442 UTSW 2 150,250,983 (GRCm39) missense probably damaging 0.99
R1868:Zfp442 UTSW 2 150,250,100 (GRCm39) missense probably damaging 1.00
R1898:Zfp442 UTSW 2 150,250,582 (GRCm39) missense probably damaging 1.00
R2030:Zfp442 UTSW 2 150,250,042 (GRCm39) missense possibly damaging 0.58
R4676:Zfp442 UTSW 2 150,251,526 (GRCm39) missense probably damaging 1.00
R4717:Zfp442 UTSW 2 150,250,149 (GRCm39) missense probably damaging 1.00
R4932:Zfp442 UTSW 2 150,251,635 (GRCm39) missense possibly damaging 0.53
R4963:Zfp442 UTSW 2 150,250,415 (GRCm39) missense probably damaging 1.00
R5130:Zfp442 UTSW 2 150,251,530 (GRCm39) missense possibly damaging 0.91
R5476:Zfp442 UTSW 2 150,250,079 (GRCm39) missense probably damaging 1.00
R5986:Zfp442 UTSW 2 150,249,944 (GRCm39) nonsense probably null
R6042:Zfp442 UTSW 2 150,250,016 (GRCm39) missense probably damaging 0.97
R6383:Zfp442 UTSW 2 150,293,321 (GRCm39) critical splice donor site probably null
R6452:Zfp442 UTSW 2 150,250,028 (GRCm39) missense probably damaging 1.00
R6787:Zfp442 UTSW 2 150,251,499 (GRCm39) missense possibly damaging 0.72
R6931:Zfp442 UTSW 2 150,252,860 (GRCm39) critical splice donor site probably null
R7061:Zfp442 UTSW 2 150,249,937 (GRCm39) missense probably benign 0.33
R7184:Zfp442 UTSW 2 150,250,056 (GRCm39) missense possibly damaging 0.71
R7214:Zfp442 UTSW 2 150,251,201 (GRCm39) missense probably benign 0.04
R7225:Zfp442 UTSW 2 150,250,925 (GRCm39) missense probably benign 0.00
R7513:Zfp442 UTSW 2 150,250,676 (GRCm39) missense unknown
R7591:Zfp442 UTSW 2 150,250,092 (GRCm39) nonsense probably null
R7679:Zfp442 UTSW 2 150,252,917 (GRCm39) nonsense probably null
R7768:Zfp442 UTSW 2 150,250,241 (GRCm39) missense possibly damaging 0.53
R7801:Zfp442 UTSW 2 150,251,639 (GRCm39) missense probably benign 0.28
R7814:Zfp442 UTSW 2 150,251,402 (GRCm39) missense possibly damaging 0.92
R7848:Zfp442 UTSW 2 150,253,146 (GRCm39) missense possibly damaging 0.71
R8158:Zfp442 UTSW 2 150,251,096 (GRCm39) missense possibly damaging 0.83
R8192:Zfp442 UTSW 2 150,250,629 (GRCm39) missense unknown
R8528:Zfp442 UTSW 2 150,250,962 (GRCm39) missense probably damaging 1.00
R9110:Zfp442 UTSW 2 150,250,093 (GRCm39) missense probably benign 0.30
R9269:Zfp442 UTSW 2 150,251,287 (GRCm39) missense probably benign 0.19
R9371:Zfp442 UTSW 2 150,250,676 (GRCm39) missense unknown
R9401:Zfp442 UTSW 2 150,251,615 (GRCm39) missense possibly damaging 0.53
R9459:Zfp442 UTSW 2 150,250,668 (GRCm39) missense unknown
R9711:Zfp442 UTSW 2 150,250,207 (GRCm39) missense possibly damaging 0.93
Z1177:Zfp442 UTSW 2 150,250,399 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AGGCATTGGTGTACATGGTT -3'
(R):5'- GTGTTGTCCGTATTACGCTTTC -3'

Sequencing Primer
(F):5'- ATCAGTTTCCACATGCAGATTACC -3'
(R):5'- CGTATTACGCTTTCTCATGTACAC -3'
Posted On 2016-03-17