Incidental Mutation 'R4913:Or10al5'
ID 379751
Institutional Source Beutler Lab
Gene Symbol Or10al5
Ensembl Gene ENSMUSG00000060017
Gene Name olfactory receptor family 10 subfamily AL member 5
Synonyms Olfr121, GA_x6K02T2PSCP-2211113-2212078, MOR263-4
MMRRC Submission 042515-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R4913 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 38059757-38063895 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38063315 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 190 (V190D)
Ref Sequence ENSEMBL: ENSMUSP00000133865 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074555] [ENSMUST00000174675]
AlphaFold Q5CZY0
Predicted Effect possibly damaging
Transcript: ENSMUST00000074555
AA Change: V190D

PolyPhen 2 Score 0.858 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000084377
Gene: ENSMUSG00000060017
AA Change: V190D

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 2.9e-56 PFAM
Pfam:7TM_GPCR_Srsx 41 311 2.1e-5 PFAM
Pfam:7tm_1 47 296 8.3e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000174675
AA Change: V190D

PolyPhen 2 Score 0.858 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000133865
Gene: ENSMUSG00000060017
AA Change: V190D

DomainStartEndE-ValueType
transmembrane domain 33 55 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.0%
  • 20x: 91.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm1 T A 4: 144,255,381 (GRCm39) M267K possibly damaging Het
Acsm5 T C 7: 119,133,566 (GRCm39) S244P probably damaging Het
Actr6 A G 10: 89,550,808 (GRCm39) F329L probably benign Het
Actrt3 A G 3: 30,652,588 (GRCm39) S169P probably benign Het
Agtpbp1 C A 13: 59,647,886 (GRCm39) G645C probably damaging Het
AI661453 C T 17: 47,779,480 (GRCm39) R1069* probably null Het
Akr1c6 T C 13: 4,504,524 (GRCm39) I303T probably benign Het
Arnt A G 3: 95,397,965 (GRCm39) R588G probably damaging Het
Atf1 A G 15: 100,149,979 (GRCm39) probably null Het
Casp12 T C 9: 5,358,726 (GRCm39) V318A probably damaging Het
Cblb C T 16: 51,986,392 (GRCm39) P545L possibly damaging Het
Cc2d2a A T 5: 43,896,665 (GRCm39) I1521F probably benign Het
Ccn2 T C 10: 24,473,225 (GRCm39) C255R probably damaging Het
Ccnb1ip1 T A 14: 51,029,601 (GRCm39) K154* probably null Het
Cd300a A T 11: 114,784,198 (GRCm39) K69* probably null Het
Cdin1 A G 2: 115,500,568 (GRCm39) probably null Het
Clec10a A G 11: 70,060,851 (GRCm39) Y78C probably damaging Het
Cnot1 T C 8: 96,489,695 (GRCm39) I503V possibly damaging Het
Cpa2 A G 6: 30,554,292 (GRCm39) H304R probably damaging Het
Crb2 A T 2: 37,680,257 (GRCm39) H395L probably benign Het
Dnah8 T A 17: 31,038,113 (GRCm39) N4257K probably damaging Het
Dnase2a G A 8: 85,635,477 (GRCm39) D25N probably damaging Het
Drd1 T C 13: 54,207,186 (GRCm39) T343A probably benign Het
Emid1 G A 11: 5,082,012 (GRCm39) T161I probably benign Het
Epn2 A G 11: 61,425,402 (GRCm39) probably null Het
Esp36 A T 17: 38,728,055 (GRCm39) N75K possibly damaging Het
Faf1 A G 4: 109,792,746 (GRCm39) S573G possibly damaging Het
Fam149a T G 8: 45,806,920 (GRCm39) S231R probably damaging Het
Fam78a T C 2: 31,959,774 (GRCm39) E112G probably damaging Het
Fgf18 T C 11: 33,084,316 (GRCm39) D46G probably benign Het
Fggy G A 4: 95,585,313 (GRCm39) probably null Het
Foxb1 T C 9: 69,666,859 (GRCm39) M224V probably benign Het
Gpr75 T C 11: 30,841,808 (GRCm39) C238R possibly damaging Het
Gsdmc3 A G 15: 63,730,122 (GRCm39) *481R probably null Het
H2az2 C A 11: 6,383,750 (GRCm39) A57S probably damaging Het
Hsd17b11 T C 5: 104,140,748 (GRCm39) I250V probably benign Het
Hus1 C A 11: 8,946,856 (GRCm39) L280F probably benign Het
Ide A T 19: 37,306,469 (GRCm39) H101Q unknown Het
Ido1 T C 8: 25,074,533 (GRCm39) D279G probably benign Het
Inpp5b T C 4: 124,674,214 (GRCm39) V307A probably benign Het
Ipo5 G A 14: 121,172,498 (GRCm39) V519I probably damaging Het
Krba1 T C 6: 48,383,891 (GRCm39) V239A probably benign Het
Lmod3 A G 6: 97,224,125 (GRCm39) probably null Het
Macf1 T C 4: 123,393,682 (GRCm39) D836G probably damaging Het
Malt1 G T 18: 65,609,351 (GRCm39) C774F probably damaging Het
Map2k4 C A 11: 65,600,758 (GRCm39) D58Y probably damaging Het
Mc2r T C 18: 68,540,411 (GRCm39) N294S probably benign Het
Mybpc1 A G 10: 88,389,116 (GRCm39) probably null Het
Mybpc3 A G 2: 90,956,609 (GRCm39) E637G possibly damaging Het
Narf A G 11: 121,135,469 (GRCm39) Q107R probably damaging Het
Nlrp3 G A 11: 59,440,064 (GRCm39) G547D probably benign Het
Nucb2 G T 7: 116,123,540 (GRCm39) G51* probably null Het
Otog C A 7: 45,913,526 (GRCm39) D786E probably benign Het
Otogl T C 10: 107,712,716 (GRCm39) T543A probably damaging Het
Pgap6 T C 17: 26,339,513 (GRCm39) F584L probably damaging Het
Phf20l1 A G 15: 66,476,704 (GRCm39) N266S probably benign Het
Pink1 G T 4: 138,042,866 (GRCm39) S446* probably null Het
Pkp4 T G 2: 59,135,794 (GRCm39) H186Q probably damaging Het
Prl3b1 T C 13: 27,433,460 (GRCm39) V205A probably damaging Het
Prss32 T C 17: 24,078,157 (GRCm39) V281A probably damaging Het
Psd3 C T 8: 68,573,821 (GRCm39) C120Y probably damaging Het
Ptcra A G 17: 47,069,574 (GRCm39) L99P probably damaging Het
Rab3gap2 C T 1: 184,995,026 (GRCm39) T855I probably benign Het
Rabgap1l T C 1: 160,066,111 (GRCm39) E199G probably damaging Het
Rbm44 T A 1: 91,083,216 (GRCm39) C580S probably damaging Het
Resf1 C G 6: 149,230,887 (GRCm39) S1311C probably damaging Het
Rhoq T C 17: 87,302,493 (GRCm39) V143A probably benign Het
Sacs T A 14: 61,451,246 (GRCm39) Y4431N probably benign Het
Sec24b A T 3: 129,796,028 (GRCm39) S367T probably benign Het
Sema4c G A 1: 36,589,266 (GRCm39) S620F probably benign Het
Slc12a1 G A 2: 125,070,670 (GRCm39) G1054E probably damaging Het
Slc16a3 A G 11: 120,848,794 (GRCm39) R417G probably benign Het
Slc22a29 A T 19: 8,195,722 (GRCm39) S106T probably benign Het
Slc41a2 T C 10: 83,149,284 (GRCm39) T220A probably damaging Het
Tap1 T C 17: 34,412,468 (GRCm39) F474L possibly damaging Het
Tas2r106 G T 6: 131,655,422 (GRCm39) A143D probably benign Het
Tbx6 A T 7: 126,383,707 (GRCm39) probably null Het
Tfap2a T A 13: 40,870,706 (GRCm39) N402I probably damaging Het
Tle3 T A 9: 61,281,275 (GRCm39) V22E probably damaging Het
Trip4 T C 9: 65,765,639 (GRCm39) I353M probably damaging Het
Ubr2 C A 17: 47,270,385 (GRCm39) probably null Het
Ugdh A G 5: 65,580,791 (GRCm39) probably null Het
Uhrf1 T C 17: 56,622,478 (GRCm39) V431A probably damaging Het
Usp5 C G 6: 124,799,593 (GRCm39) K318N possibly damaging Het
Zfp820 T C 17: 22,038,200 (GRCm39) K376R probably benign Het
Other mutations in Or10al5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01348:Or10al5 APN 17 38,063,177 (GRCm39) missense probably benign 0.03
R0100:Or10al5 UTSW 17 38,063,594 (GRCm39) missense probably benign 0.12
R0328:Or10al5 UTSW 17 38,063,284 (GRCm39) missense possibly damaging 0.57
R1641:Or10al5 UTSW 17 38,062,916 (GRCm39) missense possibly damaging 0.90
R2358:Or10al5 UTSW 17 38,063,271 (GRCm39) nonsense probably null
R3711:Or10al5 UTSW 17 38,063,271 (GRCm39) nonsense probably null
R3712:Or10al5 UTSW 17 38,063,271 (GRCm39) nonsense probably null
R4658:Or10al5 UTSW 17 38,063,054 (GRCm39) missense probably damaging 1.00
R5229:Or10al5 UTSW 17 38,063,192 (GRCm39) missense probably benign 0.00
R5611:Or10al5 UTSW 17 38,062,975 (GRCm39) missense possibly damaging 0.94
R6159:Or10al5 UTSW 17 38,063,038 (GRCm39) missense probably damaging 1.00
R6375:Or10al5 UTSW 17 38,062,990 (GRCm39) missense probably benign
R6500:Or10al5 UTSW 17 38,063,577 (GRCm39) missense probably damaging 1.00
R6818:Or10al5 UTSW 17 38,063,315 (GRCm39) missense possibly damaging 0.86
R7027:Or10al5 UTSW 17 38,063,300 (GRCm39) missense probably damaging 1.00
R7498:Or10al5 UTSW 17 38,063,242 (GRCm39) missense probably damaging 0.96
R7888:Or10al5 UTSW 17 38,062,888 (GRCm39) missense probably damaging 1.00
R8299:Or10al5 UTSW 17 38,062,891 (GRCm39) nonsense probably null
R9497:Or10al5 UTSW 17 38,062,942 (GRCm39) missense probably damaging 1.00
Z1176:Or10al5 UTSW 17 38,063,658 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTGGTATAACTGAGTGCTGTCTAC -3'
(R):5'- TGGAGAGAGCTTTATGGCGC -3'

Sequencing Primer
(F):5'- ATAACTGAGTGCTGTCTACTGGCAG -3'
(R):5'- AGAGCTTTATGGCGCCCCTC -3'
Posted On 2016-04-15