Incidental Mutation 'R4921:Robo4'
| ID |
378601 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo4
|
| Ensembl Gene |
ENSMUSG00000032125 |
| Gene Name |
roundabout guidance receptor 4 |
| Synonyms |
Magic roundabout, 1200012D01Rik |
| MMRRC Submission |
042523-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.217)
|
| Stock # |
R4921 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
37313198-37325319 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 37313856 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Lysine
at position 36
(E36K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150722
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102895]
[ENSMUST00000115046]
[ENSMUST00000115048]
[ENSMUST00000156972]
[ENSMUST00000214185]
|
| AlphaFold |
Q8C310 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102895
AA Change: E36K
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000099959
Gene: ENSMUSG00000032125
AA Change: E36K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
748 |
762 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
799 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
866 |
N/A |
INTRINSIC |
|
low complexity region
|
871 |
880 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115046
AA Change: E36K
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000110698
Gene: ENSMUSG00000032125
AA Change: E36K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
484 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
540 |
546 |
N/A |
INTRINSIC |
|
low complexity region
|
596 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
756 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
821 |
N/A |
INTRINSIC |
|
low complexity region
|
834 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
914 |
925 |
N/A |
INTRINSIC |
|
low complexity region
|
930 |
939 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115048
|
| SMART Domains |
Protein: ENSMUSP00000110700
Gene: ENSMUSG00000032125
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
695 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
727 |
740 |
N/A |
INTRINSIC |
|
low complexity region
|
755 |
769 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
806 |
N/A |
INTRINSIC |
|
low complexity region
|
862 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
887 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156972
AA Change: E36K
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000214185
AA Change: E36K
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.7%
- 20x: 90.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a reporter/null allele display enhanced VEGF-induced endothelial migration, tube formation and vascular permeability, and show increased pathologic angiogenesis and vascular leak in models of oxygen-induced retinopathy and choroidal neovascularization. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
A |
T |
5: 109,885,662 (GRCm39) |
N65K |
probably benign |
Het |
| Abcc9 |
T |
C |
6: 142,536,162 (GRCm39) |
Y1524C |
probably benign |
Het |
| Acap1 |
A |
G |
11: 69,778,019 (GRCm39) |
I102T |
probably damaging |
Het |
| Acvr2a |
T |
C |
2: 48,783,553 (GRCm39) |
V284A |
possibly damaging |
Het |
| Adam3 |
T |
C |
8: 25,174,630 (GRCm39) |
M712V |
probably benign |
Het |
| Adck1 |
T |
C |
12: 88,407,908 (GRCm39) |
V213A |
probably benign |
Het |
| Adgrl3 |
G |
T |
5: 81,659,957 (GRCm39) |
W242L |
probably damaging |
Het |
| Alk |
T |
C |
17: 72,211,310 (GRCm39) |
T857A |
probably benign |
Het |
| Alms1 |
A |
G |
6: 85,605,528 (GRCm39) |
T2393A |
probably benign |
Het |
| Ank3 |
C |
T |
10: 69,837,939 (GRCm39) |
P240L |
probably damaging |
Het |
| Ankrd35 |
C |
A |
3: 96,592,140 (GRCm39) |
L809M |
possibly damaging |
Het |
| Birc6 |
T |
A |
17: 74,957,094 (GRCm39) |
L3690Q |
probably damaging |
Het |
| Bmp3 |
C |
A |
5: 99,019,920 (GRCm39) |
F114L |
probably damaging |
Het |
| Cage1 |
G |
A |
13: 38,203,184 (GRCm39) |
H627Y |
probably benign |
Het |
| Cars1 |
T |
C |
7: 143,123,212 (GRCm39) |
D468G |
probably damaging |
Het |
| Ccdc148 |
T |
C |
2: 58,719,814 (GRCm39) |
E487G |
probably damaging |
Het |
| Ccdc80 |
A |
T |
16: 44,938,530 (GRCm39) |
I746F |
probably damaging |
Het |
| Ccl25 |
A |
G |
8: 4,403,913 (GRCm39) |
Q119R |
possibly damaging |
Het |
| Cdh24 |
C |
T |
14: 54,870,672 (GRCm39) |
D178N |
probably damaging |
Het |
| Cdk12 |
A |
T |
11: 98,113,513 (GRCm39) |
T766S |
unknown |
Het |
| Chst15 |
T |
A |
7: 131,849,613 (GRCm39) |
T443S |
probably benign |
Het |
| Cnbp |
T |
C |
6: 87,822,128 (GRCm39) |
D125G |
possibly damaging |
Het |
| Cntn2 |
A |
T |
1: 132,443,770 (GRCm39) |
V1003E |
possibly damaging |
Het |
| Crct1 |
A |
G |
3: 92,922,132 (GRCm39) |
|
probably benign |
Het |
| Dand5 |
C |
T |
8: 85,543,113 (GRCm39) |
C121Y |
probably damaging |
Het |
| Dmkn |
A |
T |
7: 30,470,658 (GRCm39) |
D382V |
probably damaging |
Het |
| Dnase2b |
T |
A |
3: 146,299,196 (GRCm39) |
T86S |
probably damaging |
Het |
| Dusp8 |
GCCACCACCACCACCACCACCACC |
GCCACCACCACCACCACCACC |
7: 141,635,891 (GRCm39) |
|
probably benign |
Het |
| Eef1akmt1 |
C |
T |
14: 57,788,089 (GRCm39) |
V90M |
probably damaging |
Het |
| Egfl7 |
G |
T |
2: 26,480,992 (GRCm39) |
W168L |
probably benign |
Het |
| Ep400 |
A |
G |
5: 110,813,676 (GRCm39) |
C2908R |
probably damaging |
Het |
| Espl1 |
A |
G |
15: 102,223,676 (GRCm39) |
K1076E |
probably damaging |
Het |
| Exoc4 |
A |
G |
6: 33,887,452 (GRCm39) |
N747D |
probably benign |
Het |
| Fancm |
T |
C |
12: 65,123,915 (GRCm39) |
V191A |
probably benign |
Het |
| Fbxo17 |
A |
G |
7: 28,432,214 (GRCm39) |
D97G |
probably benign |
Het |
| Fer1l6 |
G |
T |
15: 58,472,160 (GRCm39) |
|
probably null |
Het |
| Flt4 |
T |
C |
11: 49,517,970 (GRCm39) |
W337R |
probably damaging |
Het |
| Fpr-rs7 |
T |
C |
17: 20,334,082 (GRCm39) |
H136R |
possibly damaging |
Het |
| Frem3 |
T |
A |
8: 81,339,765 (GRCm39) |
I686N |
possibly damaging |
Het |
| Galnt9 |
A |
G |
5: 110,725,315 (GRCm39) |
K84R |
probably damaging |
Het |
| Gfm2 |
T |
A |
13: 97,312,184 (GRCm39) |
M760K |
probably damaging |
Het |
| Glis3 |
T |
C |
19: 28,643,504 (GRCm39) |
T13A |
probably damaging |
Het |
| H2-K2 |
A |
G |
17: 34,216,050 (GRCm39) |
V323A |
possibly damaging |
Het |
| Hbb-bs |
G |
A |
7: 103,475,927 (GRCm39) |
A130V |
probably damaging |
Het |
| Herc2 |
T |
A |
7: 55,879,438 (GRCm39) |
H4685Q |
probably benign |
Het |
| Ighv5-9-1 |
C |
T |
12: 113,699,914 (GRCm39) |
R56H |
possibly damaging |
Het |
| Itgb4 |
A |
G |
11: 115,897,431 (GRCm39) |
N1548S |
probably benign |
Het |
| Itpr3 |
T |
C |
17: 27,316,979 (GRCm39) |
Y745H |
probably damaging |
Het |
| Kank3 |
G |
T |
17: 34,036,174 (GRCm39) |
G14V |
probably damaging |
Het |
| Kif24 |
G |
T |
4: 41,394,329 (GRCm39) |
S982Y |
probably damaging |
Het |
| Kifc5b |
C |
T |
17: 27,139,997 (GRCm39) |
R53W |
probably damaging |
Het |
| Krt39 |
A |
G |
11: 99,405,575 (GRCm39) |
S442P |
possibly damaging |
Het |
| Lcat |
G |
A |
8: 106,669,074 (GRCm39) |
P67L |
possibly damaging |
Het |
| Maml2 |
T |
C |
9: 13,532,471 (GRCm39) |
S562P |
probably damaging |
Het |
| Map3k8 |
G |
A |
18: 4,349,124 (GRCm39) |
R65W |
possibly damaging |
Het |
| Mbd3 |
G |
T |
10: 80,231,410 (GRCm39) |
R12S |
probably damaging |
Het |
| Msr1 |
T |
C |
8: 40,077,292 (GRCm39) |
E106G |
possibly damaging |
Het |
| Myh4 |
T |
A |
11: 67,144,854 (GRCm39) |
L1256Q |
probably damaging |
Het |
| Mypn |
G |
A |
10: 62,983,715 (GRCm39) |
T511M |
possibly damaging |
Het |
| Nub1 |
A |
T |
5: 24,906,467 (GRCm39) |
N331I |
probably benign |
Het |
| Nup107 |
A |
G |
10: 117,606,416 (GRCm39) |
V440A |
possibly damaging |
Het |
| Ofcc1 |
A |
G |
13: 40,367,993 (GRCm39) |
F174L |
probably benign |
Het |
| Or10d5 |
A |
C |
9: 39,861,521 (GRCm39) |
V182G |
probably damaging |
Het |
| Or52ab2 |
A |
T |
7: 102,969,750 (GRCm39) |
N44I |
probably damaging |
Het |
| Or9q2 |
T |
C |
19: 13,772,829 (GRCm39) |
I49V |
probably benign |
Het |
| Parp2 |
C |
A |
14: 51,056,725 (GRCm39) |
L310I |
probably damaging |
Het |
| Pcdh20 |
A |
G |
14: 88,707,162 (GRCm39) |
V46A |
probably benign |
Het |
| Pcdhgb6 |
A |
G |
18: 37,876,525 (GRCm39) |
D411G |
probably damaging |
Het |
| Pkd1l2 |
T |
C |
8: 117,781,624 (GRCm39) |
E807G |
probably benign |
Het |
| Pkd1l2 |
A |
T |
8: 117,799,288 (GRCm39) |
N267K |
probably damaging |
Het |
| Pramel24 |
A |
T |
4: 143,454,896 (GRCm39) |
K398M |
possibly damaging |
Het |
| Rell1 |
C |
A |
5: 64,093,376 (GRCm39) |
M126I |
probably damaging |
Het |
| Rpgrip1l |
T |
C |
8: 91,987,637 (GRCm39) |
S807G |
probably benign |
Het |
| Rpl10a |
T |
C |
17: 28,549,826 (GRCm39) |
V169A |
probably benign |
Het |
| Rubcn |
C |
T |
16: 32,667,664 (GRCm39) |
V166I |
probably damaging |
Het |
| Sall2 |
T |
C |
14: 52,552,850 (GRCm39) |
E113G |
possibly damaging |
Het |
| Sars2 |
T |
C |
7: 28,451,863 (GRCm39) |
S423P |
possibly damaging |
Het |
| Scaper |
A |
G |
9: 55,799,519 (GRCm39) |
I182T |
probably benign |
Het |
| Selp |
A |
G |
1: 163,968,966 (GRCm39) |
D522G |
possibly damaging |
Het |
| Sema4b |
T |
A |
7: 79,848,504 (GRCm39) |
I35N |
possibly damaging |
Het |
| Sgce |
A |
T |
6: 4,694,153 (GRCm39) |
F268I |
probably damaging |
Het |
| Slc14a2 |
G |
T |
18: 78,235,403 (GRCm39) |
A258E |
probably damaging |
Het |
| Slc17a9 |
T |
C |
2: 180,377,742 (GRCm39) |
Y213H |
probably benign |
Het |
| Slc22a7 |
T |
G |
17: 46,747,859 (GRCm39) |
I233L |
probably benign |
Het |
| Slc35f1 |
A |
G |
10: 52,938,698 (GRCm39) |
Q210R |
probably damaging |
Het |
| Slc6a21 |
A |
G |
7: 44,937,734 (GRCm39) |
E350G |
possibly damaging |
Het |
| Spata21 |
A |
T |
4: 140,839,402 (GRCm39) |
D639V |
probably damaging |
Het |
| Svil |
A |
G |
18: 5,108,631 (GRCm39) |
D1519G |
probably damaging |
Het |
| Tbccd1 |
T |
C |
16: 22,660,649 (GRCm39) |
T56A |
probably benign |
Het |
| Tigit |
A |
T |
16: 43,482,380 (GRCm39) |
I118N |
probably damaging |
Het |
| Tlr11 |
A |
T |
14: 50,600,342 (GRCm39) |
Q776L |
possibly damaging |
Het |
| Tspan12 |
A |
C |
6: 21,835,448 (GRCm39) |
I9S |
possibly damaging |
Het |
| Unc5c |
T |
A |
3: 141,494,727 (GRCm39) |
Y347N |
probably damaging |
Het |
| Unk |
A |
G |
11: 115,945,771 (GRCm39) |
T481A |
probably benign |
Het |
| Vmn1r192 |
A |
C |
13: 22,371,650 (GRCm39) |
V190G |
probably damaging |
Het |
| Vnn3 |
A |
T |
10: 23,740,473 (GRCm39) |
M259L |
probably benign |
Het |
| Zan |
T |
C |
5: 137,406,632 (GRCm39) |
|
probably benign |
Het |
| Zdhhc6 |
T |
C |
19: 55,301,642 (GRCm39) |
H113R |
probably damaging |
Het |
|
| Other mutations in Robo4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Robo4
|
APN |
9 |
37,322,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00392:Robo4
|
APN |
9 |
37,319,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00491:Robo4
|
APN |
9 |
37,317,231 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL00792:Robo4
|
APN |
9 |
37,319,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01062:Robo4
|
APN |
9 |
37,317,296 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01287:Robo4
|
APN |
9 |
37,324,336 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02289:Robo4
|
APN |
9 |
37,319,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02486:Robo4
|
APN |
9 |
37,319,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02851:Robo4
|
APN |
9 |
37,324,678 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02898:Robo4
|
APN |
9 |
37,319,472 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02965:Robo4
|
APN |
9 |
37,321,765 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03071:Robo4
|
APN |
9 |
37,315,580 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Robo4
|
APN |
9 |
37,315,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8562:Robo4
|
UTSW |
9 |
37,317,106 (GRCm39) |
intron |
probably benign |
|
|
PIT4305001:Robo4
|
UTSW |
9 |
37,322,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0068:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0416:Robo4
|
UTSW |
9 |
37,316,062 (GRCm39) |
splice site |
probably benign |
|
|
R1005:Robo4
|
UTSW |
9 |
37,319,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1174:Robo4
|
UTSW |
9 |
37,324,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1183:Robo4
|
UTSW |
9 |
37,319,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1254:Robo4
|
UTSW |
9 |
37,322,136 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1398:Robo4
|
UTSW |
9 |
37,319,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1505:Robo4
|
UTSW |
9 |
37,314,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Robo4
|
UTSW |
9 |
37,314,739 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1834:Robo4
|
UTSW |
9 |
37,324,355 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1899:Robo4
|
UTSW |
9 |
37,315,366 (GRCm39) |
splice site |
probably benign |
|
|
R2203:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2204:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2351:Robo4
|
UTSW |
9 |
37,322,956 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2448:Robo4
|
UTSW |
9 |
37,313,958 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2847:Robo4
|
UTSW |
9 |
37,315,772 (GRCm39) |
nonsense |
probably null |
|
|
R2851:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2852:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2877:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3123:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3124:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3125:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3805:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3806:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3892:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3905:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R3938:Robo4
|
UTSW |
9 |
37,313,313 (GRCm39) |
start gained |
probably benign |
|
|
R4261:Robo4
|
UTSW |
9 |
37,316,877 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4434:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4435:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4561:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4562:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4568:Robo4
|
UTSW |
9 |
37,316,118 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4695:Robo4
|
UTSW |
9 |
37,314,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5000:Robo4
|
UTSW |
9 |
37,319,664 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5056:Robo4
|
UTSW |
9 |
37,316,102 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5125:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5178:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5279:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5285:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5347:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5348:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5361:Robo4
|
UTSW |
9 |
37,324,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5403:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5404:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5488:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5489:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5490:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5494:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5629:Robo4
|
UTSW |
9 |
37,319,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5736:Robo4
|
UTSW |
9 |
37,316,093 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5796:Robo4
|
UTSW |
9 |
37,322,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5987:Robo4
|
UTSW |
9 |
37,322,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6178:Robo4
|
UTSW |
9 |
37,316,926 (GRCm39) |
nonsense |
probably null |
|
|
R6189:Robo4
|
UTSW |
9 |
37,314,829 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6365:Robo4
|
UTSW |
9 |
37,322,008 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6528:Robo4
|
UTSW |
9 |
37,315,664 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6887:Robo4
|
UTSW |
9 |
37,313,363 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7196:Robo4
|
UTSW |
9 |
37,314,001 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7408:Robo4
|
UTSW |
9 |
37,322,277 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7419:Robo4
|
UTSW |
9 |
37,314,105 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7486:Robo4
|
UTSW |
9 |
37,316,870 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7707:Robo4
|
UTSW |
9 |
37,324,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7839:Robo4
|
UTSW |
9 |
37,322,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8079:Robo4
|
UTSW |
9 |
37,313,931 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8081:Robo4
|
UTSW |
9 |
37,316,936 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8280:Robo4
|
UTSW |
9 |
37,315,372 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8526:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R8547:Robo4
|
UTSW |
9 |
37,315,674 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8735:Robo4
|
UTSW |
9 |
37,319,577 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8836:Robo4
|
UTSW |
9 |
37,317,130 (GRCm39) |
missense |
unknown |
|
|
R8889:Robo4
|
UTSW |
9 |
37,314,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9018:Robo4
|
UTSW |
9 |
37,315,520 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Robo4
|
UTSW |
9 |
37,313,206 (GRCm39) |
start gained |
probably benign |
|
|
R9375:Robo4
|
UTSW |
9 |
37,316,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9621:Robo4
|
UTSW |
9 |
37,317,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGAGCATCTCTGTTGTCTGG -3'
(R):5'- CCGGCAAAAGGTAATGTAGGTC -3'
Sequencing Primer
(F):5'- CCTTTCTTCTAGTTAGCAGTGAAG -3'
(R):5'- CAAAAGGTAATGTAGGTCTGGGGTG -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation