Incidental Mutation 'R4919:Vmn2r2'
ID 378464
Institutional Source Beutler Lab
Gene Symbol Vmn2r2
Ensembl Gene ENSMUSG00000043897
Gene Name vomeronasal 2, receptor 2
Synonyms
MMRRC Submission 042521-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R4919 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 64022699-64049349 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 64024578 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 668 (S668P)
Ref Sequence ENSEMBL: ENSMUSP00000135110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077958] [ENSMUST00000177151]
AlphaFold L7N2E9
Predicted Effect possibly damaging
Transcript: ENSMUST00000077958
AA Change: S584P

PolyPhen 2 Score 0.559 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000077109
Gene: ENSMUSG00000043897
AA Change: S584P

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 4.5e-80 PFAM
Pfam:NCD3G 458 511 8.3e-18 PFAM
Pfam:7tm_3 542 779 1.3e-75 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000177151
AA Change: S668P

PolyPhen 2 Score 0.559 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000135110
Gene: ENSMUSG00000043897
AA Change: S668P

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 83 500 1.6e-84 PFAM
Pfam:NCD3G 542 595 2.6e-17 PFAM
Pfam:7tm_3 628 862 1.9e-47 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 91.9%
Validation Efficiency 100% (46/46)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
3425401B19Rik T C 14: 32,385,245 (GRCm39) D240G possibly damaging Het
Aplf T C 6: 87,607,046 (GRCm39) D456G possibly damaging Het
Brd8 A G 18: 34,740,489 (GRCm39) F445S probably damaging Het
Coro1b C T 19: 4,200,709 (GRCm39) R214C possibly damaging Het
Dop1a T A 9: 86,402,109 (GRCm39) I1101K possibly damaging Het
Enpp1 A G 10: 24,523,983 (GRCm39) V728A probably benign Het
Gosr1 T A 11: 76,625,392 (GRCm39) probably null Het
Grhl3 T A 4: 135,286,415 (GRCm39) K89* probably null Het
Ino80 T A 2: 119,273,073 (GRCm39) T468S probably damaging Het
Kcnab2 T C 4: 152,486,397 (GRCm39) K134E probably damaging Het
Klhl17 C T 4: 156,318,344 (GRCm39) V93I possibly damaging Het
Kmt2c G T 5: 25,519,393 (GRCm39) P2239Q possibly damaging Het
Lnpep A G 17: 17,799,173 (GRCm39) F161L probably damaging Het
Lrp1b T A 2: 40,537,246 (GRCm39) I14F probably benign Het
Mbtd1 T A 11: 93,813,974 (GRCm39) probably null Het
Musk A C 4: 58,366,899 (GRCm39) I506L probably damaging Het
Mydgf C T 17: 56,483,953 (GRCm39) V158I probably damaging Het
Ncapd3 C T 9: 26,963,071 (GRCm39) P459S possibly damaging Het
Ofcc1 G A 13: 40,168,864 (GRCm39) T841I probably damaging Het
Or13a19 A T 7: 139,903,427 (GRCm39) K272* probably null Het
Or2w6 A T 13: 21,842,794 (GRCm39) I233N possibly damaging Het
Or5d45 A G 2: 88,153,992 (GRCm39) V19A probably benign Het
Pnmt T A 11: 98,277,477 (GRCm39) L7Q probably benign Het
Rerg T C 6: 137,033,142 (GRCm39) I197V probably damaging Het
Sgo2a T C 1: 58,037,293 (GRCm39) S13P probably damaging Het
Sim2 T C 16: 93,910,194 (GRCm39) S199P probably benign Het
Smc1b T C 15: 85,001,305 (GRCm39) probably benign Het
Spata7 T C 12: 98,614,712 (GRCm39) S115P possibly damaging Het
Ssh2 A G 11: 77,316,146 (GRCm39) T250A possibly damaging Het
Sv2a A G 3: 96,098,071 (GRCm39) N558S probably benign Het
Tia1 T A 6: 86,401,305 (GRCm39) probably benign Het
Tmem39a A G 16: 38,405,561 (GRCm39) Y46C probably benign Het
Vwa1 C A 4: 155,855,057 (GRCm39) A326S probably benign Het
Xpo6 A G 7: 125,752,115 (GRCm39) M327T probably benign Het
Other mutations in Vmn2r2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00326:Vmn2r2 APN 3 64,041,319 (GRCm39) splice site probably benign
IGL00980:Vmn2r2 APN 3 64,024,601 (GRCm39) missense probably benign 0.11
IGL01389:Vmn2r2 APN 3 64,024,430 (GRCm39) missense probably damaging 0.97
IGL01804:Vmn2r2 APN 3 64,041,677 (GRCm39) missense possibly damaging 0.91
IGL02750:Vmn2r2 APN 3 64,024,823 (GRCm39) missense probably damaging 1.00
IGL02829:Vmn2r2 APN 3 64,026,172 (GRCm39) splice site probably benign
IGL03036:Vmn2r2 APN 3 64,024,321 (GRCm39) missense probably benign 0.01
IGL03174:Vmn2r2 APN 3 64,024,544 (GRCm39) nonsense probably null
PIT4151001:Vmn2r2 UTSW 3 64,024,334 (GRCm39) missense possibly damaging 0.67
R0029:Vmn2r2 UTSW 3 64,024,365 (GRCm39) missense probably benign 0.00
R0310:Vmn2r2 UTSW 3 64,042,039 (GRCm39) missense probably damaging 1.00
R0357:Vmn2r2 UTSW 3 64,041,320 (GRCm39) splice site probably null
R0637:Vmn2r2 UTSW 3 64,033,999 (GRCm39) missense probably benign 0.00
R1626:Vmn2r2 UTSW 3 64,041,921 (GRCm39) missense possibly damaging 0.61
R1662:Vmn2r2 UTSW 3 64,024,551 (GRCm39) missense probably benign 0.00
R1710:Vmn2r2 UTSW 3 64,024,820 (GRCm39) missense probably benign 0.19
R1797:Vmn2r2 UTSW 3 64,042,128 (GRCm39) missense probably benign 0.00
R1862:Vmn2r2 UTSW 3 64,041,942 (GRCm39) missense possibly damaging 0.79
R1971:Vmn2r2 UTSW 3 64,034,121 (GRCm39) missense probably damaging 1.00
R2051:Vmn2r2 UTSW 3 64,024,766 (GRCm39) missense possibly damaging 0.77
R2099:Vmn2r2 UTSW 3 64,024,474 (GRCm39) missense probably damaging 1.00
R2275:Vmn2r2 UTSW 3 64,023,930 (GRCm39) missense probably benign 0.00
R3078:Vmn2r2 UTSW 3 64,042,053 (GRCm39) missense probably benign 0.22
R3418:Vmn2r2 UTSW 3 64,024,320 (GRCm39) missense probably benign 0.00
R3419:Vmn2r2 UTSW 3 64,024,320 (GRCm39) missense probably benign 0.00
R3959:Vmn2r2 UTSW 3 64,047,947 (GRCm39) missense probably benign
R4230:Vmn2r2 UTSW 3 64,041,912 (GRCm39) missense probably benign 0.00
R4258:Vmn2r2 UTSW 3 64,042,118 (GRCm39) missense probably damaging 1.00
R4810:Vmn2r2 UTSW 3 64,044,883 (GRCm39) missense probably damaging 1.00
R4822:Vmn2r2 UTSW 3 64,041,960 (GRCm39) missense probably damaging 0.99
R4925:Vmn2r2 UTSW 3 64,044,892 (GRCm39) start codon destroyed probably null 0.03
R4954:Vmn2r2 UTSW 3 64,047,905 (GRCm39) missense probably benign 0.00
R5071:Vmn2r2 UTSW 3 64,024,321 (GRCm39) missense probably benign 0.01
R5315:Vmn2r2 UTSW 3 64,024,377 (GRCm39) missense probably benign 0.37
R5450:Vmn2r2 UTSW 3 64,034,011 (GRCm39) missense probably benign
R5577:Vmn2r2 UTSW 3 64,024,416 (GRCm39) missense probably benign 0.00
R5595:Vmn2r2 UTSW 3 64,034,036 (GRCm39) missense possibly damaging 0.74
R5727:Vmn2r2 UTSW 3 64,024,608 (GRCm39) missense probably benign 0.41
R5810:Vmn2r2 UTSW 3 64,024,815 (GRCm39) missense probably damaging 1.00
R5919:Vmn2r2 UTSW 3 64,044,723 (GRCm39) missense probably benign 0.39
R6052:Vmn2r2 UTSW 3 64,024,782 (GRCm39) missense possibly damaging 0.56
R6084:Vmn2r2 UTSW 3 64,024,467 (GRCm39) missense probably benign 0.01
R6299:Vmn2r2 UTSW 3 64,024,074 (GRCm39) nonsense probably null
R6762:Vmn2r2 UTSW 3 64,041,870 (GRCm39) missense probably damaging 1.00
R6858:Vmn2r2 UTSW 3 64,044,915 (GRCm39) missense probably damaging 1.00
R6889:Vmn2r2 UTSW 3 64,024,688 (GRCm39) missense probably damaging 0.99
R6990:Vmn2r2 UTSW 3 64,024,608 (GRCm39) missense probably benign 0.02
R7195:Vmn2r2 UTSW 3 64,023,900 (GRCm39) missense probably benign 0.01
R7269:Vmn2r2 UTSW 3 64,033,998 (GRCm39) missense probably benign 0.32
R7699:Vmn2r2 UTSW 3 64,024,536 (GRCm39) missense possibly damaging 0.69
R7717:Vmn2r2 UTSW 3 64,042,019 (GRCm39) missense possibly damaging 0.95
R7798:Vmn2r2 UTSW 3 64,041,518 (GRCm39) missense possibly damaging 0.60
R7914:Vmn2r2 UTSW 3 64,041,526 (GRCm39) missense probably benign 0.20
R7974:Vmn2r2 UTSW 3 64,024,808 (GRCm39) missense probably damaging 0.99
R8394:Vmn2r2 UTSW 3 64,044,858 (GRCm39) missense probably damaging 1.00
R8478:Vmn2r2 UTSW 3 64,024,257 (GRCm39) missense possibly damaging 0.87
R8731:Vmn2r2 UTSW 3 64,024,404 (GRCm39) missense probably benign 0.16
R9035:Vmn2r2 UTSW 3 64,024,172 (GRCm39) missense probably damaging 1.00
R9182:Vmn2r2 UTSW 3 64,044,802 (GRCm39) missense probably damaging 1.00
R9225:Vmn2r2 UTSW 3 64,034,021 (GRCm39) missense probably benign 0.00
R9266:Vmn2r2 UTSW 3 64,024,057 (GRCm39) missense probably damaging 0.98
R9427:Vmn2r2 UTSW 3 64,041,945 (GRCm39) missense probably damaging 1.00
R9659:Vmn2r2 UTSW 3 64,041,942 (GRCm39) missense possibly damaging 0.79
R9666:Vmn2r2 UTSW 3 64,023,870 (GRCm39) missense probably benign 0.08
R9771:Vmn2r2 UTSW 3 64,042,079 (GRCm39) missense possibly damaging 0.88
R9788:Vmn2r2 UTSW 3 64,041,942 (GRCm39) missense possibly damaging 0.79
X0024:Vmn2r2 UTSW 3 64,044,707 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TCCAACACCAAGTATGCTGC -3'
(R):5'- TTGCTTATGGAGAGGCACTG -3'

Sequencing Primer
(F):5'- CGCAGACCAGTACAATTAGTTTTCG -3'
(R):5'- AGAGGCACTGGGGTTCACTC -3'
Posted On 2016-04-15