Incidental Mutation 'R4896:Abcb4'
| ID |
377622 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Abcb4
|
| Ensembl Gene |
ENSMUSG00000042476 |
| Gene Name |
ATP-binding cassette, sub-family B member 4 |
| Synonyms |
mdr-2, Mdr2, Pgy2, Pgy-2 |
| MMRRC Submission |
042500-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4896 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
8943717-9009231 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 8957267 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 132
(V132A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142425
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000003717]
[ENSMUST00000196067]
|
| AlphaFold |
P21440 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000003717
AA Change: V132A
PolyPhen 2
Score 0.701 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000003717
Gene: ENSMUSG00000042476
AA Change: V132A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
54 |
342 |
2e-94 |
PFAM |
|
AAA
|
418 |
610 |
3.97e-20 |
SMART |
|
Pfam:ABC_membrane
|
708 |
982 |
6.3e-77 |
PFAM |
|
AAA
|
1058 |
1246 |
4.49e-19 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000196067
AA Change: V132A
PolyPhen 2
Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000142425
Gene: ENSMUSG00000042476
AA Change: V132A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
54 |
344 |
2.4e-95 |
PFAM |
|
AAA
|
418 |
610 |
6.2e-22 |
SMART |
|
Pfam:ABC_membrane
|
708 |
882 |
1.6e-37 |
PFAM |
|
| Meta Mutation Damage Score |
0.1027 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.5%
|
| Validation Efficiency |
99% (101/102) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene are unable to secrete phospholipids into bile, leading to progressive hepatic disease, with an end stage of 3 months. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(3) : Targeted(3)
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acp3 |
A |
T |
9: 104,184,174 (GRCm39) |
V292E |
probably damaging |
Het |
| Adamts10 |
T |
C |
17: 33,747,870 (GRCm39) |
V102A |
possibly damaging |
Het |
| Add2 |
A |
G |
6: 86,073,728 (GRCm39) |
T206A |
probably benign |
Het |
| Alg12 |
A |
T |
15: 88,700,391 (GRCm39) |
L15Q |
probably damaging |
Het |
| Ankrd27 |
T |
A |
7: 35,307,800 (GRCm39) |
D346E |
probably damaging |
Het |
| Armc2 |
A |
T |
10: 41,799,790 (GRCm39) |
N689K |
probably damaging |
Het |
| Best3 |
T |
A |
10: 116,860,460 (GRCm39) |
D573E |
probably benign |
Het |
| Bltp1 |
T |
G |
3: 37,020,086 (GRCm39) |
N2108K |
probably damaging |
Het |
| Ccdc80 |
A |
T |
16: 44,916,261 (GRCm39) |
Q339L |
probably benign |
Het |
| Cdh9 |
T |
C |
15: 16,778,242 (GRCm39) |
V19A |
probably benign |
Het |
| Cimap1a |
G |
A |
7: 140,428,398 (GRCm39) |
|
probably benign |
Het |
| Cnksr1 |
A |
T |
4: 133,956,986 (GRCm39) |
|
probably null |
Het |
| Col7a1 |
T |
A |
9: 108,786,345 (GRCm39) |
V525E |
unknown |
Het |
| Cplane1 |
T |
C |
15: 8,251,421 (GRCm39) |
S1898P |
probably benign |
Het |
| Crebrf |
T |
C |
17: 26,961,394 (GRCm39) |
S172P |
possibly damaging |
Het |
| Csmd1 |
T |
C |
8: 16,059,439 (GRCm39) |
I2099V |
probably benign |
Het |
| Dcaf4 |
T |
A |
12: 83,586,233 (GRCm39) |
M400K |
possibly damaging |
Het |
| Dnah11 |
A |
T |
12: 117,958,935 (GRCm39) |
F2983I |
probably damaging |
Het |
| Dock6 |
A |
G |
9: 21,735,733 (GRCm39) |
V1005A |
possibly damaging |
Het |
| Dyrk2 |
C |
A |
10: 118,704,153 (GRCm39) |
G34C |
probably damaging |
Het |
| Eif4a1 |
A |
T |
11: 69,559,423 (GRCm39) |
|
probably benign |
Het |
| Eno4 |
G |
T |
19: 58,952,975 (GRCm39) |
D330Y |
probably damaging |
Het |
| Faf1 |
G |
A |
4: 109,699,496 (GRCm39) |
C347Y |
probably benign |
Het |
| Fam169a |
A |
G |
13: 97,234,100 (GRCm39) |
Y124C |
probably damaging |
Het |
| Fam227a |
G |
T |
15: 79,521,255 (GRCm39) |
F269L |
probably benign |
Het |
| Fancm |
C |
A |
12: 65,122,605 (GRCm39) |
D42E |
probably damaging |
Het |
| Fat1 |
T |
A |
8: 45,404,317 (GRCm39) |
I356N |
possibly damaging |
Het |
| Fer1l6 |
A |
T |
15: 58,509,869 (GRCm39) |
T1444S |
probably damaging |
Het |
| Galr1 |
A |
G |
18: 82,412,065 (GRCm39) |
L267P |
probably damaging |
Het |
| Gbx1 |
T |
C |
5: 24,709,837 (GRCm39) |
H336R |
probably damaging |
Het |
| Gimap8 |
A |
T |
6: 48,636,281 (GRCm39) |
Q682L |
possibly damaging |
Het |
| Gm2396 |
T |
G |
9: 88,813,281 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5798 |
T |
C |
14: 41,070,614 (GRCm39) |
L8S |
probably damaging |
Het |
| Hmgcll1 |
C |
T |
9: 75,963,460 (GRCm39) |
S39F |
possibly damaging |
Het |
| Hspg2 |
C |
T |
4: 137,246,251 (GRCm39) |
R1010C |
probably damaging |
Het |
| Il3ra |
A |
T |
14: 14,355,381 (GRCm38) |
E289D |
probably benign |
Het |
| Isoc1 |
T |
A |
18: 58,806,350 (GRCm39) |
L220Q |
probably damaging |
Het |
| Itga2 |
T |
A |
13: 114,990,302 (GRCm39) |
K918* |
probably null |
Het |
| Kat6a |
C |
T |
8: 23,428,329 (GRCm39) |
T1228I |
probably benign |
Het |
| Klhl30 |
T |
A |
1: 91,287,046 (GRCm39) |
|
probably null |
Het |
| Krtap6-2 |
A |
T |
16: 89,216,806 (GRCm39) |
C54S |
unknown |
Het |
| Lmf2 |
G |
A |
15: 89,236,003 (GRCm39) |
P634S |
probably benign |
Het |
| Map3k4 |
A |
G |
17: 12,490,906 (GRCm39) |
V175A |
possibly damaging |
Het |
| Mcm3 |
A |
C |
1: 20,890,480 (GRCm39) |
|
probably benign |
Het |
| Mon1b |
T |
C |
8: 114,365,859 (GRCm39) |
S396P |
probably damaging |
Het |
| Mroh2a |
T |
C |
1: 88,184,476 (GRCm39) |
V1453A |
probably benign |
Het |
| Ncor2 |
A |
G |
5: 125,126,404 (GRCm39) |
|
probably null |
Het |
| Nlrc5 |
T |
G |
8: 95,247,844 (GRCm39) |
|
probably benign |
Het |
| Nlrp14 |
GT |
GTT |
7: 106,796,386 (GRCm39) |
|
probably null |
Het |
| Nwd2 |
T |
G |
5: 63,962,151 (GRCm39) |
S578R |
probably damaging |
Het |
| Or12k7 |
A |
G |
2: 36,958,422 (GRCm39) |
Y35C |
probably damaging |
Het |
| Or4f4b |
G |
A |
2: 111,314,005 (GRCm39) |
V105I |
possibly damaging |
Het |
| Otoa |
C |
A |
7: 120,701,902 (GRCm39) |
P194T |
probably damaging |
Het |
| Pde1b |
A |
C |
15: 103,429,801 (GRCm39) |
D98A |
probably damaging |
Het |
| Pi4ka |
A |
T |
16: 17,195,033 (GRCm39) |
C122S |
probably damaging |
Het |
| Pole2 |
C |
T |
12: 69,269,924 (GRCm39) |
V67M |
probably damaging |
Het |
| Prickle2 |
A |
T |
6: 92,393,736 (GRCm39) |
D312E |
probably benign |
Het |
| Prkd1 |
T |
C |
12: 50,436,745 (GRCm39) |
D453G |
probably damaging |
Het |
| Prrc1 |
T |
A |
18: 57,507,626 (GRCm39) |
V260E |
probably damaging |
Het |
| Reg3g |
A |
T |
6: 78,444,793 (GRCm39) |
Y62N |
probably benign |
Het |
| Reln |
C |
T |
