Incidental Mutation 'R4935:Adgrf1'
ID 380330
Institutional Source Beutler Lab
Gene Symbol Adgrf1
Ensembl Gene ENSMUSG00000041293
Gene Name adhesion G protein-coupled receptor F1
Synonyms 5031409J19Rik, Gpr110
MMRRC Submission 042535-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4935 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 43581220-43635628 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 43606130 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 85 (I85L)
Ref Sequence ENSEMBL: ENSMUSP00000049380 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047399]
AlphaFold Q8VEC3
Predicted Effect probably benign
Transcript: ENSMUST00000047399
AA Change: I85L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000049380
Gene: ENSMUSG00000041293
AA Change: I85L

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
low complexity region 59 83 N/A INTRINSIC
Pfam:SEA 150 238 3.7e-10 PFAM
low complexity region 341 363 N/A INTRINSIC
GPS 528 576 5.56e-15 SMART
Pfam:7tm_2 580 832 2.1e-38 PFAM
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 94.8%
  • 20x: 86.9%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a reporter allele exhibit normal viability and fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A730071L15Rik A G 11: 6,150,442 (GRCm39) *138W probably null Het
Abcb1a T A 5: 8,787,773 (GRCm39) probably null Het
Acp6 T C 3: 97,079,060 (GRCm39) probably null Het
Adcyap1 A T 17: 93,511,541 (GRCm39) I172L probably benign Het
Afdn A T 17: 14,111,228 (GRCm39) T1604S probably benign Het
Angpt2 T C 8: 18,742,131 (GRCm39) Y475C probably damaging Het
Ank2 A G 3: 126,749,713 (GRCm39) S439P probably damaging Het
Ank3 T A 10: 69,812,033 (GRCm39) N366K probably damaging Het
Ankrd11 A G 8: 123,626,922 (GRCm39) S87P probably benign Het
Ano7 T A 1: 93,323,036 (GRCm39) S459T possibly damaging Het
Asxl3 G A 18: 22,656,369 (GRCm39) V1460M probably benign Het
Atg16l1 A C 1: 87,694,764 (GRCm39) N147T possibly damaging Het
Atp10a T C 7: 58,463,512 (GRCm39) V1015A probably damaging Het
Atxn7 T A 14: 14,100,401 (GRCm38) S696T probably benign Het
Babam1 C T 8: 71,852,446 (GRCm39) T184I probably benign Het
Blk A G 14: 63,618,711 (GRCm39) S175P possibly damaging Het
Col5a1 T A 2: 27,914,754 (GRCm39) F123L probably damaging Het
Csmd3 T C 15: 48,024,480 (GRCm39) Y496C probably damaging Het
Dnah3 A T 7: 119,615,700 (GRCm39) Y1676* probably null Het
Fdxacb1 T A 9: 50,683,243 (GRCm39) M402K probably benign Het
Frmd5 A G 2: 121,393,405 (GRCm39) V141A possibly damaging Het
Gapvd1 G A 2: 34,594,504 (GRCm39) R685* probably null Het
Grik2 A G 10: 49,116,826 (GRCm39) L645P probably damaging Het
H2aj T A 6: 136,785,681 (GRCm39) V115E possibly damaging Het
Hrh3 T C 2: 179,743,061 (GRCm39) Y189C probably damaging Het
Kcnc2 A G 10: 112,108,133 (GRCm39) T175A probably benign Het
Kcnv2 A G 19: 27,300,332 (GRCm39) Y61C probably damaging Het
Kif24 T C 4: 41,394,939 (GRCm39) R645G probably damaging Het
Knl1 A G 2: 118,899,438 (GRCm39) I380V possibly damaging Het
Lamb2 A G 9: 108,364,700 (GRCm39) I1151M possibly damaging Het
Leo1 A G 9: 75,353,159 (GRCm39) D234G probably benign Het
Lrp1b T G 2: 41,388,405 (GRCm39) N407H probably benign Het
Matn2 T C 15: 34,428,831 (GRCm39) S732P probably damaging Het
Mrps30 A T 13: 118,523,431 (GRCm39) F114I possibly damaging Het
Or1l8 T C 2: 36,817,713 (GRCm39) N138D probably benign Het
Or4f17-ps1 G A 2: 111,357,793 (GRCm39) V45I probably damaging Het
Or5b123 T C 19: 13,597,066 (GRCm39) I180T probably benign Het
Oxr1 T C 15: 41,676,980 (GRCm39) V179A probably benign Het
Plaur A T 7: 24,166,141 (GRCm39) S71C possibly damaging Het
Plbd2 T C 5: 120,624,786 (GRCm39) N461D possibly damaging Het
Plcb2 T A 2: 118,549,396 (GRCm39) Y322F probably damaging Het
Prkab2 T C 3: 97,569,671 (GRCm39) V79A probably damaging Het
Ptpn3 A T 4: 57,197,568 (GRCm39) C774S probably damaging Het
Ring1 A C 17: 34,242,016 (GRCm39) L131R probably benign Het
Rxfp2 G A 5: 149,975,097 (GRCm39) probably null Het
Selenbp1 A T 3: 94,845,269 (GRCm39) I122F probably benign Het
Septin7 A G 9: 25,217,468 (GRCm39) H394R probably benign Het
Slc1a7 G A 4: 107,864,758 (GRCm39) V266I probably damaging Het
Slc2a10 A G 2: 165,359,578 (GRCm39) T481A probably benign Het
Spmap2l T C 5: 77,185,200 (GRCm39) probably null Het
Tapbp A G 17: 34,144,596 (GRCm39) M231V probably benign Het
Tbxas1 A T 6: 38,999,981 (GRCm39) N256I probably benign Het
Uimc1 A G 13: 55,240,998 (GRCm39) I30T probably damaging Het
Usp48 C A 4: 137,377,669 (GRCm39) N231K probably benign Het
Zfhx3 T G 8: 109,674,482 (GRCm39) V1844G possibly damaging Het
Znrf3 A T 11: 5,233,422 (GRCm39) C212S probably damaging Het
Other mutations in Adgrf1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01343:Adgrf1 APN 17 43,624,086 (GRCm39) missense probably null 0.92
IGL01359:Adgrf1 APN 17 43,621,577 (GRCm39) missense probably damaging 0.99
IGL02131:Adgrf1 APN 17 43,614,638 (GRCm39) missense probably damaging 0.99
IGL02692:Adgrf1 APN 17 43,614,669 (GRCm39) missense probably damaging 1.00
IGL02891:Adgrf1 APN 17 43,622,052 (GRCm39) missense probably damaging 0.96
IGL03027:Adgrf1 APN 17 43,607,605 (GRCm39) missense probably damaging 1.00
IGL03296:Adgrf1 APN 17 43,632,044 (GRCm39) splice site probably benign
R0211:Adgrf1 UTSW 17 43,607,581 (GRCm39) missense probably damaging 1.00
R0211:Adgrf1 UTSW 17 43,607,581 (GRCm39) missense probably damaging 1.00
R0389:Adgrf1 UTSW 17 43,614,679 (GRCm39) critical splice donor site probably null
R0488:Adgrf1 UTSW 17 43,621,302 (GRCm39) missense probably damaging 0.99
R1591:Adgrf1 UTSW 17 43,621,872 (GRCm39) missense probably damaging 1.00
R1817:Adgrf1 UTSW 17 43,620,924 (GRCm39) missense probably benign 0.01
R1819:Adgrf1 UTSW 17 43,620,924 (GRCm39) missense probably benign 0.01
R2009:Adgrf1 UTSW 17 43,632,112 (GRCm39) nonsense probably null
R2032:Adgrf1 UTSW 17 43,622,166 (GRCm39) missense probably damaging 1.00
R2140:Adgrf1 UTSW 17 43,611,693 (GRCm39) missense probably damaging 0.99
R3953:Adgrf1 UTSW 17 43,621,098 (GRCm39) missense probably benign 0.08
R4679:Adgrf1 UTSW 17 43,621,384 (GRCm39) missense probably damaging 1.00
R4775:Adgrf1 UTSW 17 43,622,054 (GRCm39) missense probably damaging 1.00
R4858:Adgrf1 UTSW 17 43,614,563 (GRCm39) missense probably damaging 1.00
R4894:Adgrf1 UTSW 17 43,609,975 (GRCm39) nonsense probably null
R4895:Adgrf1 UTSW 17 43,621,511 (GRCm39) missense probably benign 0.33
R5027:Adgrf1 UTSW 17 43,614,638 (GRCm39) missense probably damaging 0.99
R5373:Adgrf1 UTSW 17 43,601,896 (GRCm39) start gained probably benign
R5374:Adgrf1 UTSW 17 43,601,896 (GRCm39) start gained probably benign
R5455:Adgrf1 UTSW 17 43,632,034 (GRCm39) splice site probably null
R5579:Adgrf1 UTSW 17 43,621,955 (GRCm39) missense probably damaging 1.00
R5985:Adgrf1 UTSW 17 43,604,146 (GRCm39) missense probably benign 0.00
R6038:Adgrf1 UTSW 17 43,606,100 (GRCm39) missense probably benign 0.00
R6038:Adgrf1 UTSW 17 43,606,100 (GRCm39) missense probably benign 0.00
R6160:Adgrf1 UTSW 17 43,621,578 (GRCm39) missense probably damaging 1.00
R6227:Adgrf1 UTSW 17 43,621,164 (GRCm39) missense probably benign 0.05
R6500:Adgrf1 UTSW 17 43,621,263 (GRCm39) missense probably damaging 1.00
R7066:Adgrf1 UTSW 17 43,621,151 (GRCm39) missense probably benign 0.05
R7099:Adgrf1 UTSW 17 43,621,493 (GRCm39) missense probably benign 0.00
R7561:Adgrf1 UTSW 17 43,622,000 (GRCm39) missense possibly damaging 0.94
R8359:Adgrf1 UTSW 17 43,621,286 (GRCm39) missense probably damaging 0.99
R8480:Adgrf1 UTSW 17 43,606,055 (GRCm39) missense probably benign 0.08
R8543:Adgrf1 UTSW 17 43,624,097 (GRCm39) missense probably null 0.99
R9023:Adgrf1 UTSW 17 43,614,651 (GRCm39) missense possibly damaging 0.53
R9074:Adgrf1 UTSW 17 43,601,879 (GRCm39) start gained probably benign
R9207:Adgrf1 UTSW 17 43,621,164 (GRCm39) missense probably benign 0.05
R9232:Adgrf1 UTSW 17 43,621,295 (GRCm39) missense probably benign 0.07
R9425:Adgrf1 UTSW 17 43,621,274 (GRCm39) missense possibly damaging 0.84
R9526:Adgrf1 UTSW 17 43,616,237 (GRCm39) missense possibly damaging 0.95
R9697:Adgrf1 UTSW 17 43,625,362 (GRCm39) missense possibly damaging 0.71
R9711:Adgrf1 UTSW 17 43,621,580 (GRCm39) missense possibly damaging 0.81
Z1177:Adgrf1 UTSW 17 43,621,038 (GRCm39) missense probably benign 0.14
Predicted Primers PCR Primer
(F):5'- AAGTGATCCTCCCCATAGACG -3'
(R):5'- GATTGAACTTCGCGGGGAAC -3'

Sequencing Primer
(F):5'- TGATCCTCCCCATAGACGGGTAC -3'
(R):5'- CCAAAGAATGTCACTGCCTGTGTG -3'
Posted On 2016-04-15