Incidental Mutation 'R4608:Qars1'
ID 377703
Institutional Source Beutler Lab
Gene Symbol Qars1
Ensembl Gene ENSMUSG00000032604
Gene Name glutaminyl-tRNA synthetase 1
Synonyms 1200016L19Rik, Qars, 1110018N24Rik
MMRRC Submission 041819-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.962) question?
Stock # R4608 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 108385204-108393140 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 108386625 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000146436 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006838] [ENSMUST00000134939] [ENSMUST00000194045] [ENSMUST00000208581] [ENSMUST00000208581] [ENSMUST00000208214] [ENSMUST00000207810] [ENSMUST00000207810] [ENSMUST00000207862] [ENSMUST00000207862] [ENSMUST00000207947] [ENSMUST00000208162] [ENSMUST00000207790] [ENSMUST00000208177]
AlphaFold Q8BML9
Predicted Effect probably null
Transcript: ENSMUST00000006838
SMART Domains Protein: ENSMUSP00000006838
Gene: ENSMUSG00000032604

DomainStartEndE-ValueType
Pfam:tRNA_synt_1c_R1 4 162 1.2e-54 PFAM
Pfam:tRNA_synt_1c_R2 165 256 6.5e-31 PFAM
Pfam:tRNA-synt_1c 263 563 4.5e-119 PFAM
Pfam:tRNA-synt_1c_C 565 752 6.9e-48 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131005
Predicted Effect probably null
Transcript: ENSMUST00000134939
SMART Domains Protein: ENSMUSP00000122918
Gene: ENSMUSG00000032604

DomainStartEndE-ValueType
Pfam:tRNA_synt_1c_R1 1 163 1.1e-55 PFAM
Pfam:tRNA_synt_1c_R2 164 256 6.9e-31 PFAM
Pfam:tRNA-synt_1c 263 563 2.5e-115 PFAM
Pfam:tRNA-synt_1c_C 565 720 5.7e-35 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137655
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137980
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141201
Predicted Effect probably null
Transcript: ENSMUST00000207713
Predicted Effect probably null
Transcript: ENSMUST00000207713
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144253
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154324
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207126
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192627
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192659
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207062
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154311
Predicted Effect probably benign
Transcript: ENSMUST00000207180
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141780
Predicted Effect probably benign
Transcript: ENSMUST00000194045
Predicted Effect probably benign
Transcript: ENSMUST00000141903
SMART Domains Protein: ENSMUSP00000121146
Gene: ENSMUSG00000032604

DomainStartEndE-ValueType
Pfam:tRNA-synt_1c 2 148 2.1e-50 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000208581
Predicted Effect probably null
Transcript: ENSMUST00000208581
Predicted Effect probably benign
Transcript: ENSMUST00000208214
Predicted Effect probably null
Transcript: ENSMUST00000207810
Predicted Effect probably null
Transcript: ENSMUST00000207810
Predicted Effect probably null
Transcript: ENSMUST00000207862
Predicted Effect probably null
Transcript: ENSMUST00000207862
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208069
Predicted Effect probably benign
Transcript: ENSMUST00000207947
Predicted Effect probably benign
Transcript: ENSMUST00000208162
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208102
Predicted Effect probably benign
Transcript: ENSMUST00000207790
Predicted Effect probably benign
Transcript: ENSMUST00000208506
Predicted Effect probably benign
Transcript: ENSMUST00000207734
Predicted Effect probably benign
Transcript: ENSMUST00000208074
Predicted Effect probably benign
Transcript: ENSMUST00000208177
Meta Mutation Damage Score 0.8617 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 100% (80/80)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930022D16Rik A G 11: 109,308,855 (GRCm39) I74V unknown Het
Acss3 T A 10: 106,802,890 (GRCm39) I452F possibly damaging Het
Adam10 T C 9: 70,651,173 (GRCm39) L66P probably damaging Het
Adamts18 A T 8: 114,464,245 (GRCm39) C738S probably damaging Het
Adamts7 T G 9: 90,056,593 (GRCm39) S221A probably damaging Het
Adrm1 A G 2: 179,816,648 (GRCm39) probably benign Het
Aqp1 T C 6: 55,313,624 (GRCm39) V50A possibly damaging Het
Aqp4 T C 18: 15,531,183 (GRCm39) I193V probably benign Het
B130006D01Rik A T 11: 95,617,066 (GRCm39) probably benign Het
Bbs10 T G 10: 111,136,681 (GRCm39) I598S probably damaging Het
Bbs10 A G 10: 111,136,995 (GRCm39) K703E probably benign Het
Ccdc121rt2 A G 5: 112,597,764 (GRCm39) S104G possibly damaging Het
Ccnl1 C T 3: 65,854,131 (GRCm39) probably benign Het
Crocc2 G A 1: 93,096,516 (GRCm39) V24M possibly damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dcdc2a T A 13: 25,245,223 (GRCm39) L100* probably null Het
Eif4g3 G T 4: 137,853,769 (GRCm39) R618L probably benign Het
F5 C T 1: 164,036,598 (GRCm39) P1920S probably benign Het
Fam187b T A 7: 30,677,170 (GRCm39) N226K probably benign Het
Fancc C A 13: 63,479,637 (GRCm39) probably benign Het
Fastk G T 5: 24,648,117 (GRCm39) P233H probably damaging Het
Fbn1 A C 2: 125,148,420 (GRCm39) D2609E probably benign Het
Fes G A 7: 80,036,959 (GRCm39) R42W probably damaging Het
Fmnl2 T A 2: 52,993,728 (GRCm39) N374K possibly damaging Het
Fpgt G A 3: 154,792,333 (GRCm39) Q565* probably null Het
Gckr A G 5: 31,465,141 (GRCm39) D370G probably damaging Het
Ggt6 T C 11: 72,328,769 (GRCm39) M385T probably benign Het
Gm26657 C A 4: 56,741,114 (GRCm39) H100N probably benign Het
Gsg1l T A 7: 125,557,721 (GRCm39) I136F probably damaging Het
Hhip C T 8: 80,724,192 (GRCm39) R350Q probably damaging Het
Ints1 C T 5: 139,745,599 (GRCm39) S1353N probably benign Het
Ints10 G A 8: 69,263,271 (GRCm39) R394Q probably damaging Het
Ints6 T G 14: 62,940,678 (GRCm39) R557S probably damaging Het
Ints9 T A 14: 65,269,729 (GRCm39) I473N possibly damaging Het
Itih4 G A 14: 30,623,626 (GRCm39) G915R probably damaging Het
Kif1a C A 1: 92,952,368 (GRCm39) A1304S possibly damaging Het
Kif21b C T 1: 136,075,924 (GRCm39) probably benign Het
Klk13 C A 7: 43,363,284 (GRCm39) C10* probably null Het
Krtap4-8 C T 11: 99,671,321 (GRCm39) probably benign Het
Lef1 T C 3: 130,978,382 (GRCm39) S167P probably benign Het
Leng8 T A 7: 4,147,796 (GRCm39) I607N probably damaging Het
Lrch4 T A 5: 137,637,408 (GRCm39) L526* probably null Het
Memo1 G A 17: 74,565,456 (GRCm39) Q36* probably null Het
Nod1 C A 6: 54,920,741 (GRCm39) A526S probably damaging Het
Nostrin G A 2: 69,014,243 (GRCm39) V400M possibly damaging Het
Nrip1 T C 16: 76,089,920 (GRCm39) T546A probably benign Het
Nxf1 A G 19: 8,740,127 (GRCm39) D98G probably benign Het
Or13a24 A G 7: 140,154,554 (GRCm39) M163V probably benign Het
Or1l4 T A 2: 37,092,094 (GRCm39) Y280* probably null Het
Or2h2b-ps1 A T 17: 37,481,173 (GRCm39) V20E probably damaging Het
Or2t1 A G 14: 14,328,887 (GRCm38) M259V probably benign Het
Or4c114 G T 2: 88,904,656 (GRCm39) P260T probably benign Het
Or6aa1 A T 7: 86,043,718 (GRCm39) probably null Het
Osgep T C 14: 51,155,378 (GRCm39) Y60C probably damaging Het
P2ry6 A G 7: 100,587,511 (GRCm39) Y283H probably damaging Het
Pcdha7 A T 18: 37,108,870 (GRCm39) S632C possibly damaging Het
