Incidental Mutation 'R4953:Cntn4'
| ID |
381378 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cntn4
|
| Ensembl Gene |
ENSMUSG00000064293 |
| Gene Name |
contactin 4 |
| Synonyms |
BIG-2A, Axcam |
| MMRRC Submission |
042550-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.318)
|
| Stock # |
R4953 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
105654621-106676271 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 106502379 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 379
(A379T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078385
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079416]
[ENSMUST00000089208]
[ENSMUST00000113258]
[ENSMUST00000113260]
[ENSMUST00000113261]
[ENSMUST00000113264]
|
| AlphaFold |
Q69Z26 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079416
AA Change: A379T
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000078385
Gene: ENSMUSG00000064293
AA Change: A379T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000089208
AA Change: A379T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000086616
Gene: ENSMUSG00000064293
AA Change: A379T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
FN3
|
700 |
786 |
8.39e0 |
SMART |
|
FN3
|
801 |
886 |
1.33e-6 |
SMART |
|
FN3
|
901 |
981 |
9.85e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113258
AA Change: A379T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000108883
Gene: ENSMUSG00000064293
AA Change: A379T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113260
AA Change: A379T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000108885
Gene: ENSMUSG00000064293
AA Change: A379T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113261
AA Change: A379T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000108886
Gene: ENSMUSG00000064293
AA Change: A379T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113264
AA Change: A379T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000108889
Gene: ENSMUSG00000064293
AA Change: A379T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
FN3
|
700 |
786 |
8.39e0 |
SMART |
|
FN3
|
801 |
886 |
1.33e-6 |
SMART |
|
FN3
|
901 |
981 |
9.85e-1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125904
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132395
|
| Meta Mutation Damage Score |
0.1575 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
97% (113/116) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit aberrant projection of olfactory axons to multiple glomeruli in the olfactory bulb. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acad9 |
T |
C |
3: 36,128,525 (GRCm39) |
Y129H |
probably damaging |
Het |
| Adcy4 |
C |
T |
14: 56,016,486 (GRCm39) |
D322N |
probably damaging |
Het |
| Adgre1 |
G |
A |
17: 57,748,321 (GRCm39) |
G507E |
probably damaging |
Het |
| Agpat5 |
G |
A |
8: 18,918,971 (GRCm39) |
V118I |
probably benign |
Het |
| Aif1 |
T |
C |
17: 35,390,074 (GRCm39) |
|
probably null |
Het |
| Akr1c6 |
A |
T |
13: 4,488,608 (GRCm39) |
|
probably null |
Het |
| Akt2 |
T |
A |
7: 27,337,597 (GRCm39) |
|
probably null |
Het |
| Ankrd35 |
T |
A |
3: 96,590,989 (GRCm39) |
L425Q |
possibly damaging |
Het |
| Arhgap40 |
A |
G |
2: 158,385,326 (GRCm39) |
T520A |
possibly damaging |
Het |
| Arhgef28 |
T |
A |
13: 98,066,062 (GRCm39) |
D1597V |
possibly damaging |
Het |
| Aspm |
A |
G |
1: 139,399,472 (GRCm39) |
D1079G |
probably benign |
Het |
| Atp1a2 |
A |
T |
1: 172,119,009 (GRCm39) |
|
probably benign |
Het |
| Cage1 |
C |
A |
13: 38,207,406 (GRCm39) |
E252D |
possibly damaging |
Het |
| Ccdc185 |
A |
G |
1: 182,576,582 (GRCm39) |
S36P |
possibly damaging |
Het |
| Cd300a |
T |
C |
11: 114,784,247 (GRCm39) |
V85A |
probably damaging |
Het |
| Cd38 |
A |
C |
5: 44,064,887 (GRCm39) |
D235A |
possibly damaging |
Het |
| Cdcp1 |
T |
C |
9: 123,009,088 (GRCm39) |
K530R |
probably benign |
Het |
| Ceacam20 |
T |
A |
7: 19,705,651 (GRCm39) |
L214Q |
probably damaging |
Het |
| Col4a2 |
A |
T |
8: 11,479,505 (GRCm39) |
E796V |
probably benign |
Het |
| Copa |
A |
G |
1: 171,910,453 (GRCm39) |
|
probably benign |
Het |
| Cpa5 |
A |
G |
6: 30,631,363 (GRCm39) |
T426A |
possibly damaging |
Het |
| Csmd1 |
A |
G |
8: 16,249,931 (GRCm39) |
F1016L |
probably damaging |
Het |
| Cyb5r3 |
A |
T |
15: 83,042,822 (GRCm39) |
L290* |
probably null |
Het |
| Ddx42 |
A |
G |
11: 106,133,766 (GRCm39) |
T581A |
probably damaging |
Het |
| Deaf1 |
C |
T |
7: 140,902,381 (GRCm39) |
G221S |
probably damaging |
Het |
| Dnah6 |
A |
G |
6: 73,165,366 (GRCm39) |
S580P |
probably benign |
Het |
| Dock1 |
A |
G |
7: 134,754,017 (GRCm39) |
E1598G |
probably benign |
Het |
| Drg2 |
T |
C |
11: 60,350,262 (GRCm39) |
|
probably benign |
Het |
| Eif3f |
C |
A |
7: 108,533,847 (GRCm39) |
|
probably benign |
Het |
| Fam184a |
G |
T |
10: 53,574,901 (GRCm39) |
T236K |
probably benign |
Het |
| Gas7 |
C |
T |
11: 67,550,876 (GRCm39) |
T126M |
possibly damaging |
Het |
| Gckr |
T |
G |
5: 31,465,608 (GRCm39) |
F408C |
probably damaging |
Het |
| Gm17472 |
A |
G |
6: 42,958,004 (GRCm39) |
D91G |
probably damaging |
Het |
| Gm5117 |
G |
A |
8: 32,228,608 (GRCm39) |
|
noncoding transcript |
Het |
| Gsto1 |
T |
A |
19: 47,843,759 (GRCm39) |
I47N |
probably damaging |
Het |
| Hck |
C |
T |
2: 152,976,597 (GRCm39) |
P244S |
probably damaging |
Het |
| Hif3a |
T |
C |
7: 16,784,490 (GRCm39) |
T250A |
probably damaging |
Het |
| Hmcn1 |
A |
T |
1: 150,752,111 (GRCm39) |
|
probably benign |
Het |
| Impa1 |
G |
A |
3: 10,380,340 (GRCm39) |
S247F |
probably damaging |
Het |
| Ints14 |
G |
C |
9: 64,889,340 (GRCm39) |
R397P |
probably damaging |
Het |
| Iqgap1 |
T |
C |
7: 80,373,524 (GRCm39) |
|
probably null |
Het |
| Krt1c |
T |
C |
15: 101,722,377 (GRCm39) |
K436R |
probably damaging |
Het |
| Lama3 |
G |
A |
18: 12,581,362 (GRCm39) |
C607Y |
probably damaging |
Het |
| Loxl4 |
G |
T |
19: 42,599,133 (GRCm39) |
|
probably benign |
Het |
| Lrrc8d |
C |
T |
5: 105,961,234 (GRCm39) |
T548M |
probably damaging |
Het |
| Man1b1 |
T |
A |
2: 25,228,196 (GRCm39) |
D155E |
probably damaging |
Het |
| Mapk8ip2 |
C |
T |
15: 89,341,431 (GRCm39) |
P214L |
probably benign |
Het |
| Mast1 |
G |
A |
8: 85,645,357 (GRCm39) |
T696I |
probably damaging |
Het |
| Muc15 |
C |
T |
2: 110,561,617 (GRCm39) |
P18S |
probably damaging |
Het |
| Mybl2 |
T |
C |
2: 162,922,716 (GRCm39) |
S205P |
probably damaging |
Het |
| Mylk |
T |
C |
16: 34,809,331 (GRCm39) |
S1763P |
probably damaging |
Het |
| Nek10 |
T |
A |
14: 14,860,986 (GRCm38) |
L513M |
possibly damaging |
Het |
| Nfib |
A |
G |
4: 82,271,808 (GRCm39) |
M252T |
probably benign |
Het |
| Nid2 |
C |
A |
14: 19,828,146 (GRCm39) |
Y261* |
probably null |
Het |
| Nmd3 |
C |
T |
3: 69,638,970 (GRCm39) |
R187C |
possibly damaging |
Het |
| Nomo1 |
G |
T |
7: 45,700,155 (GRCm39) |
|
probably benign |
Het |
| Npy4r |
A |
G |
14: 33,868,437 (GRCm39) |
F284L |
probably damaging |
Het |
| Nt5dc2 |
T |
C |
14: 30,860,878 (GRCm39) |
V351A |
possibly damaging |
Het |
| Ofcc1 |
G |
A |
13: 40,168,864 (GRCm39) |
T841I |
probably damaging |
Het |
| Or5b121 |
T |
A |
19: 13,507,178 (GRCm39) |
L91Q |
probably null |
Het |
| Or5g27 |
T |
A |
2: 85,410,069 (GRCm39) |
L162* |
probably null |
Het |
| Pcdhb12 |
T |
A |
18: 37,569,209 (GRCm39) |
D118E |
probably damaging |
Het |
| Pdcd11 |
C |
T |
19: 47,116,404 (GRCm39) |
T1518I |
probably benign |
Het |
| Pde6a |
T |
A |
18: 61,364,434 (GRCm39) |
C163* |
probably null |
Het |
| Pign |
A |
T |
1: 105,572,227 (GRCm39) |
W314R |
probably benign |
Het |
| Pip5k1b |
T |
A |
19: 24,367,799 (GRCm39) |
H76L |
probably damaging |
Het |
| Plcz1 |
T |
C |
6: 139,974,277 (GRCm39) |
N55S |
possibly damaging |
Het |
| Pou5f1 |
A |
T |
17: 35,821,438 (GRCm39) |
H350L |
possibly damaging |
Het |
| Rchy1 |
A |
T |
5: 92,110,487 (GRCm39) |
|
probably null |
Het |
| Ric8b |
A |
G |
10: 84,793,946 (GRCm39) |
T270A |
possibly damaging |
Het |
| Rprml |
A |
G |
11: 103,540,644 (GRCm39) |
E13G |
probably benign |
Het |
| Secisbp2 |
T |
A |
13: 51,836,063 (GRCm39) |
I719N |
probably damaging |
Het |
| Sergef |
C |
T |
7: 46,283,259 (GRCm39) |
R148H |
probably benign |
Het |
| Serpina6 |
T |
A |
12: 103,618,221 (GRCm39) |
|
probably null |
Het |
| Sirpb1b |
C |
A |
3: 15,613,887 (GRCm39) |
W65L |
probably damaging |
Het |
| Slc32a1 |
A |
T |
2: 158,455,977 (GRCm39) |
I211F |
possibly damaging |
Het |
| Slc5a9 |
C |
A |
4: 111,748,941 (GRCm39) |
|
probably null |
Het |
| Smarce1 |
A |
G |
11: 99,105,977 (GRCm39) |
V226A |
probably benign |
Het |
| Spata31d1b |
A |
T |
13: 59,864,097 (GRCm39) |
E415V |
probably damaging |
Het |
| Speg |
G |
A |
1: 75,400,508 (GRCm39) |
R2556H |
possibly damaging |
Het |
| Suclg2 |
A |
C |
6: 95,543,417 (GRCm39) |
V338G |
probably damaging |
Het |
| Tarbp1 |
T |
C |
8: 127,174,184 (GRCm39) |
E874G |
possibly damaging |
Het |
| Tex14 |
G |
T |
11: 87,427,727 (GRCm39) |
|
probably null |
Het |
| Trim36 |
T |
A |
18: 46,329,245 (GRCm39) |
D53V |
possibly damaging |
Het |
| Tsga10ip |
T |
A |
19: 5,444,368 (GRCm39) |
Y21F |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,620,289 (GRCm39) |
V15849M |
probably damaging |
Het |
| Ube3b |
T |
C |
5: 114,539,471 (GRCm39) |
S421P |
probably benign |
Het |
| Unc5a |
A |
T |
13: 55,147,683 (GRCm39) |
M498L |
probably benign |
Het |
| Vipr2 |
A |
G |
12: 116,107,876 (GRCm39) |
I420M |
probably benign |
Het |
| Vmn1r179 |
T |
A |
7: 23,628,515 (GRCm39) |
H235Q |
probably damaging |
Het |
| Vps35 |
T |
A |
8: 86,008,475 (GRCm39) |
I267F |
probably damaging |
Het |
| Wdr26 |
G |
A |
1: 181,025,216 (GRCm39) |
R279W |
probably damaging |
Het |
| Xpo6 |
C |
A |
7: 125,768,443 (GRCm39) |
R88L |
probably damaging |
Het |
| Zdhhc1 |
CGGGGG |
CGGGGGG |
8: 106,210,376 (GRCm39) |
|
probably null |
Het |
| Zfp105 |
T |
A |
9: 122,758,880 (GRCm39) |
S184T |
probably benign |
Het |
| Zfp574 |
G |
A |
7: 24,780,388 (GRCm39) |
R470H |
probably damaging |
Het |
| Zswim9 |
T |
A |
7: 13,003,484 (GRCm39) |
H122L |
probably damaging |
Het |
|
| Other mutations in Cntn4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Cntn4
|
APN |
6 |
106,483,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00725:Cntn4
|
APN |
6 |
106,639,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01062:Cntn4
|
APN |
6 |
106,595,239 (GRCm39) |
splice site |
probably benign |
