Incidental Mutation 'R4953:Adgre1'
| ID |
381437 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgre1
|
| Ensembl Gene |
ENSMUSG00000004730 |
| Gene Name |
adhesion G protein-coupled receptor E1 |
| Synonyms |
DD7A5-7, EGF-TM7, Emr1, Ly71, F4/80, TM7LN3 |
| MMRRC Submission |
042550-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.188)
|
| Stock # |
R4953 (G1)
|
| Quality Score |
220 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
57665691-57790527 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 57748321 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Glutamic Acid
at position 507
(G507E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000083971
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000004850]
[ENSMUST00000086763]
|
| AlphaFold |
Q61549 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000004850
AA Change: G507E
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000004850
Gene: ENSMUSG00000004730
AA Change: G507E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
32 |
N/A |
INTRINSIC |
|
EGF
|
35 |
80 |
1.43e-1 |
SMART |
|
EGF_CA
|
81 |
122 |
3.59e-7 |
SMART |
|
EGF_CA
|
133 |
172 |
4.56e-9 |
SMART |
|
EGF_CA
|
173 |
221 |
1.29e-8 |
SMART |
|
EGF_CA
|
222 |
271 |
2.31e-10 |
SMART |
|
EGF_CA
|
272 |
318 |
1.06e-9 |
SMART |
|
EGF_CA
|
319 |
367 |
1.18e-7 |
SMART |
|
GPS
|
591 |
641 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
644 |
885 |
2.1e-63 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000086763
AA Change: G507E
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000083971
Gene: ENSMUSG00000004730
AA Change: G507E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
32 |
N/A |
INTRINSIC |
|
EGF
|
35 |
80 |
1.43e-1 |
SMART |
|
EGF_CA
|
81 |
122 |
3.59e-7 |
SMART |
|
EGF_CA
|
133 |
172 |
4.56e-9 |
SMART |
|
EGF_CA
|
173 |
221 |
1.29e-8 |
SMART |
|
EGF_CA
|
222 |
271 |
2.31e-10 |
SMART |
|
EGF_CA
|
272 |
318 |
1.06e-9 |
SMART |
|
EGF_CA
|
319 |
367 |
1.18e-7 |
SMART |
|
GPS
|
591 |
641 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
644 |
885 |
2.1e-63 |
PFAM |
|
| Meta Mutation Damage Score |
0.1894 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
97% (113/116) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
PHENOTYPE: Homozygous null mice fail to develop peripheral tolerance after inoculation with antigen because of a lack of efferent regulatory T cell development. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted(3) Chemically induced(1)
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acad9 |
T |
C |
3: 36,128,525 (GRCm39) |
Y129H |
probably damaging |
Het |
| Adcy4 |
C |
T |
14: 56,016,486 (GRCm39) |
D322N |
probably damaging |
Het |
| Agpat5 |
G |
A |
8: 18,918,971 (GRCm39) |
V118I |
probably benign |
Het |
| Aif1 |
T |
C |
17: 35,390,074 (GRCm39) |
|
probably null |
Het |
| Akr1c6 |
A |
T |
13: 4,488,608 (GRCm39) |
|
probably null |
Het |
| Akt2 |
T |
A |
7: 27,337,597 (GRCm39) |
|
probably null |
Het |
| Ankrd35 |
T |
A |
3: 96,590,989 (GRCm39) |
L425Q |
possibly damaging |
Het |
| Arhgap40 |
A |
G |
2: 158,385,326 (GRCm39) |
T520A |
possibly damaging |
Het |
| Arhgef28 |
T |
A |
13: 98,066,062 (GRCm39) |
D1597V |
possibly damaging |
Het |
| Aspm |
A |
G |
1: 139,399,472 (GRCm39) |
D1079G |
probably benign |
Het |
| Atp1a2 |
A |
T |
1: 172,119,009 (GRCm39) |
|
probably benign |
Het |
| Cage1 |
C |
A |
13: 38,207,406 (GRCm39) |
E252D |
possibly damaging |
Het |
| Ccdc185 |
A |
G |
1: 182,576,582 (GRCm39) |
S36P |
possibly damaging |
Het |
| Cd300a |
T |
C |
11: 114,784,247 (GRCm39) |
V85A |
probably damaging |
Het |
| Cd38 |
A |
C |
5: 44,064,887 (GRCm39) |
D235A |
possibly damaging |
Het |
| Cdcp1 |
T |
C |
9: 123,009,088 (GRCm39) |
K530R |
probably benign |
Het |
| Ceacam20 |
T |
A |
7: 19,705,651 (GRCm39) |
L214Q |
probably damaging |
Het |
| Cntn4 |
G |
A |
6: 106,502,379 (GRCm39) |
A379T |
probably benign |
Het |
| Col4a2 |
A |
T |
8: 11,479,505 (GRCm39) |
E796V |
probably benign |
Het |
| Copa |
A |
G |
1: 171,910,453 (GRCm39) |
|
probably benign |
Het |
| Cpa5 |
A |
G |
6: 30,631,363 (GRCm39) |
T426A |
possibly damaging |
Het |
| Csmd1 |
A |
G |
8: 16,249,931 (GRCm39) |
F1016L |
probably damaging |
Het |
| Cyb5r3 |
A |
T |
15: 83,042,822 (GRCm39) |
L290* |
probably null |
Het |
| Ddx42 |
A |
G |
11: 106,133,766 (GRCm39) |
T581A |
probably damaging |
Het |
| Deaf1 |
C |
T |
7: 140,902,381 (GRCm39) |
G221S |
probably damaging |
Het |
| Dnah6 |
A |
G |
6: 73,165,366 (GRCm39) |
S580P |
probably benign |
Het |
| Dock1 |
A |
G |
7: 134,754,017 (GRCm39) |
E1598G |
probably benign |
Het |
| Drg2 |
T |
C |
11: 60,350,262 (GRCm39) |
|
probably benign |
Het |
| Eif3f |
C |
A |
7: 108,533,847 (GRCm39) |
|
probably benign |
Het |
| Fam184a |
G |
T |
10: 53,574,901 (GRCm39) |
T236K |
probably benign |
Het |
| Gas7 |
C |
T |
11: 67,550,876 (GRCm39) |
T126M |
possibly damaging |
Het |
| Gckr |
T |
G |
5: 31,465,608 (GRCm39) |
F408C |
probably damaging |
Het |
| Gm17472 |
A |
G |
6: 42,958,004 (GRCm39) |
D91G |
probably damaging |
Het |
| Gm5117 |
G |
A |
8: 32,228,608 (GRCm39) |
|
noncoding transcript |
Het |
| Gsto1 |
T |
A |
19: 47,843,759 (GRCm39) |
I47N |
probably damaging |
Het |
| Hck |
C |
T |
2: 152,976,597 (GRCm39) |
P244S |
probably damaging |
Het |
| Hif3a |
T |
C |
7: 16,784,490 (GRCm39) |
T250A |
probably damaging |
Het |
| Hmcn1 |
A |
T |
1: 150,752,111 (GRCm39) |
|
probably benign |
Het |
| Impa1 |
G |
A |
3: 10,380,340 (GRCm39) |
S247F |
probably damaging |
Het |
| Ints14 |
G |
C |
9: 64,889,340 (GRCm39) |
R397P |
probably damaging |
Het |
| Iqgap1 |
T |
C |
7: 80,373,524 (GRCm39) |
|
probably null |
Het |
| Krt1c |
T |
C |
15: 101,722,377 (GRCm39) |
K436R |
probably damaging |
Het |
| Lama3 |
G |
A |
18: 12,581,362 (GRCm39) |
C607Y |
probably damaging |
Het |
| Loxl4 |
G |
T |
19: 42,599,133 (GRCm39) |
|
probably benign |
Het |
| Lrrc8d |
C |
T |
5: 105,961,234 (GRCm39) |
T548M |
probably damaging |
Het |
| Man1b1 |
T |
A |
2: 25,228,196 (GRCm39) |
D155E |
probably damaging |
Het |
| Mapk8ip2 |
C |
T |
15: 89,341,431 (GRCm39) |
P214L |
probably benign |
Het |
| Mast1 |
G |
A |
8: 85,645,357 (GRCm39) |
T696I |
probably damaging |
Het |
| Muc15 |
C |
T |
2: 110,561,617 (GRCm39) |
P18S |
probably damaging |
Het |
| Mybl2 |
T |
C |
2: 162,922,716 (GRCm39) |
S205P |
probably damaging |
Het |
| Mylk |
T |
C |
16: 34,809,331 (GRCm39) |
S1763P |
probably damaging |
Het |
| Nek10 |
T |
A |
14: 14,860,986 (GRCm38) |
L513M |
possibly damaging |
Het |
| Nfib |
A |
G |
4: 82,271,808 (GRCm39) |
M252T |
probably benign |
Het |
| Nid2 |
C |
A |
14: 19,828,146 (GRCm39) |
Y261* |
probably null |
Het |
| Nmd3 |
C |
T |
3: 69,638,970 (GRCm39) |
R187C |
possibly damaging |
Het |
| Nomo1 |
G |
T |
7: 45,700,155 (GRCm39) |
|
probably benign |
Het |
| Npy4r |
A |
G |
14: 33,868,437 (GRCm39) |
F284L |
probably damaging |
Het |
| Nt5dc2 |
T |
C |
14: 30,860,878 (GRCm39) |
V351A |
possibly damaging |
Het |
| Ofcc1 |
G |
A |
13: 40,168,864 (GRCm39) |
T841I |
probably damaging |
Het |
| Or5b121 |
T |
A |
19: 13,507,178 (GRCm39) |
L91Q |
probably null |
Het |
| Or5g27 |
T |
A |
2: 85,410,069 (GRCm39) |
L162* |
probably null |
Het |
| Pcdhb12 |
T |
A |
18: 37,569,209 (GRCm39) |
D118E |
probably damaging |
Het |
| Pdcd11 |
C |
T |
