Incidental Mutation 'R4910:Cnot1'
ID |
379414 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cnot1
|
Ensembl Gene |
ENSMUSG00000036550 |
Gene Name |
CCR4-NOT transcription complex, subunit 1 |
Synonyms |
6030411K04Rik |
MMRRC Submission |
042512-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R4910 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
8 |
Chromosomal Location |
96446079-96534092 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 96459859 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Asparagine
at position 1836
(I1836N)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000096073
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068452]
[ENSMUST00000098473]
[ENSMUST00000211887]
[ENSMUST00000213006]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably benign
Transcript: ENSMUST00000068452
AA Change: I1831N
PolyPhen 2
Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
|
SMART Domains |
Protein: ENSMUSP00000063565 Gene: ENSMUSG00000036550 AA Change: I1831N
Domain | Start | End | E-Value | Type |
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
PDB:4J8S|A
|
798 |
999 |
1e-137 |
PDB |
low complexity region
|
1011 |
1028 |
N/A |
INTRINSIC |
low complexity region
|
1031 |
1055 |
N/A |
INTRINSIC |
PDB:4CT4|C
|
1056 |
1295 |
1e-148 |
PDB |
low complexity region
|
1296 |
1308 |
N/A |
INTRINSIC |
low complexity region
|
1328 |
1345 |
N/A |
INTRINSIC |
Pfam:DUF3819
|
1381 |
1530 |
2.5e-56 |
PFAM |
low complexity region
|
1634 |
1648 |
N/A |
INTRINSIC |
Pfam:Not1
|
1991 |
2305 |
2.4e-125 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000098473
AA Change: I1836N
PolyPhen 2
Score 0.432 (Sensitivity: 0.89; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000096073 Gene: ENSMUSG00000036550 AA Change: I1836N
Domain | Start | End | E-Value | Type |
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
Pfam:CNOT1_HEAT
|
500 |
656 |
2.4e-57 |
PFAM |
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
Pfam:CNOT1_TTP_bind
|
812 |
1004 |
1.4e-87 |
PFAM |
low complexity region
|
1016 |
1033 |
N/A |
INTRINSIC |
low complexity region
|
1036 |
1060 |
N/A |
INTRINSIC |
Pfam:CNOT1_CAF1_bind
|
1087 |
1313 |
5.7e-99 |
PFAM |
low complexity region
|
1333 |
1350 |
N/A |
INTRINSIC |
Pfam:DUF3819
|
1387 |
1534 |
2.3e-57 |
PFAM |
low complexity region
|
1639 |
1653 |
N/A |
INTRINSIC |
Pfam:Not1
|
1998 |
2357 |
5.7e-157 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000211887
AA Change: I1829N
PolyPhen 2
Score 0.096 (Sensitivity: 0.93; Specificity: 0.85)
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212195
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212302
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212340
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212369
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212535
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000213006
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212712
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000212415
|
Meta Mutation Damage Score |
0.4710 |
Coding Region Coverage |
- 1x: 98.9%
- 3x: 97.9%
- 10x: 94.6%
- 20x: 86.1%
|