|
|
IGL01432:Cntn4
|
APN |
6 |
106,655,295 (GRCm39) |
splice site |
probably benign |
|
|
IGL01585:Cntn4
|
APN |
6 |
106,595,289 (GRCm39) |
nonsense |
probably null |
|
|
IGL01710:Cntn4
|
APN |
6 |
106,527,392 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01870:Cntn4
|
APN |
6 |
106,466,676 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01933:Cntn4
|
APN |
6 |
106,671,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01937:Cntn4
|
APN |
6 |
106,414,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01945:Cntn4
|
APN |
6 |
106,414,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02007:Cntn4
|
APN |
6 |
106,632,490 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02506:Cntn4
|
APN |
6 |
106,595,349 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02561:Cntn4
|
APN |
6 |
106,500,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03080:Cntn4
|
APN |
6 |
106,632,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03338:Cntn4
|
APN |
6 |
106,632,550 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03097:Cntn4
|
UTSW |
6 |
106,330,673 (GRCm39) |
missense |
probably benign |
0.10 |
|
LCD18:Cntn4
|
UTSW |
6 |
106,530,901 (GRCm39) |
intron |
probably benign |
|
|
R0083:Cntn4
|
UTSW |
6 |
106,502,330 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0098:Cntn4
|
UTSW |
6 |
106,595,385 (GRCm39) |
splice site |
probably benign |
|
|
R0501:Cntn4
|
UTSW |
6 |
106,595,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0626:Cntn4
|
UTSW |
6 |
106,639,539 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0633:Cntn4
|
UTSW |
6 |
106,656,209 (GRCm39) |
splice site |
probably null |
|
|
R0730:Cntn4
|
UTSW |
6 |
106,527,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0849:Cntn4
|
UTSW |
6 |
106,644,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0883:Cntn4
|
UTSW |
6 |
106,644,501 (GRCm39) |
splice site |
probably benign |
|
|
R0926:Cntn4
|
UTSW |
6 |
106,632,542 (GRCm39) |
missense |
probably benign |
0.21 |
|
R1199:Cntn4
|
UTSW |
6 |
106,330,558 (GRCm39) |
splice site |
probably benign |
|
|
R1293:Cntn4
|
UTSW |
6 |
106,330,685 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1296:Cntn4
|
UTSW |
6 |
106,486,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1344:Cntn4
|
UTSW |
6 |
106,321,831 (GRCm39) |
splice site |
probably null |
|
|
R1418:Cntn4
|
UTSW |
6 |
106,321,831 (GRCm39) |
splice site |
probably null |
|
|
R1660:Cntn4
|
UTSW |
6 |
106,656,258 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1751:Cntn4
|
UTSW |
6 |
106,595,371 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1883:Cntn4
|
UTSW |
6 |
106,656,353 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1884:Cntn4
|
UTSW |
6 |
106,656,353 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1899:Cntn4
|
UTSW |
6 |
106,652,774 (GRCm39) |
missense |
probably benign |
0.21 |
|
R1906:Cntn4
|
UTSW |
6 |
106,330,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2048:Cntn4
|
UTSW |
6 |
106,414,825 (GRCm39) |
splice site |
probably benign |
|
|
R2113:Cntn4
|
UTSW |
6 |
106,466,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3177:Cntn4
|
UTSW |
6 |
106,414,925 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3277:Cntn4
|
UTSW |
6 |
106,414,925 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3944:Cntn4
|
UTSW |
6 |
106,595,375 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4401:Cntn4
|
UTSW |
6 |
106,466,625 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4540:Cntn4
|
UTSW |
6 |
106,652,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4688:Cntn4
|
UTSW |
6 |
106,414,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4697:Cntn4
|
UTSW |
6 |
106,502,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4810:Cntn4
|
UTSW |
6 |
106,632,572 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4816:Cntn4
|
UTSW |
6 |
106,527,458 (GRCm39) |
missense |
probably benign |
|
|
R4873:Cntn4
|
UTSW |
6 |
106,414,874 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4875:Cntn4
|
UTSW |
6 |
106,414,874 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5288:Cntn4
|
UTSW |
6 |
106,158,765 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R5336:Cntn4
|
UTSW |
6 |
106,639,595 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5386:Cntn4
|
UTSW |
6 |
106,158,765 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R5477:Cntn4
|
UTSW |
6 |
106,650,911 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5514:Cntn4
|
UTSW |
6 |
106,649,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5668:Cntn4
|
UTSW |
6 |
106,656,397 (GRCm39) |
splice site |
silent |
|
|
R6334:Cntn4
|
UTSW |
6 |
106,321,747 (GRCm39) |
missense |
probably benign |
|
|
R6334:Cntn4
|
UTSW |
6 |
106,483,153 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6904:Cntn4
|
UTSW |
6 |
106,674,544 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6985:Cntn4
|
UTSW |
6 |
106,656,378 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7246:Cntn4
|
UTSW |
6 |
106,483,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7282:Cntn4
|
UTSW |
6 |
106,502,421 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7585:Cntn4
|
UTSW |
6 |
106,466,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7667:Cntn4
|
UTSW |
6 |
106,656,856 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7781:Cntn4
|
UTSW |
6 |
106,500,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7882:Cntn4
|
UTSW |
6 |
106,330,684 (GRCm39) |
missense |
probably benign |
|
|
R8081:Cntn4
|
UTSW |
6 |
106,651,568 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8105:Cntn4
|
UTSW |
6 |
106,330,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8221:Cntn4
|
UTSW |
6 |
106,486,471 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8910:Cntn4
|
UTSW |
6 |
106,632,497 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8911:Cntn4
|
UTSW |
6 |
106,330,743 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8916:Cntn4
|
UTSW |
6 |
106,652,915 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9249:Cntn4
|
UTSW |
6 |
106,466,722 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9376:Cntn4
|
UTSW |
6 |
106,639,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9616:Cntn4
|
UTSW |
6 |
106,674,525 (GRCm39) |
nonsense |
probably null |
|
|
R9767:Cntn4
|
UTSW |
6 |
106,655,395 (GRCm39) |
missense |
probably benign |
0.40 |
|
Z1176:Cntn4
|
UTSW |
6 |
106,500,524 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Cntn4
|
UTSW |
6 |
106,486,425 (GRCm39) |
missense |
probably benign |
0.28 |
|
Z1177:Cntn4
|
UTSW |
6 |
106,639,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cntn4
|
UTSW |
6 |
106,527,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCATTTGCCATCTGACCTGG -3'
(R):5'- CCATTGCTTGCAGGCTATATG -3'
Sequencing Primer
(F):5'- ACTTGACAAATAAGCAGATCGTG -3'
(R):5'- CCATTGCTTGCAGGCTATATGACTTG -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation