Incidental Mutation 'R4919:Mydgf'
ID 378493
Institutional Source Beutler Lab
Gene Symbol Mydgf
Ensembl Gene ENSMUSG00000019579
Gene Name myeloid derived growth factor
Synonyms D17Wsu104e
MMRRC Submission 042521-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R4919 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 56483541-56490920 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 56483953 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 158 (V158I)
Ref Sequence ENSEMBL: ENSMUSP00000019723 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019723] [ENSMUST00000077788]
AlphaFold Q9CPT4
Predicted Effect probably damaging
Transcript: ENSMUST00000019723
AA Change: V158I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000019723
Gene: ENSMUSG00000019579
AA Change: V158I

DomainStartEndE-ValueType
Pfam:UPF0556 11 166 4.8e-82 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000077788
SMART Domains Protein: ENSMUSP00000076961
Gene: ENSMUSG00000044469

DomainStartEndE-ValueType
Pfam:DUF758 4 184 5.8e-75 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140885
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151093
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195950
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 91.9%
Validation Efficiency 100% (46/46)
MGI Phenotype FUNCTION: The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was identified in error as interleukin 25. This activity has not been reproducible, however, and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation display normal cardiac and vascular development but develop larger myocardial infactions with reduced angiogenesis and increased scarring. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
3425401B19Rik T C 14: 32,385,245 (GRCm39) D240G possibly damaging Het
Aplf T C 6: 87,607,046 (GRCm39) D456G possibly damaging Het
Brd8 A G 18: 34,740,489 (GRCm39) F445S probably damaging Het
Coro1b C T 19: 4,200,709 (GRCm39) R214C possibly damaging Het
Dop1a T A 9: 86,402,109 (GRCm39) I1101K possibly damaging Het
Enpp1 A G 10: 24,523,983 (GRCm39) V728A probably benign Het
Gosr1 T A 11: 76,625,392 (GRCm39) probably null Het
Grhl3 T A 4: 135,286,415 (GRCm39) K89* probably null Het
Ino80 T A 2: 119,273,073 (GRCm39) T468S probably damaging Het
Kcnab2 T C 4: 152,486,397 (GRCm39) K134E probably damaging Het
Klhl17 C T 4: 156,318,344 (GRCm39) V93I possibly damaging Het
Kmt2c G T 5: 25,519,393 (GRCm39) P2239Q possibly damaging Het
Lnpep A G 17: 17,799,173 (GRCm39) F161L probably damaging Het
Lrp1b T A 2: 40,537,246 (GRCm39) I14F probably benign Het
Mbtd1 T A 11: 93,813,974 (GRCm39) probably null Het
Musk A C 4: 58,366,899 (GRCm39) I506L probably damaging Het
Ncapd3 C T 9: 26,963,071 (GRCm39) P459S possibly damaging Het
Ofcc1 G A 13: 40,168,864 (GRCm39) T841I probably damaging Het
Or13a19 A T 7: 139,903,427 (GRCm39) K272* probably null Het
Or2w6 A T 13: 21,842,794 (GRCm39) I233N possibly damaging Het
Or5d45 A G 2: 88,153,992 (GRCm39) V19A probably benign Het
Pnmt T A 11: 98,277,477 (GRCm39) L7Q probably benign Het
Rerg T C 6: 137,033,142 (GRCm39) I197V probably damaging Het
Sgo2a T C 1: 58,037,293 (GRCm39) S13P probably damaging Het
Sim2 T C 16: 93,910,194 (GRCm39) S199P probably benign Het
Smc1b T C 15: 85,001,305 (GRCm39) probably benign Het
Spata7 T C 12: 98,614,712 (GRCm39) S115P possibly damaging Het
Ssh2 A G 11: 77,316,146 (GRCm39) T250A possibly damaging Het
Sv2a A G 3: 96,098,071 (GRCm39) N558S probably benign Het
Tia1 T A 6: 86,401,305 (GRCm39) probably benign Het
Tmem39a A G 16: 38,405,561 (GRCm39) Y46C probably benign Het
Vmn2r2 A G 3: 64,024,578 (GRCm39) S668P possibly damaging Het
Vwa1 C A 4: 155,855,057 (GRCm39) A326S probably benign Het
Xpo6 A G 7: 125,752,115 (GRCm39) M327T probably benign Het
Other mutations in Mydgf
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00953:Mydgf APN 17 56,486,407 (GRCm39) missense probably damaging 0.99
R1276:Mydgf UTSW 17 56,486,362 (GRCm39) critical splice donor site probably null
R1616:Mydgf UTSW 17 56,486,415 (GRCm39) missense possibly damaging 0.92
R5784:Mydgf UTSW 17 56,485,254 (GRCm39) unclassified probably benign
R6863:Mydgf UTSW 17 56,490,789 (GRCm39) missense probably damaging 0.99
R6939:Mydgf UTSW 17 56,490,737 (GRCm39) critical splice donor site probably null
R8520:Mydgf UTSW 17 56,490,734 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- GGAAAGCCAGGAAGTCCTTC -3'
(R):5'- AGGATCTCCTTGTGTCACACTG -3'

Sequencing Primer
(F):5'- TGCATCTTCCCTGGCAAAACAG -3'
(R):5'- TTGTGTCACACTGCCCGG -3'
Posted On 2016-04-15