|Institutional Source||Beutler Lab|
|Gene Name||zinc finger protein 91|
|Synonyms||Pzf, 9130014I08Rik, A530054C17Rik|
|Is this an essential gene?||Possibly non essential (E-score: 0.352)|
|Stock #||R4927 (G1)|
|Chromosomal Location||12763660-12796126 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to G at 12776410 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000037971 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000038627] [ENSMUST00000142247]|
|Predicted Effect||probably null
|Predicted Effect||noncoding transcript
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.522|
|Coding Region Coverage||
|Validation Efficiency||97% (76/78)|
|MGI Phenotype||FUNCTION: The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. The homologous human protein has been shown to function as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. A read-through transcript variant composed of Zfp91 and the downstream Cntf gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. A Zfp91-related pseudogene has also been identified on chromosome 17. [provided by RefSeq, Oct 2010]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Zfp91||
(F):5'- CAAACTGCCAAATGTTTGCTG -3'
(R):5'- TCTTCAGGGATACAGAGAAAACC -3'
(F):5'- GCCAAATGTTTGCTGGTTTAAAAAC -3'
(R):5'- ACCAGAAAAATTATCTCAAGTGTGTG -3'