Incidental Mutation 'R4933:Cabyr'
ID |
380747 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cabyr
|
Ensembl Gene |
ENSMUSG00000024430 |
Gene Name |
calcium binding tyrosine phosphorylation regulated |
Synonyms |
FSP-2, 1700016C01Rik, 4933421A18Rik, CBP86 |
MMRRC Submission |
042533-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.091)
|
Stock # |
R4933 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
18 |
Chromosomal Location |
12874141-12888203 bp(+) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
T to C
at 12877549 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000140894
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080415]
[ENSMUST00000115857]
[ENSMUST00000119108]
[ENSMUST00000121018]
[ENSMUST00000150758]
[ENSMUST00000186263]
[ENSMUST00000191078]
|
AlphaFold |
Q9D424 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000080415
|
SMART Domains |
Protein: ENSMUSP00000079277 Gene: ENSMUSG00000024430
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
2.3e-12 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115857
|
SMART Domains |
Protein: ENSMUSP00000111523 Gene: ENSMUSG00000024430
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
2.2e-12 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000119108
|
SMART Domains |
Protein: ENSMUSP00000113760 Gene: ENSMUSG00000024430
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
8.5e-13 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000121018
|
SMART Domains |
Protein: ENSMUSP00000113131 Gene: ENSMUSG00000024430
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
6.7e-12 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
low complexity region
|
213 |
223 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000121453
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000150758
|
SMART Domains |
Protein: ENSMUSP00000118330 Gene: ENSMUSG00000024430
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
2.3e-12 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000186263
|
SMART Domains |
Protein: ENSMUSP00000140870 Gene: ENSMUSG00000024430
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
2.3e-12 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000191078
|
SMART Domains |
Protein: ENSMUSP00000140894 Gene: ENSMUSG00000024430
Domain | Start | End | E-Value | Type |
Pfam:RIIa
|
12 |
46 |
2.3e-12 |
PFAM |
low complexity region
|
77 |
96 |
N/A |
INTRINSIC |
low complexity region
|
141 |
172 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.4%
- 20x: 89.3%
|
Validation Efficiency |
97% (73/75) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013] PHENOTYPE: Homozygous knockout affects sperm flagellum morphology, resulting in reduced sperm motility. These mutant males are subfertile. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 55 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2610021A01Rik |
A |
G |
7: 41,276,226 (GRCm39) |
E643G |
probably damaging |
Het |
Abca2 |
T |
C |
2: 25,334,839 (GRCm39) |
V1937A |
probably benign |
Het |
Acot10 |
A |
T |
15: 20,666,416 (GRCm39) |
N108K |
possibly damaging |
Het |
Agtpbp1 |
A |
T |
13: 59,648,386 (GRCm39) |
M478K |
probably benign |
Het |
Akirin1 |
G |
A |
4: 123,630,651 (GRCm39) |
S191F |
probably damaging |
Het |
Aoc1l3 |
T |
C |
6: 48,964,426 (GRCm39) |
S145P |
probably damaging |
Het |
Aurkb |
T |
C |
11: 68,938,970 (GRCm39) |
|
probably benign |
Het |
Ccp110 |
A |
G |
7: 118,324,542 (GRCm39) |
E688G |
probably damaging |
Het |
Champ1 |
T |
A |
8: 13,929,137 (GRCm39) |
S432T |
probably benign |
Het |
Crybg1 |
T |
A |
10: 43,875,209 (GRCm39) |
N633I |
probably damaging |
Het |
Dagla |
A |
T |
19: 10,247,079 (GRCm39) |
|
probably null |
Het |
Dkkl1 |
A |
T |
7: 44,860,949 (GRCm39) |
L10Q |
probably null |
Het |
Dnah8 |
G |
A |
17: 30,967,542 (GRCm39) |
D2585N |
probably benign |
Het |
Fndc7 |
G |
T |
3: 108,783,986 (GRCm39) |
Q208K |
probably benign |
Het |
Gins4 |
A |
T |
8: 23,724,796 (GRCm39) |
C53S |
probably damaging |
Het |
Gja8 |
T |
A |
3: 96,826,351 (GRCm39) |
|
probably benign |
Het |
Golph3l |
T |
A |
3: 95,524,734 (GRCm39) |
N328K |
probably benign |
Het |
Haus6 |
A |
C |
4: 86,503,524 (GRCm39) |
|
probably benign |
Het |
Hdac5 |
A |
G |
11: 102,091,389 (GRCm39) |
|
probably benign |
Het |
Ide |
A |
G |
19: 37,255,155 (GRCm39) |
Y883H |
unknown |
Het |
Igf2r |
A |
G |
17: 12,910,764 (GRCm39) |
|
probably null |
Het |
Kdm3b |
T |
C |
18: 34,943,446 (GRCm39) |
Y723H |
probably damaging |
Het |
Kif21b |
G |
A |
1: 136,079,063 (GRCm39) |
|
probably null |
Het |
Lancl1 |
A |
T |
1: 67,060,193 (GRCm39) |
N77K |
probably benign |
Het |
Lyst |
T |
A |
13: 13,812,349 (GRCm39) |
N920K |
probably damaging |
Het |
Lyst |
G |
A |
13: 13,933,963 (GRCm39) |
V3554I |
probably benign |
Het |
Map1a |
G |
A |
2: 121,136,386 (GRCm39) |
A2163T |
probably damaging |
Het |
Mapk7 |
G |
T |
11: 61,384,734 (GRCm39) |
|
probably benign |
Het |
Myo10 |
C |
A |
15: 25,781,204 (GRCm39) |
Q154K |
probably damaging |
Het |
Or2a7 |
C |
T |
6: 43,151,255 (GRCm39) |
L112F |
probably benign |
Het |
Or2h15 |
A |
G |
17: 38,441,441 (GRCm39) |
I214T |
probably damaging |
Het |
Pcdhgb2 |
G |
A |
18: 37,825,267 (GRCm39) |
V753M |
probably benign |
Het |
Pnn |
T |
A |
12: 59,117,013 (GRCm39) |
L195Q |
probably damaging |
Het |
Pot1a |
A |
G |
6: 25,771,540 (GRCm39) |
V227A |
possibly damaging |
Het |
Ppp1r21 |
T |
A |
17: 88,855,049 (GRCm39) |
D109E |
probably benign |
Het |
Prr15l |
G |
A |
11: 96,825,588 (GRCm39) |
G73S |
probably damaging |
Het |
Rnf148 |
A |
G |
6: 23,654,339 (GRCm39) |
F219S |
probably benign |
Het |
Rnpep |
C |
A |
1: 135,194,764 (GRCm39) |
|
probably benign |
Het |
Ryr1 |
T |
C |
7: 28,803,723 (GRCm39) |
T643A |
probably damaging |
Het |
Ryr2 |
A |
T |
13: 11,960,831 (GRCm39) |
C36S |
probably damaging |
Het |
Shc3 |
G |
T |
13: 51,596,805 (GRCm39) |
T406N |
probably benign |
Het |
Slit3 |
G |
T |
11: 35,579,420 (GRCm39) |
G1199V |
probably damaging |
Het |
Spata6l |
G |
T |
19: 28,919,175 (GRCm39) |
H195N |
possibly damaging |
Het |
Sptbn5 |
G |
A |
2: 119,880,601 (GRCm39) |
|
noncoding transcript |
Het |
St8sia6 |
T |
C |
2: 13,670,253 (GRCm39) |
N236D |
probably damaging |
Het |
Stpg1 |
A |
T |
4: 135,233,727 (GRCm39) |
Q3L |
probably benign |
Het |
Sult3a1 |
T |
A |
10: 33,742,550 (GRCm39) |
I59N |
probably damaging |
Het |
Vmn1r208 |
T |
G |
13: 22,956,958 (GRCm39) |
I180L |
probably benign |
Het |
Vmn2r51 |
A |
T |
7: 9,832,247 (GRCm39) |
N446K |
probably damaging |
Het |
Vmn2r63 |
A |
T |
7: 42,553,402 (GRCm39) |
I618N |
probably damaging |
Het |
Wrn |
T |
C |
8: 33,812,371 (GRCm39) |
N182S |
probably benign |
Het |
Zfp296 |
G |
T |
7: 19,313,637 (GRCm39) |
C164F |
possibly damaging |
Het |
Zfp764l1 |
A |
G |
7: 126,992,521 (GRCm39) |
Y30H |
probably damaging |
Het |
Zmynd8 |
A |
G |
2: 165,676,871 (GRCm39) |
V249A |
possibly damaging |
Het |
Zswim2 |
A |
G |
2: 83,755,571 (GRCm39) |
L110P |
probably damaging |
Het |
|
Other mutations in Cabyr |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00544:Cabyr
|
APN |
18 |
12,877,667 (GRCm39) |
missense |
probably damaging |
0.99 |
R0547:Cabyr
|
UTSW |
18 |
12,884,073 (GRCm39) |
missense |
probably benign |
0.07 |
R0571:Cabyr
|
UTSW |
18 |
12,883,909 (GRCm39) |
missense |
probably damaging |
1.00 |
R1556:Cabyr
|
UTSW |
18 |
12,877,837 (GRCm39) |
missense |
probably damaging |
1.00 |
R3084:Cabyr
|
UTSW |
18 |
12,884,023 (GRCm39) |
missense |
probably damaging |
1.00 |
R3085:Cabyr
|
UTSW |
18 |
12,884,023 (GRCm39) |
missense |
probably damaging |
1.00 |
R3086:Cabyr
|
UTSW |
18 |
12,884,023 (GRCm39) |
missense |
probably damaging |
1.00 |
R3824:Cabyr
|
UTSW |
18 |
12,884,747 (GRCm39) |
missense |
probably benign |
0.04 |
R3898:Cabyr
|
UTSW |
18 |
12,884,580 (GRCm39) |
missense |
probably benign |
0.00 |
R4869:Cabyr
|
UTSW |
18 |
12,884,875 (GRCm39) |
makesense |
probably null |
|
R5036:Cabyr
|
UTSW |
18 |
12,884,303 (GRCm39) |
missense |
probably damaging |
1.00 |
R5482:Cabyr
|
UTSW |
18 |
12,884,496 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5932:Cabyr
|
UTSW |
18 |
12,887,407 (GRCm39) |
missense |
probably damaging |
1.00 |
R6515:Cabyr
|
UTSW |
18 |
12,887,340 (GRCm39) |
missense |
possibly damaging |
0.93 |
R6556:Cabyr
|
UTSW |
18 |
12,884,073 (GRCm39) |
missense |
probably benign |
0.07 |
R6852:Cabyr
|
UTSW |
18 |
12,887,154 (GRCm39) |
missense |
probably benign |
0.35 |
R6907:Cabyr
|
UTSW |
18 |
12,883,969 (GRCm39) |
missense |
probably benign |
0.05 |
R7193:Cabyr
|
UTSW |
18 |
12,884,815 (GRCm39) |
missense |
probably damaging |
1.00 |
R7565:Cabyr
|
UTSW |
18 |
12,877,656 (GRCm39) |
missense |
possibly damaging |
0.50 |
R7777:Cabyr
|
UTSW |
18 |
12,877,828 (GRCm39) |
missense |
probably damaging |
1.00 |
R7941:Cabyr
|
UTSW |
18 |
12,877,825 (GRCm39) |
missense |
probably damaging |
1.00 |
R8243:Cabyr
|
UTSW |
18 |
12,883,759 (GRCm39) |
missense |
probably benign |
0.00 |
R8406:Cabyr
|
UTSW |
18 |
12,883,804 (GRCm39) |
missense |
probably benign |
0.04 |
R8914:Cabyr
|
UTSW |
18 |
12,884,077 (GRCm39) |
missense |
probably damaging |
0.98 |
R9224:Cabyr
|
UTSW |
18 |
12,887,278 (GRCm39) |
missense |
possibly damaging |
0.64 |
R9635:Cabyr
|
UTSW |
18 |
12,883,816 (GRCm39) |
missense |
probably damaging |
1.00 |
R9697:Cabyr
|
UTSW |
18 |
12,884,407 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Predicted Primers |
|
Posted On |
2016-04-15 |