Incidental Mutation 'R4912:Vmn1r28'
ID 379620
Institutional Source Beutler Lab
Gene Symbol Vmn1r28
Ensembl Gene ENSMUSG00000115705
Gene Name vomeronasal 1 receptor 28
Synonyms V1rc25
MMRRC Submission 042514-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R4912 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 58239279-58243645 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58242525 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 123 (I123F)
Ref Sequence ENSEMBL: ENSMUSP00000153785 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176874] [ENSMUST00000226813] [ENSMUST00000227805] [ENSMUST00000228678]
AlphaFold Q8R2C9
Predicted Effect possibly damaging
Transcript: ENSMUST00000176874
AA Change: I123F

PolyPhen 2 Score 0.864 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000135311
Gene: ENSMUSG00000094291
AA Change: I123F

DomainStartEndE-ValueType
Pfam:V1R 28 293 8.4e-59 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226813
AA Change: I123F

PolyPhen 2 Score 0.864 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227805
AA Change: I123F

PolyPhen 2 Score 0.864 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228678
AA Change: I123F

PolyPhen 2 Score 0.864 (Sensitivity: 0.83; Specificity: 0.93)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 91.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik T C 3: 124,213,505 (GRCm39) D52G possibly damaging Het
Acaa1a C A 9: 119,171,827 (GRCm39) R102S probably damaging Het
Arhgef12 G A 9: 42,904,361 (GRCm39) R706* probably null Het
Best3 A G 10: 116,844,886 (GRCm39) Y347C probably damaging Het
Birc6 T A 17: 74,872,900 (GRCm39) D386E probably damaging Het
C130050O18Rik A T 5: 139,400,144 (GRCm39) T66S probably benign Het
Chd9 A T 8: 91,760,858 (GRCm39) D2201V possibly damaging Het
Csk A G 9: 57,538,063 (GRCm39) Y48H probably damaging Het
Dffb T A 4: 154,049,864 (GRCm39) probably benign Het
Diaph3 A C 14: 87,244,635 (GRCm39) C217W probably damaging Het
Eml2 T A 7: 18,927,924 (GRCm39) probably null Het
Ercc5 T C 1: 44,196,217 (GRCm39) I70T probably damaging Het
Fryl AGTGTGT AGTGT 5: 73,226,125 (GRCm39) probably null Het
Fsd1 C T 17: 56,298,241 (GRCm39) P189S possibly damaging Het
Gm42669 A G 5: 107,656,683 (GRCm39) K982R probably damaging Het
Gm5414 A G 15: 101,533,445 (GRCm39) I373T possibly damaging Het
Gm7356 A G 17: 14,221,498 (GRCm39) L177P possibly damaging Het
Grip1 G A 10: 119,767,153 (GRCm39) D93N probably damaging Het
Hbq1b T A 11: 32,237,014 (GRCm39) M1K probably null Het
Hps3 C A 3: 20,068,337 (GRCm39) L572F probably damaging Het
Ighj2 T A 12: 113,393,100 (GRCm39) probably benign Het
Kcna3 T C 3: 106,945,207 (GRCm39) M490T probably benign Het
Krt76 T A 15: 101,796,597 (GRCm39) K404* probably null Het
Lgr4 A T 2: 109,836,847 (GRCm39) probably null Het
Ltbp4 G T 7: 27,005,541 (GRCm39) C1533* probably null Het
Mapre2 A G 18: 23,965,990 (GRCm39) N25S probably damaging Het
Mark3 T A 12: 111,559,087 (GRCm39) I43K probably benign Het
Mon1b T A 8: 114,368,585 (GRCm39) Y495* probably null Het
Mrfap1 A G 5: 36,954,089 (GRCm39) probably benign Het
Mxra8 A G 4: 155,925,361 (GRCm39) probably null Het
Myoz1 A T 14: 20,699,606 (GRCm39) L244Q probably damaging Het
Ndfip2 C T 14: 105,496,120 (GRCm39) R5W probably benign Het
Nek11 T C 9: 105,164,857 (GRCm39) D423G probably benign Het
Nin A T 12: 70,090,837 (GRCm39) D859E probably damaging Het
Nup210 G A 6: 90,994,511 (GRCm39) A1729V probably benign Het
Olfm3 A G 3: 114,895,589 (GRCm39) E157G probably damaging Het
Or1e1f A T 11: 73,856,166 (GRCm39) H244L probably damaging Het
Prickle1 A G 15: 93,398,429 (GRCm39) S800P probably benign Het
Reln A G 5: 22,130,191 (GRCm39) S2707P probably benign Het
Resf1 C G 6: 149,230,887 (GRCm39) S1311C probably damaging Het
Rexo4 G A 2: 26,852,404 (GRCm39) T200M possibly damaging Het
Saxo2 T A 7: 82,283,743 (GRCm39) I372L probably benign Het
Scgb2b2 T A 7: 31,003,056 (GRCm39) D50E probably benign Het
Sipa1l1 T C 12: 82,443,452 (GRCm39) L914P possibly damaging Het
Slf1 T A 13: 77,199,413 (GRCm39) D656V probably damaging Het
Sorbs1 T C 19: 40,300,171 (GRCm39) D1192G probably damaging Het
Tdrd6 A C 17: 43,935,218 (GRCm39) D1943E probably benign Het
Tmem163 G A 1: 127,419,362 (GRCm39) T281M probably damaging Het
Tmod3 A G 9: 75,439,730 (GRCm39) V35A probably damaging Het
Ttc39c A T 18: 12,867,951 (GRCm39) Q448L probably benign Het
Ulk1 A T 5: 110,935,455 (GRCm39) S937T probably damaging Het
Unc13c T A 9: 73,481,304 (GRCm39) D1711V probably damaging Het
Usp5 C G 6: 124,799,593 (GRCm39) K318N possibly damaging Het
Utp20 G T 10: 88,607,822 (GRCm39) Q1596K probably benign Het
Vmn1r73 T A 7: 11,490,596 (GRCm39) V138E probably damaging Het
Vmn2r112 A G 17: 22,822,363 (GRCm39) D347G probably damaging Het
Vmn2r3 T G 3: 64,166,618 (GRCm39) T838P probably damaging Het
Vps13d A T 4: 144,882,427 (GRCm39) D1055E probably benign Het
Wdr17 T C 8: 55,082,896 (GRCm39) D1268G probably damaging Het
Zfp108 T A 7: 23,960,739 (GRCm39) H443Q probably damaging Het
Zfp608 A G 18: 55,079,663 (GRCm39) V374A probably damaging Het
Zfp831 G T 2: 174,486,417 (GRCm39) G364V probably damaging Het
Zfp94 A G 7: 24,003,166 (GRCm39) V86A probably benign Het
Zkscan16 A C 4: 58,946,506 (GRCm39) N127T possibly damaging Het
Other mutations in Vmn1r28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01365:Vmn1r28 APN 6 58,242,176 (GRCm39) missense possibly damaging 0.76
IGL01712:Vmn1r28 APN 6 58,242,393 (GRCm39) missense probably benign 0.00
IGL01788:Vmn1r28 APN 6 58,242,522 (GRCm39) missense probably benign 0.00
IGL02629:Vmn1r28 APN 6 58,242,801 (GRCm39) missense probably benign 0.00
R0001:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0009:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0040:Vmn1r28 UTSW 6 58,242,879 (GRCm39) missense probably damaging 1.00
R0078:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0079:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0081:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0164:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0164:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0165:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0166:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0167:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0172:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0173:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0284:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0288:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R0704:Vmn1r28 UTSW 6 58,242,702 (GRCm39) missense probably benign 0.00
R1143:Vmn1r28 UTSW 6 58,242,727 (GRCm39) missense probably benign 0.00
R1225:Vmn1r28 UTSW 6 58,242,951 (GRCm39) nonsense probably null
R1464:Vmn1r28 UTSW 6 58,242,217 (GRCm39) missense probably benign 0.05
R1464:Vmn1r28 UTSW 6 58,242,217 (GRCm39) missense probably benign 0.05
R1836:Vmn1r28 UTSW 6 58,242,237 (GRCm39) missense probably damaging 0.98
R1882:Vmn1r28 UTSW 6 58,242,963 (GRCm39) missense probably benign
R1905:Vmn1r28 UTSW 6 58,242,912 (GRCm39) missense probably benign 0.01
R5071:Vmn1r28 UTSW 6 58,242,894 (GRCm39) missense probably benign 0.25
R5113:Vmn1r28 UTSW 6 58,242,843 (GRCm39) missense probably benign 0.12
R5261:Vmn1r28 UTSW 6 58,242,524 (GRCm39) missense probably benign 0.02
R5265:Vmn1r28 UTSW 6 58,242,949 (GRCm39) missense probably damaging 0.98
R5839:Vmn1r28 UTSW 6 58,242,280 (GRCm39) missense possibly damaging 0.94
R6180:Vmn1r28 UTSW 6 58,242,476 (GRCm39) missense probably damaging 0.99
R6643:Vmn1r28 UTSW 6 58,242,945 (GRCm39) missense probably benign 0.17
R6884:Vmn1r28 UTSW 6 58,242,633 (GRCm39) missense probably benign 0.03
R7393:Vmn1r28 UTSW 6 58,242,574 (GRCm39) missense possibly damaging 0.81
R7471:Vmn1r28 UTSW 6 58,242,850 (GRCm39) nonsense probably null
R7738:Vmn1r28 UTSW 6 58,243,039 (GRCm39) missense probably benign 0.00
R7961:Vmn1r28 UTSW 6 58,242,178 (GRCm39) missense probably benign
R8009:Vmn1r28 UTSW 6 58,242,178 (GRCm39) missense probably benign
R8156:Vmn1r28 UTSW 6 58,242,183 (GRCm39) missense probably damaging 1.00
R8167:Vmn1r28 UTSW 6 58,243,052 (GRCm39) missense noncoding transcript
R8879:Vmn1r28 UTSW 6 58,242,669 (GRCm39) missense probably benign 0.05
R9639:Vmn1r28 UTSW 6 58,242,996 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCTCAGTGAAGGAGATAACTTGC -3'
(R):5'- TACAAGAAATACATCCCTGGCG -3'

Sequencing Primer
(F):5'- AGGAGATAACTTGCTTGCAAAC -3'
(R):5'- AATACATCCCTGGCGATTATCACTG -3'
Posted On 2016-04-15