Incidental Mutation 'R4489:Xlr5b'
ID 377811
Institutional Source Beutler Lab
Gene Symbol Xlr5b
Ensembl Gene ENSMUSG00000072479
Gene Name X-linked lymphocyte-regulated 5B
Synonyms OTTMUSG00000017646
MMRRC Submission 041745-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R4489 (G1)
Quality Score 222
Status Validated
Chromosome X
Chromosomal Location 72192402-72202478 bp(+) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) T to C at 72201504 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000110164 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097221] [ENSMUST00000114518] [ENSMUST00000135742] [ENSMUST00000179600]
AlphaFold A2BI50
Predicted Effect probably null
Transcript: ENSMUST00000097221
SMART Domains Protein: ENSMUSP00000110163
Gene: ENSMUSG00000072479

DomainStartEndE-ValueType
low complexity region 42 53 N/A INTRINSIC
Pfam:Cor1 76 204 1.1e-24 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000114518
SMART Domains Protein: ENSMUSP00000110164
Gene: ENSMUSG00000072479

DomainStartEndE-ValueType
low complexity region 42 53 N/A INTRINSIC
Pfam:Cor1 76 204 1.1e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135742
SMART Domains Protein: ENSMUSP00000120174
Gene: ENSMUSG00000072479

DomainStartEndE-ValueType
low complexity region 42 53 N/A INTRINSIC
Pfam:Cor1 76 197 2.3e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000179600
SMART Domains Protein: ENSMUSP00000137006
Gene: ENSMUSG00000058328

DomainStartEndE-ValueType
low complexity region 42 53 N/A INTRINSIC
Pfam:Cor1 76 204 7.4e-24 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 94% (50/53)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd2 A G 15: 91,062,486 (GRCm39) V484A probably damaging Het
Ank3 C T 10: 69,734,086 (GRCm39) A754V probably damaging Het
Ano1 T C 7: 144,165,479 (GRCm39) N582S probably benign Het
Arnt2 T A 7: 83,924,553 (GRCm39) T425S probably benign Het
Bltp1 A T 3: 37,058,082 (GRCm39) Q3224L probably null Het
Cand2 A G 6: 115,766,427 (GRCm39) D344G probably damaging Het
Clta T G 4: 44,032,417 (GRCm39) F198V probably damaging Het
Cnga2 T A X: 71,049,733 (GRCm39) F133I possibly damaging Het
Csmd2 G A 4: 128,275,738 (GRCm39) V826M possibly damaging Het
Dnah11 C T 12: 117,880,631 (GRCm39) V3830I probably benign Het
Fhl4 T C 10: 84,934,319 (GRCm39) D154G possibly damaging Het
Gbp4 T A 5: 105,269,773 (GRCm39) T352S probably damaging Het
Gigyf2 A G 1: 87,368,548 (GRCm39) D1076G probably damaging Het
Gm21370 T A 13: 120,488,378 (GRCm39) Y57F probably benign Het
Gm6489 A G 1: 31,326,320 (GRCm39) noncoding transcript Het
Grm6 T C 11: 50,750,816 (GRCm39) S660P probably damaging Het
Hectd4 T G 5: 121,424,320 (GRCm39) I660R possibly damaging Het
Homer3 G A 8: 70,742,793 (GRCm39) probably null Het
Htr1b A T 9: 81,513,592 (GRCm39) D338E probably benign Het
Kifbp A G 10: 62,398,806 (GRCm39) probably benign Het
Lrp1b T C 2: 40,551,501 (GRCm39) probably benign Het
Lzts1 T A 8: 69,588,347 (GRCm39) K536N possibly damaging Het
Mrpl22 T A 11: 58,063,928 (GRCm39) N49K probably benign Het
Mzt1 T C 14: 99,273,926 (GRCm39) *42W probably null Het
Nkx3-2 T G 5: 41,919,304 (GRCm39) Q228P probably damaging Het
Nufip2 T G 11: 77,577,055 (GRCm39) M1R probably null Het
Obscn G A 11: 58,922,417 (GRCm39) T5921M possibly damaging Het
Or4c116 T C 2: 88,941,916 (GRCm39) probably null Het
Or52e7 T C 7: 104,684,510 (GRCm39) F35S probably benign Het
Pcdha11 C A 18: 37,139,969 (GRCm39) Q533K possibly damaging Het
Pgm5 T C 19: 24,793,809 (GRCm39) E285G probably benign Het
Plxna2 C T 1: 194,431,625 (GRCm39) S538F probably damaging Het
Potefam1 A G 2: 111,051,047 (GRCm39) Y250H probably benign Het
Rgs21 T C 1: 144,395,613 (GRCm39) T92A possibly damaging Het
Rgsl1 T A 1: 153,703,282 (GRCm39) Y123F probably benign Het
Rnf13 A C 3: 57,728,010 (GRCm39) K230T probably damaging Het
Sgf29 T C 7: 126,263,110 (GRCm39) S29P possibly damaging Het
Smchd1 T C 17: 71,714,230 (GRCm39) T878A probably benign Het
Specc1 T G 11: 62,042,653 (GRCm39) probably null Het
Tg A T 15: 66,579,791 (GRCm39) Q1532L probably damaging Het
Timm44 A C 8: 4,316,654 (GRCm39) S297A possibly damaging Het
Txndc9 G T 1: 38,034,871 (GRCm39) S11* probably null Het
Uggt1 C T 1: 36,185,749 (GRCm39) W1478* probably null Het
Washc3 T C 10: 88,051,893 (GRCm39) V87A probably benign Het
Other mutations in Xlr5b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4486:Xlr5b UTSW X 72,201,504 (GRCm39) splice site probably null
R4487:Xlr5b UTSW X 72,201,504 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- TGGGATACGCAAAGTCTGTAC -3'
(R):5'- TAGCATGGCTAACGCTTCC -3'

Sequencing Primer
(F):5'- ACTTTTAAGTTAAATGAGGTGAGGTG -3'
(R):5'- ATCCTATGTGTGATCTTCAGATGG -3'
Posted On 2016-04-07