19: 47,116,404 (GRCm39) |
T1518I |
probably benign |
Het |
| Pde6a |
T |
A |
18: 61,364,434 (GRCm39) |
C163* |
probably null |
Het |
| Pign |
A |
T |
1: 105,572,227 (GRCm39) |
W314R |
probably benign |
Het |
| Pip5k1b |
T |
A |
19: 24,367,799 (GRCm39) |
H76L |
probably damaging |
Het |
| Plcz1 |
T |
C |
6: 139,974,277 (GRCm39) |
N55S |
possibly damaging |
Het |
| Pou5f1 |
A |
T |
17: 35,821,438 (GRCm39) |
H350L |
possibly damaging |
Het |
| Rchy1 |
A |
T |
5: 92,110,487 (GRCm39) |
|
probably null |
Het |
| Ric8b |
A |
G |
10: 84,793,946 (GRCm39) |
T270A |
possibly damaging |
Het |
| Rprml |
A |
G |
11: 103,540,644 (GRCm39) |
E13G |
probably benign |
Het |
| Secisbp2 |
T |
A |
13: 51,836,063 (GRCm39) |
I719N |
probably damaging |
Het |
| Sergef |
C |
T |
7: 46,283,259 (GRCm39) |
R148H |
probably benign |
Het |
| Serpina6 |
T |
A |
12: 103,618,221 (GRCm39) |
|
probably null |
Het |
| Sirpb1b |
C |
A |
3: 15,613,887 (GRCm39) |
W65L |
probably damaging |
Het |
| Slc32a1 |
A |
T |
2: 158,455,977 (GRCm39) |
I211F |
possibly damaging |
Het |
| Slc5a9 |
C |
A |
4: 111,748,941 (GRCm39) |
|
probably null |
Het |
| Smarce1 |
A |
G |
11: 99,105,977 (GRCm39) |
V226A |
probably benign |
Het |
| Spata31d1b |
A |
T |
13: 59,864,097 (GRCm39) |
E415V |
probably damaging |
Het |
| Speg |
G |
A |
1: 75,400,508 (GRCm39) |
R2556H |
possibly damaging |
Het |
| Suclg2 |
A |
C |
6: 95,543,417 (GRCm39) |
V338G |
probably damaging |
Het |
| Tarbp1 |
T |
C |
8: 127,174,184 (GRCm39) |
E874G |
possibly damaging |
Het |
| Tex14 |
G |
T |
11: 87,427,727 (GRCm39) |
|
probably null |
Het |
| Trim36 |
T |
A |
18: 46,329,245 (GRCm39) |
D53V |
possibly damaging |
Het |
| Tsga10ip |
T |
A |
19: 5,444,368 (GRCm39) |
Y21F |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,620,289 (GRCm39) |
V15849M |
probably damaging |
Het |
| Ube3b |
T |
C |
5: 114,539,471 (GRCm39) |
S421P |
probably benign |
Het |
| Unc5a |
A |
T |
13: 55,147,683 (GRCm39) |
M498L |
probably benign |
Het |
| Vipr2 |
A |
G |
12: 116,107,876 (GRCm39) |
I420M |
probably benign |
Het |
| Vmn1r179 |
T |
A |
7: 23,628,515 (GRCm39) |
H235Q |
probably damaging |
Het |
| Vps35 |
T |
A |
8: 86,008,475 (GRCm39) |
I267F |
probably damaging |
Het |
| Wdr26 |
G |
A |
1: 181,025,216 (GRCm39) |
R279W |
probably damaging |
Het |
| Xpo6 |
C |
A |
7: 125,768,443 (GRCm39) |
R88L |
probably damaging |
Het |
| Zdhhc1 |
CGGGGG |
CGGGGGG |
8: 106,210,376 (GRCm39) |
|
probably null |
Het |
| Zfp105 |
T |
A |
9: 122,758,880 (GRCm39) |
S184T |
probably benign |
Het |
| Zfp574 |
G |
A |
7: 24,780,388 (GRCm39) |
R470H |
probably damaging |
Het |
| Zswim9 |
T |
A |
7: 13,003,484 (GRCm39) |
H122L |
probably damaging |
Het |
|
| Other mutations in Adgre1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Adgre1
|
APN |
17 |
57,757,055 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00966:Adgre1
|
APN |
17 |
57,726,335 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01680:Adgre1
|
APN |
17 |
57,709,620 (GRCm39) |
missense |
unknown |
|
|
IGL01724:Adgre1
|
APN |
17 |
57,751,064 (GRCm39) |
nonsense |
probably null |
|
|
IGL02172:Adgre1
|
APN |
17 |
57,785,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02260:Adgre1
|
APN |
17 |
57,754,891 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02272:Adgre1
|
APN |
17 |
57,757,021 (GRCm39) |
nonsense |
probably null |
|
|
IGL02336:Adgre1
|
APN |
17 |
57,718,024 (GRCm39) |
nonsense |
probably null |
|
|
IGL02346:Adgre1
|
APN |
17 |
57,750,919 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02398:Adgre1
|
APN |
17 |
57,709,824 (GRCm39) |
nonsense |
probably null |
|
|
IGL02618:Adgre1
|
APN |
17 |
57,751,021 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL02690:Adgre1
|
APN |
17 |
57,787,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02936:Adgre1
|
APN |
17 |
57,785,833 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL03112:Adgre1
|
APN |
17 |
57,755,029 (GRCm39) |
splice site |
probably null |
|
|
IGL03350:Adgre1
|
APN |
17 |
57,708,908 (GRCm39) |
missense |
probably benign |
0.16 |
|
F480
|
UTSW |
17 |
57,751,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
lomax
|
UTSW |
17 |
57,709,811 (GRCm39) |
missense |
unknown |
|
|
Onion
|
UTSW |
17 |
57,709,841 (GRCm39) |
nonsense |
probably null |
|
|
Scallion
|
UTSW |
17 |
57,708,977 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0049:Adgre1
|
UTSW |
17 |
57,709,841 (GRCm39) |
nonsense |
probably null |
|
|
R0153:Adgre1
|
UTSW |
17 |
57,750,939 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0277:Adgre1
|
UTSW |
17 |
57,751,060 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0278:Adgre1
|
UTSW |
17 |
57,754,872 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0323:Adgre1
|
UTSW |
17 |
57,751,060 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0389:Adgre1
|
UTSW |
17 |
57,713,839 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0492:Adgre1
|
UTSW |
17 |
57,709,742 (GRCm39) |
missense |
unknown |
|
|
R0621:Adgre1
|
UTSW |
17 |
57,748,359 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0647:Adgre1
|
UTSW |
17 |
57,718,003 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1310:Adgre1
|
UTSW |
17 |
57,754,936 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1601:Adgre1
|
UTSW |
17 |
57,748,353 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1689:Adgre1
|
UTSW |
17 |
57,756,921 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1708:Adgre1
|
UTSW |
17 |
57,708,974 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1796:Adgre1
|
UTSW |
17 |
57,748,350 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1839:Adgre1
|
UTSW |
17 |
57,748,299 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1860:Adgre1
|
UTSW |
17 |
57,748,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2165:Adgre1
|
UTSW |
17 |
57,726,338 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2219:Adgre1
|
UTSW |
17 |
57,708,912 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2519:Adgre1
|
UTSW |
17 |
57,717,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3874:Adgre1
|
UTSW |
17 |
57,708,925 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3911:Adgre1
|
UTSW |
17 |
57,754,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4190:Adgre1
|
UTSW |
17 |
57,709,811 (GRCm39) |
missense |
unknown |
|
|
R4439:Adgre1
|
UTSW |
17 |
57,754,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4513:Adgre1
|
UTSW |
17 |
57,717,947 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4529:Adgre1
|
UTSW |
17 |
57,727,519 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4543:Adgre1
|
UTSW |
17 |
57,713,874 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4610:Adgre1
|
UTSW |
17 |
57,757,073 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4665:Adgre1
|
UTSW |
17 |
57,787,947 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4911:Adgre1
|
UTSW |
17 |
57,754,832 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R4928:Adgre1
|
UTSW |
17 |
57,751,064 (GRCm39) |
nonsense |
probably null |
|
|
R4942:Adgre1
|
UTSW |
17 |
57,713,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4946:Adgre1
|
UTSW |
17 |
57,750,918 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5107:Adgre1
|
UTSW |
17 |
57,708,977 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5366:Adgre1
|
UTSW |
17 |
57,709,817 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5590:Adgre1
|
UTSW |
17 |
57,752,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5619:Adgre1
|
UTSW |
17 |
57,727,437 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5699:Adgre1
|
UTSW |
17 |
57,788,007 (GRCm39) |
missense |
probably benign |
0.43 |
|
R5734:Adgre1
|
UTSW |
17 |
57,750,990 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5860:Adgre1
|
UTSW |
17 |
57,752,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6039:Adgre1
|
UTSW |
17 |
57,713,859 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6039:Adgre1
|
UTSW |
17 |
57,713,859 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6149:Adgre1
|
UTSW |
17 |
57,752,018 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6478:Adgre1
|
UTSW |
17 |
57,708,955 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6709:Adgre1
|
UTSW |
17 |
57,713,917 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6864:Adgre1
|
UTSW |
17 |
57,785,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6945:Adgre1
|
UTSW |
17 |
57,727,399 (GRCm39) |
missense |
probably benign |
0.39 |
|
R6945:Adgre1
|
UTSW |
17 |
57,717,844 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6988:Adgre1
|
UTSW |
17 |
57,715,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7019:Adgre1
|
UTSW |
17 |
57,717,945 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7154:Adgre1
|
UTSW |
17 |
57,751,087 (GRCm39) |
splice site |
probably null |
|
|
R7347:Adgre1
|
UTSW |
17 |
57,727,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7459:Adgre1
|
UTSW |
17 |
57,756,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7709:Adgre1
|
UTSW |
17 |
57,709,519 (GRCm39) |
missense |
unknown |
|
|
R7939:Adgre1
|
UTSW |
17 |
57,756,938 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7977:Adgre1
|
UTSW |
17 |
57,754,987 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7987:Adgre1
|
UTSW |
17 |
57,754,987 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8187:Adgre1
|
UTSW |
17 |
57,727,349 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8210:Adgre1
|
UTSW |
17 |
57,752,061 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8223:Adgre1
|
UTSW |
17 |
57,668,692 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8344:Adgre1
|
UTSW |
17 |
57,715,459 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8698:Adgre1
|
UTSW |
17 |
57,709,003 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9236:Adgre1
|
UTSW |
17 |
57,709,782 (GRCm39) |
nonsense |
probably null |
|
|
R9262:Adgre1
|
UTSW |
17 |
57,754,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9303:Adgre1
|
UTSW |
17 |
57,748,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9305:Adgre1
|
UTSW |
17 |
57,748,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9605:Adgre1
|
UTSW |
17 |
57,718,083 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9661:Adgre1
|
UTSW |
17 |
57,748,368 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9678:Adgre1
|
UTSW |
17 |
57,750,997 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9751:Adgre1
|
UTSW |
17 |
57,757,101 (GRCm39) |
missense |
probably null |
0.06 |
|
R9785:Adgre1
|
UTSW |
17 |
57,785,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adgre1
|
UTSW |
17 |
57,668,729 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
Z1177:Adgre1
|
UTSW |
17 |
57,726,374 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGAGCCACCCTTTAAAGCTTC -3'
(R):5'- CTGCCTGTACATAGAGCCATC -3'
Sequencing Primer
(F):5'- AAAGCTTCTTGGTTTCTTGGACAG -3'
(R):5'- TAGAACTCAGTGGAAAGCCTTAC -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation