Incidental Mutation 'R4923:Dennd4c'
| ID |
378761 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd4c
|
| Ensembl Gene |
ENSMUSG00000038024 |
| Gene Name |
DENN domain containing 4C |
| Synonyms |
1700065A05Rik |
| MMRRC Submission |
042525-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4923 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
86666792-86768840 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 86725775 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 743
(L743P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123367
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045512]
[ENSMUST00000082026]
[ENSMUST00000142837]
|
| AlphaFold |
A6H8H2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000045512
AA Change: L743P
PolyPhen 2
Score 0.921 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000039860
Gene: ENSMUSG00000038024
AA Change: L743P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.15e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000082026
AA Change: L743P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000080685
Gene: ENSMUSG00000038024
AA Change: L743P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
3.19e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1724 |
1739 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000142837
AA Change: L743P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000123367
Gene: ENSMUSG00000038024
AA Change: L743P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.68e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
934 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
964 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
996 |
1003 |
N/A |
INTRINSIC |
|
low complexity region
|
1053 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1343 |
N/A |
INTRINSIC |
|
low complexity region
|
1423 |
1437 |
N/A |
INTRINSIC |
|
low complexity region
|
1675 |
1690 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1456 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.2%
- 10x: 96.0%
- 20x: 91.3%
|
| Validation Efficiency |
98% (107/109) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aim2 |
A |
G |
1: 173,287,372 (GRCm39) |
D124G |
probably benign |
Het |
| Akr1c6 |
T |
C |
13: 4,504,494 (GRCm39) |
M293T |
probably damaging |
Het |
| Albfm1 |
A |
G |
5: 90,709,158 (GRCm39) |
T23A |
probably benign |
Het |
| Ankhd1 |
A |
G |
18: 36,722,505 (GRCm39) |
T343A |
probably damaging |
Het |
| Ano2 |
T |
C |
6: 125,880,018 (GRCm39) |
|
probably benign |
Het |
| Arfgap2 |
G |
A |
2: 91,104,004 (GRCm39) |
G353R |
probably damaging |
Het |
| Armc3 |
A |
G |
2: 19,297,791 (GRCm39) |
|
probably null |
Het |
| Atp11b |
T |
C |
3: 35,889,528 (GRCm39) |
|
probably null |
Het |
| Brd4 |
A |
G |
17: 32,418,214 (GRCm39) |
M13T |
probably benign |
Het |
| Btd |
T |
A |
14: 31,384,044 (GRCm39) |
M10K |
possibly damaging |
Het |
| C1s2 |
T |
C |
6: 124,602,649 (GRCm39) |
K515E |
probably benign |
Het |
| Cars1 |
A |
T |
7: 143,123,587 (GRCm39) |
Y455N |
probably damaging |
Het |
| Ccdc110 |
A |
G |
8: 46,396,460 (GRCm39) |
S784G |
probably benign |
Het |
| Chic2 |
A |
G |
5: 75,171,872 (GRCm39) |
|
probably benign |
Het |
| Chka |
A |
T |
19: 3,942,105 (GRCm39) |
|
probably null |
Het |
| Chrne |
A |
G |
11: 70,506,101 (GRCm39) |
I420T |
possibly damaging |
Het |
| Clstn1 |
T |
C |
4: 149,729,486 (GRCm39) |
V747A |
probably benign |
Het |
| Cobll1 |
A |
G |
2: 64,929,602 (GRCm39) |
S575P |
possibly damaging |
Het |
| Col6a6 |
A |
T |
9: 105,666,147 (GRCm39) |
L3Q |
probably damaging |
Het |
| Comtd1 |
A |
T |
14: 21,898,813 (GRCm39) |
|
probably benign |
Het |
| Cpsf2 |
T |
C |
12: 101,948,243 (GRCm39) |
V13A |
probably benign |
Het |
| Creb3l4 |
T |
A |
3: 90,149,521 (GRCm39) |
I115L |
probably benign |
Het |
| Cyp2j12 |
C |
T |
4: 95,990,346 (GRCm39) |
A407T |
possibly damaging |
Het |
| Ddr2 |
A |
G |
1: 169,825,498 (GRCm39) |
|
probably null |
Het |
| Egfl8 |
T |
C |
17: 34,833,171 (GRCm39) |
T192A |
probably benign |
Het |
| Elapor1 |
C |
T |
3: 108,379,284 (GRCm39) |
|
probably null |
Het |
| Elf3 |
A |
G |
1: 135,184,473 (GRCm39) |
|
probably benign |
Het |
| Entrep2 |
A |
G |
7: 64,417,439 (GRCm39) |
S322P |
probably benign |
Het |
| Etv3 |
T |
G |
3: 87,443,223 (GRCm39) |
L269R |
possibly damaging |
Het |
| Fah |
C |
A |
7: 84,251,260 (GRCm39) |
|
probably benign |
Het |
| Fbll1 |
C |
A |
11: 35,688,407 (GRCm39) |
L285F |
probably benign |
Het |
| Fcrla |
A |
T |
1: 170,748,682 (GRCm39) |
F154I |
probably damaging |
Het |
| Fnip2 |
T |
A |
3: 79,396,701 (GRCm39) |
|
probably null |
Het |
| Focad |
T |
C |
4: 88,115,083 (GRCm39) |
|
probably benign |
Het |
| Gabrr1 |
T |
A |
4: 33,162,820 (GRCm39) |
I462N |
possibly damaging |
Het |
| Gm57859 |
C |
A |
11: 113,579,805 (GRCm39) |
T400K |
probably benign |
Het |
| Gnptab |
A |
G |
10: 88,265,485 (GRCm39) |
T366A |
probably benign |
Het |
| Hnrnpu |
G |
A |
1: 178,159,017 (GRCm39) |
|
probably benign |
Het |
| Il17ra |
T |
A |
6: 120,454,406 (GRCm39) |
V299E |
possibly damaging |
Het |
| Impg1 |
G |
A |
9: 80,252,360 (GRCm39) |
Q607* |
probably null |
Het |
| Impg1 |
T |
A |
9: 80,252,827 (GRCm39) |
E374V |
probably damaging |
Het |
| Itgax |
C |
T |
7: 127,747,700 (GRCm39) |
L1039F |
probably benign |
Het |
| Kcnk2 |
A |
T |
1: 189,072,133 (GRCm39) |
V65D |
probably damaging |
Het |
| Kif20b |
A |
C |
19: 34,918,611 (GRCm39) |
|
probably null |
Het |
| Krt9 |
TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC |
TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC |
11: 100,079,903 (GRCm39) |
|
probably benign |
Het |
| Lama5 |
T |
G |
2: 179,825,942 (GRCm39) |
I2372L |
probably benign |
Het |
| Lilrb4a |
A |
G |
10: 51,368,139 (GRCm39) |
T85A |
possibly damaging |
Het |
| Mapk13 |
C |
A |
17: 28,997,197 (GRCm39) |
H330N |
probably benign |
Het |
| Mars1 |
C |
A |
10: 127,132,549 (GRCm39) |
|
probably benign |
Het |
| Mdga1 |
C |
A |
17: 30,057,052 (GRCm39) |
R818L |
probably damaging |
Het |
| Mdn1 |
T |
A |
4: 32,671,608 (GRCm39) |
L476Q |
possibly damaging |
Het |
| Mup21 |
T |
C |
4: 62,066,202 (GRCm39) |
E178G |
probably benign |
Het |
| Myg1 |
A |
G |
15: 102,240,288 (GRCm39) |
N38S |
probably benign |
Het |
| Ncam1 |
A |
T |
9: 49,416,779 (GRCm39) |
D837E |
probably benign |
Het |
| Ncam2 |
C |
T |
16: 81,386,679 (GRCm39) |
P686L |
possibly damaging |
Het |
| Nck2 |
T |
C |
1: 43,500,231 (GRCm39) |
|
probably benign |
Het |
| Nfya |
T |
C |
17: 48,707,563 (GRCm39) |
|
probably benign |
Het |
| Npat |
A |
G |
9: 53,482,330 (GRCm39) |
K1346R |
probably damaging |
Het |
| Odad2 |
C |
G |
18: 7,181,787 (GRCm39) |
D846H |
probably damaging |
Het |
| Or12j3 |
G |
T |
7: 139,952,920 (GRCm39) |
T201K |
probably benign |
Het |
| Or4a72 |
T |
C |
2: 89,406,023 (GRCm39) |
T16A |
probably damaging |
Het |
| Or6c212 |
A |
G |
10: 129,558,681 (GRCm39) |
V244A |
probably benign |
Het |
| Pde7b |
G |
T |
10: 20,288,873 (GRCm39) |
Q325K |
probably damaging |
Het |
| Pla2r1 |
A |
T |
2: 60,253,056 (GRCm39) |
M1345K |
probably benign |
Het |
| Prkcz |
T |
C |
4: 155,441,946 (GRCm39) |
D62G |
probably damaging |
Het |
| Pros1 |
T |
A |
16: 62,723,935 (GRCm39) |
C228S |
possibly damaging |
Het |
| Ptprc |
A |
G |
1: 138,006,236 (GRCm39) |
M782T |
possibly damaging |
Het |
| Rcn1 |
T |
C |
2: 105,219,518 (GRCm39) |
D225G |
probably benign |
Het |
| Recql4 |
G |
A |
15: 76,594,381 (GRCm39) |
R46C |
probably damaging |
Het |
| Rnf220 |
C |
T |
4: 117,346,797 (GRCm39) |
R205Q |
possibly damaging |
Het |
| Samd13 |
T |
C |
3: 146,368,502 (GRCm39) |
D11G |
probably benign |
Het |
| Scp2d1 |
T |
A |
2: 144,666,030 (GRCm39) |
I123K |
probably benign |
Het |
| Skap1 |
A |
T |
11: 96,644,870 (GRCm39) |
Y311F |
probably damaging |
Het |
| Slc2a10 |
T |
C |
2: 165,356,676 (GRCm39) |
I112T |
possibly damaging |
Het |
| Slc34a1 |
G |
A |
13: 24,003,078 (GRCm39) |
V243M |
probably benign |
Het |
| Slc39a2 |
G |
A |
14: 52,132,711 (GRCm39) |
G218D |
probably damaging |
Het |
| Sos1 |
T |
C |
17: 80,742,381 (GRCm39) |
N382S |
probably benign |
Het |
| Spam1 |
C |
T |
6: 24,796,655 (GRCm39) |
T202I |
probably damaging |
Het |
| Tas2r138 |
T |
A |
6: 40,589,820 (GRCm39) |
Q142L |
possibly damaging |
Het |
| Tec |
T |
A |
5: 72,939,365 (GRCm39) |
R217* |
probably null |
Het |
| Tmeff2 |
T |
A |
1: 50,969,804 (GRCm39) |
V90D |
probably benign |
Het |
| Tmem119 |
T |
C |
5: 113,933,405 (GRCm39) |
Y132C |
probably damaging |
Het |
| Topbp1 |
A |
G |
9: 103,190,035 (GRCm39) |
I204V |
probably benign |
Het |
| Trappc14 |
A |
T |
5: 138,260,641 (GRCm39) |
|
probably benign |
Het |
| Ttn |
A |
T |
2: 76,601,232 (GRCm39) |
I17001N |
probably damaging |
Het |
| Vit |
T |
A |
17: 78,894,270 (GRCm39) |
M224K |
probably benign |
Het |
| Vmn1r179 |
T |
G |
7: 23,628,491 (GRCm39) |
H227Q |
possibly damaging |
Het |
| Vmn1r84 |
T |
C |
7: 12,095,743 (GRCm39) |
N305D |
probably benign |
Het |
| Vmn2r61 |
A |
G |
7: 41,916,520 (GRCm39) |
N378D |
probably damaging |
Het |
| Vmn2r87 |
A |
G |
10: 130,314,435 (GRCm39) |
Y384H |
probably damaging |
Het |
| Wiz |
C |
T |
17: 32,580,570 (GRCm39) |
A294T |
probably benign |
Het |
| Xdh |
C |
A |
17: 74,231,931 (GRCm39) |
V260L |
possibly damaging |
Het |
| Xirp2 |
A |
G |
2: 67,343,237 (GRCm39) |
K1826R |
probably benign |
Het |
| Zfp445 |
A |
C |
9: 122,681,358 (GRCm39) |
I861R |
probably benign |
Het |
| Zfp691 |
T |
C |
4: 119,027,999 (GRCm39) |
T78A |
probably benign |
Het |
|
| Other mutations in Dennd4c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01309:Dennd4c
|
APN |
4 |
86,723,724 (GRCm39) |
splice site |
probably benign |
|
|
IGL01810:Dennd4c
|
APN |
4 |
86,717,788 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02203:Dennd4c
|
APN |
4 |
86,721,173 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02217:Dennd4c
|
APN |
4 |
86,732,036 (GRCm39) |
missense |
probably benign |
|
|
IGL02236:Dennd4c
|
APN |
4 |
86,725,672 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02256:Dennd4c
|
APN |
4 |
86,717,778 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02396:Dennd4c
|
APN |
4 |
86,743,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02523:Dennd4c
|
APN |
4 |
86,692,490 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02615:Dennd4c
|
APN |
4 |
86,739,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03069:Dennd4c
|
APN |
4 |
86,692,674 (GRCm39) |
nonsense |
probably null |
|
|
IGL03116:Dennd4c
|
APN |
4 |
86,707,057 (GRCm39) |
splice site |
probably benign |
|
|
IGL03117:Dennd4c
|
APN |
4 |
86,696,140 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03273:Dennd4c
|
APN |
4 |
86,696,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03329:Dennd4c
|
APN |
4 |
86,696,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03365:Dennd4c
|
APN |
4 |
86,725,663 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
PIT4486001:Dennd4c
|
UTSW |
4 |
86,717,701 (GRCm39) |
nonsense |
probably null |
|
|
R0010:Dennd4c
|
UTSW |
4 |
86,699,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0032:Dennd4c
|
UTSW |
4 |
86,746,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0032:Dennd4c
|
UTSW |
4 |
86,746,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0092:Dennd4c
|
UTSW |
4 |
86,699,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,730,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,730,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0511:Dennd4c
|
UTSW |
4 |
86,744,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0515:Dennd4c
|
UTSW |
4 |
86,731,703 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0578:Dennd4c
|
UTSW |
4 |
86,730,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0759:Dennd4c
|
UTSW |
4 |
86,707,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0784:Dennd4c
|
UTSW |
4 |
86,763,145 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1156:Dennd4c
|
UTSW |
4 |
86,725,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1370:Dennd4c
|
UTSW |
4 |
86,729,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1381:Dennd4c
|
UTSW |
4 |
86,692,769 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1569:Dennd4c
|
UTSW |
4 |
86,704,331 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1747:Dennd4c
|
UTSW |
4 |
86,725,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1764:Dennd4c
|
UTSW |
4 |
86,721,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Dennd4c
|
UTSW |
4 |
86,743,415 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1997:Dennd4c
|
UTSW |
4 |
86,755,634 (GRCm39) |
missense |
probably benign |
|
|
R2244:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2348:Dennd4c
|
UTSW |
4 |
86,729,764 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2968:Dennd4c
|
UTSW |
4 |
86,699,881 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3033:Dennd4c
|
UTSW |
4 |
86,743,557 (GRCm39) |
small deletion |
probably benign |
|
|
R3401:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3402:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3403:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3855:Dennd4c
|
UTSW |
4 |
86,698,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3939:Dennd4c
|
UTSW |
4 |
86,692,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4164:Dennd4c
|
UTSW |
4 |
86,725,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4384:Dennd4c
|
UTSW |
4 |
86,729,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4435:Dennd4c
|
UTSW |
4 |
86,716,312 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4788:Dennd4c
|
UTSW |
4 |
86,738,200 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4801:Dennd4c
|
UTSW |
4 |
86,738,121 (GRCm39) |
nonsense |
probably null |
|
|
R4802:Dennd4c
|
UTSW |
4 |
86,738,121 (GRCm39) |
nonsense |
probably null |
|
|
R4818:Dennd4c
|
UTSW |
4 |
86,743,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4958:Dennd4c
|
UTSW |
4 |
86,699,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Dennd4c
|
UTSW |
4 |
86,713,536 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5434:Dennd4c
|
UTSW |
4 |
86,729,693 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5662:Dennd4c
|
UTSW |
4 |
86,713,525 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5802:Dennd4c
|
UTSW |
4 |
86,729,690 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5849:Dennd4c
|
UTSW |
4 |
86,744,223 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5861:Dennd4c
|
UTSW |
4 |
86,709,589 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5970:Dennd4c
|
UTSW |
4 |
86,743,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Dennd4c
|
UTSW |
4 |
86,723,828 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6356:Dennd4c
|
UTSW |
4 |
86,743,686 (GRCm39) |
missense |
probably benign |
|
|
R6661:Dennd4c
|
UTSW |
4 |
86,717,626 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6855:Dennd4c
|
UTSW |
4 |
86,754,694 (GRCm39) |
missense |
probably benign |
|
|
R6983:Dennd4c
|
UTSW |
4 |
86,717,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7035:Dennd4c
|
UTSW |
4 |
86,730,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7126:Dennd4c
|
UTSW |
4 |
86,725,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7185:Dennd4c
|
UTSW |
4 |
86,729,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7212:Dennd4c
|
UTSW |
4 |
86,721,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7324:Dennd4c
|
UTSW |
4 |
86,747,975 (GRCm39) |
missense |
unknown |
|
|
R7329:Dennd4c
|
UTSW |
4 |
86,698,111 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7329:Dennd4c
|
UTSW |
4 |
86,759,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7466:Dennd4c
|
UTSW |
4 |
86,692,568 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7479:Dennd4c
|
UTSW |
4 |
86,717,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7538:Dennd4c
|
UTSW |
4 |
86,692,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7599:Dennd4c
|
UTSW |
4 |
86,729,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7688:Dennd4c
|
UTSW |
4 |
86,713,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7725:Dennd4c
|
UTSW |
4 |
86,704,330 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7751:Dennd4c
|
UTSW |
4 |
86,747,179 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7790:Dennd4c
|
UTSW |
4 |
86,717,754 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8056:Dennd4c
|
UTSW |
4 |
86,763,213 (GRCm39) |
missense |
probably null |
0.71 |
|
R8307:Dennd4c
|
UTSW |
4 |
86,744,109 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8494:Dennd4c
|
UTSW |
4 |
86,759,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8531:Dennd4c
|
UTSW |
4 |
86,744,319 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9014:Dennd4c
|
UTSW |
4 |
86,754,666 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9014:Dennd4c
|
UTSW |
4 |
86,739,702 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9017:Dennd4c
|
UTSW |
4 |
86,743,349 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9142:Dennd4c
|
UTSW |
4 |
86,755,637 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9224:Dennd4c
|
UTSW |
4 |
86,738,170 (GRCm39) |
nonsense |
probably null |
|
|
R9570:Dennd4c
|
UTSW |
4 |
86,747,208 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9644:Dennd4c
|
UTSW |
4 |
86,713,363 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9649:Dennd4c
|
UTSW |
4 |
86,743,160 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9658:Dennd4c
|
UTSW |
4 |
86,754,625 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGGACATTCTGTAATACGAGC -3'
(R):5'- GTTTGTTTGAATCTCAAGACTTCCC -3'
Sequencing Primer
(F):5'- CGAGCAATGTTTTCTCATACTTTG -3'
(R):5'- GACTTCCCTTAAATATAAATGGGTGC -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation