Incidental Mutation 'R4908:Pgc'
ID 379246
Institutional Source Beutler Lab
Gene Symbol Pgc
Ensembl Gene ENSMUSG00000023987
Gene Name progastricsin (pepsinogen C)
Synonyms Upg-1, 2210410L06Rik, Upg1
MMRRC Submission 042510-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R4908 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 48037767-48045403 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 48039819 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 71 (Y71F)
Ref Sequence ENSEMBL: ENSMUSP00000123459 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024782] [ENSMUST00000144955]
AlphaFold Q9D7R7
Predicted Effect possibly damaging
Transcript: ENSMUST00000024782
AA Change: Y71F

PolyPhen 2 Score 0.514 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000024782
Gene: ENSMUSG00000023987
AA Change: Y71F

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:A1_Propeptide 18 46 2.1e-17 PFAM
Pfam:Asp 75 391 6.3e-118 PFAM
Pfam:TAXi_N 76 232 7.2e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000144955
AA Change: Y71F

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000123459
Gene: ENSMUSG00000023987
AA Change: Y71F

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:A1_Propeptide 18 46 1.5e-18 PFAM
Pfam:Asp 63 143 1.4e-19 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
Allele List at MGI
Other mutations in this stock
Total: 99 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110059G10Rik T A 9: 122,778,008 (GRCm39) I79L probably benign Het
Ablim2 C T 5: 35,959,766 (GRCm39) R73C possibly damaging Het
Acaa1a G A 9: 119,177,772 (GRCm39) S218N probably benign Het
Acsm5 A T 7: 119,137,314 (GRCm39) I377F probably damaging Het
Ahnak2 T C 12: 112,741,706 (GRCm39) T789A probably benign Het
Ak9 A T 10: 41,296,678 (GRCm39) T1475S unknown Het
AU040320 A T 4: 126,747,081 (GRCm39) N1028Y probably damaging Het
Bahcc1 T A 11: 120,178,580 (GRCm39) S2380T probably benign Het
Cadps A G 14: 12,536,386 (GRCm38) Y525H probably damaging Het
Casp8ap2 A G 4: 32,639,905 (GRCm39) T320A possibly damaging Het
Ccdc138 A G 10: 58,380,817 (GRCm39) N483D possibly damaging Het
Ccdc39 G A 3: 33,893,242 (GRCm39) probably null Het
Cd300c2 T C 11: 114,887,772 (GRCm39) N210S probably damaging Het
Cd84 A G 1: 171,700,432 (GRCm39) D183G probably damaging Het
Cep95 C T 11: 106,702,172 (GRCm39) P390S probably damaging Het
Chd9 A T 8: 91,741,877 (GRCm39) H1622L possibly damaging Het
Cilp C A 9: 65,185,302 (GRCm39) Q466K probably benign Het
Cinp T A 12: 110,850,487 (GRCm39) T5S probably damaging Het
Clec4a2 T C 6: 123,119,462 (GRCm39) L238S probably damaging Het
Cntrob T C 11: 69,211,732 (GRCm39) Y164C probably damaging Het
Col6a3 A G 1: 90,735,246 (GRCm39) L1408P probably damaging Het
Cul3 G A 1: 80,258,632 (GRCm39) S468L possibly damaging Het
Dnah11 T A 12: 118,090,618 (GRCm39) D1081V probably benign Het
Dnah2 C A 11: 69,411,973 (GRCm39) V263L probably benign Het
Efna3 C G 3: 89,222,805 (GRCm39) R185P probably damaging Het
F5 A T 1: 164,039,389 (GRCm39) I2000F probably damaging Het
Fancm G A 12: 65,141,645 (GRCm39) G422E probably benign Het
Gcnt2 A T 13: 41,014,210 (GRCm39) D127V probably damaging Het
Gm21798 G T 15: 64,689,618 (GRCm39) probably benign Het
Gramd1a A C 7: 30,838,292 (GRCm39) S320R probably benign Het
Grn T C 11: 102,327,344 (GRCm39) probably benign Het
Helq A T 5: 100,910,507 (GRCm39) probably null Het
Herc2 A G 7: 55,827,660 (GRCm39) I2914V probably benign Het
Hnrnph1 T C 11: 50,269,237 (GRCm39) V27A probably damaging Het
Hs1bp3 G T 12: 8,374,007 (GRCm39) G182C probably damaging Het
Idnk C T 13: 58,311,267 (GRCm39) P78L probably benign Het
Il10ra T C 9: 45,166,919 (GRCm39) D544G probably benign Het
Inpp5e T C 2: 26,290,918 (GRCm39) D383G probably damaging Het
Jak1 A T 4: 101,036,911 (GRCm39) V243D probably damaging Het
Kcnma1 A T 14: 23,359,220 (GRCm39) S1036T probably damaging Het
Kif26a G A 12: 112,123,776 (GRCm39) C127Y probably damaging Het
Kif2c T C 4: 117,023,608 (GRCm39) E368G probably damaging Het
Lasp1 T A 11: 97,724,530 (GRCm39) probably null Het
Lcor T A 19: 41,572,601 (GRCm39) V452D probably benign Het
Lrrtm1 C G 6: 77,221,661 (GRCm39) H373D probably benign Het
Matr3 T A 18: 35,705,754 (GRCm39) D226E probably damaging Het
Mmp17 G A 5: 129,682,730 (GRCm39) W456* probably null Het
Mpp4 T C 1: 59,164,748 (GRCm39) E463G probably damaging Het
Myh6 A C 14: 55,194,419 (GRCm39) F737V probably damaging Het
Nars2 T A 7: 96,672,948 (GRCm39) D271E probably benign Het
Nav2 A G 7: 49,254,258 (GRCm39) E2352G probably damaging Het
Nckap1 A G 2: 80,353,718 (GRCm39) probably null Het
Nckap5 A T 1: 125,955,324 (GRCm39) S477R probably damaging Het
Nek11 T G 9: 105,175,488 (GRCm39) I319L probably benign Het
Neto2 A G 8: 86,396,393 (GRCm39) I84T probably damaging Het
Nlrp9a A T 7: 26,250,369 (GRCm39) I45F probably damaging Het
Numa1 G A 7: 101,662,012 (GRCm39) R548H probably damaging Het
Or10a5 A C 7: 106,635,364 (GRCm39) M1L probably benign Het
Or14c39 A C 7: 86,344,395 (GRCm39) I244L probably benign Het
Or2ag1b A T 7: 106,288,740 (GRCm39) L66H probably damaging Het
Or4c10 A T 2: 89,760,923 (GRCm39) M257L probably benign Het
Or4c100 T A 2: 88,356,254 (GRCm39) I109N probably damaging Het
Or4k36 T A 2: 111,146,574 (GRCm39) F250Y probably benign Het
Or7g25 A G 9: 19,160,149 (GRCm39) V182A probably benign Het
Or9m1 A T 2: 87,733,533 (GRCm39) N162K probably damaging Het
Pcdhb16 T A 18: 37,612,894 (GRCm39) probably null Het
Pdcd10 T C 3: 75,448,553 (GRCm39) T4A probably damaging Het
Phlpp1 G A 1: 106,317,481 (GRCm39) G1234E probably damaging Het
Prr27 T C 5: 87,990,888 (GRCm39) F167L probably benign Het
Prrc2b T A 2: 32,116,330 (GRCm39) S1421T possibly damaging Het
Pxmp2 A G 5: 110,431,518 (GRCm39) V75A probably benign Het
Pygl A T 12: 70,243,807 (GRCm39) M545K probably null Het
Ranbp9 A G 13: 43,574,733 (GRCm39) Y412H possibly damaging Het
Rcc1 A G 4: 132,065,064 (GRCm39) V140A probably damaging Het
Reln A G 5: 22,184,718 (GRCm39) V1599A probably benign Het
Rhebl1 A T 15: 98,776,903 (GRCm39) D122E probably damaging Het
Rock2 C T 12: 17,009,492 (GRCm39) L676F probably benign Het
Scn9a A T 2: 66,357,087 (GRCm39) D1062E probably benign Het
Sec63 T C 10: 42,681,186 (GRCm39) I390T probably damaging Het
Slc10a6 T C 5: 103,754,493 (GRCm39) E346G probably benign Het
Slc12a3 G A 8: 95,075,216 (GRCm39) V737M possibly damaging Het
Slc12a8 T C 16: 33,426,629 (GRCm39) probably null Het
Slc25a38 T A 9: 119,949,354 (GRCm39) I102N probably damaging Het
Spg7 T A 8: 123,807,394 (GRCm39) V390E probably damaging Het
Tbc1d20 T C 2: 152,144,228 (GRCm39) V75A probably benign Het
Tesk1 T A 4: 43,445,555 (GRCm39) C243* probably null Het
Ttk T A 9: 83,725,739 (GRCm39) N220K possibly damaging Het
Ttll5 A G 12: 85,965,948 (GRCm39) E651G probably benign Het
Tubd1 T C 11: 86,457,879 (GRCm39) Y426H probably damaging Het
Uba6 T C 5: 86,288,293 (GRCm39) silent Het
Ube2ql1 G A 13: 69,852,289 (GRCm39) R263W probably damaging Het
Vmn2r117 C T 17: 23,678,812 (GRCm39) G804D probably damaging Het
Vmn2r25 C T 6: 123,805,406 (GRCm39) E484K probably benign Het
Vmn2r4 T A 3: 64,296,476 (GRCm39) I770F possibly damaging Het
Vmn2r82 G A 10: 79,214,589 (GRCm39) V191M probably benign Het
Zbtb45 C T 7: 12,742,037 (GRCm39) V74M probably damaging Het
Zfp366 T C 13: 99,370,609 (GRCm39) V443A possibly damaging Het
Zfyve1 A T 12: 83,598,345 (GRCm39) C628S probably damaging Het
Zfyve26 A T 12: 79,296,469 (GRCm39) probably null Het
Other mutations in Pgc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01358:Pgc APN 17 48,041,591 (GRCm39) missense probably benign 0.09
IGL01410:Pgc APN 17 48,045,165 (GRCm39) missense probably damaging 0.98
IGL01647:Pgc APN 17 48,043,329 (GRCm39) missense probably damaging 1.00
IGL02141:Pgc APN 17 48,037,856 (GRCm39) missense probably damaging 1.00
IGL02719:Pgc APN 17 48,039,792 (GRCm39) missense probably damaging 0.98
PIT4469001:Pgc UTSW 17 48,039,680 (GRCm39) nonsense probably null
R0736:Pgc UTSW 17 48,039,705 (GRCm39) missense probably damaging 1.00
R1118:Pgc UTSW 17 48,039,828 (GRCm39) critical splice donor site probably null
R1669:Pgc UTSW 17 48,044,715 (GRCm39) missense probably damaging 1.00
R2162:Pgc UTSW 17 48,040,236 (GRCm39) missense probably null 0.96
R3831:Pgc UTSW 17 48,040,236 (GRCm39) missense probably null 0.96
R3833:Pgc UTSW 17 48,040,236 (GRCm39) missense probably null 0.96
R4454:Pgc UTSW 17 48,043,335 (GRCm39) missense probably benign 0.00
R5544:Pgc UTSW 17 48,043,429 (GRCm39) missense probably benign 0.00
R6829:Pgc UTSW 17 48,043,706 (GRCm39) splice site probably null
R7042:Pgc UTSW 17 48,044,745 (GRCm39) missense probably benign 0.00
R7508:Pgc UTSW 17 48,045,111 (GRCm39) missense probably benign 0.00
R8022:Pgc UTSW 17 48,039,701 (GRCm39) missense probably benign 0.00
R9028:Pgc UTSW 17 48,043,983 (GRCm39) missense possibly damaging 0.51
R9074:Pgc UTSW 17 48,043,351 (GRCm39) missense probably damaging 0.98
Z1176:Pgc UTSW 17 48,039,793 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TAGAGATTCAGTGGGCGTGC -3'
(R):5'- CAACGGATGCTCAGTCTGTG -3'

Sequencing Primer
(F):5'- GGGCCTGACACATCCAC -3'
(R):5'- GCGTGGGCTCAGCTGAAAG -3'
Posted On 2016-04-15