Incidental Mutation 'R4936:Rims2'
| ID |
380408 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rims2
|
| Ensembl Gene |
ENSMUSG00000037386 |
| Gene Name |
regulating synaptic membrane exocytosis 2 |
| Synonyms |
RIM2, 2810036I15Rik, Syt3-rs |
| MMRRC Submission |
042536-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.539)
|
| Stock # |
R4936 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
39061681-39547768 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 39301124 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 285
(M285K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154645
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042917]
[ENSMUST00000082054]
[ENSMUST00000227243]
[ENSMUST00000228839]
|
| AlphaFold |
Q9EQZ7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000042917
AA Change: M477K
PolyPhen 2
Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000048719
Gene: ENSMUSG00000037386
AA Change: M477K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
24 |
N/A |
INTRINSIC |
|
Pfam:FYVE_2
|
30 |
154 |
9.5e-18 |
PFAM |
|
low complexity region
|
315 |
335 |
N/A |
INTRINSIC |
|
low complexity region
|
492 |
498 |
N/A |
INTRINSIC |
|
low complexity region
|
511 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
527 |
540 |
N/A |
INTRINSIC |
|
PDZ
|
646 |
725 |
8.27e-16 |
SMART |
|
low complexity region
|
740 |
748 |
N/A |
INTRINSIC |
|
C2
|
790 |
897 |
4.08e-21 |
SMART |
|
low complexity region
|
905 |
919 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1101 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1130 |
N/A |
INTRINSIC |
|
low complexity region
|
1208 |
1238 |
N/A |
INTRINSIC |
|
C2
|
1432 |
1535 |
3.78e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000082054
AA Change: M517K
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000080711
Gene: ENSMUSG00000037386
AA Change: M517K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
24 |
N/A |
INTRINSIC |
|
Pfam:FYVE_2
|
76 |
194 |
2.2e-11 |
PFAM |
|
low complexity region
|
355 |
375 |
N/A |
INTRINSIC |
|
low complexity region
|
532 |
538 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
561 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
580 |
N/A |
INTRINSIC |
|
PDZ
|
686 |
765 |
8.27e-16 |
SMART |
|
low complexity region
|
780 |
788 |
N/A |
INTRINSIC |
|
C2
|
830 |
937 |
4.08e-21 |
SMART |
|
low complexity region
|
945 |
959 |
N/A |
INTRINSIC |
|
low complexity region
|
1075 |
1086 |
N/A |
INTRINSIC |
|
low complexity region
|
1166 |
1196 |
N/A |
INTRINSIC |
|
C2
|
1390 |
1493 |
3.78e-16 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226243
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000227243
AA Change: M477K
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000227381
AA Change: M244K
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000228839
AA Change: M285K
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228867
|
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 95.0%
- 20x: 87.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
PHENOTYPE: Mice homozygous for a knock-out allele show reduced body size, aberrant insulin granule exocytosis, and impaired secretion of hormones associated with glucose homeostasis. Mice homozygous for another knock-out allele show a slightly reduced body size, abnormal maternal behavior and premature death. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2300002M23Rik |
T |
A |
17: 35,879,212 (GRCm39) |
F183L |
possibly damaging |
Het |
| 4930590J08Rik |
T |
A |
6: 91,921,245 (GRCm39) |
M775K |
probably damaging |
Het |
| Actn1 |
T |
G |
12: 80,219,772 (GRCm39) |
I700L |
probably benign |
Het |
| Adam5 |
T |
C |
8: 25,276,287 (GRCm39) |
Y460C |
probably damaging |
Het |
| Akna |
C |
T |
4: 63,313,502 (GRCm39) |
G207E |
probably damaging |
Het |
| Ank2 |
T |
A |
3: 126,748,688 (GRCm39) |
H527L |
possibly damaging |
Het |
| Anks1 |
C |
A |
17: 28,207,779 (GRCm39) |
N383K |
probably damaging |
Het |
| Apba3 |
C |
T |
10: 81,105,204 (GRCm39) |
|
probably null |
Het |
| Atp9b |
C |
A |
18: 80,779,308 (GRCm39) |
V1121F |
possibly damaging |
Het |
| Bsn |
T |
C |
9: 107,988,960 (GRCm39) |
Y2264C |
probably damaging |
Het |
| Bst1 |
A |
G |
5: 43,997,799 (GRCm39) |
D266G |
probably damaging |
Het |
| Cep55 |
A |
G |
19: 38,060,202 (GRCm39) |
|
probably null |
Het |
| Ces4a |
G |
A |
8: 105,864,729 (GRCm39) |
G69S |
probably damaging |
Het |
| Ckb |
T |
C |
12: 111,637,664 (GRCm39) |
K156E |
probably benign |
Het |
| Cln3 |
T |
A |
7: 126,174,393 (GRCm39) |
H315L |
probably damaging |
Het |
| Cnot6l |
A |
G |
5: 96,227,796 (GRCm39) |
F479S |
probably damaging |
Het |
| Col1a1 |
A |
G |
11: 94,837,958 (GRCm39) |
D826G |
unknown |
Het |
| Cyp27a1 |
T |
C |
1: 74,774,564 (GRCm39) |
V194A |
probably benign |
Het |
| Dis3l2 |
C |
T |
1: 86,971,890 (GRCm39) |
P643S |
probably benign |
Het |
| Dpf3 |
T |
C |
12: 83,378,740 (GRCm39) |
D108G |
probably damaging |
Het |
| Eif2b4 |
C |
T |
5: 31,350,241 (GRCm39) |
G27D |
probably benign |
Het |
| Eif4a1 |
T |
G |
11: 69,563,251 (GRCm39) |
|
probably benign |
Het |
| Espl1 |
A |
T |
15: 102,213,372 (GRCm39) |
D566V |
probably damaging |
Het |
| Ext2 |
T |
A |
2: 93,644,024 (GRCm39) |
R86* |
probably null |
Het |
| Fasn |
A |
T |
11: 120,706,911 (GRCm39) |
F914I |
probably damaging |
Het |
| Fbf1 |
A |
G |
11: 116,043,378 (GRCm39) |
L477P |
probably benign |
Het |
| Fsd1 |
A |
T |
17: 56,303,452 (GRCm39) |
K441N |
possibly damaging |
Het |
| Fsip2 |
T |
A |
2: 82,815,384 (GRCm39) |
S3706T |
probably benign |
Het |
| Gabra5 |
A |
T |
7: 57,058,547 (GRCm39) |
N400K |
probably benign |
Het |
| Gimap8 |
G |
T |
6: 48,633,068 (GRCm39) |
G296W |
probably damaging |
Het |
| Gli2 |
A |
G |
1: 118,763,870 (GRCm39) |
V1427A |
probably benign |
Het |
| Gm7334 |
A |
T |
17: 51,005,855 (GRCm39) |
Y47F |
probably damaging |
Het |
| Gm8674 |
T |
G |
13: 50,054,791 (GRCm39) |
|
noncoding transcript |
Het |
| Gmeb2 |
G |
T |
2: 180,896,039 (GRCm39) |
T377K |
probably benign |
Het |
| Gp9 |
T |
A |
6: 87,756,229 (GRCm39) |
D81E |
probably benign |
Het |
| Il5ra |
T |
A |
6: 106,715,123 (GRCm39) |
I212F |
possibly damaging |
Het |
| Klhl18 |
G |
T |
9: 110,258,029 (GRCm39) |
N470K |
possibly damaging |
Het |
| Lfng |
G |
T |
5: 140,598,150 (GRCm39) |
|
probably null |
Het |
| Lpo |
A |
G |
11: 87,701,166 (GRCm39) |
I430T |
probably benign |
Het |
| Lrrc31 |
C |
T |
3: 30,743,417 (GRCm39) |
D183N |
probably damaging |
Het |
| Meis2 |
T |
C |
2: 115,694,893 (GRCm39) |
T410A |
probably benign |
Het |
| Myo6 |
A |
G |
9: 80,214,963 (GRCm39) |
D1232G |
probably damaging |
Het |
| Ncapd2 |
C |
T |
6: 125,146,803 (GRCm39) |
R1261H |
probably benign |
Het |
| Nfkb1 |
C |
T |
3: 135,319,743 (GRCm39) |
V251M |
probably damaging |
Het |
| Nmbr |
C |
A |
10: 14,642,730 (GRCm39) |
H96Q |
probably damaging |
Het |
| Nop14 |
C |
T |
5: 34,809,737 (GRCm39) |
R256H |
probably damaging |
Het |
| Nqo2 |
T |
A |
13: 34,165,501 (GRCm39) |
Y133N |
probably damaging |
Het |
| Or1f12 |
T |
C |
13: 21,721,357 (GRCm39) |
I273V |
probably benign |
Het |
| Or5w20 |
A |
G |
2: 87,727,157 (GRCm39) |
I213V |
probably benign |
Het |
| Pbld2 |
C |
A |
10: 62,888,017 (GRCm39) |
S168R |
probably damaging |
Het |
| Pcdhb7 |
G |
T |
18: 37,475,202 (GRCm39) |
G113* |
probably null |
Het |
| Pcdhb7 |
G |
T |
18: 37,475,203 (GRCm39) |
G113V |
probably damaging |
Het |
| Pdgfra |
A |
T |
5: 75,355,687 (GRCm39) |
T1066S |
probably damaging |
Het |
| Prdm8 |
A |
T |
5: 98,332,881 (GRCm39) |
|
probably null |
Het |
| Prdm8 |
G |
T |
5: 98,332,882 (GRCm39) |
|
probably null |
Het |
| Prkg1 |
T |
C |
19: 30,563,775 (GRCm39) |
Y479C |
probably benign |
Het |
| Pudp |
T |
C |
18: 50,701,539 (GRCm39) |
T65A |
probably benign |
Het |
| Rbbp6 |
C |
T |
7: 122,598,926 (GRCm39) |
|
probably benign |
Het |
| Rcc1 |
C |
G |
4: 132,063,046 (GRCm39) |
V187L |
probably damaging |
Het |
| Rtkn2 |
T |
C |
10: 67,877,745 (GRCm39) |
*602Q |
probably null |
Het |
| Rxfp3 |
T |
G |
15: 11,036,866 (GRCm39) |
S169R |
probably damaging |
Het |
| Sardh |
T |
C |
2: 27,118,253 (GRCm39) |
|
probably null |
Het |
| Slc24a2 |
A |
T |
4: 87,145,584 (GRCm39) |
F157I |
probably damaging |
Het |
| Slc25a20 |
T |
C |
9: 108,559,191 (GRCm39) |
Y186H |
probably damaging |
Het |
| Slc25a24 |
A |
G |
3: 109,070,864 (GRCm39) |
R408G |
probably damaging |
Het |
| Slc44a5 |
T |
G |
3: 153,959,353 (GRCm39) |
I348S |
probably damaging |
Het |
| Slc8a2 |
A |
T |
7: 15,868,100 (GRCm39) |
K111* |
probably null |
Het |
| Smc5 |
A |
G |
19: 23,211,367 (GRCm39) |
V589A |
probably damaging |
Het |
| Thbd |
A |
T |
2: 148,249,655 (GRCm39) |
I71N |
probably damaging |
Het |
| Thsd7b |
T |
C |
1: 129,605,882 (GRCm39) |
M541T |
probably benign |
Het |
| Tie1 |
T |
A |
4: 118,341,968 (GRCm39) |
|
silent |
Het |
| Tln1 |
A |
G |
4: 43,547,522 (GRCm39) |
F813S |
possibly damaging |
Het |
| Tnrc18 |
A |
T |
5: 142,751,732 (GRCm39) |
L1191* |
probably null |
Het |
| Tubb2a |
A |
C |
13: 34,259,240 (GRCm39) |
Y183* |
probably null |
Het |
| Ubr4 |
T |
A |
4: 139,123,877 (GRCm39) |
V343E |
probably damaging |
Het |
| Vmn2r93 |
A |
T |
17: 18,524,327 (GRCm39) |
D107V |
possibly damaging |
Het |
| Vwa5a |
T |
G |
9: 38,647,494 (GRCm39) |
S624R |
probably benign |
Het |
| Wwox |
G |
A |
8: 115,433,098 (GRCm39) |
V255I |
probably benign |
Het |
| Wwp1 |
T |
C |
4: 19,638,804 (GRCm39) |
K546E |
probably damaging |
Het |
| Xirp2 |
T |
A |
2: 67,340,163 (GRCm39) |
F801L |
possibly damaging |
Het |
| Zfp407 |
T |
C |
18: 84,577,589 (GRCm39) |
I1175V |
probably benign |
Het |
| Zfp646 |
T |
A |
7: 127,480,933 (GRCm39) |
C1037S |
possibly damaging |
Het |
| Zfp786 |
A |
T |
6: 47,798,202 (GRCm39) |
C245* |
probably null |
Het |
| Zfp827 |
T |
C |
8: 79,787,812 (GRCm39) |
V326A |
probably benign |
Het |
|
| Other mutations in Rims2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00339:Rims2
|
APN |
15 |
39,323,011 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL00502:Rims2
|
APN |
15 |
39,370,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00556:Rims2
|
APN |
15 |
39,320,070 (GRCm39) |
splice site |
probably null |
|
|
IGL00811:Rims2
|
APN |
15 |
39,155,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00827:Rims2
|
APN |
15 |
39,335,755 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01642:Rims2
|
APN |
15 |
39,321,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02951:Rims2
|
APN |
15 |
39,398,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03009:Rims2
|
APN |
15 |
39,430,393 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03080:Rims2
|
APN |
15 |
39,399,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Rims2
|
APN |
15 |
39,322,989 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03252:Rims2
|
APN |
15 |
39,315,748 (GRCm39) |
missense |
probably benign |
|
|
IGL03365:Rims2
|
APN |
15 |
39,339,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03393:Rims2
|
APN |
15 |
39,326,009 (GRCm39) |
splice site |
probably null |
|
|
IGL03409:Rims2
|
APN |
15 |
39,320,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
rhyme
|
UTSW |
15 |
39,315,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4486001:Rims2
|
UTSW |
15 |
39,339,916 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0009:Rims2
|
UTSW |
15 |
39,398,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0009:Rims2
|
UTSW |
15 |
39,398,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0078:Rims2
|
UTSW |
15 |
39,398,251 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0367:Rims2
|
UTSW |
15 |
39,326,011 (GRCm39) |
splice site |
probably null |
|
|
R0401:Rims2
|
UTSW |
15 |
39,373,028 (GRCm39) |
splice site |
probably benign |
|
|
R0531:Rims2
|
UTSW |
15 |
39,430,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0791:Rims2
|
UTSW |
15 |
39,543,021 (GRCm39) |
splice site |
probably benign |
|
|
R0838:Rims2
|
UTSW |
15 |
39,544,421 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1201:Rims2
|
UTSW |
15 |
39,479,720 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1318:Rims2
|
UTSW |
15 |
39,381,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1457:Rims2
|
UTSW |
15 |
39,374,710 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1619:Rims2
|
UTSW |
15 |
39,370,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1672:Rims2
|
UTSW |
15 |
39,155,584 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1743:Rims2
|
UTSW |
15 |
39,543,046 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1766:Rims2
|
UTSW |
15 |
39,325,976 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1779:Rims2
|
UTSW |
15 |
39,545,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1804:Rims2
|
UTSW |
15 |
39,300,439 (GRCm39) |
nonsense |
probably null |
|
|
R1985:Rims2
|
UTSW |
15 |
39,208,710 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1986:Rims2
|
UTSW |
15 |
39,208,710 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2113:Rims2
|
UTSW |
15 |
39,374,722 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2260:Rims2
|
UTSW |
15 |
39,341,962 (GRCm39) |
nonsense |
probably null |
|
|
R2510:Rims2
|
UTSW |
15 |
39,449,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3693:Rims2
|
UTSW |
15 |
39,341,971 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3937:Rims2
|
UTSW |
15 |
39,301,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4425:Rims2
|
UTSW |
15 |
39,301,320 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4453:Rims2
|
UTSW |
15 |
39,155,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4474:Rims2
|
UTSW |
15 |
39,325,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4518:Rims2
|
UTSW |
15 |
39,300,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4526:Rims2
|
UTSW |
15 |
39,301,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4833:Rims2
|
UTSW |
15 |
39,399,310 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4993:Rims2
|
UTSW |
15 |
39,317,841 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5001:Rims2
|
UTSW |
15 |
39,315,824 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5054:Rims2
|
UTSW |
15 |
39,381,265 (GRCm39) |
splice site |
probably null |
|
|
R5072:Rims2
|
UTSW |
15 |
39,325,986 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5171:Rims2
|
UTSW |
15 |
39,300,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5429:Rims2
|
UTSW |
15 |
39,208,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5623:Rims2
|
UTSW |
15 |
39,342,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5624:Rims2
|
UTSW |
15 |
39,208,809 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5685:Rims2
|
UTSW |
15 |
39,300,602 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5784:Rims2
|
UTSW |
15 |
39,399,383 (GRCm39) |
splice site |
probably null |
|
|
R5790:Rims2
|
UTSW |
15 |
39,544,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5822:Rims2
|
UTSW |
15 |
39,339,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5963:Rims2
|
UTSW |
15 |
39,300,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5988:Rims2
|
UTSW |
15 |
39,155,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Rims2
|
UTSW |
15 |
39,538,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6239:Rims2
|
UTSW |
15 |
39,061,758 (GRCm39) |
start codon destroyed |
unknown |
|
|
R6407:Rims2
|
UTSW |
15 |
39,315,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6418:Rims2
|
UTSW |
15 |
39,373,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6495:Rims2
|
UTSW |
15 |
39,381,208 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6502:Rims2
|
UTSW |
15 |
39,398,251 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6753:Rims2
|
UTSW |
15 |
39,430,369 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6855:Rims2
|
UTSW |
15 |
39,208,911 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6948:Rims2
|
UTSW |
15 |
39,374,737 (GRCm39) |
missense |
probably benign |
|
|
R7058:Rims2
|
UTSW |
15 |
39,449,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Rims2
|
UTSW |
15 |
39,300,473 (GRCm39) |
missense |
probably benign |
|
|
R7217:Rims2
|
UTSW |
15 |
39,339,885 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7223:Rims2
|
UTSW |
15 |
39,300,428 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7289:Rims2
|
UTSW |
15 |
39,301,114 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7459:Rims2
|
UTSW |
15 |
39,381,235 (GRCm39) |
missense |
probably benign |
|
|
R7663:Rims2
|
UTSW |
15 |
39,370,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7792:Rims2
|
UTSW |
15 |
39,061,923 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7836:Rims2
|
UTSW |
15 |
39,544,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8082:Rims2
|
UTSW |
15 |
39,339,919 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8489:Rims2
|
UTSW |
15 |
39,479,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8730:Rims2
|
UTSW |
15 |
39,381,239 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8830:Rims2
|
UTSW |
15 |
39,300,758 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8857:Rims2
|
UTSW |
15 |
39,543,044 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8893:Rims2
|
UTSW |
15 |
39,398,350 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9010:Rims2
|
UTSW |
15 |
39,315,786 (GRCm39) |
nonsense |
probably null |
|
|
R9030:Rims2
|
UTSW |
15 |
39,339,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9287:Rims2
|
UTSW |
15 |
39,543,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9395:Rims2
|
UTSW |
15 |
39,155,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9451:Rims2
|
UTSW |
15 |
39,300,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9506:Rims2
|
UTSW |
15 |
39,335,832 (GRCm39) |
missense |
probably damaging |
0.97 |
|
X0034:Rims2
|
UTSW |
15 |
39,300,930 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Rims2
|
UTSW |
15 |
39,544,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Rims2
|
UTSW |
15 |
39,342,086 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Rims2
|
UTSW |
15 |
39,301,165 (GRCm39) |
missense |
probably benign |
0.24 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGTAGAGCTGCAATGGAAAACC -3'
(R):5'- GCTCCACATCATCACAGCTTG -3'
Sequencing Primer
(F):5'- GAGGCTCAGGGACAAAGTTCTTATC -3'
(R):5'- CATCACAGCTTGTATACTCAGGTGTG -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation