Incidental Mutation 'R4920:Ear2'
ID 378528
Institutional Source Beutler Lab
Gene Symbol Ear2
Ensembl Gene ENSMUSG00000072596
Gene Name eosinophil-associated, ribonuclease A family, member 2
Synonyms Rnase2, eosinophil-derived neurotoxin, liver
MMRRC Submission 042522-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R4920 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 44340111-44340988 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 44340582 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Glutamic Acid at position 80 (G80E)
Ref Sequence ENSEMBL: ENSMUSP00000074386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074839]
AlphaFold P97425
Predicted Effect probably damaging
Transcript: ENSMUST00000074839
AA Change: G80E

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000074386
Gene: ENSMUSG00000072596
AA Change: G80E

DomainStartEndE-ValueType
low complexity region 5 26 N/A INTRINSIC
RNAse_Pc 27 156 1.09e-57 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226587
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.1%
  • 20x: 87.9%
Validation Efficiency 96% (55/57)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700092K14Rik A T 11: 114,089,871 (GRCm39) noncoding transcript Het
Adcy4 C T 14: 56,016,486 (GRCm39) D322N probably damaging Het
Apbb1ip A G 2: 22,709,696 (GRCm39) D51G unknown Het
Bmal1 A G 7: 112,884,321 (GRCm39) T120A probably damaging Het
Brca1 A T 11: 101,415,785 (GRCm39) V783D probably damaging Het
Ccdc141 T C 2: 76,998,907 (GRCm39) D58G probably damaging Het
Ccr9 G T 9: 123,608,504 (GRCm39) G62V probably damaging Het
Ces2b T C 8: 105,563,538 (GRCm39) Y422H probably benign Het
Cpa4 T C 6: 30,568,462 (GRCm39) probably null Het
Dennd3 A G 15: 73,412,574 (GRCm39) H412R probably benign Het
Dpy19l3 A T 7: 35,407,467 (GRCm39) probably benign Het
Dtwd2 G T 18: 49,831,507 (GRCm39) R167S possibly damaging Het
Dync1i2 G A 2: 71,077,668 (GRCm39) R243Q probably damaging Het
Fam171b A G 2: 83,710,703 (GRCm39) K792E possibly damaging Het
Fam83b G A 9: 76,399,150 (GRCm39) T651I probably benign Het
Fcrl5 T G 3: 87,351,480 (GRCm39) F243V probably damaging Het
Galntl6 T C 8: 58,880,807 (GRCm39) I115M probably damaging Het
Glrx3 A G 7: 137,065,859 (GRCm39) D163G probably null Het
Gm14488 A T 2: 30,605,044 (GRCm39) noncoding transcript Het
Gm973 T C 1: 59,666,725 (GRCm39) S683P probably benign Het
Grhl3 T A 4: 135,286,415 (GRCm39) K89* probably null Het
Gsdmd T C 15: 75,736,206 (GRCm39) S112P probably damaging Het
Ighv14-3 A G 12: 114,023,877 (GRCm39) V6A probably benign Het
Lca5l T A 16: 95,980,035 (GRCm39) S32C probably damaging Het
Lrba T A 3: 86,571,765 (GRCm39) Y260* probably null Het
Lyst T C 13: 13,821,645 (GRCm39) S1340P possibly damaging Het
Mfsd13a T G 19: 46,355,655 (GRCm39) F59V probably damaging Het
Nek10 T A 14: 14,860,986 (GRCm38) L513M possibly damaging Het
Noa1 T C 5: 77,454,334 (GRCm39) probably null Het
Ofcc1 G A 13: 40,168,864 (GRCm39) T841I probably damaging Het
Pgm1 C T 4: 99,843,930 (GRCm39) T571M probably damaging Het
Pramel23 T C 4: 143,425,853 (GRCm39) D30G probably benign Het
Rfc1 C A 5: 65,445,271 (GRCm39) V460F probably damaging Het
Rrn3 A G 16: 13,608,503 (GRCm39) D182G probably benign Het
Sap25 T A 5: 137,640,507 (GRCm39) probably benign Het
Slc9a2 A G 1: 40,794,878 (GRCm39) I480V probably benign Het
Smo T C 6: 29,759,593 (GRCm39) S642P probably damaging Het
Tbc1d22a A C 15: 86,195,949 (GRCm39) I307L probably benign Het
Tent2 G A 13: 93,322,833 (GRCm39) Q39* probably null Het
Ubr3 A G 2: 69,783,212 (GRCm39) Q716R probably benign Het
Vmn2r96 A G 17: 18,802,918 (GRCm39) E276G probably benign Het
Zfp189 G A 4: 49,529,302 (GRCm39) C135Y probably damaging Het
Other mutations in Ear2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01700:Ear2 APN 14 44,340,716 (GRCm39) nonsense probably null
IGL01729:Ear2 APN 14 44,340,701 (GRCm39) nonsense probably null
R0346:Ear2 UTSW 14 44,340,363 (GRCm39) missense probably damaging 1.00
R0458:Ear2 UTSW 14 44,340,705 (GRCm39) missense probably damaging 1.00
R1035:Ear2 UTSW 14 44,340,344 (GRCm39) start codon destroyed possibly damaging 0.59
R5845:Ear2 UTSW 14 44,340,618 (GRCm39) missense probably benign 0.00
R6008:Ear2 UTSW 14 44,340,546 (GRCm39) missense probably damaging 1.00
R6432:Ear2 UTSW 14 44,340,660 (GRCm39) missense probably damaging 1.00
R6720:Ear2 UTSW 14 44,340,416 (GRCm39) missense probably damaging 0.99
R7721:Ear2 UTSW 14 44,340,495 (GRCm39) missense probably damaging 1.00
R8251:Ear2 UTSW 14 44,340,477 (GRCm39) missense probably benign 0.00
R8719:Ear2 UTSW 14 44,340,734 (GRCm39) missense possibly damaging 0.94
R9659:Ear2 UTSW 14 44,340,705 (GRCm39) missense probably damaging 1.00
R9776:Ear2 UTSW 14 44,340,729 (GRCm39) missense probably benign 0.02
R9788:Ear2 UTSW 14 44,340,705 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAATGCTTGCCTCATGCCTGG -3'
(R):5'- TCCAAGTGAACTGGAACCACTG -3'

Sequencing Primer
(F):5'- GCCTCATGCCTGGGACAAAC -3'
(R):5'- TGAACTGGAACCACTGGATAC -3'
Posted On 2016-04-15