Incidental Mutation 'R4927:Vmn2r102'
| ID |
380937 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r102
|
| Ensembl Gene |
ENSMUSG00000095961 |
| Gene Name |
vomeronasal 2, receptor 102 |
| Synonyms |
EG224572 |
| MMRRC Submission |
042528-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4927 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
19880661-19915010 bp(+) (GRCm39) |
| Type of Mutation |
start codon destroyed |
| DNA Base Change (assembly) |
A to T
at 19880661 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 1
(M1L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126559
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171741]
|
| AlphaFold |
L7N279 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171741
AA Change: M1L
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: M1L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
448 |
5.2e-38 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
1.1e-21 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.8e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.4%
|
| Validation Efficiency |
97% (76/78) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 67 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ablim2 |
C |
T |
5: 35,959,766 (GRCm39) |
R73C |
possibly damaging |
Het |
| Adamts2 |
T |
A |
11: 50,694,639 (GRCm39) |
L1142* |
probably null |
Het |
| Arl13b |
C |
A |
16: 62,622,150 (GRCm39) |
G381V |
probably damaging |
Het |
| Ash1l |
G |
T |
3: 88,892,641 (GRCm39) |
V1507F |
probably damaging |
Het |
| Babam2 |
T |
A |
5: 31,859,408 (GRCm39) |
F38I |
probably benign |
Het |
| Bend4 |
T |
C |
5: 67,557,619 (GRCm39) |
Y399C |
probably damaging |
Het |
| Btn1a1 |
A |
T |
13: 23,644,794 (GRCm39) |
|
probably null |
Het |
| Cacna1g |
A |
T |
11: 94,319,973 (GRCm39) |
L1401Q |
probably damaging |
Het |
| Ccdc192 |
C |
T |
18: 57,863,888 (GRCm39) |
Q213* |
probably null |
Het |
| Cep192 |
T |
C |
18: 67,968,195 (GRCm39) |
V893A |
probably benign |
Het |
| Cnot10 |
A |
T |
9: 114,447,012 (GRCm39) |
Y355N |
probably damaging |
Het |
| Col6a5 |
G |
C |
9: 105,811,163 (GRCm39) |
S785R |
unknown |
Het |
| Cpa3 |
A |
G |
3: 20,276,303 (GRCm39) |
L310P |
probably damaging |
Het |
| Cux2 |
A |
G |
5: 122,015,152 (GRCm39) |
I247T |
probably benign |
Het |
| Dab1 |
A |
G |
4: 104,561,449 (GRCm39) |
T245A |
probably benign |
Het |
| Dmrta1 |
A |
T |
4: 89,579,985 (GRCm39) |
D315V |
probably damaging |
Het |
| Dnah12 |
T |
A |
14: 26,583,762 (GRCm39) |
L599* |
probably null |
Het |
| Dync1h1 |
T |
C |
12: 110,629,289 (GRCm39) |
I4231T |
possibly damaging |
Het |
| Fat1 |
T |
C |
8: 45,476,000 (GRCm39) |
V1659A |
probably damaging |
Het |
| Flot2 |
G |
A |
11: 77,949,888 (GRCm39) |
V406M |
probably damaging |
Het |
| Galnt2 |
A |
G |
8: 125,032,362 (GRCm39) |
D75G |
probably damaging |
Het |
| Gcnt3 |
A |
T |
9: 69,942,464 (GRCm39) |
C35S |
probably damaging |
Het |
| Gp2 |
A |
G |
7: 119,052,118 (GRCm39) |
F199L |
probably benign |
Het |
| Gramd2b |
C |
T |
18: 56,618,523 (GRCm39) |
P244S |
probably damaging |
Het |
| Hhipl1 |
T |
C |
12: 108,278,203 (GRCm39) |
L177P |
probably damaging |
Het |
| Homez |
T |
C |
14: 55,095,264 (GRCm39) |
E148G |
possibly damaging |
Het |
| Kcnab3 |
G |
A |
11: 69,217,572 (GRCm39) |
C22Y |
possibly damaging |
Het |
| Kcnh8 |
C |
A |
17: 53,185,009 (GRCm39) |
S430R |
probably damaging |
Het |
| Kcnn2 |
T |
C |
18: 45,692,798 (GRCm39) |
C125R |
probably benign |
Het |
| Klhl7 |
G |
A |
5: 24,346,185 (GRCm39) |
R277Q |
possibly damaging |
Het |
| Krt78 |
A |
G |
15: 101,855,334 (GRCm39) |
S826P |
probably benign |
Het |
| Krtap14 |
T |
C |
16: 88,622,919 (GRCm39) |
Y20C |
possibly damaging |
Het |
| Lrcol1 |
A |
G |
5: 110,502,163 (GRCm39) |
|
probably null |
Het |
| Lrrc10b |
G |
A |
19: 10,434,226 (GRCm39) |
P152S |
probably damaging |
Het |
| Lrrn3 |
C |
G |
12: 41,503,124 (GRCm39) |
D398H |
probably damaging |
Het |
| Map3k19 |
T |
C |
1: 127,749,932 (GRCm39) |
I1140V |
probably benign |
Het |
| Mos |
G |
A |
4: 3,871,093 (GRCm39) |
T241M |
probably damaging |
Het |
| Nol8 |
A |
G |
13: 49,807,901 (GRCm39) |
E39G |
possibly damaging |
Het |
| Olfm1 |
T |
G |
2: 28,104,798 (GRCm39) |
S212A |
probably benign |
Het |
| Or2ak6 |
T |
A |
11: 58,592,633 (GRCm39) |
F35L |
probably damaging |
Het |
| Pip4p2 |
G |
T |
4: 14,912,458 (GRCm39) |
R189L |
probably damaging |
Het |
| Plec |
G |
T |
15: 76,061,162 (GRCm39) |
T2947K |
probably damaging |
Het |
| Pramel27 |
A |
T |
4: 143,578,187 (GRCm39) |
Q149L |
probably damaging |
Het |
| Rasgrp3 |
A |
G |
17: 75,823,350 (GRCm39) |
M474V |
probably benign |
Het |
| Ryr1 |
T |
C |
7: 28,719,408 (GRCm39) |
Y4333C |
unknown |
Het |
| Scrn2 |
G |
C |
11: 96,924,326 (GRCm39) |
|
probably null |
Het |
| Slc22a12 |
C |
A |
19: 6,587,791 (GRCm39) |
V388L |
probably benign |
Het |
| Slc4a11 |
A |
G |
2: 130,526,866 (GRCm39) |
V754A |
probably damaging |
Het |
| Slco2b1 |
A |
G |
7: 99,335,195 (GRCm39) |
F195S |
probably damaging |
Het |
| Slfn9 |
A |
C |
11: 82,872,216 (GRCm39) |
M840R |
possibly damaging |
Het |
| Speer4b |
T |
C |
5: 27,706,263 (GRCm39) |
N35D |
probably damaging |
Het |
| Taf1d |
T |
A |
9: 15,221,250 (GRCm39) |
D185E |
probably damaging |
Het |
| Taok2 |
A |
G |
7: 126,475,213 (GRCm39) |
L245P |
probably damaging |
Het |
| Tent4a |
A |
T |
13: 69,651,019 (GRCm39) |
|
probably null |
Het |
| Ticam2 |
T |
C |
18: 46,693,846 (GRCm39) |
I80M |
probably damaging |
Het |
| Tmem268 |
G |
A |
4: 63,502,164 (GRCm39) |
V331I |
probably benign |
Het |
| Tsga10 |
T |
C |
1: 37,840,931 (GRCm39) |
E425G |
probably damaging |
Het |
| Ttc7 |
A |
G |
17: 87,654,133 (GRCm39) |
|
probably null |
Het |
| Ttf1 |
C |
T |
2: 28,954,668 (GRCm39) |
H11Y |
possibly damaging |
Het |
| Unc13a |
T |
C |
8: 72,107,489 (GRCm39) |
H601R |
probably damaging |
Het |
| Vmn2r120 |
G |
T |
17: 57,816,125 (GRCm39) |
N743K |
probably damaging |
Het |
| Wnt6 |
C |
A |
1: 74,823,295 (GRCm39) |
|
probably null |
Het |
| Wnt6 |
A |
C |
1: 74,823,296 (GRCm39) |
|
probably null |
Het |
| Wnt8a |
T |
A |
18: 34,680,525 (GRCm39) |
C297S |
probably damaging |
Het |
| Zfp786 |
T |
C |
6: 47,797,087 (GRCm39) |
Q617R |
probably benign |
Het |
| Zfp91 |
A |
G |
19: 12,753,774 (GRCm39) |
|
probably null |
Het |
| Zw10 |
T |
A |
9: 48,979,983 (GRCm39) |
F371L |
probably damaging |
Het |
|
| Other mutations in Vmn2r102 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Vmn2r102
|
APN |
17 |
19,899,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00974:Vmn2r102
|
APN |
17 |
19,897,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00978:Vmn2r102
|
APN |
17 |
19,899,185 (GRCm39) |
splice site |
probably null |
|
|
IGL01589:Vmn2r102
|
APN |
17 |
19,899,066 (GRCm39) |
missense |
probably benign |
|
|
IGL01738:Vmn2r102
|
APN |
17 |
19,898,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01994:Vmn2r102
|
APN |
17 |
19,880,731 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02066:Vmn2r102
|
APN |
17 |
19,914,191 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02525:Vmn2r102
|
APN |
17 |
19,901,447 (GRCm39) |
missense |
probably benign |
|
|
IGL02589:Vmn2r102
|
APN |
17 |
19,901,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02814:Vmn2r102
|
APN |
17 |
19,898,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03028:Vmn2r102
|
APN |
17 |
19,914,328 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL03162:Vmn2r102
|
APN |
17 |
19,914,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4431001:Vmn2r102
|
UTSW |
17 |
19,896,958 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0042:Vmn2r102
|
UTSW |
17 |
19,880,851 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0132:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0268:Vmn2r102
|
UTSW |
17 |
19,898,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0441:Vmn2r102
|
UTSW |
17 |
19,914,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0583:Vmn2r102
|
UTSW |
17 |
19,897,043 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Vmn2r102
|
UTSW |
17 |
19,898,277 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0606:Vmn2r102
|
UTSW |
17 |
19,899,106 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0674:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0709:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0879:Vmn2r102
|
UTSW |
17 |
19,914,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Vmn2r102
|
UTSW |
17 |
19,880,887 (GRCm39) |
splice site |
probably benign |
|
|
R1473:Vmn2r102
|
UTSW |
17 |
19,914,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1630:Vmn2r102
|
UTSW |
17 |
19,899,032 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1727:Vmn2r102
|
UTSW |
17 |
19,897,770 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1759:Vmn2r102
|
UTSW |
17 |
19,914,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1809:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2013:Vmn2r102
|
UTSW |
17 |
19,897,006 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2086:Vmn2r102
|
UTSW |
17 |
19,896,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2241:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Vmn2r102
|
UTSW |
17 |
19,914,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3814:Vmn2r102
|
UTSW |
17 |
19,899,093 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3827:Vmn2r102
|
UTSW |
17 |
19,914,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4159:Vmn2r102
|
UTSW |
17 |
19,898,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4505:Vmn2r102
|
UTSW |
17 |
19,880,845 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4515:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4517:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4534:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
|
R4535:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
|
R4662:Vmn2r102
|
UTSW |
17 |
19,901,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r102
|
UTSW |
17 |
19,914,576 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4734:Vmn2r102
|
UTSW |
17 |
19,897,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4834:Vmn2r102
|
UTSW |
17 |
19,898,203 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5077:Vmn2r102
|
UTSW |
17 |
19,897,834 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5181:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5277:Vmn2r102
|
UTSW |
17 |
19,914,393 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5418:Vmn2r102
|
UTSW |
17 |
19,914,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Vmn2r102
|
UTSW |
17 |
19,897,804 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5864:Vmn2r102
|
UTSW |
17 |
19,914,943 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6168:Vmn2r102
|
UTSW |
17 |
19,914,402 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6266:Vmn2r102
|
UTSW |
17 |
19,899,007 (GRCm39) |
missense |
probably benign |
|
|
R6432:Vmn2r102
|
UTSW |
17 |
19,901,483 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6487:Vmn2r102
|
UTSW |
17 |
19,898,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6597:Vmn2r102
|
UTSW |
17 |
19,914,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6797:Vmn2r102
|
UTSW |
17 |
19,880,694 (GRCm39) |
nonsense |
probably null |
|
|
R7009:Vmn2r102
|
UTSW |
17 |
19,914,456 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7098:Vmn2r102
|
UTSW |
17 |
19,914,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7134:Vmn2r102
|
UTSW |
17 |
19,897,749 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7463:Vmn2r102
|
UTSW |
17 |
19,896,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7511:Vmn2r102
|
UTSW |
17 |
19,901,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7512:Vmn2r102
|
UTSW |
17 |
19,914,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7556:Vmn2r102
|
UTSW |
17 |
19,898,093 (GRCm39) |
missense |
probably benign |
|
|
R8126:Vmn2r102
|
UTSW |
17 |
19,880,712 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8385:Vmn2r102
|
UTSW |
17 |
19,914,088 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8410:Vmn2r102
|
UTSW |
17 |
19,898,196 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9045:Vmn2r102
|
UTSW |
17 |
19,880,841 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9267:Vmn2r102
|
UTSW |
17 |
19,896,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9325:Vmn2r102
|
UTSW |
17 |
19,897,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9363:Vmn2r102
|
UTSW |
17 |
19,897,614 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9524:Vmn2r102
|
UTSW |
17 |
19,897,564 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9747:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r102
|
UTSW |
17 |
19,914,305 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
|
| Posted On |
2016-04-15 |
Incidental Mutation