Incidental Mutation 'R4915:Cyp2a22'
ID 379937
Institutional Source Beutler Lab
Gene Symbol Cyp2a22
Ensembl Gene ENSMUSG00000091867
Gene Name cytochrome P450, family 2, subfamily a, polypeptide 22
Synonyms EG233005
MMRRC Submission 042517-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R4915 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 26631056-26638809 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 26637195 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 196 (E196D)
Ref Sequence ENSEMBL: ENSMUSP00000128030 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170227]
AlphaFold B2RXZ2
Predicted Effect probably benign
Transcript: ENSMUST00000170227
AA Change: E196D

PolyPhen 2 Score 0.330 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000128030
Gene: ENSMUSG00000091867
AA Change: E196D

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
Pfam:p450 33 489 7.4e-148 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206638
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206957
Meta Mutation Damage Score 0.0684 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.1%
  • 20x: 87.9%
Validation Efficiency 98% (162/166)
Allele List at MGI
Other mutations in this stock
Total: 135 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik C T 12: 71,236,420 (GRCm39) A1257V possibly damaging Het
Aldh8a1 T C 10: 21,271,662 (GRCm39) S463P probably damaging Het
Angptl1 T G 1: 156,672,388 (GRCm39) D71E probably benign Het
Ank2 T A 3: 126,736,320 (GRCm39) probably benign Het
Ano1 A G 7: 144,165,112 (GRCm39) S649P possibly damaging Het
Arhgef40 A G 14: 52,227,556 (GRCm39) E434G probably damaging Het
Asb15 A T 6: 24,566,292 (GRCm39) D415V probably damaging Het
Baz2b T A 2: 59,744,387 (GRCm39) T1373S possibly damaging Het
Bcas1 T C 2: 170,220,806 (GRCm39) D324G probably damaging Het
Bfsp1 C T 2: 143,669,391 (GRCm39) R396Q probably benign Het
Bmi1 G A 2: 18,687,143 (GRCm39) probably benign Het
Bpifb9b T A 2: 154,156,026 (GRCm39) probably null Het
Brd9 A G 13: 74,086,574 (GRCm39) E25G probably damaging Het
Btbd7 A T 12: 102,804,046 (GRCm39) C331* probably null Het
Ccdc198 A T 14: 49,470,351 (GRCm39) N189K probably benign Het
Cdh26 T C 2: 178,091,614 (GRCm39) S58P probably benign Het
Cenpj T C 14: 56,791,175 (GRCm39) D328G probably damaging Het
Cherp T C 8: 73,222,241 (GRCm39) D255G probably damaging Het
Clec5a T A 6: 40,562,165 (GRCm39) probably benign Het
Cntnap2 T C 6: 46,506,969 (GRCm39) probably benign Het
Col7a1 G A 9: 108,795,532 (GRCm39) G1529E unknown Het
Cybb C G X: 9,316,989 (GRCm39) D246H probably benign Het
Cyp4f18 T A 8: 72,762,898 (GRCm39) H63L probably damaging Het
Dclk2 A T 3: 86,732,049 (GRCm39) probably null Het
Ddx6 T A 9: 44,524,170 (GRCm39) D82E probably damaging Het
Defb42 A G 14: 63,285,790 (GRCm39) I57V probably benign Het
Dennd5a A G 7: 109,500,296 (GRCm39) F943S probably damaging Het
Dip2c T A 13: 9,671,905 (GRCm39) probably null Het
Disp2 A T 2: 118,620,935 (GRCm39) S556C probably damaging Het
Dnah12 A T 14: 26,455,725 (GRCm39) D816V probably damaging Het
Dpy19l3 T C 7: 35,452,167 (GRCm39) probably benign Het
Efcab11 T C 12: 99,685,321 (GRCm39) D151G probably damaging Het
Ehbp1 T C 11: 22,096,592 (GRCm39) D299G probably benign Het
Evl G T 12: 108,652,365 (GRCm39) R359L probably damaging Het
Fasn T G 11: 120,707,472 (GRCm39) N799T probably benign Het
Fbxo3 T G 2: 103,885,311 (GRCm39) N388K probably damaging Het
Fbxw14 A T 9: 109,103,592 (GRCm39) F40Y possibly damaging Het
Fbxw22 A G 9: 109,213,009 (GRCm39) F313L probably damaging Het
Fer1l4 T C 2: 155,873,220 (GRCm39) K1287E probably benign Het
Fn1 A T 1: 71,634,968 (GRCm39) probably null Het
Fry A T 5: 150,402,328 (GRCm39) T790S probably benign Het
Fut8 G T 12: 77,521,818 (GRCm39) A486S probably damaging Het
Gfra1 A T 19: 58,255,522 (GRCm39) S308R probably damaging Het
Gm13030 T A 4: 138,601,239 (GRCm39) probably benign Het
Gm37150 C T 9: 72,292,772 (GRCm39) noncoding transcript Het
Gm6788 C T 19: 28,740,664 (GRCm39) noncoding transcript Het
Gm8122 T C 14: 43,091,573 (GRCm39) N65S unknown Het
Gnb4 C T 3: 32,639,236 (GRCm39) probably benign Het
Gprin1 G T 13: 54,885,886 (GRCm39) P796Q probably damaging Het
Grin1 A G 2: 25,188,565 (GRCm39) probably benign Het
Helz2 T C 2: 180,874,231 (GRCm39) R2088G possibly damaging Het
Hsd3b9 C T 3: 98,357,845 (GRCm39) V56M probably damaging Het
Ighv6-6 C A 12: 114,398,595 (GRCm39) R57L probably damaging Het
Inhca A C 9: 103,129,054 (GRCm39) Y235* probably null Het
Inpp5f A T 7: 128,286,840 (GRCm39) D573V probably damaging Het
Iqgap3 T A 3: 88,008,834 (GRCm39) I643K possibly damaging Het
Itga11 C A 9: 62,659,530 (GRCm39) Y427* probably null Het
Kbtbd8 T G 6: 95,103,515 (GRCm39) M388R possibly damaging Het
Kif1a T A 1: 93,002,700 (GRCm39) E233V probably benign Het
Krt10 T C 11: 99,278,334 (GRCm39) N275S probably damaging Het
Lrrc3 T C 10: 77,737,253 (GRCm39) D61G probably benign Het
Mapk8ip3 A G 17: 25,128,127 (GRCm39) S377P possibly damaging Het
Mccc1 A G 3: 36,051,703 (GRCm39) L32S probably benign Het
Meis1 T C 11: 18,959,222 (GRCm39) probably benign Het
Mmp11 C T 10: 75,761,419 (GRCm39) A31T probably damaging Het
Mthfsl A C 9: 88,597,550 (GRCm39) L67V probably damaging Het
Myo1c T G 11: 75,547,135 (GRCm39) M1R probably null Het
N4bp2 T A 5: 65,960,847 (GRCm39) M506K probably damaging Het
Nfix T C 8: 85,498,458 (GRCm39) I172V probably benign Het
Nid1 A G 13: 13,674,171 (GRCm39) E850G possibly damaging Het
Nlrp9c T C 7: 26,083,885 (GRCm39) T565A probably benign Het
Nomo1 T C 7: 45,693,656 (GRCm39) F163L probably benign Het
Nsd1 T C 13: 55,395,681 (GRCm39) V1197A possibly damaging Het
Nsd1 A G 13: 55,424,341 (GRCm39) T1463A probably benign Het
Nsf G A 11: 103,801,185 (GRCm39) probably benign Het
Or3a1b A T 11: 74,012,705 (GRCm39) I197F probably benign Het
Or4k51 A T 2: 111,584,725 (GRCm39) I44F probably benign Het
Or5an1c A G 19: 12,218,737 (GRCm39) V96A probably benign Het
Or5b106 T A 19: 13,123,355 (GRCm39) I223L possibly damaging Het
Or8k33 A G 2: 86,384,399 (GRCm39) L23P probably damaging Het
Or9g10 T C 2: 85,584,465 (GRCm39) probably benign Het
Pcdha6 T A 18: 37,101,510 (GRCm39) D234E probably damaging Het
Pcnx1 C A 12: 82,021,269 (GRCm39) F1425L probably benign Het
Pdzd9 T G 7: 120,269,391 (GRCm39) N10T possibly damaging Het
Pex6 A T 17: 47,024,982 (GRCm39) H345L probably damaging Het
Pfkfb3 G A 2: 11,495,109 (GRCm39) Q100* probably null Het
Pgm2 G A 5: 64,258,291 (GRCm39) G92E probably damaging Het
Pip4k2c T C 10: 127,035,196 (GRCm39) T391A possibly damaging Het
Plcxd2 C T 16: 45,800,941 (GRCm39) W94* probably null Het
Ppm1k T A 6: 57,487,762 (GRCm39) N354Y probably damaging Het
Prkcg T G 7: 3,378,781 (GRCm39) Y624* probably null Het
Rabep2 T C 7: 126,044,094 (GRCm39) S517P probably damaging Het
Rabgap1l A G 1: 160,269,412 (GRCm39) I717T probably benign Het
Rasef A G 4: 73,649,696 (GRCm39) C484R probably damaging Het
Rdh19 A G 10: 127,686,113 (GRCm39) D75G probably benign Het
Rpl21-ps10 T C 3: 38,161,617 (GRCm39) noncoding transcript Het
Rsl1d1 A T 16: 11,017,593 (GRCm39) probably null Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Rwdd1 T C 10: 33,885,074 (GRCm39) D62G possibly damaging Het
Scin T A 12: 40,119,373 (GRCm39) I552F possibly damaging Het
Scn3a T C 2: 65,291,799 (GRCm39) N1649S probably damaging Het
Slc20a2 C T 8: 23,051,020 (GRCm39) S351L probably damaging Het
Slc24a1 A T 9: 64,855,213 (GRCm39) F565I unknown Het
Slc4a1 A G 11: 102,243,279 (GRCm39) V784A probably damaging Het
Slf2 T G 19: 44,960,100 (GRCm39) D1022E probably damaging Het
Sox6 T C 7: 115,076,199 (GRCm39) D814G probably damaging Het
Spata4 T C 8: 55,055,471 (GRCm39) probably null Het
Spats2l A T 1: 57,941,347 (GRCm39) K202M probably damaging Het
Speer4b C T 5: 27,705,134 (GRCm39) E80K probably benign Het
Sqle T G 15: 59,193,218 (GRCm39) Y198* probably null Het
Srek1 T C 13: 103,889,194 (GRCm39) probably benign Het
Srek1 T C 13: 103,889,071 (GRCm39) probably benign Het
St14 G A 9: 31,019,960 (GRCm39) R50* probably null Het
Tcaf1 A G 6: 42,652,130 (GRCm39) V784A probably damaging Het
Tfr2 C T 5: 137,581,673 (GRCm39) R587W probably damaging Het
Tmpo A G 10: 90,985,411 (GRCm39) V357A probably damaging Het
Trrap A T 5: 144,742,545 (GRCm39) I1101F probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ttpal G A 2: 163,449,397 (GRCm39) R84H probably damaging Het
Tyk2 T C 9: 21,022,433 (GRCm39) T799A probably benign Het
Ugt1a10 A T 1: 87,983,646 (GRCm39) D148V probably damaging Het
Usp29 C T 7: 6,964,504 (GRCm39) P116S probably benign Het
Usp8 A T 2: 126,562,060 (GRCm39) K85* probably null Het
Usp9y C T Y: 1,316,735 (GRCm39) R1938H probably damaging Het
Vmn1r90 T G 7: 14,295,950 (GRCm39) R49S possibly damaging Het
Vmn2r71 C A 7: 85,270,476 (GRCm39) N547K probably damaging Het
Vps45 T C 3: 95,926,943 (GRCm39) T535A probably damaging Het
Yars1 A T 4: 129,104,384 (GRCm39) probably benign Het
Zfp114 T C 7: 23,877,290 (GRCm39) L44P probably damaging Het
Zfp36l2 A G 17: 84,493,690 (GRCm39) probably benign Het
Zfp512 T C 5: 31,634,209 (GRCm39) S407P probably damaging Het
Zfp574 C T 7: 24,780,151 (GRCm39) P391L probably damaging Het
Zfp607a T G 7: 27,577,985 (GRCm39) C352G probably benign Het
Zfp791 T A 8: 85,837,580 (GRCm39) I95L probably benign Het
Zfr A C 15: 12,162,198 (GRCm39) probably null Het
Other mutations in Cyp2a22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00156:Cyp2a22 APN 7 26,637,163 (GRCm39) missense probably benign 0.09
IGL01111:Cyp2a22 APN 7 26,635,883 (GRCm39) missense probably damaging 1.00
IGL01388:Cyp2a22 APN 7 26,637,217 (GRCm39) missense probably benign 0.02
IGL01449:Cyp2a22 APN 7 26,632,978 (GRCm39) missense probably benign 0.01
IGL01642:Cyp2a22 APN 7 26,638,184 (GRCm39) missense possibly damaging 0.81
IGL02253:Cyp2a22 APN 7 26,637,662 (GRCm39) splice site probably benign
IGL02327:Cyp2a22 APN 7 26,634,206 (GRCm39) missense probably damaging 0.99
IGL02673:Cyp2a22 APN 7 26,637,525 (GRCm39) missense probably benign 0.00
IGL02813:Cyp2a22 APN 7 26,635,859 (GRCm39) missense probably benign 0.19
IGL02896:Cyp2a22 APN 7 26,635,886 (GRCm39) missense probably damaging 0.98
IGL03193:Cyp2a22 APN 7 26,635,846 (GRCm39) missense probably benign 0.00
IGL03350:Cyp2a22 APN 7 26,634,279 (GRCm39) missense possibly damaging 0.88
R1648:Cyp2a22 UTSW 7 26,631,793 (GRCm39) missense probably damaging 0.98
R1679:Cyp2a22 UTSW 7 26,635,736 (GRCm39) nonsense probably null
R1733:Cyp2a22 UTSW 7 26,634,187 (GRCm39) missense possibly damaging 0.78
R2001:Cyp2a22 UTSW 7 26,634,197 (GRCm39) missense probably damaging 1.00
R2858:Cyp2a22 UTSW 7 26,633,687 (GRCm39) missense probably damaging 0.99
R3054:Cyp2a22 UTSW 7 26,638,254 (GRCm39) missense probably damaging 1.00
R4528:Cyp2a22 UTSW 7 26,634,194 (GRCm39) missense possibly damaging 0.95
R4623:Cyp2a22 UTSW 7 26,632,916 (GRCm39) missense probably damaging 1.00
R4669:Cyp2a22 UTSW 7 26,637,280 (GRCm39) missense possibly damaging 0.88
R4690:Cyp2a22 UTSW 7 26,638,634 (GRCm39) nonsense probably null
R4840:Cyp2a22 UTSW 7 26,631,949 (GRCm39) missense probably benign 0.13
R5071:Cyp2a22 UTSW 7 26,631,906 (GRCm39) missense probably benign 0.01
R5072:Cyp2a22 UTSW 7 26,631,906 (GRCm39) missense probably benign 0.01
R5074:Cyp2a22 UTSW 7 26,631,906 (GRCm39) missense probably benign 0.01
R5147:Cyp2a22 UTSW 7 26,635,750 (GRCm39) missense probably damaging 1.00
R5363:Cyp2a22 UTSW 7 26,635,858 (GRCm39) missense probably damaging 0.99
R5705:Cyp2a22 UTSW 7 26,638,640 (GRCm39) missense probably benign 0.05
R6014:Cyp2a22 UTSW 7 26,638,605 (GRCm39) splice site probably null
R6042:Cyp2a22 UTSW 7 26,633,664 (GRCm39) missense probably damaging 1.00
R6253:Cyp2a22 UTSW 7 26,633,657 (GRCm39) missense probably benign 0.18
R6757:Cyp2a22 UTSW 7 26,638,629 (GRCm39) missense probably benign 0.00
R6994:Cyp2a22 UTSW 7 26,638,606 (GRCm39) critical splice donor site probably null
R7581:Cyp2a22 UTSW 7 26,637,573 (GRCm39) missense possibly damaging 0.87
R8212:Cyp2a22 UTSW 7 26,637,205 (GRCm39) missense possibly damaging 0.89
R9225:Cyp2a22 UTSW 7 26,637,202 (GRCm39) missense possibly damaging 0.81
R9749:Cyp2a22 UTSW 7 26,638,715 (GRCm39) missense probably null 0.41
Predicted Primers PCR Primer
(F):5'- CTCGATAGCTCCCATGAGTTC -3'
(R):5'- TTGGTGCCTCACTCCAAAGC -3'

Sequencing Primer
(F):5'- AGCTCCCATGAGTTCTGATGTAAAGG -3'
(R):5'- AAGCCCATACCATCTTCTAGCTC -3'
Posted On 2016-04-15