Incidental Mutation 'R4936:Fasn'
| ID |
380399 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fasn
|
| Ensembl Gene |
ENSMUSG00000025153 |
| Gene Name |
fatty acid synthase |
| Synonyms |
A630082H08Rik, FAS |
| MMRRC Submission |
042536-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4936 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
120696672-120715373 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 120706911 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Isoleucine
at position 914
(F914I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000145585
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055655]
[ENSMUST00000206589]
|
| AlphaFold |
P19096 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055655
AA Change: F914I
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000052872
Gene: ENSMUSG00000025153
AA Change: F914I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ketoacyl-synt
|
1 |
239 |
6.8e-73 |
PFAM |
|
Pfam:Ketoacyl-synt_C
|
243 |
360 |
3.7e-38 |
PFAM |
|
Pfam:KAsynt_C_assoc
|
362 |
474 |
8.2e-46 |
PFAM |
|
Pfam:Acyl_transf_1
|
493 |
810 |
9.5e-115 |
PFAM |
|
Pfam:PS-DH
|
853 |
1169 |
9.9e-24 |
PFAM |
|
low complexity region
|
1175 |
1204 |
N/A |
INTRINSIC |
|
Pfam:Methyltransf_12
|
1238 |
1337 |
2e-9 |
PFAM |
|
PKS_ER
|
1532 |
1847 |
1.44e-147 |
SMART |
|
PKS_KR
|
1878 |
2059 |
2.33e-42 |
SMART |
|
Pfam:PP-binding
|
2119 |
2185 |
1.1e-10 |
PFAM |
|
Pfam:Thioesterase
|
2235 |
2494 |
1.6e-62 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000206589
AA Change: F914I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206637
|
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 95.0%
- 20x: 87.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted mutation of this locus has implicated its product in embryogenesis as all homozygotes and most heterozygotes die prior to birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2300002M23Rik |
T |
A |
17: 35,879,212 (GRCm39) |
F183L |
possibly damaging |
Het |
| 4930590J08Rik |
T |
A |
6: 91,921,245 (GRCm39) |
M775K |
probably damaging |
Het |
| Actn1 |
T |
G |
12: 80,219,772 (GRCm39) |
I700L |
probably benign |
Het |
| Adam5 |
T |
C |
8: 25,276,287 (GRCm39) |
Y460C |
probably damaging |
Het |
| Akna |
C |
T |
4: 63,313,502 (GRCm39) |
G207E |
probably damaging |
Het |
| Ank2 |
T |
A |
3: 126,748,688 (GRCm39) |
H527L |
possibly damaging |
Het |
| Anks1 |
C |
A |
17: 28,207,779 (GRCm39) |
N383K |
probably damaging |
Het |
| Apba3 |
C |
T |
10: 81,105,204 (GRCm39) |
|
probably null |
Het |
| Atp9b |
C |
A |
18: 80,779,308 (GRCm39) |
V1121F |
possibly damaging |
Het |
| Bsn |
T |
C |
9: 107,988,960 (GRCm39) |
Y2264C |
probably damaging |
Het |
| Bst1 |
A |
G |
5: 43,997,799 (GRCm39) |
D266G |
probably damaging |
Het |
| Cep55 |
A |
G |
19: 38,060,202 (GRCm39) |
|
probably null |
Het |
| Ces4a |
G |
A |
8: 105,864,729 (GRCm39) |
G69S |
probably damaging |
Het |
| Ckb |
T |
C |
12: 111,637,664 (GRCm39) |
K156E |
probably benign |
Het |
| Cln3 |
T |
A |
7: 126,174,393 (GRCm39) |
H315L |
probably damaging |
Het |
| Cnot6l |
A |
G |
5: 96,227,796 (GRCm39) |
F479S |
probably damaging |
Het |
| Col1a1 |
A |
G |
11: 94,837,958 (GRCm39) |
D826G |
unknown |
Het |
| Cyp27a1 |
T |
C |
1: 74,774,564 (GRCm39) |
V194A |
probably benign |
Het |
| Dis3l2 |
C |
T |
1: 86,971,890 (GRCm39) |
P643S |
probably benign |
Het |
| Dpf3 |
T |
C |
12: 83,378,740 (GRCm39) |
D108G |
probably damaging |
Het |
| Eif2b4 |
C |
T |
5: 31,350,241 (GRCm39) |
G27D |
probably benign |
Het |
| Eif4a1 |
T |
G |
11: 69,563,251 (GRCm39) |
|
probably benign |
Het |
| Espl1 |
A |
T |
15: 102,213,372 (GRCm39) |
D566V |
probably damaging |
Het |
| Ext2 |
T |
A |
2: 93,644,024 (GRCm39) |
R86* |
probably null |
Het |
| Fbf1 |
A |
G |
11: 116,043,378 (GRCm39) |
L477P |
probably benign |
Het |
| Fsd1 |
A |
T |
17: 56,303,452 (GRCm39) |
K441N |
possibly damaging |
Het |
| Fsip2 |
T |
A |
2: 82,815,384 (GRCm39) |
S3706T |
probably benign |
Het |
| Gabra5 |
A |
T |
7: 57,058,547 (GRCm39) |
N400K |
probably benign |
Het |
| Gimap8 |
G |
T |
6: 48,633,068 (GRCm39) |
G296W |
probably damaging |
Het |
| Gli2 |
A |
G |
1: 118,763,870 (GRCm39) |
V1427A |
probably benign |
Het |
| Gm7334 |
A |
T |
17: 51,005,855 (GRCm39) |
Y47F |
probably damaging |
Het |
| Gm8674 |
T |
G |
13: 50,054,791 (GRCm39) |
|
noncoding transcript |
Het |
| Gmeb2 |
G |
T |
2: 180,896,039 (GRCm39) |
T377K |
probably benign |
Het |
| Gp9 |
T |
A |
6: 87,756,229 (GRCm39) |
D81E |
probably benign |
Het |
| Il5ra |
T |
A |
6: 106,715,123 (GRCm39) |
I212F |
possibly damaging |
Het |
| Klhl18 |
G |
T |
9: 110,258,029 (GRCm39) |
N470K |
possibly damaging |
Het |
| Lfng |
G |
T |
5: 140,598,150 (GRCm39) |
|
probably null |
Het |
| Lpo |
A |
G |
11: 87,701,166 (GRCm39) |
I430T |
probably benign |
Het |
| Lrrc31 |
C |
T |
3: 30,743,417 (GRCm39) |
D183N |
probably damaging |
Het |
| Meis2 |
T |
C |
2: 115,694,893 (GRCm39) |
T410A |
probably benign |
Het |
| Myo6 |
A |
G |
9: 80,214,963 (GRCm39) |
D1232G |
probably damaging |
Het |
| Ncapd2 |
C |
T |
6: 125,146,803 (GRCm39) |
R1261H |
probably benign |
Het |
| Nfkb1 |
C |
T |
3: 135,319,743 (GRCm39) |
V251M |
probably damaging |
Het |
| Nmbr |
C |
A |
10: 14,642,730 (GRCm39) |
H96Q |
probably damaging |
Het |
| Nop14 |
C |
T |
5: 34,809,737 (GRCm39) |
R256H |
probably damaging |
Het |
| Nqo2 |
T |
A |
13: 34,165,501 (GRCm39) |
Y133N |
probably damaging |
Het |
| Or1f12 |
T |
C |
13: 21,721,357 (GRCm39) |
I273V |
probably benign |
Het |
| Or5w20 |
A |
G |
2: 87,727,157 (GRCm39) |
I213V |
probably benign |
Het |
| Pbld2 |
C |
A |
10: 62,888,017 (GRCm39) |
S168R |
probably damaging |
Het |
| Pcdhb7 |
G |
T |
18: 37,475,202 (GRCm39) |
G113* |
probably null |
Het |
| Pcdhb7 |
G |
T |
18: 37,475,203 (GRCm39) |
G113V |
probably damaging |
Het |
| Pdgfra |
A |
T |
5: 75,355,687 (GRCm39) |
T1066S |
probably damaging |
Het |
| Prdm8 |
A |
T |
5: 98,332,881 (GRCm39) |
|
probably null |
Het |
| Prdm8 |
G |
T |
5: 98,332,882 (GRCm39) |
|
probably null |
Het |
| Prkg1 |
T |
C |
19: 30,563,775 (GRCm39) |
Y479C |
probably benign |
Het |
| Pudp |
T |
C |
18: 50,701,539 (GRCm39) |
T65A |
probably benign |
Het |
| Rbbp6 |
C |
T |
7: 122,598,926 (GRCm39) |
|
probably benign |
Het |
| Rcc1 |
C |
G |
4: 132,063,046 (GRCm39) |
V187L |
probably damaging |
Het |
| Rims2 |
T |
A |
15: 39,301,124 (GRCm39) |
M285K |
probably damaging |
Het |
| Rtkn2 |
T |
C |
10: 67,877,745 (GRCm39) |
*602Q |
probably null |
Het |
| Rxfp3 |
T |
G |
15: 11,036,866 (GRCm39) |
S169R |
probably damaging |
Het |
| Sardh |
T |
C |
2: 27,118,253 (GRCm39) |
|
probably null |
Het |
| Slc24a2 |
A |
T |
4: 87,145,584 (GRCm39) |
F157I |
probably damaging |
Het |
| Slc25a20 |
T |
C |
9: 108,559,191 (GRCm39) |
Y186H |
probably damaging |
Het |
| Slc25a24 |
A |
G |
3: 109,070,864 (GRCm39) |
R408G |
probably damaging |
Het |
| Slc44a5 |
T |
G |
3: 153,959,353 (GRCm39) |
I348S |
probably damaging |
Het |
| Slc8a2 |
A |
T |
7: 15,868,100 (GRCm39) |
K111* |
probably null |
Het |
| Smc5 |
A |
G |
19: 23,211,367 (GRCm39) |
V589A |
probably damaging |
Het |
| Thbd |
A |
T |
2: 148,249,655 (GRCm39) |
I71N |
probably damaging |
Het |
| Thsd7b |
T |
C |
1: 129,605,882 (GRCm39) |
M541T |
probably benign |
Het |
| Tie1 |
T |
A |
4: 118,341,968 (GRCm39) |
|
silent |
Het |
| Tln1 |
A |
G |
4: 43,547,522 (GRCm39) |
F813S |
possibly damaging |
Het |
| Tnrc18 |
A |
T |
5: 142,751,732 (GRCm39) |
L1191* |
probably null |
Het |
| Tubb2a |
A |
C |
13: 34,259,240 (GRCm39) |
Y183* |
probably null |
Het |
| Ubr4 |
T |
A |
4: 139,123,877 (GRCm39) |
V343E |
probably damaging |
Het |
| Vmn2r93 |
A |
T |
17: 18,524,327 (GRCm39) |
D107V |
possibly damaging |
Het |
| Vwa5a |
T |
G |
9: 38,647,494 (GRCm39) |
S624R |
probably benign |
Het |
| Wwox |
G |
A |
8: 115,433,098 (GRCm39) |
V255I |
probably benign |
Het |
| Wwp1 |
T |
C |
4: 19,638,804 (GRCm39) |
K546E |
probably damaging |
Het |
| Xirp2 |
T |
A |
2: 67,340,163 (GRCm39) |
F801L |
possibly damaging |
Het |
| Zfp407 |
T |
C |
18: 84,577,589 (GRCm39) |
I1175V |
probably benign |
Het |
| Zfp646 |
T |
A |
7: 127,480,933 (GRCm39) |
C1037S |
possibly damaging |
Het |
| Zfp786 |
A |
T |
6: 47,798,202 (GRCm39) |
C245* |
probably null |
Het |
| Zfp827 |
T |
C |
8: 79,787,812 (GRCm39) |
V326A |
probably benign |
Het |
|
| Other mutations in Fasn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00468:Fasn
|
APN |
11 |
120,711,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Fasn
|
APN |
11 |
120,708,055 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01131:Fasn
|
APN |
11 |
120,705,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01603:Fasn
|
APN |
11 |
120,706,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01606:Fasn
|
APN |
11 |
120,699,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01897:Fasn
|
APN |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Fasn
|
APN |
11 |
120,710,975 (GRCm39) |
splice site |
probably benign |
|
|
IGL01987:Fasn
|
APN |
11 |
120,708,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02103:Fasn
|
APN |
11 |
120,702,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Fasn
|
APN |
11 |
120,698,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02294:Fasn
|
APN |
11 |
120,701,102 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02336:Fasn
|
APN |
11 |
120,704,562 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02417:Fasn
|
APN |
11 |
120,711,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02452:Fasn
|
APN |
11 |
120,699,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Fasn
|
APN |
11 |
120,699,892 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02724:Fasn
|
APN |
11 |
120,700,659 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02862:Fasn
|
APN |
11 |
120,709,805 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02947:Fasn
|
APN |
11 |
120,706,502 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03025:Fasn
|
APN |
11 |
120,708,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03131:Fasn
|
APN |
11 |
120,701,550 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03157:Fasn
|
APN |
11 |
120,698,735 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03182:Fasn
|
APN |
11 |
120,703,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03370:Fasn
|
APN |
11 |
120,703,621 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
BB007:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
BB017:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0243:Fasn
|
UTSW |
11 |
120,706,141 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0304:Fasn
|
UTSW |
11 |
120,710,762 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0389:Fasn
|
UTSW |
11 |
120,707,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0449:Fasn
|
UTSW |
11 |
120,701,894 (GRCm39) |
missense |
probably benign |
|
|
R0626:Fasn
|
UTSW |
11 |
120,702,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1037:Fasn
|
UTSW |
11 |
120,700,277 (GRCm39) |
missense |
probably benign |
|
|
R1061:Fasn
|
UTSW |
11 |
120,713,008 (GRCm39) |
splice site |
probably null |
|
|
R1109:Fasn
|
UTSW |
11 |
120,703,150 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1498:Fasn
|
UTSW |
11 |
120,706,245 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1552:Fasn
|
UTSW |
11 |
120,709,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Fasn
|
UTSW |
11 |
120,704,075 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1624:Fasn
|
UTSW |
11 |
120,703,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Fasn
|
UTSW |
11 |
120,707,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1826:Fasn
|
UTSW |
11 |
120,699,325 (GRCm39) |
splice site |
probably benign |
|
|
R1846:Fasn
|
UTSW |
11 |
120,704,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2298:Fasn
|
UTSW |
11 |
120,704,642 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2513:Fasn
|
UTSW |
11 |
120,705,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3002:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3154:Fasn
|
UTSW |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3434:Fasn
|
UTSW |
11 |
120,713,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4794:Fasn
|
UTSW |
11 |
120,702,121 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4840:Fasn
|
UTSW |
11 |
120,703,885 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4863:Fasn
|
UTSW |
11 |
120,699,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4876:Fasn
|
UTSW |
11 |
120,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4915:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4916:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4918:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5025:Fasn
|
UTSW |
11 |
120,702,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5092:Fasn
|
UTSW |
11 |
120,705,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Fasn
|
UTSW |
11 |
120,702,217 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5175:Fasn
|
UTSW |
11 |
120,707,195 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5183:Fasn
|
UTSW |
11 |
120,699,708 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5506:Fasn
|
UTSW |
11 |
120,700,336 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5557:Fasn
|
UTSW |
11 |
120,703,252 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5614:Fasn
|
UTSW |
11 |
120,704,154 (GRCm39) |
missense |
probably benign |
|
|
R5728:Fasn
|
UTSW |
11 |
120,704,339 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5838:Fasn
|
UTSW |
11 |
120,706,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5959:Fasn
|
UTSW |
11 |
120,699,390 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6029:Fasn
|
UTSW |
11 |
120,711,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6134:Fasn
|
UTSW |
11 |
120,713,012 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6335:Fasn
|
UTSW |
11 |
120,706,185 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6452:Fasn
|
UTSW |
11 |
120,706,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6627:Fasn
|
UTSW |
11 |
120,709,753 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6742:Fasn
|
UTSW |
11 |
120,701,279 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6767:Fasn
|
UTSW |
11 |
120,708,313 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6927:Fasn
|
UTSW |
11 |
120,699,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6976:Fasn
|
UTSW |
11 |
120,710,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Fasn
|
UTSW |
11 |
120,710,946 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7157:Fasn
|
UTSW |
11 |
120,701,291 (GRCm39) |
nonsense |
probably null |
|
|
R7373:Fasn
|
UTSW |
11 |
120,704,802 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7575:Fasn
|
UTSW |
11 |
120,703,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7652:Fasn
|
UTSW |
11 |
120,707,154 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7670:Fasn
|
UTSW |
11 |
120,704,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Fasn
|
UTSW |
11 |
120,700,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7930:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R8007:Fasn
|
UTSW |
11 |
120,700,353 (GRCm39) |
missense |
probably benign |
|
|
R8012:Fasn
|
UTSW |
11 |
120,702,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8185:Fasn
|
UTSW |
11 |
120,702,969 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8557:Fasn
|
UTSW |
11 |
120,706,610 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8711:Fasn
|
UTSW |
11 |
120,709,944 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8772:Fasn
|
UTSW |
11 |
120,711,362 (GRCm39) |
missense |
probably benign |
|
|
R8856:Fasn
|
UTSW |
11 |
120,708,979 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8875:Fasn
|
UTSW |
11 |
120,703,224 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9071:Fasn
|
UTSW |
11 |
120,708,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9153:Fasn
|
UTSW |
11 |
120,706,496 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9238:Fasn
|
UTSW |
11 |
120,705,871 (GRCm39) |
missense |
probably benign |
|
|
R9249:Fasn
|
UTSW |
11 |
120,703,915 (GRCm39) |
missense |
probably benign |
|
|
R9345:Fasn
|
UTSW |
11 |
120,706,735 (GRCm39) |
missense |
probably benign |
0.22 |
|
X0067:Fasn
|
UTSW |
11 |
120,707,129 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Fasn
|
UTSW |
11 |
120,706,297 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACACCTCAAAGGCATGGGAG -3'
(R):5'- GCTACAGTCTACAGCATCGGTG -3'
Sequencing Primer
(F):5'- ATGGGAGGCCTCTAGCAG -3'
(R):5'- TCTACAGCATCGGTGAGCCAG -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation