Incidental Mutation 'R4937:Shprh'
| ID |
380491 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Shprh
|
| Ensembl Gene |
ENSMUSG00000090112 |
| Gene Name |
SNF2 histone linker PHD RING helicase |
| Synonyms |
2610103K11Rik, D230017O13Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4937 (G1)
|
| Quality Score |
224 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
11025171-11093339 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 11032863 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 283
(T283I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125457
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044053]
[ENSMUST00000054814]
[ENSMUST00000159541]
[ENSMUST00000159810]
|
| AlphaFold |
Q7TPQ3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044053
AA Change: T283I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000039422
Gene: ENSMUSG00000090112
AA Change: T283I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
Pfam:Helicase_C
|
1500 |
1613 |
1.6e-8 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000054814
AA Change: T283I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000125849
Gene: ENSMUSG00000090112
AA Change: T283I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1616 |
6e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
4e-46 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159541
AA Change: T283I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000132870
Gene: ENSMUSG00000090112
AA Change: T283I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1619 |
4e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
6e-46 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159810
AA Change: T283I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000125457
Gene: ENSMUSG00000090112
AA Change: T283I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
2e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
Blast:DEXDc
|
948 |
1026 |
2e-9 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161858
|
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 95.1%
- 20x: 88.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
PHENOTYPE: The gene product is an E3 ligase involved in poly-ubiquitination of Pcna. Neither homozygous truncation nor KO affect B cell somatic hypermutation or class switching. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
A |
G |
5: 109,884,067 (GRCm39) |
F597S |
probably benign |
Het |
| Aasdh |
C |
A |
5: 77,036,501 (GRCm39) |
E347* |
probably null |
Het |
| Abca16 |
G |
T |
7: 120,126,309 (GRCm39) |
C1155F |
probably damaging |
Het |
| Adam26a |
T |
C |
8: 44,021,918 (GRCm39) |
D524G |
probably damaging |
Het |
| Adamts20 |
G |
C |
15: 94,277,656 (GRCm39) |
H269D |
probably benign |
Het |
| Akap9 |
T |
A |
5: 4,100,145 (GRCm39) |
|
probably null |
Het |
| Akt3 |
T |
C |
1: 176,877,693 (GRCm39) |
I358M |
possibly damaging |
Het |
| Aldh9a1 |
G |
T |
1: 167,189,376 (GRCm39) |
A375S |
probably damaging |
Het |
| Alg2 |
A |
G |
4: 47,473,974 (GRCm39) |
S105P |
probably benign |
Het |
| Amph |
A |
G |
13: 19,288,515 (GRCm39) |
T335A |
probably damaging |
Het |
| Ank2 |
C |
T |
3: 126,756,050 (GRCm39) |
V1056M |
probably damaging |
Het |
| Apoh |
A |
G |
11: 108,298,204 (GRCm39) |
D168G |
probably benign |
Het |
| Arfgef3 |
C |
T |
10: 18,465,454 (GRCm39) |
A2130T |
probably damaging |
Het |
| Arhgap30 |
A |
G |
1: 171,230,897 (GRCm39) |
D218G |
probably benign |
Het |
| Ascc3 |
C |
T |
10: 50,699,894 (GRCm39) |
P1906S |
probably damaging |
Het |
| Atp11b |
T |
G |
3: 35,861,157 (GRCm39) |
|
probably null |
Het |
| B4galnt2 |
A |
G |
11: 95,759,255 (GRCm39) |
V343A |
probably damaging |
Het |
| Barhl1 |
T |
C |
2: 28,799,785 (GRCm39) |
Y280C |
probably damaging |
Het |
| Bcar1 |
A |
T |
8: 112,447,669 (GRCm39) |
Y103N |
probably damaging |
Het |
| Bid |
A |
G |
6: 120,872,707 (GRCm39) |
I150T |
probably benign |
Het |
| Ccdc171 |
T |
C |
4: 83,467,876 (GRCm39) |
S74P |
probably damaging |
Het |
| Ccni |
A |
T |
5: 93,336,113 (GRCm39) |
|
probably null |
Het |
| Cct8l1 |
A |
G |
5: 25,721,891 (GRCm39) |
E202G |
probably benign |
Het |
| Cd200r3 |
A |
G |
16: 44,774,622 (GRCm39) |
K212E |
probably benign |
Het |
| Cdh19 |
A |
G |
1: 110,817,694 (GRCm39) |
S683P |
probably damaging |
Het |
| Ces2b |
A |
T |
8: 105,559,413 (GRCm39) |
H93L |
probably benign |
Het |
| Cimip2b |
T |
A |
4: 43,427,514 (GRCm39) |
Q270L |
possibly damaging |
Het |
| Clec4a1 |
G |
A |
6: 122,907,654 (GRCm39) |
C114Y |
probably damaging |
Het |
| Dcc |
G |
T |
18: 71,675,320 (GRCm39) |
S636* |
probably null |
Het |
| Dcdc2c |
T |
C |
12: 28,580,472 (GRCm39) |
D187G |
possibly damaging |
Het |
| Dgkb |
G |
T |
12: 38,164,657 (GRCm39) |
E150* |
probably null |
Het |
| Dhx30 |
A |
G |
9: 109,915,029 (GRCm39) |
L884P |
probably damaging |
Het |
| Dmwd |
T |
G |
7: 18,815,228 (GRCm39) |
|
probably null |
Het |
| Dnah17 |
T |
A |
11: 117,932,980 (GRCm39) |
N3593Y |
probably damaging |
Het |
| Dnm2 |
G |
A |
9: 21,392,633 (GRCm39) |
S447N |
probably benign |
Het |
| Elk4 |
G |
A |
1: 131,945,419 (GRCm39) |
G99D |
probably damaging |
Het |
| Entpd1 |
A |
T |
19: 40,727,965 (GRCm39) |
|
probably benign |
Het |
| Fam114a1 |
T |
A |
5: 65,137,070 (GRCm39) |
D4E |
probably damaging |
Het |
| Fbln2 |
A |
G |
6: 91,241,681 (GRCm39) |
D754G |
probably damaging |
Het |
| Fhip2a |
T |
C |
19: 57,367,069 (GRCm39) |
V204A |
probably benign |
Het |
| Foxred2 |
T |
C |
15: 77,840,035 (GRCm39) |
N85S |
probably damaging |
Het |
| Fut9 |
A |
G |
4: 25,799,591 (GRCm39) |
|
probably benign |
Het |
| Gm1818 |
G |
A |
12: 48,606,607 (GRCm39) |
|
noncoding transcript |
Het |
| Gm4894 |
C |
A |
9: 49,190,000 (GRCm39) |
Q92K |
unknown |
Het |
| Gpx2 |
T |
C |
12: 76,839,574 (GRCm39) |
I141M |
probably benign |
Het |
| Gusb |
T |
C |
5: 130,024,326 (GRCm39) |
T476A |
probably damaging |
Het |
| Hmmr |
G |
A |
11: 40,612,667 (GRCm39) |
T180I |
possibly damaging |
Het |
| Itgbl1 |
T |
C |
14: 124,210,780 (GRCm39) |
Y493H |
probably benign |
Het |
| Klhdc9 |
G |
T |
1: 171,187,951 (GRCm39) |
C93* |
probably null |
Het |
| Ldaf1 |
T |
C |
7: 119,715,535 (GRCm39) |
S120P |
probably damaging |
Het |
| Lpar3 |
A |
G |
3: 145,990,506 (GRCm39) |
K275E |
probably damaging |
Het |
| Lrp1b |
A |
G |
2: 40,692,897 (GRCm39) |
|
probably null |
Het |
| Lrrc63 |
C |
T |
14: 75,322,389 (GRCm39) |
G572S |
probably damaging |
Het |
| Mapk11 |
A |
T |
15: 89,030,685 (GRCm39) |
D98E |
probably benign |
Het |
| Mgat4f |
T |
A |
1: 134,317,714 (GRCm39) |
M162K |
probably benign |
Het |
| Net1 |
G |
A |
13: 3,934,905 (GRCm39) |
R374W |
probably damaging |
Het |
| Nlrp4g |
T |
A |
9: 124,354,005 (GRCm38) |
|
noncoding transcript |
Het |
| Nrap |
T |
A |
19: 56,335,652 (GRCm39) |
Y923F |
probably damaging |
Het |
| Or13a20 |
T |
A |
7: 140,232,534 (GRCm39) |
M214K |
probably benign |
Het |
| Or4c108 |
T |
A |
2: 88,803,834 (GRCm39) |
I134F |
probably damaging |
Het |
| Or6c215 |
A |
T |
10: 129,637,932 (GRCm39) |
V154E |
probably benign |
Het |
| Plxnc1 |
A |
G |
10: 94,677,335 (GRCm39) |
V964A |
probably damaging |
Het |
| Pmfbp1 |
A |
G |
8: 110,262,498 (GRCm39) |
I731V |
probably benign |
Het |
| Polq |
T |
A |
16: 36,848,274 (GRCm39) |
S294T |
probably benign |
Het |
| Pomgnt2 |
T |
C |
9: 121,811,620 (GRCm39) |
D387G |
probably benign |
Het |
| Pramel25 |
T |
C |
4: 143,520,407 (GRCm39) |
V53A |
possibly damaging |
Het |
| Prmt2 |
G |
A |
10: 76,056,842 (GRCm39) |
T227I |
probably damaging |
Het |
| Psmd1 |
T |
A |
1: 86,010,947 (GRCm39) |
F341I |
probably damaging |
Het |
| Ptpn23 |
T |
C |
9: 110,221,806 (GRCm39) |
M127V |
probably benign |
Het |
| Ptprc |
A |
G |
1: 138,017,238 (GRCm39) |
F483L |
probably damaging |
Het |
| Rab35 |
A |
C |
5: 115,778,147 (GRCm39) |
I38L |
probably damaging |
Het |
| Rapgef6 |
A |
G |
11: 54,548,143 (GRCm39) |
T486A |
probably damaging |
Het |
| Rgl3 |
A |
T |
9: 21,899,004 (GRCm39) |
C68* |
probably null |
Het |
| Rilpl1 |
T |
C |
5: 124,653,594 (GRCm39) |
E189G |
possibly damaging |
Het |
| Rnf217 |
T |
C |
10: 31,393,520 (GRCm39) |
I354V |
probably benign |
Het |
| Rspo3 |
T |
C |
10: 29,382,524 (GRCm39) |
D50G |
probably damaging |
Het |
| Sbno1 |
A |
G |
5: 124,512,672 (GRCm39) |
S1366P |
possibly damaging |
Het |
| Sema3c |
A |
G |
5: 17,899,684 (GRCm39) |
D392G |
probably benign |
Het |
| Serpinb9e |
A |
T |
13: 33,436,935 (GRCm39) |
Y85F |
probably benign |
Het |
| Sipa1l1 |
T |
C |
12: 82,388,103 (GRCm39) |
S110P |
probably benign |
Het |
| Slc16a12 |
T |
A |
19: 34,652,643 (GRCm39) |
I168F |
probably damaging |
Het |
| Slc23a3 |
A |
G |
1: 75,109,268 (GRCm39) |
S221P |
probably damaging |
Het |
| Slc35b3 |
A |
T |
13: 39,116,887 (GRCm39) |
I366K |
possibly damaging |
Het |
| Slc44a5 |
T |
C |
3: 153,949,252 (GRCm39) |
|
probably null |
Het |
| Slc5a12 |
A |
T |
2: 110,450,753 (GRCm39) |
D316V |
probably damaging |
Het |
| Ssr3 |
A |
G |
3: 65,299,874 (GRCm39) |
S29P |
probably damaging |
Het |
| Taf2 |
G |
A |
15: 54,890,619 (GRCm39) |
Q1055* |
probably null |
Het |
| Them6 |
A |
T |
15: 74,593,367 (GRCm39) |
D75V |
probably damaging |
Het |
| Tom1l2 |
A |
G |
11: 60,149,744 (GRCm39) |
S239P |
probably damaging |
Het |
| Tspear |
A |
G |
10: 77,710,877 (GRCm39) |
T500A |
probably damaging |
Het |
| Tubgcp6 |
G |
A |
15: 88,985,752 (GRCm39) |
A1487V |
probably damaging |
Het |
| Uba7 |
G |
A |
9: 107,856,190 (GRCm39) |
V522I |
possibly damaging |
Het |
| Virma |
C |
A |
4: 11,521,147 (GRCm39) |
C901* |
probably null |
Het |
| Vmn1r172 |
A |
T |
7: 23,359,312 (GRCm39) |
I66F |
possibly damaging |
Het |
| Vmn2r82 |
A |
T |
10: 79,215,010 (GRCm39) |
Y331F |
probably benign |
Het |
| Wdr55 |
G |
A |
18: 36,895,451 (GRCm39) |
V143I |
probably benign |
Het |
| Zbtb49 |
A |
T |
5: 38,371,307 (GRCm39) |
D191E |
possibly damaging |
Het |
| Zfhx4 |
A |
G |
3: 5,307,071 (GRCm39) |
H99R |
probably damaging |
Het |
| Zfp1005 |
C |
T |
2: 150,110,680 (GRCm39) |
H457Y |
unknown |
Het |
| Zfp560 |
C |
T |
9: 20,259,263 (GRCm39) |
C533Y |
probably damaging |
Het |
| Zfp646 |
C |
T |
7: 127,478,354 (GRCm39) |
A177V |
probably benign |
Het |
| Zfp653 |
C |
T |
9: 21,967,074 (GRCm39) |
E604K |
probably damaging |
Het |
|
| Other mutations in Shprh |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Shprh
|
APN |
10 |
11,063,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00583:Shprh
|
APN |
10 |
11,063,764 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00684:Shprh
|
APN |
10 |
11,038,781 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL01295:Shprh
|
APN |
10 |
11,059,612 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01387:Shprh
|
APN |
10 |
11,045,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01635:Shprh
|
APN |
10 |
11,045,763 (GRCm39) |
nonsense |
probably null |
|
|
IGL01833:Shprh
|
APN |
10 |
11,066,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02013:Shprh
|
APN |
10 |
11,057,246 (GRCm39) |
splice site |
probably benign |
|
|
IGL02502:Shprh
|
APN |
10 |
11,070,101 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL02819:Shprh
|
APN |
10 |
11,030,509 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
PIT4581001:Shprh
|
UTSW |
10 |
11,068,238 (GRCm39) |
frame shift |
probably null |
|
|
R0010:Shprh
|
UTSW |
10 |
11,027,675 (GRCm39) |
missense |
probably benign |
|
|
R0010:Shprh
|
UTSW |
10 |
11,027,675 (GRCm39) |
missense |
probably benign |
|
|
R0053:Shprh
|
UTSW |
10 |
11,070,116 (GRCm39) |
splice site |
probably null |
|
|
R0053:Shprh
|
UTSW |
10 |
11,070,116 (GRCm39) |
splice site |
probably null |
|
|
R0255:Shprh
|
UTSW |
10 |
11,062,135 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0325:Shprh
|
UTSW |
10 |
11,045,853 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0331:Shprh
|
UTSW |
10 |
11,069,914 (GRCm39) |
splice site |
probably benign |
|
|
R0494:Shprh
|
UTSW |
10 |
11,032,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Shprh
|
UTSW |
10 |
11,038,556 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0546:Shprh
|
UTSW |
10 |
11,059,631 (GRCm39) |
splice site |
probably benign |
|
|
R0574:Shprh
|
UTSW |
10 |
11,038,821 (GRCm39) |
unclassified |
probably benign |
|
|
R0605:Shprh
|
UTSW |
10 |
11,082,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0662:Shprh
|
UTSW |
10 |
11,062,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1148:Shprh
|
UTSW |
10 |
11,089,226 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1148:Shprh
|
UTSW |
10 |
11,089,226 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1263:Shprh
|
UTSW |
10 |
11,035,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1588:Shprh
|
UTSW |
10 |
11,040,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Shprh
|
UTSW |
10 |
11,032,822 (GRCm39) |
missense |
probably benign |
|
|
R1830:Shprh
|
UTSW |
10 |
11,062,655 (GRCm39) |
splice site |
probably null |
|
|
R1898:Shprh
|
UTSW |
10 |
11,062,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1903:Shprh
|
UTSW |
10 |
11,059,541 (GRCm39) |
nonsense |
probably null |
|
|
R2060:Shprh
|
UTSW |
10 |
11,027,864 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2225:Shprh
|
UTSW |
10 |
11,037,979 (GRCm39) |
unclassified |
probably benign |
|
|
R2363:Shprh
|
UTSW |
10 |
11,047,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Shprh
|
UTSW |
10 |
11,042,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2891:Shprh
|
UTSW |
10 |
11,040,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3077:Shprh
|
UTSW |
10 |
11,046,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3150:Shprh
|
UTSW |
10 |
11,045,774 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3796:Shprh
|
UTSW |
10 |
11,054,501 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4196:Shprh
|
UTSW |
10 |
11,083,604 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4423:Shprh
|
UTSW |
10 |
11,062,262 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4488:Shprh
|
UTSW |
10 |
11,036,215 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4748:Shprh
|
UTSW |
10 |
11,046,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4768:Shprh
|
UTSW |
10 |
11,057,284 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4867:Shprh
|
UTSW |
10 |
11,040,301 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5140:Shprh
|
UTSW |
10 |
11,030,449 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5318:Shprh
|
UTSW |
10 |
11,042,301 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5323:Shprh
|
UTSW |
10 |
11,046,041 (GRCm39) |
splice site |
probably null |
|
|
R5450:Shprh
|
UTSW |
10 |
11,088,074 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R5872:Shprh
|
UTSW |
10 |
11,063,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6030:Shprh
|
UTSW |
10 |
11,027,735 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6030:Shprh
|
UTSW |
10 |
11,027,735 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6392:Shprh
|
UTSW |
10 |
11,054,485 (GRCm39) |
nonsense |
probably null |
|
|
R6416:Shprh
|
UTSW |
10 |
11,043,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6470:Shprh
|
UTSW |
10 |
11,047,681 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6513:Shprh
|
UTSW |
10 |
11,062,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6530:Shprh
|
UTSW |
10 |
11,070,011 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6678:Shprh
|
UTSW |
10 |
11,042,289 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6757:Shprh
|
UTSW |
10 |
11,057,252 (GRCm39) |
splice site |
probably null |
|
|
R6971:Shprh
|
UTSW |
10 |
11,042,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7158:Shprh
|
UTSW |
10 |
11,042,474 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7582:Shprh
|
UTSW |
10 |
11,040,449 (GRCm39) |
missense |
probably benign |
|
|
R7757:Shprh
|
UTSW |
10 |
11,037,924 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7812:Shprh
|
UTSW |
10 |
11,027,735 (GRCm39) |
missense |
probably benign |
|
|
R7998:Shprh
|
UTSW |
10 |
11,061,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8061:Shprh
|
UTSW |
10 |
11,088,077 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8082:Shprh
|
UTSW |
10 |
11,027,555 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8116:Shprh
|
UTSW |
10 |
11,089,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8390:Shprh
|
UTSW |
10 |
11,063,727 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8445:Shprh
|
UTSW |
10 |
11,057,313 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8530:Shprh
|
UTSW |
10 |
11,027,678 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8759:Shprh
|
UTSW |
10 |
11,032,908 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8937:Shprh
|
UTSW |
10 |
11,061,181 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8995:Shprh
|
UTSW |
10 |
11,040,574 (GRCm39) |
nonsense |
probably null |
|
|
R9053:Shprh
|
UTSW |
10 |
11,030,446 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9131:Shprh
|
UTSW |
10 |
11,038,589 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9176:Shprh
|
UTSW |
10 |
11,036,320 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9391:Shprh
|
UTSW |
10 |
11,038,633 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9423:Shprh
|
UTSW |
10 |
11,081,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9563:Shprh
|
UTSW |
10 |
11,042,235 (GRCm39) |
nonsense |
probably null |
|
|
R9668:Shprh
|
UTSW |
10 |
11,082,076 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9709:Shprh
|
UTSW |
10 |
11,038,574 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9718:Shprh
|
UTSW |
10 |
11,089,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9750:Shprh
|
UTSW |
10 |
11,040,204 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF012:Shprh
|
UTSW |
10 |
11,040,585 (GRCm39) |
missense |
probably benign |
0.02 |
|
V8831:Shprh
|
UTSW |
10 |
11,062,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,062,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,040,297 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Shprh
|
UTSW |
10 |
11,027,506 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTAGGGGTGAGACCAATCCAG -3'
(R):5'- TTGCCGTCACCCCAATACATG -3'
Sequencing Primer
(F):5'- GTGAGACCAATCCAGAGATTATTG -3'
(R):5'- ATGCCCCACTATTAACTATCTGTAAC -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation