Incidental Mutation 'R4910:Apob'
ID 379436
Institutional Source Beutler Lab
Gene Symbol Apob
Ensembl Gene ENSMUSG00000020609
Gene Name apolipoprotein B
Synonyms apob-100, apob-48
MMRRC Submission 042512-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.859) question?
Stock # R4910 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 8027648-8066835 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 8057848 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 2077 (Y2077C)
Ref Sequence ENSEMBL: ENSMUSP00000035761 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037520] [ENSMUST00000037811] [ENSMUST00000171239]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000037520
AA Change: Y2077C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035761
Gene: ENSMUSG00000020609
AA Change: Y2077C

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
LPD_N 33 585 6.03e-94 SMART
DUF1943 619 932 7.88e-97 SMART
Pfam:DUF1081 945 1059 9.4e-32 PFAM
low complexity region 1100 1109 N/A INTRINSIC
Blast:LPD_N 1249 1311 9e-22 BLAST
low complexity region 1632 1644 N/A INTRINSIC
internal_repeat_1 1882 2038 6.61e-9 PROSPERO
SCOP:d1gw5a_ 2105 2577 9e-5 SMART
internal_repeat_1 2973 3150 6.61e-9 PROSPERO
low complexity region 3561 3580 N/A INTRINSIC
low complexity region 3928 3936 N/A INTRINSIC
Pfam:ApoB100_C 4401 4456 5.6e-34 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000037811
AA Change: Y2110C

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000036044
Gene: ENSMUSG00000020609
AA Change: Y2110C

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
LPD_N 46 598 6.03e-94 SMART
DUF1943 632 945 7.88e-97 SMART
Pfam:DUF1081 960 1070 6.3e-39 PFAM
low complexity region 1113 1122 N/A INTRINSIC
Blast:LPD_N 1282 1344 1e-21 BLAST
low complexity region 1665 1677 N/A INTRINSIC
internal_repeat_1 1915 2071 6.6e-9 PROSPERO
SCOP:d1gw5a_ 2138 2610 9e-5 SMART
internal_repeat_1 3006 3183 6.6e-9 PROSPERO
low complexity region 3594 3613 N/A INTRINSIC
low complexity region 3961 3969 N/A INTRINSIC
Pfam:ApoB100_C 4434 4490 1.6e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000171239
SMART Domains Protein: ENSMUSP00000129496
Gene: ENSMUSG00000020609

DomainStartEndE-ValueType
low complexity region 348 356 N/A INTRINSIC
Meta Mutation Damage Score 0.3340 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 94.6%
  • 20x: 86.1%
Validation Efficiency 95% (144/151)
MGI Phenotype FUNCTION: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the mouse apoB-48 isoform is also found in mouse liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2179 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants usually die by midgestation and longer survivors exhibit exencephaly. Heterozygotes show reduced plasma cholesterol and apolipoprotein levels. Single isoform B100 and B48 null mutants are viable. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 123 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm3 T A 3: 59,776,435 (GRCm39) probably null Het
Adam3 T A 8: 25,184,321 (GRCm39) I560L probably benign Het
Agxt T C 1: 93,063,436 (GRCm39) F113L probably benign Het
Aknad1 T A 3: 108,688,568 (GRCm39) probably null Het
Alpk2 T A 18: 65,399,357 (GRCm39) K2074* probably null Het
Arhgap17 A T 7: 122,907,600 (GRCm39) L254Q probably damaging Het
Arhgap26 T A 18: 39,126,690 (GRCm39) probably benign Het
Arhgef5 A G 6: 43,249,762 (GRCm39) D171G probably benign Het
Arid1b T A 17: 5,392,478 (GRCm39) S2003T probably damaging Het
Armc5 T G 7: 127,839,900 (GRCm39) L406R possibly damaging Het
Arsb T C 13: 93,908,485 (GRCm39) V67A probably benign Het
Aspm A G 1: 139,419,281 (GRCm39) Y2982C probably damaging Het
Bltp1 C A 3: 37,052,348 (GRCm39) T3016K probably damaging Het
Btbd7 A G 12: 102,774,307 (GRCm39) L487P probably damaging Het
Card11 C G 5: 140,860,169 (GRCm39) D1063H probably damaging Het
Ccdc186 G A 19: 56,787,123 (GRCm39) T615M probably damaging Het
Cd101 T A 3: 100,901,205 (GRCm39) T960S probably benign Het
Cdca7l C A 12: 117,837,520 (GRCm39) S191* probably null Het
Cemip A T 7: 83,646,619 (GRCm39) I143N probably damaging Het
Cep170 C T 1: 176,609,829 (GRCm39) E161K possibly damaging Het
Cfhr4 T G 1: 139,702,301 (GRCm39) D61A probably damaging Het
Chrm2 A T 6: 36,501,168 (GRCm39) T342S probably benign Het
Cib2 A G 9: 54,457,163 (GRCm39) F34L probably benign Het
Cnot1 A T 8: 96,459,859 (GRCm39) I1836N probably benign Het
Col4a3 C A 1: 82,650,400 (GRCm39) P552Q unknown Het
Cp T A 3: 20,043,388 (GRCm39) probably benign Het
Cul3 C T 1: 80,267,806 (GRCm39) V112I probably benign Het
Dcdc5 A G 2: 106,195,895 (GRCm39) noncoding transcript Het
Disp1 A T 1: 182,917,027 (GRCm39) V133E probably damaging Het
Dlg4 A G 11: 69,921,751 (GRCm39) D30G probably damaging Het
Dop1a C T 9: 86,374,114 (GRCm39) T191I probably damaging Het
Enam T G 5: 88,650,173 (GRCm39) S561A probably benign Het
Fbxw8 G T 5: 118,263,092 (GRCm39) probably null Het
Filip1 A G 9: 79,725,214 (GRCm39) V1135A probably benign Het
Galnt6 T C 15: 100,614,059 (GRCm39) T81A probably benign Het
Ghdc T C 11: 100,657,814 (GRCm39) K472E probably benign Het
Gm10568 T G 1: 3,751,164 (GRCm39) noncoding transcript Het
Gm4953 T A 1: 158,995,929 (GRCm39) noncoding transcript Het
Gm6871 T A 7: 41,223,016 (GRCm39) H24L probably benign Het
Gpr155 G A 2: 73,197,882 (GRCm39) Q413* probably null Het
Grhl2 A G 15: 37,291,920 (GRCm39) probably null Het
Ighv1-31 G C 12: 114,793,128 (GRCm39) S36* probably null Het
Ighv8-5 A G 12: 115,031,462 (GRCm39) S26P probably damaging Het
Igkv17-134 A C 6: 67,697,910 (GRCm39) probably benign Het
Igkv5-48 A C 6: 69,703,833 (GRCm39) L24R probably damaging Het
Isg20l2 T A 3: 87,846,570 (GRCm39) V340E probably damaging Het
Lrrtm1 A G 6: 77,221,884 (GRCm39) Y447C probably damaging Het
Ltbp1 T C 17: 75,634,287 (GRCm39) S855P probably damaging Het
Mgat4e A T 1: 134,469,602 (GRCm39) N147K probably damaging Het
Mlc1 A G 15: 88,842,415 (GRCm39) L315P possibly damaging Het
Mrgpra2a A G 7: 47,076,292 (GRCm39) V322A probably benign Het
Mroh7 T C 4: 106,567,152 (GRCm39) probably null Het
Mybpc1 T A 10: 88,391,586 (GRCm39) K304* probably null Het
Nlrp14 A C 7: 106,785,790 (GRCm39) D622A possibly damaging Het
Nlrp1b T A 11: 71,108,103 (GRCm39) H466L probably benign Het
Nlrp4d T A 7: 10,112,336 (GRCm39) noncoding transcript Het
Nrxn3 A G 12: 89,227,130 (GRCm39) E628G possibly damaging Het
Nup133 T C 8: 124,653,870 (GRCm39) R530G possibly damaging Het
Nup98 A G 7: 101,845,007 (GRCm39) S21P unknown Het
Or2h2b-ps1 T C 17: 37,480,934 (GRCm39) I202V probably benign Het
Or2l13b T C 16: 19,348,768 (GRCm39) T301A probably benign Het
Or4f14b A T 2: 111,775,423 (GRCm39) I126K possibly damaging Het
Or52e8 G A 7: 104,624,686 (GRCm39) P169S possibly damaging Het
Or5k1 T A 16: 58,617,805 (GRCm39) T135S probably benign Het
Or6c66 T C 10: 129,461,676 (GRCm39) T85A probably damaging Het
Or8c11 T A 9: 38,290,038 (GRCm39) V287E probably null Het
Otog A T 7: 45,913,486 (GRCm39) Y773F probably damaging Het
Otog A T 7: 45,947,958 (GRCm39) I2320F probably damaging Het
Otogl T C 10: 107,715,378 (GRCm39) S433G probably benign Het
Pcdhb17 A T 18: 37,618,212 (GRCm39) M1L possibly damaging Het
Pde7b T A 10: 20,600,480 (GRCm39) probably benign Het
Pgm1 T C 4: 99,820,724 (GRCm39) V207A probably damaging Het
Pkd1 T A 17: 24,791,661 (GRCm39) V1116E probably damaging Het
Pkd1l1 T A 11: 8,879,360 (GRCm39) Y497F possibly damaging Het
Pomgnt2 T C 9: 121,812,013 (GRCm39) N256S probably benign Het
Pot1a A T 6: 25,746,020 (GRCm39) probably benign Het
Prdm9 T C 17: 15,764,585 (GRCm39) T732A probably benign Het
Prg4 T A 1: 150,331,574 (GRCm39) probably benign Het
Ptpro T C 6: 137,345,336 (GRCm39) V114A probably damaging Het
Pyurf A G 6: 57,668,933 (GRCm39) S20P unknown Het
Rasgrf1 A G 9: 89,858,805 (GRCm39) T488A probably benign Het
Rassf8 A T 6: 145,761,006 (GRCm39) K111* probably null Het
Reps1 A T 10: 17,983,436 (GRCm39) E426D probably damaging Het
Robo2 T C 16: 73,730,666 (GRCm39) K982R probably damaging Het
Rps23 T C 13: 91,071,871 (GRCm39) probably null Het
Scamp4 T A 10: 80,445,505 (GRCm39) V56E probably damaging Het
Serpina1c C T 12: 103,861,291 (GRCm39) V408I probably benign Het
Sigirr A G 7: 140,673,701 (GRCm39) W49R probably damaging Het
Slc17a6 A T 7: 51,308,489 (GRCm39) H271L possibly damaging Het
Slc7a5 G T 8: 122,611,861 (GRCm39) T389K probably damaging Het
Slf1 T A 13: 77,191,999 (GRCm39) H945L probably benign Het
Slit3 T C 11: 35,523,549 (GRCm39) S662P probably damaging Het
Snta1 C A 2: 154,218,938 (GRCm39) E466* probably null Het
Sowaha A G 11: 53,369,272 (GRCm39) L488P probably damaging Het
Spata17 C A 1: 186,926,208 (GRCm39) V41F probably damaging Het
Spta1 T A 1: 174,045,429 (GRCm39) probably null Het
Srrm2 T A 17: 24,034,362 (GRCm39) probably benign Het
Stard13 T C 5: 150,985,992 (GRCm39) N388S probably benign Het
Stmn3 T C 2: 180,950,630 (GRCm39) K59E probably damaging Het
Sval1 A G 6: 41,932,378 (GRCm39) N76S probably benign Het
Svep1 T C 4: 58,096,276 (GRCm39) H1448R possibly damaging Het
Sycp2 A T 2: 178,000,017 (GRCm39) D986E probably benign Het
Sytl5 C T X: 9,781,841 (GRCm39) P181L possibly damaging Het
Tbkbp1 G A 11: 97,029,956 (GRCm39) S400L probably benign Het
Tesc G T 5: 118,194,531 (GRCm39) probably benign Het
Tjp1 C T 7: 64,993,475 (GRCm39) G33R probably damaging Het
Tlr11 C A 14: 50,600,346 (GRCm39) F777L probably benign Het
Tmem156 A G 5: 65,248,805 (GRCm39) probably benign Het
Top3a A G 11: 60,643,204 (GRCm39) probably benign Het
Tpcn1 A G 5: 120,694,584 (GRCm39) W162R probably damaging Het
Tpd52l2 A T 2: 181,157,005 (GRCm39) probably benign Het
Trim80 G A 11: 115,337,281 (GRCm39) G381D probably damaging Het
Ugt1a10 C T 1: 88,142,845 (GRCm39) P113L probably damaging Het
Vmn2r117 TC T 17: 23,698,487 (GRCm39) probably null Het
Vmn2r56 T A 7: 12,449,462 (GRCm39) I259F possibly damaging Het
Vmn2r59 T C 7: 41,693,077 (GRCm39) T508A probably benign Het
Wdr73 A G 7: 80,541,456 (GRCm39) V362A probably damaging Het
Zdhhc21 G T 4: 82,738,568 (GRCm39) T207K possibly damaging Het
Zfp120 T A 2: 149,959,872 (GRCm39) Q150L probably damaging Het
Zfp212 C A 6: 47,908,433 (GRCm39) Q471K possibly damaging Het
Zfp804b C T 5: 6,820,540 (GRCm39) G841D possibly damaging Het
Znfx1 A T 2: 166,878,724 (GRCm39) M1884K probably damaging Het
Znfx1 G T 2: 166,879,402 (GRCm39) A1658D probably benign Het
Other mutations in Apob
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00402:Apob APN 12 8,043,065 (GRCm39) splice site probably benign
IGL00421:Apob APN 12 8,060,197 (GRCm39) missense probably damaging 0.99
IGL00658:Apob APN 12 8,059,471 (GRCm39) missense probably benign 0.08
IGL00768:Apob APN 12 8,052,107 (GRCm39) missense probably damaging 1.00
IGL00833:Apob APN 12 8,060,101 (GRCm39) missense probably benign 0.14
IGL00926:Apob APN 12 8,065,421 (GRCm39) missense probably benign 0.01
IGL01065:Apob APN 12 8,053,299 (GRCm39) missense probably damaging 0.99
IGL01313:Apob APN 12 8,050,898 (GRCm39) missense probably damaging 1.00
IGL01419:Apob APN 12 8,052,251 (GRCm39) missense probably damaging 0.99
IGL01461:Apob APN 12 8,051,884 (GRCm39) missense probably benign 0.13
IGL02002:Apob APN 12 8,044,822 (GRCm39) missense probably benign 0.03
IGL02031:Apob APN 12 8,065,222 (GRCm39) missense probably benign
IGL02102:Apob APN 12 8,039,407 (GRCm39) missense possibly damaging 0.94
IGL02115:Apob APN 12 8,042,923 (GRCm39) missense probably benign 0.06
IGL02513:Apob APN 12 8,042,979 (GRCm39) missense probably benign 0.01
IGL02967:Apob APN 12 8,065,366 (GRCm39) nonsense probably null
IGL03005:Apob APN 12 8,043,059 (GRCm39) splice site probably benign
IGL03011:Apob APN 12 8,047,883 (GRCm39) missense probably damaging 1.00
IGL03116:Apob APN 12 8,066,350 (GRCm39) missense probably damaging 0.98
IGL03215:Apob APN 12 8,063,818 (GRCm39) missense possibly damaging 0.92
IGL03227:Apob APN 12 8,066,089 (GRCm39) missense probably benign 0.04
Aesthete UTSW 12 8,060,080 (GRCm39) nonsense probably null
Essence UTSW 12 8,057,769 (GRCm39) nonsense probably null
Ethos UTSW 12 8,040,394 (GRCm39) missense probably null 1.00
IGL02835:Apob UTSW 12 8,065,097 (GRCm39) missense possibly damaging 0.86
IGL02837:Apob UTSW 12 8,055,102 (GRCm39) missense probably damaging 1.00
R0071:Apob UTSW 12 8,052,111 (GRCm39) missense probably damaging 0.98
R0071:Apob UTSW 12 8,052,111 (GRCm39) missense probably damaging 0.98
R0116:Apob UTSW 12 8,039,113 (GRCm39) unclassified probably benign
R0180:Apob UTSW 12 8,058,285 (GRCm39) nonsense probably null
R0288:Apob UTSW 12 8,040,779 (GRCm39) nonsense probably null
R0295:Apob UTSW 12 8,052,181 (GRCm39) nonsense probably null
R0305:Apob UTSW 12 8,062,210 (GRCm39) missense probably damaging 1.00
R0312:Apob UTSW 12 8,059,034 (GRCm39) missense probably benign
R0324:Apob UTSW 12 8,060,521 (GRCm39) missense probably benign 0.41
R0326:Apob UTSW 12 8,040,307 (GRCm39) missense probably damaging 1.00
R0363:Apob UTSW 12 8,060,136 (GRCm39) missense probably damaging 1.00
R0390:Apob UTSW 12 8,038,678 (GRCm39) missense probably damaging 0.99
R0462:Apob UTSW 12 8,050,896 (GRCm39) missense probably damaging 1.00
R0471:Apob UTSW 12 8,040,406 (GRCm39) missense probably damaging 1.00
R0532:Apob UTSW 12 8,066,188 (GRCm39) missense possibly damaging 0.48
R0548:Apob UTSW 12 8,056,282 (GRCm39) missense probably damaging 1.00
R0560:Apob UTSW 12 8,055,101 (GRCm39) missense probably damaging 1.00
R0595:Apob UTSW 12 8,058,369 (GRCm39) missense probably benign 0.01
R0600:Apob UTSW 12 8,056,440 (GRCm39) missense probably damaging 1.00
R0626:Apob UTSW 12 8,066,193 (GRCm39) missense probably benign 0.45
R0685:Apob UTSW 12 8,060,742 (GRCm39) missense probably benign
R0765:Apob UTSW 12 8,066,518 (GRCm39) missense probably benign
R0790:Apob UTSW 12 8,060,245 (GRCm39) missense probably damaging 1.00
R0918:Apob UTSW 12 8,033,941 (GRCm39) missense probably benign 0.10
R0962:Apob UTSW 12 8,039,191 (GRCm39) missense probably damaging 0.98
R1055:Apob UTSW 12 8,044,963 (GRCm39) missense probably damaging 1.00
R1077:Apob UTSW 12 8,056,017 (GRCm39) missense probably benign
R1143:Apob UTSW 12 8,062,354 (GRCm39) missense probably benign 0.26
R1163:Apob UTSW 12 8,061,654 (GRCm39) missense probably damaging 1.00
R1266:Apob UTSW 12 8,056,093 (GRCm39) missense probably benign 0.37
R1434:Apob UTSW 12 8,059,715 (GRCm39) missense probably damaging 1.00
R1442:Apob UTSW 12 8,036,165 (GRCm39) missense probably benign 0.31
R1445:Apob UTSW 12 8,066,084 (GRCm39) missense possibly damaging 0.48
R1459:Apob UTSW 12 8,061,937 (GRCm39) missense possibly damaging 0.92
R1459:Apob UTSW 12 8,056,047 (GRCm39) missense probably benign
R1465:Apob UTSW 12 8,061,421 (GRCm39) missense possibly damaging 0.91
R1465:Apob UTSW 12 8,061,421 (GRCm39) missense possibly damaging 0.91
R1508:Apob UTSW 12 8,061,481 (GRCm39) missense possibly damaging 0.92
R1518:Apob UTSW 12 8,039,207 (GRCm39) missense probably benign 0.01
R1531:Apob UTSW 12 8,047,880 (GRCm39) missense possibly damaging 0.65
R1547:Apob UTSW 12 8,053,368 (GRCm39) missense probably benign 0.08
R1574:Apob UTSW 12 8,040,839 (GRCm39) missense possibly damaging 0.51
R1574:Apob UTSW 12 8,040,839 (GRCm39) missense possibly damaging 0.51
R1682:Apob UTSW 12 8,062,365 (GRCm39) missense probably benign 0.00
R1709:Apob UTSW 12 8,059,306 (GRCm39) missense probably damaging 0.98
R1718:Apob UTSW 12 8,066,087 (GRCm39) missense probably benign 0.02
R1752:Apob UTSW 12 8,038,766 (GRCm39) missense probably benign 0.01
R1781:Apob UTSW 12 8,059,603 (GRCm39) missense possibly damaging 0.96
R1818:Apob UTSW 12 8,063,064 (GRCm39) missense possibly damaging 0.93
R1818:Apob UTSW 12 8,056,834 (GRCm39) missense probably damaging 0.98
R1842:Apob UTSW 12 8,061,559 (GRCm39) missense probably damaging 1.00
R1843:Apob UTSW 12 8,057,602 (GRCm39) missense possibly damaging 0.65
R1853:Apob UTSW 12 8,060,928 (GRCm39) nonsense probably null
R1990:Apob UTSW 12 8,051,039 (GRCm39) missense probably damaging 1.00
R2016:Apob UTSW 12 8,057,751 (GRCm39) missense possibly damaging 0.48
R2017:Apob UTSW 12 8,057,751 (GRCm39) missense possibly damaging 0.48
R2023:Apob UTSW 12 8,061,090 (GRCm39) missense probably benign 0.01
R2037:Apob UTSW 12 8,057,488 (GRCm39) missense probably benign 0.37
R2054:Apob UTSW 12 8,063,134 (GRCm39) missense probably damaging 1.00
R2057:Apob UTSW 12 8,052,164 (GRCm39) nonsense probably null
R2085:Apob UTSW 12 8,062,240 (GRCm39) missense probably damaging 1.00
R2159:Apob UTSW 12 8,060,081 (GRCm39) missense probably benign 0.12
R2209:Apob UTSW 12 8,057,752 (GRCm39) missense probably benign 0.28
R2249:Apob UTSW 12 8,057,499 (GRCm39) missense probably damaging 1.00
R2254:Apob UTSW 12 8,061,256 (GRCm39) missense possibly damaging 0.92
R2265:Apob UTSW 12 8,065,475 (GRCm39) missense possibly damaging 0.74
R2266:Apob UTSW 12 8,065,475 (GRCm39) missense possibly damaging 0.74
R2267:Apob UTSW 12 8,065,475 (GRCm39) missense possibly damaging 0.74
R2268:Apob UTSW 12 8,065,475 (GRCm39) missense possibly damaging 0.74
R2296:Apob UTSW 12 8,044,879 (GRCm39) missense probably damaging 0.97
R2897:Apob UTSW 12 8,060,356 (GRCm39) missense probably damaging 1.00
R3431:Apob UTSW 12 8,060,778 (GRCm39) missense probably damaging 1.00
R3723:Apob UTSW 12 8,056,327 (GRCm39) missense probably damaging 1.00
R3723:Apob UTSW 12 8,061,763 (GRCm39) missense possibly damaging 0.46
R3899:Apob UTSW 12 8,065,849 (GRCm39) missense possibly damaging 0.87
R4020:Apob UTSW 12 8,044,914 (GRCm39) nonsense probably null
R4050:Apob UTSW 12 8,065,390 (GRCm39) missense probably benign 0.02
R4351:Apob UTSW 12 8,043,054 (GRCm39) missense probably benign 0.03
R4365:Apob UTSW 12 8,066,083 (GRCm39) missense possibly damaging 0.95
R4366:Apob UTSW 12 8,066,083 (GRCm39) missense possibly damaging 0.95
R4456:Apob UTSW 12 8,065,445 (GRCm39) missense probably damaging 1.00
R4458:Apob UTSW 12 8,065,445 (GRCm39) missense probably damaging 1.00
R4600:Apob UTSW 12 8,058,568 (GRCm39) missense probably damaging 1.00
R4611:Apob UTSW 12 8,061,331 (GRCm39) missense probably damaging 1.00
R4646:Apob UTSW 12 8,062,759 (GRCm39) missense probably benign 0.21
R4678:Apob UTSW 12 8,045,585 (GRCm39) missense probably damaging 1.00
R4685:Apob UTSW 12 8,056,456 (GRCm39) missense probably benign 0.00
R4707:Apob UTSW 12 8,056,205 (GRCm39) missense probably damaging 0.96
R4726:Apob UTSW 12 8,040,267 (GRCm39) missense probably damaging 0.98
R4792:Apob UTSW 12 8,058,051 (GRCm39) missense probably benign 0.26
R4822:Apob UTSW 12 8,065,741 (GRCm39) missense probably benign 0.04
R4834:Apob UTSW 12 8,064,101 (GRCm39) missense possibly damaging 0.49
R4835:Apob UTSW 12 8,065,391 (GRCm39) missense possibly damaging 0.56
R4887:Apob UTSW 12 8,063,099 (GRCm39) missense probably damaging 1.00
R5072:Apob UTSW 12 8,058,714 (GRCm39) missense probably benign 0.00
R5073:Apob UTSW 12 8,055,219 (GRCm39) critical splice donor site probably null
R5074:Apob UTSW 12 8,055,219 (GRCm39) critical splice donor site probably null
R5101:Apob UTSW 12 8,061,934 (GRCm39) missense probably benign 0.09
R5123:Apob UTSW 12 8,057,630 (GRCm39) splice site probably null
R5133:Apob UTSW 12 8,058,898 (GRCm39) missense probably damaging 0.99
R5135:Apob UTSW 12 8,060,086 (GRCm39) missense probably damaging 1.00
R5137:Apob UTSW 12 8,061,384 (GRCm39) missense possibly damaging 0.63
R5160:Apob UTSW 12 8,062,126 (GRCm39) missense possibly damaging 0.90
R5173:Apob UTSW 12 8,058,238 (GRCm39) missense probably benign 0.00
R5202:Apob UTSW 12 8,063,737 (GRCm39) missense probably damaging 0.98
R5229:Apob UTSW 12 8,027,806 (GRCm39) missense probably benign
R5292:Apob UTSW 12 8,055,912 (GRCm39) missense probably benign 0.01
R5378:Apob UTSW 12 8,061,865 (GRCm39) missense probably damaging 0.99
R5494:Apob UTSW 12 8,061,762 (GRCm39) missense probably damaging 0.99
R5517:Apob UTSW 12 8,040,906 (GRCm39) missense probably damaging 1.00
R5576:Apob UTSW 12 8,048,662 (GRCm39) missense probably damaging 1.00
R5582:Apob UTSW 12 8,060,788 (GRCm39) missense probably damaging 1.00
R5629:Apob UTSW 12 8,057,847 (GRCm39) missense probably damaging 1.00
R5678:Apob UTSW 12 8,041,494 (GRCm39) missense possibly damaging 0.92
R5732:Apob UTSW 12 8,060,353 (GRCm39) missense probably benign 0.15
R5734:Apob UTSW 12 8,038,781 (GRCm39) missense probably damaging 1.00
R5742:Apob UTSW 12 8,057,191 (GRCm39) missense probably damaging 1.00
R5751:Apob UTSW 12 8,062,619 (GRCm39) nonsense probably null
R5776:Apob UTSW 12 8,056,149 (GRCm39) missense possibly damaging 0.57
R5778:Apob UTSW 12 8,065,074 (GRCm39) missense probably benign 0.45
R5783:Apob UTSW 12 8,051,022 (GRCm39) missense probably damaging 1.00
R5786:Apob UTSW 12 8,065,304 (GRCm39) missense possibly damaging 0.48
R5837:Apob UTSW 12 8,053,277 (GRCm39) missense probably benign 0.04
R5857:Apob UTSW 12 8,065,397 (GRCm39) missense probably benign 0.00
R6029:Apob UTSW 12 8,066,243 (GRCm39) missense probably damaging 0.99
R6032:Apob UTSW 12 8,045,513 (GRCm39) missense probably benign 0.02
R6032:Apob UTSW 12 8,045,513 (GRCm39) missense probably benign 0.02
R6086:Apob UTSW 12 8,065,164 (GRCm39) missense probably benign
R6110:Apob UTSW 12 8,061,883 (GRCm39) missense probably damaging 1.00
R6131:Apob UTSW 12 8,065,874 (GRCm39) missense probably benign 0.17
R6157:Apob UTSW 12 8,056,077 (GRCm39) missense probably benign
R6179:Apob UTSW 12 8,055,060 (GRCm39) nonsense probably null
R6247:Apob UTSW 12 8,051,801 (GRCm39) missense probably damaging 1.00
R6279:Apob UTSW 12 8,057,769 (GRCm39) nonsense probably null
R6300:Apob UTSW 12 8,057,769 (GRCm39) nonsense probably null
R6320:Apob UTSW 12 8,039,194 (GRCm39) missense probably benign 0.27
R6339:Apob UTSW 12 8,066,188 (GRCm39) missense probably damaging 0.99
R6353:Apob UTSW 12 8,059,421 (GRCm39) missense probably damaging 1.00
R6395:Apob UTSW 12 8,058,507 (GRCm39) missense probably benign 0.45
R6441:Apob UTSW 12 8,037,796 (GRCm39) missense probably damaging 1.00
R6492:Apob UTSW 12 8,058,261 (GRCm39) missense probably damaging 0.99
R6495:Apob UTSW 12 8,040,394 (GRCm39) missense probably null 1.00
R6502:Apob UTSW 12 8,051,814 (GRCm39) missense probably damaging 0.99
R6520:Apob UTSW 12 8,033,124 (GRCm39) missense probably damaging 1.00
R6644:Apob UTSW 12 8,059,077 (GRCm39) missense probably damaging 0.97
R6704:Apob UTSW 12 8,060,379 (GRCm39) missense probably damaging 0.98
R6750:Apob UTSW 12 8,047,853 (GRCm39) missense probably damaging 1.00
R6759:Apob UTSW 12 8,061,049 (GRCm39) missense probably benign 0.06
R6812:Apob UTSW 12 8,033,062 (GRCm39) missense probably damaging 0.98
R6865:Apob UTSW 12 8,058,847 (GRCm39) missense probably benign 0.05
R6873:Apob UTSW 12 8,065,995 (GRCm39) missense probably benign 0.00
R7013:Apob UTSW 12 8,060,080 (GRCm39) nonsense probably null
R7067:Apob UTSW 12 8,059,423 (GRCm39) missense probably damaging 1.00
R7084:Apob UTSW 12 8,059,591 (GRCm39) missense probably benign
R7113:Apob UTSW 12 8,045,539 (GRCm39) missense probably damaging 1.00
R7175:Apob UTSW 12 8,057,034 (GRCm39) missense probably benign 0.33
R7196:Apob UTSW 12 8,033,893 (GRCm39) missense possibly damaging 0.90
R7199:Apob UTSW 12 8,055,072 (GRCm39) missense probably damaging 1.00
R7205:Apob UTSW 12 8,055,087 (GRCm39) missense probably damaging 0.98
R7251:Apob UTSW 12 8,057,037 (GRCm39) missense probably damaging 0.98
R7474:Apob UTSW 12 8,059,185 (GRCm39) missense probably benign 0.29
R7484:Apob UTSW 12 8,056,884 (GRCm39) nonsense probably null
R7538:Apob UTSW 12 8,052,219 (GRCm39) missense probably damaging 0.98
R7636:Apob UTSW 12 8,059,516 (GRCm39) missense possibly damaging 0.86
R7646:Apob UTSW 12 8,059,189 (GRCm39) missense probably damaging 0.99
R7787:Apob UTSW 12 8,040,780 (GRCm39) missense probably damaging 0.97
R7793:Apob UTSW 12 8,058,124 (GRCm39) missense probably damaging 0.99
R7836:Apob UTSW 12 8,051,885 (GRCm39) missense possibly damaging 0.72
R7895:Apob UTSW 12 8,061,933 (GRCm39) missense probably benign 0.00
R8005:Apob UTSW 12 8,059,744 (GRCm39) missense probably benign 0.01
R8013:Apob UTSW 12 8,060,798 (GRCm39) missense possibly damaging 0.94
R8014:Apob UTSW 12 8,060,798 (GRCm39) missense possibly damaging 0.94
R8111:Apob UTSW 12 8,058,801 (GRCm39) missense probably benign 0.16
R8117:Apob UTSW 12 8,056,435 (GRCm39) missense probably damaging 0.99
R8226:Apob UTSW 12 8,059,056 (GRCm39) missense probably benign 0.00
R8244:Apob UTSW 12 8,060,548 (GRCm39) missense probably damaging 0.96
R8280:Apob UTSW 12 8,060,851 (GRCm39) missense possibly damaging 0.46
R8310:Apob UTSW 12 8,059,033 (GRCm39) missense probably benign 0.00
R8327:Apob UTSW 12 8,051,015 (GRCm39) missense possibly damaging 0.72
R8329:Apob UTSW 12 8,061,135 (GRCm39) missense probably damaging 0.98
R8331:Apob UTSW 12 8,051,882 (GRCm39) missense probably benign 0.28
R8351:Apob UTSW 12 8,056,356 (GRCm39) missense probably benign 0.29
R8412:Apob UTSW 12 8,058,069 (GRCm39) missense probably benign 0.33
R8425:Apob UTSW 12 8,038,842 (GRCm39) missense possibly damaging 0.70
R8481:Apob UTSW 12 8,044,807 (GRCm39) splice site probably null
R8493:Apob UTSW 12 8,059,009 (GRCm39) missense possibly damaging 0.87
R8529:Apob UTSW 12 8,057,353 (GRCm39) missense probably damaging 1.00
R8554:Apob UTSW 12 8,037,830 (GRCm39) missense probably damaging 0.98
R8692:Apob UTSW 12 8,058,270 (GRCm39) missense probably damaging 0.98
R8695:Apob UTSW 12 8,057,830 (GRCm39) missense probably damaging 1.00
R8977:Apob UTSW 12 8,065,990 (GRCm39) missense probably damaging 0.99
R9016:Apob UTSW 12 8,035,408 (GRCm39) splice site silent
R9020:Apob UTSW 12 8,063,999 (GRCm39) missense probably damaging 1.00
R9037:Apob UTSW 12 8,066,501 (GRCm39) missense probably benign 0.15
R9053:Apob UTSW 12 8,058,954 (GRCm39) missense possibly damaging 0.72
R9062:Apob UTSW 12 8,058,046 (GRCm39) missense possibly damaging 0.91
R9142:Apob UTSW 12 8,062,705 (GRCm39) missense possibly damaging 0.95
R9180:Apob UTSW 12 8,047,925 (GRCm39) missense probably damaging 1.00
R9205:Apob UTSW 12 8,030,635 (GRCm39) missense probably damaging 0.99
R9248:Apob UTSW 12 8,065,231 (GRCm39) nonsense probably null
R9277:Apob UTSW 12 8,061,183 (GRCm39) missense probably benign 0.01
R9305:Apob UTSW 12 8,058,053 (GRCm39) missense probably benign 0.04
R9358:Apob UTSW 12 8,060,833 (GRCm39) missense probably benign 0.14
R9375:Apob UTSW 12 8,029,261 (GRCm39) missense possibly damaging 0.91
R9385:Apob UTSW 12 8,056,399 (GRCm39) missense possibly damaging 0.91
R9386:Apob UTSW 12 8,056,629 (GRCm39) missense probably damaging 0.99
R9392:Apob UTSW 12 8,057,098 (GRCm39) missense probably benign 0.45
R9470:Apob UTSW 12 8,039,219 (GRCm39) missense possibly damaging 0.94
R9523:Apob UTSW 12 8,052,069 (GRCm39) missense probably damaging 1.00
R9545:Apob UTSW 12 8,033,890 (GRCm39) missense possibly damaging 0.81
R9629:Apob UTSW 12 8,059,054 (GRCm39) missense probably damaging 1.00
R9702:Apob UTSW 12 8,057,559 (GRCm39) missense probably damaging 0.96
R9703:Apob UTSW 12 8,030,507 (GRCm39) missense probably damaging 0.99
R9719:Apob UTSW 12 8,065,464 (GRCm39) missense probably benign 0.15
R9726:Apob UTSW 12 8,056,926 (GRCm39) missense probably damaging 0.99
R9729:Apob UTSW 12 8,066,125 (GRCm39) missense probably damaging 0.99
X0027:Apob UTSW 12 8,057,975 (GRCm39) missense probably benign
Z1088:Apob UTSW 12 8,062,936 (GRCm39) missense possibly damaging 0.95
Z1088:Apob UTSW 12 8,055,945 (GRCm39) nonsense probably null
Z1088:Apob UTSW 12 8,055,074 (GRCm39) missense possibly damaging 0.91
Z1176:Apob UTSW 12 8,054,978 (GRCm39) missense probably benign 0.00
Z1176:Apob UTSW 12 8,048,011 (GRCm39) missense probably damaging 1.00
Z1177:Apob UTSW 12 8,065,249 (GRCm39) frame shift probably null
Z1177:Apob UTSW 12 8,038,765 (GRCm39) missense probably benign 0.43
Predicted Primers PCR Primer
(F):5'- TGTTGACAAGCCCCAAGAATTC -3'
(R):5'- GTATCGCGTATGTCTCAAGTTG -3'

Sequencing Primer
(F):5'- CACAATTATTGCTGTGGTGAAGTACG -3'
(R):5'- CAAGTTGAGAGAGTTTTTCATTGAAG -3'
Posted On 2016-04-15