5: 22,160,236 (GRCm39) |
G2111E |
probably damaging |
Het |
| Rsph6a |
A |
T |
7: 18,791,665 (GRCm39) |
E278V |
possibly damaging |
Het |
| Scpep1 |
T |
A |
11: 88,832,122 (GRCm39) |
I203F |
probably damaging |
Het |
| Sec24d |
T |
C |
3: 123,148,596 (GRCm39) |
C747R |
probably damaging |
Het |
| Sec31a |
A |
T |
5: 100,516,192 (GRCm39) |
N967K |
probably damaging |
Het |
| Sell |
T |
C |
1: 163,890,631 (GRCm39) |
W5R |
probably benign |
Het |
| Siglec1 |
C |
T |
2: 130,911,789 (GRCm39) |
V1697M |
probably benign |
Het |
| Sinhcaf |
A |
G |
6: 148,834,498 (GRCm39) |
|
probably null |
Het |
| Slc22a26 |
T |
A |
19: 7,768,419 (GRCm39) |
I213L |
probably benign |
Het |
| Slc2a13 |
G |
A |
15: 91,296,415 (GRCm39) |
P300S |
probably benign |
Het |
| Slco1a4 |
A |
G |
6: 141,761,231 (GRCm39) |
Y461H |
possibly damaging |
Het |
| Slco3a1 |
G |
C |
7: 73,970,304 (GRCm39) |
C434W |
probably null |
Het |
| Sp3 |
A |
T |
2: 72,768,633 (GRCm39) |
V666D |
probably benign |
Het |
| Spidr |
A |
T |
16: 15,936,806 (GRCm39) |
W100R |
possibly damaging |
Het |
| Stk33 |
T |
A |
7: 108,926,802 (GRCm39) |
M286L |
probably damaging |
Het |
| Sult1c2 |
T |
A |
17: 54,139,163 (GRCm39) |
I183F |
probably benign |
Het |
| Svep1 |
G |
T |
4: 58,087,751 (GRCm39) |
T1776K |
probably benign |
Het |
| Tesk2 |
A |
G |
4: 116,660,190 (GRCm39) |
H436R |
probably benign |
Het |
| Tex2 |
T |
C |
11: 106,459,230 (GRCm39) |
T67A |
probably damaging |
Het |
| Timm10 |
T |
C |
2: 84,660,192 (GRCm39) |
S44P |
possibly damaging |
Het |
| Tmed11 |
C |
A |
5: 108,943,048 (GRCm39) |
|
probably null |
Het |
| Trim12c |
G |
A |
7: 103,990,155 (GRCm39) |
R441C |
probably damaging |
Het |
| Trmt2a |
A |
G |
16: 18,070,793 (GRCm39) |
K509E |
probably damaging |
Het |
| Upk3a |
A |
G |
15: 84,903,624 (GRCm39) |
T108A |
probably benign |
Het |
| Usp29 |
A |
G |
7: 6,965,158 (GRCm39) |
M334V |
probably benign |
Het |
| Vash1 |
A |
G |
12: 86,726,916 (GRCm39) |
D52G |
probably benign |
Het |
| Vmn2r14 |
T |
G |
5: 109,368,246 (GRCm39) |
T249P |
probably benign |
Het |
| Vmn2r43 |
A |
T |
7: 8,247,848 (GRCm39) |
F772I |
probably damaging |
Het |
| Vmn2r75 |
G |
T |
7: 85,820,787 (GRCm39) |
S49Y |
probably benign |
Het |
| Xdh |
T |
C |
17: 74,217,238 (GRCm39) |
T677A |
probably damaging |
Het |
| Zan |
A |
G |
5: 137,384,718 (GRCm39) |
L5102P |
unknown |
Het |
| Zfp160 |
T |
A |
17: 21,240,343 (GRCm39) |
S9T |
probably benign |
Het |
| Zfp273 |
A |
T |
13: 67,973,673 (GRCm39) |
H267L |
probably damaging |
Het |
| Zfp97 |
T |
A |
17: 17,365,038 (GRCm39) |
I179K |
probably benign |
Het |
| Zfp975 |
T |
C |
7: 42,311,716 (GRCm39) |
Y299C |
probably damaging |
Het |
|
| Other mutations in Abcb4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00570:Abcb4
|
APN |
5 |
9,000,073 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00663:Abcb4
|
APN |
5 |
8,977,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00671:Abcb4
|
APN |
5 |
8,980,745 (GRCm39) |
nonsense |
probably null |
|
|
IGL00822:Abcb4
|
APN |
5 |
9,000,046 (GRCm39) |
missense |
probably benign |
|
|
IGL01080:Abcb4
|
APN |
5 |
8,984,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01152:Abcb4
|
APN |
5 |
9,000,678 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01329:Abcb4
|
APN |
5 |
8,944,166 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01483:Abcb4
|
APN |
5 |
8,977,871 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01594:Abcb4
|
APN |
5 |
8,996,071 (GRCm39) |
splice site |
probably null |
|
|
IGL01785:Abcb4
|
APN |
5 |
8,965,058 (GRCm39) |
nonsense |
probably null |
|
|
IGL01968:Abcb4
|
APN |
5 |
8,977,913 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL02579:Abcb4
|
APN |
5 |
9,005,537 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02654:Abcb4
|
APN |
5 |
8,977,826 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02658:Abcb4
|
APN |
5 |
8,984,240 (GRCm39) |
missense |
probably benign |
|
|
IGL03229:Abcb4
|
APN |
5 |
8,990,936 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03335:Abcb4
|
APN |
5 |
8,985,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
FR4737:Abcb4
|
UTSW |
5 |
8,946,597 (GRCm39) |
small deletion |
probably benign |
|
|
P0014:Abcb4
|
UTSW |
5 |
9,000,083 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0102:Abcb4
|
UTSW |
5 |
8,959,194 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0102:Abcb4
|
UTSW |
5 |
8,959,194 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0309:Abcb4
|
UTSW |
5 |
8,989,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Abcb4
|
UTSW |
5 |
8,984,243 (GRCm39) |
missense |
probably benign |
|
|
R0420:Abcb4
|
UTSW |
5 |
8,991,050 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0449:Abcb4
|
UTSW |
5 |
8,989,885 (GRCm39) |
nonsense |
probably null |
|
|
R0609:Abcb4
|
UTSW |
5 |
8,997,376 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1459:Abcb4
|
UTSW |
5 |
8,968,662 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1470:Abcb4
|
UTSW |
5 |
8,990,968 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1470:Abcb4
|
UTSW |
5 |
8,990,968 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1812:Abcb4
|
UTSW |
5 |
8,978,578 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1944:Abcb4
|
UTSW |
5 |
8,980,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2002:Abcb4
|
UTSW |
5 |
8,955,989 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2256:Abcb4
|
UTSW |
5 |
9,008,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3116:Abcb4
|
UTSW |
5 |
8,946,610 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4112:Abcb4
|
UTSW |
5 |
8,986,783 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4354:Abcb4
|
UTSW |
5 |
8,968,771 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4512:Abcb4
|
UTSW |
5 |
8,978,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4588:Abcb4
|
UTSW |
5 |
8,997,328 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4628:Abcb4
|
UTSW |
5 |
8,957,399 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4708:Abcb4
|
UTSW |
5 |
8,965,125 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4714:Abcb4
|
UTSW |
5 |
8,980,906 (GRCm39) |
splice site |
probably null |
|
|
R4754:Abcb4
|
UTSW |
5 |
8,960,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4846:Abcb4
|
UTSW |
5 |
8,985,180 (GRCm39) |
missense |
probably benign |
|
|
R4944:Abcb4
|
UTSW |
5 |
8,984,327 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4994:Abcb4
|
UTSW |
5 |
8,978,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5022:Abcb4
|
UTSW |
5 |
8,959,054 (GRCm39) |
splice site |
probably null |
|
|
R5537:Abcb4
|
UTSW |
5 |
9,005,485 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5754:Abcb4
|
UTSW |
5 |
8,984,320 (GRCm39) |
missense |
probably benign |
|
|
R5833:Abcb4
|
UTSW |
5 |
9,008,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5934:Abcb4
|
UTSW |
5 |
8,980,806 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6006:Abcb4
|
UTSW |
5 |
8,996,026 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6146:Abcb4
|
UTSW |
5 |
8,946,587 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6183:Abcb4
|
UTSW |
5 |
8,968,718 (GRCm39) |
missense |
probably benign |
|
|
R6260:Abcb4
|
UTSW |
5 |
8,984,219 (GRCm39) |
nonsense |
probably null |
|
|
R6561:Abcb4
|
UTSW |
5 |
8,977,825 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7016:Abcb4
|
UTSW |
5 |
8,986,843 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7081:Abcb4
|
UTSW |
5 |
8,984,263 (GRCm39) |
missense |
probably benign |
|
|
R7326:Abcb4
|
UTSW |
5 |
8,984,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7375:Abcb4
|
UTSW |
5 |
8,968,671 (GRCm39) |
missense |
probably benign |
|
|
R7787:Abcb4
|
UTSW |
5 |
8,959,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7836:Abcb4
|
UTSW |
5 |
8,984,203 (GRCm39) |
missense |
probably benign |
|
|
R8128:Abcb4
|
UTSW |
5 |
9,008,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8350:Abcb4
|
UTSW |
5 |
8,978,578 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8438:Abcb4
|
UTSW |
5 |
8,996,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8447:Abcb4
|
UTSW |
5 |
8,957,278 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8710:Abcb4
|
UTSW |
5 |
9,005,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8777:Abcb4
|
UTSW |
5 |
8,989,894 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8777-TAIL:Abcb4
|
UTSW |
5 |
8,989,894 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8837:Abcb4
|
UTSW |
5 |
8,986,873 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8987:Abcb4
|
UTSW |
5 |
8,977,931 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9098:Abcb4
|
UTSW |
5 |
9,008,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9167:Abcb4
|
UTSW |
5 |
8,986,849 (GRCm39) |
nonsense |
probably null |
|
|
R9210:Abcb4
|
UTSW |
5 |
9,005,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9212:Abcb4
|
UTSW |
5 |
9,005,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9218:Abcb4
|
UTSW |
5 |
8,977,960 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9242:Abcb4
|
UTSW |
5 |
8,949,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9376:Abcb4
|
UTSW |
5 |
9,008,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9476:Abcb4
|
UTSW |
5 |
8,977,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF015:Abcb4
|
UTSW |
5 |
8,946,594 (GRCm39) |
frame shift |
probably null |
|
|
RF047:Abcb4
|
UTSW |
5 |
8,946,595 (GRCm39) |
frame shift |
probably null |
|
|
Z1176:Abcb4
|
UTSW |
5 |
9,009,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Abcb4
|
UTSW |
5 |
8,989,906 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGAACTTTCTCCCCAAAAGC -3'
(R):5'- TGCTTCATTTCCTCATCAAAGTGTG -3'
Sequencing Primer
(F):5'- AAGCCTGTCTAGCTAGCATG -3'
(R):5'- CCTCATCAAAGTGTGACATTATCAAC -3'
|
| Posted On |
2016-03-17 |
Incidental Mutation