Incidental Mutation 'R4927:Ticam2'
ID 380944
Institutional Source Beutler Lab
Gene Symbol Ticam2
Ensembl Gene ENSMUSG00000056130
Gene Name TIR domain containing adaptor molecule 2
Synonyms TRAM, Tirp
MMRRC Submission 042528-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4927 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 46691298-46707600 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 46693846 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 80 (I80M)
Ref Sequence ENSEMBL: ENSMUSP00000066239 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036030] [ENSMUST00000070084]
AlphaFold Q8BJQ4
Predicted Effect probably benign
Transcript: ENSMUST00000036030
SMART Domains Protein: ENSMUSP00000043660
Gene: ENSMUSG00000033184

DomainStartEndE-ValueType
signal peptide 1 34 N/A INTRINSIC
EMP24_GP25L 36 188 1.1e-45 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000070084
AA Change: I80M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000066239
Gene: ENSMUSG00000056130
AA Change: I80M

DomainStartEndE-ValueType
Pfam:TIR_2 78 192 2e-10 PFAM
Meta Mutation Damage Score 0.3078 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.4%
Validation Efficiency 97% (76/78)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]
PHENOTYPE: Homozygous inactivation of this gene affects TLR4-mediated immune responses. [provided by MGI curators]
Allele List at MGI

All alleles(2) : Targeted, knock-out(2)

Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim2 C T 5: 35,959,766 (GRCm39) R73C possibly damaging Het
Adamts2 T A 11: 50,694,639 (GRCm39) L1142* probably null Het
Arl13b C A 16: 62,622,150 (GRCm39) G381V probably damaging Het
Ash1l G T 3: 88,892,641 (GRCm39) V1507F probably damaging Het
Babam2 T A 5: 31,859,408 (GRCm39) F38I probably benign Het
Bend4 T C 5: 67,557,619 (GRCm39) Y399C probably damaging Het
Btn1a1 A T 13: 23,644,794 (GRCm39) probably null Het
Cacna1g A T 11: 94,319,973 (GRCm39) L1401Q probably damaging Het
Ccdc192 C T 18: 57,863,888 (GRCm39) Q213* probably null Het
Cep192 T C 18: 67,968,195 (GRCm39) V893A probably benign Het
Cnot10 A T 9: 114,447,012 (GRCm39) Y355N probably damaging Het
Col6a5 G C 9: 105,811,163 (GRCm39) S785R unknown Het
Cpa3 A G 3: 20,276,303 (GRCm39) L310P probably damaging Het
Cux2 A G 5: 122,015,152 (GRCm39) I247T probably benign Het
Dab1 A G 4: 104,561,449 (GRCm39) T245A probably benign Het
Dmrta1 A T 4: 89,579,985 (GRCm39) D315V probably damaging Het
Dnah12 T A 14: 26,583,762 (GRCm39) L599* probably null Het
Dync1h1 T C 12: 110,629,289 (GRCm39) I4231T possibly damaging Het
Fat1 T C 8: 45,476,000 (GRCm39) V1659A probably damaging Het
Flot2 G A 11: 77,949,888 (GRCm39) V406M probably damaging Het
Galnt2 A G 8: 125,032,362 (GRCm39) D75G probably damaging Het
Gcnt3 A T 9: 69,942,464 (GRCm39) C35S probably damaging Het
Gp2 A G 7: 119,052,118 (GRCm39) F199L probably benign Het
Gramd2b C T 18: 56,618,523 (GRCm39) P244S probably damaging Het
Hhipl1 T C 12: 108,278,203 (GRCm39) L177P probably damaging Het
Homez T C 14: 55,095,264 (GRCm39) E148G possibly damaging Het
Kcnab3 G A 11: 69,217,572 (GRCm39) C22Y possibly damaging Het
Kcnh8 C A 17: 53,185,009 (GRCm39) S430R probably damaging Het
Kcnn2 T C 18: 45,692,798 (GRCm39) C125R probably benign Het
Klhl7 G A 5: 24,346,185 (GRCm39) R277Q possibly damaging Het
Krt78 A G 15: 101,855,334 (GRCm39) S826P probably benign Het
Krtap14 T C 16: 88,622,919 (GRCm39) Y20C possibly damaging Het
Lrcol1 A G 5: 110,502,163 (GRCm39) probably null Het
Lrrc10b G A 19: 10,434,226 (GRCm39) P152S probably damaging Het
Lrrn3 C G 12: 41,503,124 (GRCm39) D398H probably damaging Het
Map3k19 T C 1: 127,749,932 (GRCm39) I1140V probably benign Het
Mos G A 4: 3,871,093 (GRCm39) T241M probably damaging Het
Nol8 A G 13: 49,807,901 (GRCm39) E39G possibly damaging Het
Olfm1 T G 2: 28,104,798 (GRCm39) S212A probably benign Het
Or2ak6 T A 11: 58,592,633 (GRCm39) F35L probably damaging Het
Pip4p2 G T 4: 14,912,458 (GRCm39) R189L probably damaging Het
Plec G T 15: 76,061,162 (GRCm39) T2947K probably damaging Het
Pramel27 A T 4: 143,578,187 (GRCm39) Q149L probably damaging Het
Rasgrp3 A G 17: 75,823,350 (GRCm39) M474V probably benign Het
Ryr1 T C 7: 28,719,408 (GRCm39) Y4333C unknown Het
Scrn2 G C 11: 96,924,326 (GRCm39) probably null Het
Slc22a12 C A 19: 6,587,791 (GRCm39) V388L probably benign Het
Slc4a11 A G 2: 130,526,866 (GRCm39) V754A probably damaging Het
Slco2b1 A G 7: 99,335,195 (GRCm39) F195S probably damaging Het
Slfn9 A C 11: 82,872,216 (GRCm39) M840R possibly damaging Het
Speer4b T C 5: 27,706,263 (GRCm39) N35D probably damaging Het
Taf1d T A 9: 15,221,250 (GRCm39) D185E probably damaging Het
Taok2 A G 7: 126,475,213 (GRCm39) L245P probably damaging Het
Tent4a A T 13: 69,651,019 (GRCm39) probably null Het
Tmem268 G A 4: 63,502,164 (GRCm39) V331I probably benign Het
Tsga10 T C 1: 37,840,931 (GRCm39) E425G probably damaging Het
Ttc7 A G 17: 87,654,133 (GRCm39) probably null Het
Ttf1 C T 2: 28,954,668 (GRCm39) H11Y possibly damaging Het
Unc13a T C 8: 72,107,489 (GRCm39) H601R probably damaging Het
Vmn2r102 A T 17: 19,880,661 (GRCm39) M1L probably benign Het
Vmn2r120 G T 17: 57,816,125 (GRCm39) N743K probably damaging Het
Wnt6 C A 1: 74,823,295 (GRCm39) probably null Het
Wnt6 A C 1: 74,823,296 (GRCm39) probably null Het
Wnt8a T A 18: 34,680,525 (GRCm39) C297S probably damaging Het
Zfp786 T C 6: 47,797,087 (GRCm39) Q617R probably benign Het
Zfp91 A G 19: 12,753,774 (GRCm39) probably null Het
Zw10 T A 9: 48,979,983 (GRCm39) F371L probably damaging Het
Other mutations in Ticam2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00587:Ticam2 APN 18 46,693,880 (GRCm39) missense probably benign 0.04
Branch UTSW 18 46,693,718 (GRCm39) missense probably damaging 1.00
Consequential UTSW 18 46,693,846 (GRCm39) missense probably damaging 1.00
Messi UTSW 18 46,693,989 (GRCm39) nonsense probably null
R0056:Ticam2 UTSW 18 46,693,401 (GRCm39) missense possibly damaging 0.61
R0056:Ticam2 UTSW 18 46,693,401 (GRCm39) missense possibly damaging 0.61
R0666:Ticam2 UTSW 18 46,693,718 (GRCm39) missense probably damaging 1.00
R1676:Ticam2 UTSW 18 46,693,677 (GRCm39) missense probably damaging 1.00
R2209:Ticam2 UTSW 18 46,693,467 (GRCm39) missense probably damaging 1.00
R4928:Ticam2 UTSW 18 46,693,989 (GRCm39) nonsense probably null
R6841:Ticam2 UTSW 18 46,693,998 (GRCm39) missense probably benign 0.02
R7489:Ticam2 UTSW 18 46,693,584 (GRCm39) missense probably damaging 1.00
R8407:Ticam2 UTSW 18 46,693,590 (GRCm39) missense probably damaging 1.00
R9166:Ticam2 UTSW 18 46,694,048 (GRCm39) missense probably damaging 1.00
R9451:Ticam2 UTSW 18 46,693,766 (GRCm39) missense probably damaging 1.00
R9467:Ticam2 UTSW 18 46,693,748 (GRCm39) missense probably damaging 1.00
R9508:Ticam2 UTSW 18 46,693,748 (GRCm39) missense probably damaging 1.00
R9711:Ticam2 UTSW 18 46,693,658 (GRCm39) missense probably damaging 1.00
Z1177:Ticam2 UTSW 18 46,693,915 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- TCACAGAATTCATCAGGGAAGTG -3'
(R):5'- AAGACGGCCATGAGTCAGAC -3'

Sequencing Primer
(F):5'- ACTGGAAGTTACACCAGGTGTCTC -3'
(R):5'- CTCCAAGAATTCTGAGGAAGCCTG -3'
Posted On 2016-04-15