Validation Efficiency |
95% (144/151) |
MGI Phenotype |
PHENOTYPE: Mice hmozygous for a conditional allele activated in cardiomyocytes exhibit postnatal lethality, decreased cardiac muscle contractility, prolonged QT interval and cardiac muscle cell death. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 123 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadacl2fm3 |
T |
A |
3: 59,776,435 (GRCm39) |
|
probably null |
Het |
Adam3 |
T |
A |
8: 25,184,321 (GRCm39) |
I560L |
probably benign |
Het |
Agxt |
T |
C |
1: 93,063,436 (GRCm39) |
F113L |
probably benign |
Het |
Aknad1 |
T |
A |
3: 108,688,568 (GRCm39) |
|
probably null |
Het |
Alpk2 |
T |
A |
18: 65,399,357 (GRCm39) |
K2074* |
probably null |
Het |
Apob |
A |
G |
12: 8,057,848 (GRCm39) |
Y2077C |
probably damaging |
Het |
Arhgap17 |
A |
T |
7: 122,907,600 (GRCm39) |
L254Q |
probably damaging |
Het |
Arhgap26 |
T |
A |
18: 39,126,690 (GRCm39) |
|
probably benign |
Het |
Arhgef5 |
A |
G |
6: 43,249,762 (GRCm39) |
D171G |
probably benign |
Het |
Arid1b |
T |
A |
17: 5,392,478 (GRCm39) |
S2003T |
probably damaging |
Het |
Armc5 |
T |
G |
7: 127,839,900 (GRCm39) |
L406R |
possibly damaging |
Het |
Arsb |
T |
C |
13: 93,908,485 (GRCm39) |
V67A |
probably benign |
Het |
Aspm |
A |
G |
1: 139,419,281 (GRCm39) |
Y2982C |
probably damaging |
Het |
Bltp1 |
C |
A |
3: 37,052,348 (GRCm39) |
T3016K |
probably damaging |
Het |
Btbd7 |
A |
G |
12: 102,774,307 (GRCm39) |
L487P |
probably damaging |
Het |
Card11 |
C |
G |
5: 140,860,169 (GRCm39) |
D1063H |
probably damaging |
Het |
Ccdc186 |
G |
A |
19: 56,787,123 (GRCm39) |
T615M |
probably damaging |
Het |
Cd101 |
T |
A |
3: 100,901,205 (GRCm39) |
T960S |
probably benign |
Het |
Cdca7l |
C |
A |
12: 117,837,520 (GRCm39) |
S191* |
probably null |
Het |
Cemip |
A |
T |
7: 83,646,619 (GRCm39) |
I143N |
probably damaging |
Het |
Cep170 |
C |
T |
1: 176,609,829 (GRCm39) |
E161K |
possibly damaging |
Het |
Cfhr4 |
T |
G |
1: 139,702,301 (GRCm39) |
D61A |
probably damaging |
Het |
Chrm2 |
A |
T |
6: 36,501,168 (GRCm39) |
T342S |
probably benign |
Het |
Cib2 |
A |
G |
9: 54,457,163 (GRCm39) |
F34L |
probably benign |
Het |
Col4a3 |
C |
A |
1: 82,650,400 (GRCm39) |
P552Q |
unknown |
Het |
Cp |
T |
A |
3: 20,043,388 (GRCm39) |
|
probably benign |
Het |
Cul3 |
C |
T |
1: 80,267,806 (GRCm39) |
V112I |
probably benign |
Het |
Dcdc5 |
A |
G |
2: 106,195,895 (GRCm39) |
|
noncoding transcript |
Het |
Disp1 |
A |
T |
1: 182,917,027 (GRCm39) |
V133E |
probably damaging |
Het |
Dlg4 |
A |
G |
11: 69,921,751 (GRCm39) |
D30G |
probably damaging |
Het |
Dop1a |
C |
T |
9: 86,374,114 (GRCm39) |
T191I |
probably damaging |
Het |
Enam |
T |
G |
5: 88,650,173 (GRCm39) |
S561A |
probably benign |
Het |
Fbxw8 |
G |
T |
5: 118,263,092 (GRCm39) |
|
probably null |
Het |
Filip1 |
A |
G |
9: 79,725,214 (GRCm39) |
V1135A |
probably benign |
Het |
Galnt6 |
T |
C |
15: 100,614,059 (GRCm39) |
T81A |
probably benign |
Het |
Ghdc |
T |
C |
11: 100,657,814 (GRCm39) |
K472E |
probably benign |
Het |
Gm10568 |
T |
G |
1: 3,751,164 (GRCm39) |
|
noncoding transcript |
Het |
Gm4953 |
T |
A |
1: 158,995,929 (GRCm39) |
|
noncoding transcript |
Het |
Gm6871 |
T |
A |
7: 41,223,016 (GRCm39) |
H24L |
probably benign |
Het |
Gpr155 |
G |
A |
2: 73,197,882 (GRCm39) |
Q413* |
probably null |
Het |
Grhl2 |
A |
G |
15: 37,291,920 (GRCm39) |
|
probably null |
Het |
Ighv1-31 |
G |
C |
12: 114,793,128 (GRCm39) |
S36* |
probably null |
Het |
Ighv8-5 |
A |
G |
12: 115,031,462 (GRCm39) |
S26P |
probably damaging |
Het |
Igkv17-134 |
A |
C |
6: 67,697,910 (GRCm39) |
|
probably benign |
Het |
Igkv5-48 |
A |
C |
6: 69,703,833 (GRCm39) |
L24R |
probably damaging |
Het |
Isg20l2 |
T |
A |
3: 87,846,570 (GRCm39) |
V340E |
probably damaging |
Het |
Lrrtm1 |
A |
G |
6: 77,221,884 (GRCm39) |
Y447C |
probably damaging |
Het |
Ltbp1 |
T |
C |
17: 75,634,287 (GRCm39) |
S855P |
probably damaging |
Het |
Mgat4e |
A |
T |
1: 134,469,602 (GRCm39) |
N147K |
probably damaging |
Het |
Mlc1 |
A |
G |
15: 88,842,415 (GRCm39) |
L315P |
possibly damaging |
Het |
Mrgpra2a |
A |
G |
7: 47,076,292 (GRCm39) |
V322A |
probably benign |
Het |
Mroh7 |
T |
C |
4: 106,567,152 (GRCm39) |
|
probably null |
Het |
Mybpc1 |
T |
A |
10: 88,391,586 (GRCm39) |
K304* |
probably null |
Het |
Nlrp14 |
A |
C |
7: 106,785,790 (GRCm39) |
D622A |
possibly damaging |
Het |
Nlrp1b |
T |
A |
11: 71,108,103 (GRCm39) |
H466L |
probably benign |
Het |
Nlrp4d |
T |
A |
7: 10,112,336 (GRCm39) |
|
noncoding transcript |
Het |
Nrxn3 |
A |
G |
12: 89,227,130 (GRCm39) |
E628G |
possibly damaging |
Het |
Nup133 |
T |
C |
8: 124,653,870 (GRCm39) |
R530G |
possibly damaging |
Het |
Nup98 |
A |
G |
7: 101,845,007 (GRCm39) |
S21P |
unknown |
Het |
Or2h2b-ps1 |
T |
C |
17: 37,480,934 (GRCm39) |
I202V |
probably benign |
Het |
Or2l13b |
T |
C |
16: 19,348,768 (GRCm39) |
T301A |
probably benign |
Het |
Or4f14b |
A |
T |
2: 111,775,423 (GRCm39) |
I126K |
possibly damaging |
Het |
Or52e8 |
G |
A |
7: 104,624,686 (GRCm39) |
P169S |
possibly damaging |
Het |
Or5k1 |
T |
A |
16: 58,617,805 (GRCm39) |
T135S |
probably benign |
Het |
Or6c66 |
T |
C |
10: 129,461,676 (GRCm39) |
T85A |
probably damaging |
Het |
Or8c11 |
T |
A |
9: 38,290,038 (GRCm39) |
V287E |
probably null |
Het |
Otog |
A |
T |
7: 45,913,486 (GRCm39) |
Y773F |
probably damaging |
Het |
Otog |
A |
T |
7: 45,947,958 (GRCm39) |
I2320F |
probably damaging |
Het |
Otogl |
T |
C |
10: 107,715,378 (GRCm39) |
S433G |
probably benign |
Het |
Pcdhb17 |
A |
T |
18: 37,618,212 (GRCm39) |
M1L |
possibly damaging |
Het |
Pde7b |
T |
A |
10: 20,600,480 (GRCm39) |
|
probably benign |
Het |
Pgm1 |
T |
C |
4: 99,820,724 (GRCm39) |
V207A |
probably damaging |
Het |
Pkd1 |
T |
A |
17: 24,791,661 (GRCm39) |
V1116E |
probably damaging |
Het |
Pkd1l1 |
T |
A |
11: 8,879,360 (GRCm39) |
Y497F |
possibly damaging |
Het |
Pomgnt2 |
T |
C |
9: 121,812,013 (GRCm39) |
N256S |
probably benign |
Het |
Pot1a |
A |
T |
6: 25,746,020 (GRCm39) |
|
probably benign |
Het |
Prdm9 |
T |
C |
17: 15,764,585 (GRCm39) |
T732A |
probably benign |
Het |
Prg4 |
T |
A |
1: 150,331,574 (GRCm39) |
|
probably benign |
Het |
Ptpro |
T |
C |
6: 137,345,336 (GRCm39) |
V114A |
probably damaging |
Het |
Pyurf |
A |
G |
6: 57,668,933 (GRCm39) |
S20P |
unknown |
Het |
Rasgrf1 |
A |
G |
9: 89,858,805 (GRCm39) |
T488A |
probably benign |
Het |
Rassf8 |
A |
T |
6: 145,761,006 (GRCm39) |
K111* |
probably null |
Het |
Reps1 |
A |
T |
10: 17,983,436 (GRCm39) |
E426D |
probably damaging |
Het |
Robo2 |
T |
C |
16: 73,730,666 (GRCm39) |
K982R |
probably damaging |
Het |
Rps23 |
T |
C |
13: 91,071,871 (GRCm39) |
|
probably null |
Het |
Scamp4 |
T |
A |
10: 80,445,505 (GRCm39) |
V56E |
probably damaging |
Het |
Serpina1c |
C |
T |
12: 103,861,291 (GRCm39) |
V408I |
probably benign |
Het |
Sigirr |
A |
G |
7: 140,673,701 (GRCm39) |
W49R |
probably damaging |
Het |
Slc17a6 |
A |
T |
7: 51,308,489 (GRCm39) |
H271L |
possibly damaging |
Het |
Slc7a5 |
G |
T |
8: 122,611,861 (GRCm39) |
T389K |
probably damaging |
Het |
Slf1 |
T |
A |
13: 77,191,999 (GRCm39) |
H945L |
probably benign |
Het |
Slit3 |
T |
C |
11: 35,523,549 (GRCm39) |
S662P |
probably damaging |
Het |
Snta1 |
C |
A |
2: 154,218,938 (GRCm39) |
E466* |
probably null |
Het |
Sowaha |
A |
G |
11: 53,369,272 (GRCm39) |
L488P |
probably damaging |
Het |
Spata17 |
C |
A |
1: 186,926,208 (GRCm39) |
V41F |
probably damaging |
Het |
Spta1 |
T |
A |
1: 174,045,429 (GRCm39) |
|
probably null |
Het |
Srrm2 |
T |
A |
17: 24,034,362 (GRCm39) |
|
probably benign |
Het |
Stard13 |
T |
C |
5: 150,985,992 (GRCm39) |
N388S |
probably benign |
Het |
Stmn3 |
T |
C |
2: 180,950,630 (GRCm39) |
K59E |
probably damaging |
Het |
Sval1 |
A |
G |
6: 41,932,378 (GRCm39) |
N76S |
probably benign |
Het |
Svep1 |
T |
C |
4: 58,096,276 (GRCm39) |
H1448R |
possibly damaging |
Het |
Sycp2 |
A |
T |
2: 178,000,017 (GRCm39) |
D986E |
probably benign |
Het |
Sytl5 |
C |
T |
X: 9,781,841 (GRCm39) |
P181L |
possibly damaging |
Het |
Tbkbp1 |
G |
A |
11: 97,029,956 (GRCm39) |
S400L |
probably benign |
Het |
Tesc |
G |
T |
5: 118,194,531 (GRCm39) |
|
probably benign |
Het |
Tjp1 |
C |
T |
7: 64,993,475 (GRCm39) |
G33R |
probably damaging |
Het |
Tlr11 |
C |
A |
14: 50,600,346 (GRCm39) |
F777L |
probably benign |
Het |
Tmem156 |
A |
G |
5: 65,248,805 (GRCm39) |
|
probably benign |
Het |
Top3a |
A |
G |
11: 60,643,204 (GRCm39) |
|
probably benign |
Het |
Tpcn1 |
A |
G |
5: 120,694,584 (GRCm39) |
W162R |
probably damaging |
Het |
Tpd52l2 |
A |
T |
2: 181,157,005 (GRCm39) |
|
probably benign |
Het |
Trim80 |
G |
A |
11: 115,337,281 (GRCm39) |
G381D |
probably damaging |
Het |
Ugt1a10 |
C |
T |
1: 88,142,845 (GRCm39) |
P113L |
probably damaging |
Het |
Vmn2r117 |
TC |
T |
17: 23,698,487 (GRCm39) |
|
probably null |
Het |
Vmn2r56 |
T |
A |
7: 12,449,462 (GRCm39) |
I259F |
possibly damaging |
Het |
Vmn2r59 |
T |
C |
7: 41,693,077 (GRCm39) |
T508A |
probably benign |
Het |
Wdr73 |
A |
G |
7: 80,541,456 (GRCm39) |
V362A |
probably damaging |
Het |
Zdhhc21 |
G |
T |
4: 82,738,568 (GRCm39) |
T207K |
possibly damaging |
Het |
Zfp120 |
T |
A |
2: 149,959,872 (GRCm39) |
Q150L |
probably damaging |
Het |
Zfp212 |
C |
A |
6: 47,908,433 (GRCm39) |
Q471K |
possibly damaging |
Het |
Zfp804b |
C |
T |
5: 6,820,540 (GRCm39) |
G841D |
possibly damaging |
Het |
Znfx1 |
A |
T |
2: 166,878,724 (GRCm39) |
M1884K |
probably damaging |
Het |
Znfx1 |
G |
T |
2: 166,879,402 (GRCm39) |
A1658D |
probably benign |
Het |
|
Other mutations in Cnot1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00516:Cnot1
|
APN |
8 |
96,452,707 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01340:Cnot1
|
APN |
8 |
96,487,165 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01457:Cnot1
|
APN |
8 |
96,467,637 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01505:Cnot1
|
APN |
8 |
96,455,346 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02401:Cnot1
|
APN |
8 |
96,482,761 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02693:Cnot1
|
APN |
8 |
96,500,113 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02696:Cnot1
|
APN |
8 |
96,471,645 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02754:Cnot1
|
APN |
8 |
96,481,706 (GRCm39) |
missense |
probably benign |
0.03 |
IGL03092:Cnot1
|
APN |
8 |
96,496,243 (GRCm39) |
intron |
probably benign |
|
IGL03174:Cnot1
|
APN |
8 |
96,487,983 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03310:Cnot1
|
APN |
8 |
96,462,308 (GRCm39) |
splice site |
probably benign |
|
IGL03371:Cnot1
|
APN |
8 |
96,501,344 (GRCm39) |
missense |
possibly damaging |
0.85 |
Affiliate
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
Barge
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
Byproduct
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
Chairman
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
cohort
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
Director
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
kowloon
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
Quorum
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
tugboat
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
Xiao
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
BB001:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
BB003:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
BB011:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
BB013:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
R0091:Cnot1
|
UTSW |
8 |
96,489,772 (GRCm39) |
missense |
probably damaging |
1.00 |
R0335:Cnot1
|
UTSW |
8 |
96,498,628 (GRCm39) |
missense |
probably benign |
0.02 |
R0409:Cnot1
|
UTSW |
8 |
96,475,483 (GRCm39) |
missense |
probably damaging |
0.96 |
R0445:Cnot1
|
UTSW |
8 |
96,486,836 (GRCm39) |
missense |
probably damaging |
1.00 |
R1505:Cnot1
|
UTSW |
8 |
96,455,295 (GRCm39) |
missense |
probably damaging |
1.00 |
R1517:Cnot1
|
UTSW |
8 |
96,469,841 (GRCm39) |
missense |
probably benign |
0.38 |
R1640:Cnot1
|
UTSW |
8 |
96,496,460 (GRCm39) |
missense |
probably damaging |
0.98 |
R1737:Cnot1
|
UTSW |
8 |
96,474,904 (GRCm39) |
missense |
probably damaging |
0.98 |
R1755:Cnot1
|
UTSW |
8 |
96,451,205 (GRCm39) |
missense |
probably damaging |
1.00 |
R1901:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1902:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1903:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1988:Cnot1
|
UTSW |
8 |
96,468,572 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2051:Cnot1
|
UTSW |
8 |
96,451,221 (GRCm39) |
missense |
possibly damaging |
0.47 |
R2054:Cnot1
|
UTSW |
8 |
96,466,469 (GRCm39) |
missense |
possibly damaging |
0.55 |
R2072:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2074:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2075:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2093:Cnot1
|
UTSW |
8 |
96,501,986 (GRCm39) |
missense |
probably damaging |
1.00 |
R2116:Cnot1
|
UTSW |
8 |
96,452,781 (GRCm39) |
missense |
probably damaging |
1.00 |
R2191:Cnot1
|
UTSW |
8 |
96,488,054 (GRCm39) |
missense |
probably damaging |
0.98 |
R2238:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
R2239:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
R2251:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
R2252:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
R2253:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
R2315:Cnot1
|
UTSW |
8 |
96,475,690 (GRCm39) |
missense |
probably damaging |
1.00 |
R2431:Cnot1
|
UTSW |
8 |
96,501,280 (GRCm39) |
missense |
probably damaging |
1.00 |
R2988:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R2989:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R3108:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
R3109:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
R3114:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R3115:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R3153:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R3154:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R4112:Cnot1
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
R4359:Cnot1
|
UTSW |
8 |
96,466,476 (GRCm39) |
missense |
probably damaging |
1.00 |
R4382:Cnot1
|
UTSW |
8 |
96,496,407 (GRCm39) |
missense |
probably damaging |
0.97 |
R4747:Cnot1
|
UTSW |
8 |
96,501,310 (GRCm39) |
missense |
probably benign |
0.27 |
R4913:Cnot1
|
UTSW |
8 |
96,489,695 (GRCm39) |
missense |
possibly damaging |
0.63 |
R4971:Cnot1
|
UTSW |
8 |
96,448,254 (GRCm39) |
missense |
probably damaging |
1.00 |
R5056:Cnot1
|
UTSW |
8 |
96,467,636 (GRCm39) |
missense |
probably damaging |
1.00 |
R5092:Cnot1
|
UTSW |
8 |
96,479,396 (GRCm39) |
missense |
possibly damaging |
0.91 |
R5101:Cnot1
|
UTSW |
8 |
96,486,815 (GRCm39) |
missense |
possibly damaging |
0.90 |
R5498:Cnot1
|
UTSW |
8 |
96,483,983 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5719:Cnot1
|
UTSW |
8 |
96,470,924 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5850:Cnot1
|
UTSW |
8 |
96,460,775 (GRCm39) |
nonsense |
probably null |
|
R5956:Cnot1
|
UTSW |
8 |
96,481,606 (GRCm39) |
critical splice donor site |
probably null |
|
R5981:Cnot1
|
UTSW |
8 |
96,515,293 (GRCm39) |
missense |
probably damaging |
1.00 |
R6093:Cnot1
|
UTSW |
8 |
96,475,522 (GRCm39) |
missense |
probably benign |
0.03 |
R6108:Cnot1
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
R6261:Cnot1
|
UTSW |
8 |
96,468,549 (GRCm39) |
missense |
probably benign |
0.00 |
R6632:Cnot1
|
UTSW |
8 |
96,499,895 (GRCm39) |
intron |
probably benign |
|
R6882:Cnot1
|
UTSW |
8 |
96,447,054 (GRCm39) |
missense |
possibly damaging |
0.85 |
R6966:Cnot1
|
UTSW |
8 |
96,451,160 (GRCm39) |
missense |
probably damaging |
1.00 |
R6985:Cnot1
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
R7210:Cnot1
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
R7410:Cnot1
|
UTSW |
8 |
96,459,787 (GRCm39) |
missense |
possibly damaging |
0.77 |
R7623:Cnot1
|
UTSW |
8 |
96,454,276 (GRCm39) |
missense |
probably damaging |
1.00 |
R7624:Cnot1
|
UTSW |
8 |
96,478,447 (GRCm39) |
missense |
probably damaging |
1.00 |
R7695:Cnot1
|
UTSW |
8 |
96,497,260 (GRCm39) |
missense |
probably benign |
0.03 |
R7703:Cnot1
|
UTSW |
8 |
96,486,726 (GRCm39) |
critical splice donor site |
probably null |
|
R7771:Cnot1
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
R7800:Cnot1
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
R7809:Cnot1
|
UTSW |
8 |
96,478,406 (GRCm39) |
missense |
probably damaging |
1.00 |
R7857:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R7914:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R7924:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R7926:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R7981:Cnot1
|
UTSW |
8 |
96,489,797 (GRCm39) |
missense |
probably damaging |
1.00 |
R8004:Cnot1
|
UTSW |
8 |
96,479,380 (GRCm39) |
missense |
probably benign |
0.03 |
R8061:Cnot1
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8185:Cnot1
|
UTSW |
8 |
96,487,979 (GRCm39) |
missense |
probably damaging |
1.00 |
R8269:Cnot1
|
UTSW |
8 |
96,478,389 (GRCm39) |
missense |
probably damaging |
1.00 |
R8306:Cnot1
|
UTSW |
8 |
96,473,649 (GRCm39) |
missense |
probably benign |
0.05 |
R8322:Cnot1
|
UTSW |
8 |
96,496,472 (GRCm39) |
missense |
probably benign |
0.00 |
R8427:Cnot1
|
UTSW |
8 |
96,460,952 (GRCm39) |
missense |
probably benign |
0.01 |
R8723:Cnot1
|
UTSW |
8 |
96,462,907 (GRCm39) |
missense |
probably benign |
0.00 |
R8934:Cnot1
|
UTSW |
8 |
96,491,695 (GRCm39) |
missense |
probably benign |
0.04 |
R9025:Cnot1
|
UTSW |
8 |
96,475,660 (GRCm39) |
missense |
probably benign |
|
R9179:Cnot1
|
UTSW |
8 |
96,500,054 (GRCm39) |
missense |
probably benign |
0.16 |
R9280:Cnot1
|
UTSW |
8 |
96,497,227 (GRCm39) |
missense |
probably benign |
0.15 |
R9285:Cnot1
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
R9299:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
R9337:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
R9480:Cnot1
|
UTSW |
8 |
96,497,338 (GRCm39) |
missense |
possibly damaging |
0.94 |
R9548:Cnot1
|
UTSW |
8 |
96,482,854 (GRCm39) |
missense |
probably benign |
0.02 |
R9601:Cnot1
|
UTSW |
8 |
96,482,835 (GRCm39) |
missense |
probably benign |
0.02 |
R9629:Cnot1
|
UTSW |
8 |
96,455,874 (GRCm39) |
missense |
probably damaging |
0.98 |
R9752:Cnot1
|
UTSW |
8 |
96,488,019 (GRCm39) |
missense |
probably damaging |
1.00 |
R9764:Cnot1
|
UTSW |
8 |
96,496,209 (GRCm39) |
missense |
probably benign |
0.00 |
R9789:Cnot1
|
UTSW |
8 |
96,455,772 (GRCm39) |
missense |
probably damaging |
1.00 |
X0050:Cnot1
|
UTSW |
8 |
96,469,726 (GRCm39) |
splice site |
probably null |
|
Z1176:Cnot1
|
UTSW |
8 |
96,474,905 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
Predicted Primers |
PCR Primer
(F):5'- TAATAGTGGAGTAATCACACCCTAC -3'
(R):5'- TTTCAGGGTCCTTGGGAAGC -3'
Sequencing Primer
(F):5'- GTGGAGTAATCACACCCTACTTATG -3'
(R):5'- CCTAATCAGCTATGGTGAGGTCC -3'
|
Posted On |
2016-04-15 |