Pms1 T A 1: 53,234,097 (GRCm39) R806S possibly damaging Het
Rxfp1 T C 3: 79,594,196 (GRCm39) N66S probably damaging Het
Slc12a5 A T 2: 164,815,685 (GRCm39) N67I probably damaging Het
Slc1a4 G T 11: 20,254,348 (GRCm39) T506K probably damaging Het
Stimate C A 14: 30,594,490 (GRCm39) probably benign Het
Tlr9 T A 9: 106,102,173 (GRCm39) I488N probably damaging Het
Tmem74 G T 15: 43,730,554 (GRCm39) T163K probably damaging Het
Uba2 T C 7: 33,854,021 (GRCm39) D307G probably damaging Het
Uty C T Y: 1,131,134 (GRCm39) R924Q probably damaging Het
Wdr7 C T 18: 63,910,651 (GRCm39) T681I probably benign Het
Xab2 A G 8: 3,668,105 (GRCm39) S158P probably benign Het
Ythdc1 T C 5: 86,970,667 (GRCm39) S418P probably damaging Het
Zfand4 T A 6: 116,305,195 (GRCm39) C207* probably null Het
Zfp367 C T 13: 64,283,238 (GRCm39) D305N probably damaging Het
Zfp804b C T 5: 6,822,584 (GRCm39) V160I probably benign Het
Other mutations in Qars1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01570:Qars1 APN 9 108,388,738 (GRCm39) missense probably damaging 1.00
IGL02336:Qars1 APN 9 108,392,185 (GRCm39) nonsense probably null
IGL02393:Qars1 APN 9 108,391,528 (GRCm39) missense probably benign 0.00
IGL03102:Qars1 APN 9 108,386,118 (GRCm39) missense probably benign 0.35
R0576:Qars1 UTSW 9 108,392,161 (GRCm39) intron probably benign
R1777:Qars1 UTSW 9 108,385,400 (GRCm39) critical splice donor site probably null
R1824:Qars1 UTSW 9 108,391,809 (GRCm39) missense probably damaging 1.00
R1871:Qars1 UTSW 9 108,391,315 (GRCm39) splice site probably null
R1897:Qars1 UTSW 9 108,391,282 (GRCm39) nonsense probably null
R1952:Qars1 UTSW 9 108,390,380 (GRCm39) missense probably benign 0.35
R1981:Qars1 UTSW 9 108,392,227 (GRCm39) missense probably damaging 1.00
R2172:Qars1 UTSW 9 108,386,399 (GRCm39) missense probably damaging 1.00
R2698:Qars1 UTSW 9 108,385,642 (GRCm39) missense possibly damaging 0.65
R4381:Qars1 UTSW 9 108,387,382 (GRCm39) unclassified probably benign
R4677:Qars1 UTSW 9 108,386,889 (GRCm39) unclassified probably benign
R4974:Qars1 UTSW 9 108,386,130 (GRCm39) missense probably damaging 1.00
R5234:Qars1 UTSW 9 108,391,364 (GRCm39) missense probably damaging 1.00
R5548:Qars1 UTSW 9 108,390,117 (GRCm39) missense possibly damaging 0.72
R5817:Qars1 UTSW 9 108,387,441 (GRCm39) unclassified probably benign
R6029:Qars1 UTSW 9 108,390,889 (GRCm39) missense probably damaging 1.00
R6110:Qars1 UTSW 9 108,385,297 (GRCm39) missense probably benign 0.02
R6889:Qars1 UTSW 9 108,390,382 (GRCm39) missense probably damaging 0.98
R7034:Qars1 UTSW 9 108,391,976 (GRCm39) missense probably damaging 1.00
R7036:Qars1 UTSW 9 108,391,976 (GRCm39) missense probably damaging 1.00
R7136:Qars1 UTSW 9 108,389,971 (GRCm39) missense probably damaging 1.00
R7178:Qars1 UTSW 9 108,392,322 (GRCm39) missense possibly damaging 0.50
R7192:Qars1 UTSW 9 108,388,760 (GRCm39) missense probably damaging 1.00
R7235:Qars1 UTSW 9 108,387,331 (GRCm39) missense probably damaging 1.00
R7813:Qars1 UTSW 9 108,386,670 (GRCm39) missense probably damaging 1.00
R8248:Qars1 UTSW 9 108,386,651 (GRCm39) missense probably benign 0.00
R8558:Qars1 UTSW 9 108,392,422 (GRCm39) missense probably benign
R9126:Qars1 UTSW 9 108,386,399 (GRCm39) missense probably damaging 1.00
R9245:Qars1 UTSW 9 108,386,132 (GRCm39) nonsense probably null
R9632:Qars1 UTSW 9 108,391,582 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CAACATGGGGCTGCTAATGG -3'
(R):5'- AGTTAAGCGCTACTCCCTCCAC -3'

Sequencing Primer
(F):5'- CAGGGAGTTACTTGGAAGTGCATC -3'
(R):5'- TCCACACTGGGCTCCAC -3'
Posted On 2016-03-21