Incidental Mutation 'R4931:Vmn2r103'
| ID |
380594 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r103
|
| Ensembl Gene |
ENSMUSG00000091771 |
| Gene Name |
vomeronasal 2, receptor 103 |
| Synonyms |
EG627636 |
| MMRRC Submission |
042532-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R4931 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19993625-20032798 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 20032031 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 602
(I602F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126756
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172203]
|
| AlphaFold |
E9PWW0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172203
AA Change: I602F
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: I602F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
449 |
1.3e-37 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
3.5e-22 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.1e-51 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.4%
- 20x: 92.7%
|
| Validation Efficiency |
95% (78/82) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2410004B18Rik |
A |
G |
3: 145,643,875 (GRCm39) |
D21G |
probably benign |
Het |
| 4930562C15Rik |
T |
C |
16: 4,678,910 (GRCm39) |
L68P |
possibly damaging |
Het |
| Ache |
A |
G |
5: 137,290,176 (GRCm39) |
I414V |
probably benign |
Het |
| Acy1 |
G |
A |
9: 106,310,390 (GRCm39) |
H308Y |
probably damaging |
Het |
| Aldh1b1 |
A |
C |
4: 45,803,661 (GRCm39) |
I400L |
probably benign |
Het |
| Ankrd40 |
T |
A |
11: 94,225,647 (GRCm39) |
L226Q |
probably benign |
Het |
| B3gnt9 |
T |
C |
8: 105,980,876 (GRCm39) |
T171A |
probably benign |
Het |
| Ccdc33 |
T |
C |
9: 57,977,134 (GRCm39) |
Y289C |
probably damaging |
Het |
| Cd209f |
A |
T |
8: 4,153,688 (GRCm39) |
I187N |
probably damaging |
Het |
| Cers6 |
T |
G |
2: 68,935,456 (GRCm39) |
S319A |
probably damaging |
Het |
| Chrna4 |
A |
G |
2: 180,670,665 (GRCm39) |
S364P |
probably benign |
Het |
| Chrnb3 |
T |
C |
8: 27,884,258 (GRCm39) |
S317P |
probably damaging |
Het |
| Dapk1 |
T |
C |
13: 60,908,774 (GRCm39) |
V1129A |
probably benign |
Het |
| Dhx9 |
G |
A |
1: 153,348,419 (GRCm39) |
P302L |
probably benign |
Het |
| Dnaaf9 |
A |
G |
2: 130,583,793 (GRCm39) |
F496L |
possibly damaging |
Het |
| Dnah8 |
G |
A |
17: 30,967,542 (GRCm39) |
D2585N |
probably benign |
Het |
| Duox2 |
T |
C |
2: 122,127,236 (GRCm39) |
N147S |
probably benign |
Het |
| Dytn |
T |
G |
1: 63,672,837 (GRCm39) |
E522A |
probably benign |
Het |
| E130114P18Rik |
T |
C |
4: 97,608,524 (GRCm39) |
D27G |
unknown |
Het |
| Egf |
A |
G |
3: 129,505,117 (GRCm39) |
F118S |
probably damaging |
Het |
| Eif2d |
T |
A |
1: 131,082,128 (GRCm39) |
F73L |
probably damaging |
Het |
| Eps8l1 |
A |
G |
7: 4,474,240 (GRCm39) |
E237G |
possibly damaging |
Het |
| Espl1 |
A |
G |
15: 102,214,165 (GRCm39) |
E664G |
probably benign |
Het |
| Fbrsl1 |
A |
T |
5: 110,526,895 (GRCm39) |
S373T |
possibly damaging |
Het |
| Fras1 |
T |
A |
5: 96,784,699 (GRCm39) |
F894Y |
probably benign |
Het |
| Gpatch8 |
T |
C |
11: 102,372,050 (GRCm39) |
E496G |
unknown |
Het |
| Gucy1a2 |
A |
G |
9: 3,759,588 (GRCm39) |
K465E |
probably damaging |
Het |
| Igdcc4 |
A |
G |
9: 65,031,297 (GRCm39) |
T459A |
possibly damaging |
Het |
| Itgad |
A |
T |
7: 127,803,797 (GRCm39) |
I64F |
probably damaging |
Het |
| Itgb2l |
T |
A |
16: 96,238,649 (GRCm39) |
N50I |
probably damaging |
Het |
| Kif13a |
A |
G |
13: 46,962,531 (GRCm39) |
I478T |
probably damaging |
Het |
| Krt31 |
G |
A |
11: 99,940,983 (GRCm39) |
T109I |
probably benign |
Het |
| Ltbr |
G |
T |
6: 125,284,437 (GRCm39) |
|
probably null |
Het |
| Magel2 |
A |
G |
7: 62,030,372 (GRCm39) |
D1092G |
unknown |
Het |
| Minar1 |
T |
C |
9: 89,483,705 (GRCm39) |
H564R |
probably benign |
Het |
| Mindy3 |
A |
T |
2: 12,401,024 (GRCm39) |
N231K |
probably damaging |
Het |
| Mpnd |
T |
G |
17: 56,319,362 (GRCm39) |
|
probably benign |
Het |
| Mtus2 |
C |
T |
5: 148,014,226 (GRCm39) |
L340F |
probably benign |
Het |
| Nanog |
G |
A |
6: 122,684,865 (GRCm39) |
A17T |
possibly damaging |
Het |
| Ndufa9 |
G |
T |
6: 126,813,283 (GRCm39) |
A181E |
probably damaging |
Het |
| Or52z14 |
T |
G |
7: 103,253,581 (GRCm39) |
L240R |
probably benign |
Het |
| Or7e175 |
A |
T |
9: 20,048,858 (GRCm39) |
I149F |
probably benign |
Het |
| Pprc1 |
ATCCTCCTCCTCCTCCTCCTC |
ATCCTCCTCCTCCTCCTC |
19: 46,059,755 (GRCm39) |
|
probably benign |
Het |
| Pramel18 |
T |
C |
4: 101,766,367 (GRCm39) |
V17A |
possibly damaging |
Het |
| Prkacb |
T |
C |
3: 146,453,732 (GRCm39) |
I211V |
possibly damaging |
Het |
| Ptpn14 |
C |
G |
1: 189,583,474 (GRCm39) |
L774V |
probably benign |
Het |
| Rad1 |
T |
C |
15: 10,492,848 (GRCm39) |
|
probably benign |
Het |
| Rims1 |
G |
T |
1: 22,573,028 (GRCm39) |
P391Q |
probably benign |
Het |
| Rnd2 |
C |
T |
11: 101,359,825 (GRCm39) |
L57F |
probably damaging |
Het |
| Sf3b3 |
C |
T |
8: 111,542,961 (GRCm39) |
R832Q |
probably benign |
Het |
| Slc12a2 |
A |
G |
18: 58,068,035 (GRCm39) |
D975G |
possibly damaging |
Het |
| Slitrk6 |
A |
G |
14: 110,987,811 (GRCm39) |
L632P |
probably damaging |
Het |
| Spire2 |
A |
G |
8: 124,095,523 (GRCm39) |
D542G |
possibly damaging |
Het |
| Sppl3 |
A |
T |
5: 115,220,373 (GRCm39) |
Q95L |
probably damaging |
Het |
| Stat5b |
C |
A |
11: 100,675,080 (GRCm39) |
E710* |
probably null |
Het |
| Tcl1 |
G |
T |
12: 105,188,872 (GRCm39) |
H14N |
probably damaging |
Het |
| Ten1 |
T |
C |
11: 116,096,555 (GRCm39) |
F70L |
probably benign |
Het |
| Tnfrsf13b |
A |
T |
11: 61,031,763 (GRCm39) |
T35S |
possibly damaging |
Het |
| Tpcn2 |
G |
A |
7: 144,821,046 (GRCm39) |
P336L |
probably benign |
Het |
| Trf |
C |
A |
9: 103,105,247 (GRCm39) |
D22Y |
probably damaging |
Het |
| Ttyh1 |
A |
G |
7: 4,136,943 (GRCm39) |
|
probably benign |
Het |
| Zfp296 |
G |
T |
7: 19,313,637 (GRCm39) |
C164F |
possibly damaging |
Het |
| Zfp352 |
A |
G |
4: 90,112,541 (GRCm39) |
Y227C |
probably damaging |
Het |
| Zfp599 |
A |
T |
9: 22,169,419 (GRCm39) |
W18R |
probably damaging |
Het |
|
| Other mutations in Vmn2r103 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00333:Vmn2r103
|
APN |
17 |
20,013,364 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00939:Vmn2r103
|
APN |
17 |
20,015,227 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01120:Vmn2r103
|
APN |
17 |
20,013,259 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01403:Vmn2r103
|
APN |
17 |
20,013,229 (GRCm39) |
missense |
probably benign |
|
|
IGL01404:Vmn2r103
|
APN |
17 |
20,032,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01713:Vmn2r103
|
APN |
17 |
20,014,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01802:Vmn2r103
|
APN |
17 |
20,019,470 (GRCm39) |
missense |
probably benign |
|
|
IGL02251:Vmn2r103
|
APN |
17 |
20,014,231 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02466:Vmn2r103
|
APN |
17 |
19,993,631 (GRCm39) |
missense |
probably benign |
|
|
IGL02555:Vmn2r103
|
APN |
17 |
20,031,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02668:Vmn2r103
|
APN |
17 |
20,014,389 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02715:Vmn2r103
|
APN |
17 |
20,014,218 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02735:Vmn2r103
|
APN |
17 |
20,032,510 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL03101:Vmn2r103
|
APN |
17 |
19,993,782 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0003:Vmn2r103
|
UTSW |
17 |
20,032,241 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0052:Vmn2r103
|
UTSW |
17 |
20,031,903 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0375:Vmn2r103
|
UTSW |
17 |
20,013,726 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0375:Vmn2r103
|
UTSW |
17 |
20,013,121 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0755:Vmn2r103
|
UTSW |
17 |
19,993,830 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0837:Vmn2r103
|
UTSW |
17 |
20,014,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1345:Vmn2r103
|
UTSW |
17 |
20,014,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1396:Vmn2r103
|
UTSW |
17 |
20,013,230 (GRCm39) |
missense |
probably benign |
|
|
R1488:Vmn2r103
|
UTSW |
17 |
20,013,922 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1533:Vmn2r103
|
UTSW |
17 |
19,993,662 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1590:Vmn2r103
|
UTSW |
17 |
20,014,496 (GRCm39) |
missense |
probably benign |
|
|
R1928:Vmn2r103
|
UTSW |
17 |
20,032,029 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1942:Vmn2r103
|
UTSW |
17 |
20,032,562 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2071:Vmn2r103
|
UTSW |
17 |
20,014,056 (GRCm39) |
missense |
probably benign |
|
|
R2219:Vmn2r103
|
UTSW |
17 |
20,013,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2442:Vmn2r103
|
UTSW |
17 |
19,993,793 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2889:Vmn2r103
|
UTSW |
17 |
20,013,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r103
|
UTSW |
17 |
20,032,411 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4014:Vmn2r103
|
UTSW |
17 |
20,013,866 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4331:Vmn2r103
|
UTSW |
17 |
20,014,495 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4630:Vmn2r103
|
UTSW |
17 |
20,013,958 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4631:Vmn2r103
|
UTSW |
17 |
20,013,958 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4632:Vmn2r103
|
UTSW |
17 |
20,013,958 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4660:Vmn2r103
|
UTSW |
17 |
20,032,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Vmn2r103
|
UTSW |
17 |
20,015,338 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4802:Vmn2r103
|
UTSW |
17 |
20,015,338 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4995:Vmn2r103
|
UTSW |
17 |
19,993,773 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5309:Vmn2r103
|
UTSW |
17 |
20,013,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5312:Vmn2r103
|
UTSW |
17 |
20,013,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5329:Vmn2r103
|
UTSW |
17 |
20,032,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5611:Vmn2r103
|
UTSW |
17 |
20,013,904 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5684:Vmn2r103
|
UTSW |
17 |
20,013,251 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5715:Vmn2r103
|
UTSW |
17 |
20,015,201 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5907:Vmn2r103
|
UTSW |
17 |
20,032,715 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R6029:Vmn2r103
|
UTSW |
17 |
20,014,478 (GRCm39) |
nonsense |
probably null |
|
|
R6114:Vmn2r103
|
UTSW |
17 |
20,032,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6285:Vmn2r103
|
UTSW |
17 |
20,032,406 (GRCm39) |
missense |
probably benign |
|
|
R6292:Vmn2r103
|
UTSW |
17 |
20,013,866 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R6334:Vmn2r103
|
UTSW |
17 |
20,014,344 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6501:Vmn2r103
|
UTSW |
17 |
20,032,166 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6710:Vmn2r103
|
UTSW |
17 |
20,032,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6774:Vmn2r103
|
UTSW |
17 |
19,993,773 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6981:Vmn2r103
|
UTSW |
17 |
20,013,739 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7768:Vmn2r103
|
UTSW |
17 |
20,032,314 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7816:Vmn2r103
|
UTSW |
17 |
20,014,476 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7885:Vmn2r103
|
UTSW |
17 |
20,013,385 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8002:Vmn2r103
|
UTSW |
17 |
20,019,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8031:Vmn2r103
|
UTSW |
17 |
20,013,759 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8140:Vmn2r103
|
UTSW |
17 |
20,032,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8186:Vmn2r103
|
UTSW |
17 |
20,032,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8559:Vmn2r103
|
UTSW |
17 |
20,032,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9413:Vmn2r103
|
UTSW |
17 |
20,032,158 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R9591:Vmn2r103
|
UTSW |
17 |
20,031,921 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9652:Vmn2r103
|
UTSW |
17 |
20,014,027 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9680:Vmn2r103
|
UTSW |
17 |
20,019,525 (GRCm39) |
nonsense |
probably null |
|
|
R9743:Vmn2r103
|
UTSW |
17 |
20,032,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r103
|
UTSW |
17 |
20,015,309 (GRCm39) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGACTCCTGTGTTCATGATAACC -3'
(R):5'- TTTGGCCAACACAGTAGCAAGAG -3'
Sequencing Primer
(F):5'- GAAGTGTCCAGAAGGTCA -3'
(R):5'- CACAGTAGCAAGAGCCATAGTG -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation