Incidental Mutation 'R4961:Zfp51'
ID 381787
Institutional Source Beutler Lab
Gene Symbol Zfp51
Ensembl Gene ENSMUSG00000023892
Gene Name zinc finger protein 51
Synonyms zfec12, Zfp-51
MMRRC Submission 042558-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.390) question?
Stock # R4961 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 21670636-21685849 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21676615 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 29 (K29E)
Ref Sequence ENSEMBL: ENSMUSP00000045684 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039577]
AlphaFold Q3U4L8
Predicted Effect probably benign
Transcript: ENSMUST00000039577
AA Change: K29E

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000045684
Gene: ENSMUSG00000023892
AA Change: K29E

DomainStartEndE-ValueType
KRAB 43 103 1.71e-22 SMART
ZnF_C2H2 214 236 2.36e-2 SMART
ZnF_C2H2 242 264 8.94e-3 SMART
ZnF_C2H2 270 292 7.9e-4 SMART
ZnF_C2H2 298 320 3.44e-4 SMART
ZnF_C2H2 326 348 7.15e-2 SMART
ZnF_C2H2 354 376 4.54e-4 SMART
ZnF_C2H2 382 404 3.44e-4 SMART
ZnF_C2H2 410 432 9.88e-5 SMART
ZnF_C2H2 438 460 3.16e-3 SMART
ZnF_C2H2 466 488 1.58e-3 SMART
ZnF_C2H2 494 517 2.57e-3 SMART
ZnF_C2H2 523 545 3.63e-3 SMART
ZnF_C2H2 551 573 1.4e-4 SMART
ZnF_C2H2 579 601 4.17e-3 SMART
ZnF_C2H2 607 629 2.79e-4 SMART
ZnF_C2H2 635 657 4.24e-4 SMART
ZnF_C2H2 663 685 9.08e-4 SMART
ZnF_C2H2 691 713 8.47e-4 SMART
ZnF_C2H2 719 741 1.36e-2 SMART
ZnF_C2H2 747 769 6.82e1 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.1%
  • 10x: 95.3%
  • 20x: 88.3%
Validation Efficiency 95% (62/65)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110082I17Rik T C 5: 139,349,855 (GRCm39) K65E probably damaging Het
Acp5 C A 9: 22,041,233 (GRCm39) A65S probably benign Het
Adad2 G A 8: 120,342,397 (GRCm39) R345H probably damaging Het
Adamts7 G T 9: 90,067,793 (GRCm39) G428W probably damaging Het
Amy1 A G 3: 113,355,498 (GRCm39) S326P probably damaging Het
Ankrd44 C T 1: 54,703,071 (GRCm39) D482N probably damaging Het
Anks6 C T 4: 47,030,795 (GRCm39) G601S probably damaging Het
Ano8 G C 8: 71,935,640 (GRCm39) P326R probably damaging Het
Arhgef26 A G 3: 62,367,046 (GRCm39) E793G probably damaging Het
Cd9 A T 6: 125,440,703 (GRCm39) V96E probably damaging Het
Cdh9 A G 15: 16,850,914 (GRCm39) N561S probably benign Het
Col16a1 G A 4: 129,948,272 (GRCm39) probably null Het
Cpne7 G A 8: 123,860,498 (GRCm39) G484R probably damaging Het
Dcun1d4 A T 5: 73,701,463 (GRCm39) K194* probably null Het
Dock3 A G 9: 106,818,515 (GRCm39) V1193A probably damaging Het
Dst A G 1: 34,007,904 (GRCm39) R113G possibly damaging Het
Epha5 A T 5: 84,381,502 (GRCm39) S450T probably damaging Het
Gm5581 A T 6: 131,144,190 (GRCm39) noncoding transcript Het
Grhl3 A G 4: 135,279,918 (GRCm39) Y379H probably damaging Het
Herpud1 T C 8: 95,117,454 (GRCm39) S13P probably benign Het
Jam2 C T 16: 84,606,435 (GRCm39) Q150* probably null Het
Jph2 C G 2: 163,217,668 (GRCm39) R336P probably damaging Het
Kansl3 T A 1: 36,387,764 (GRCm39) probably null Het
Kctd1 G A 18: 15,195,580 (GRCm39) P348S probably damaging Het
Klhl30 T A 1: 91,285,106 (GRCm39) S321T possibly damaging Het
Klhl5 T C 5: 65,310,033 (GRCm39) probably benign Het
Letm2 T C 8: 26,084,108 (GRCm39) H41R possibly damaging Het
Ltn1 A T 16: 87,194,679 (GRCm39) C1407S probably benign Het
Map1b T C 13: 99,572,161 (GRCm39) T187A probably damaging Het
Marveld2 T C 13: 100,748,431 (GRCm39) N216S probably benign Het
Matn1 A G 4: 130,680,234 (GRCm39) Y437C probably damaging Het
Oas1h T C 5: 121,009,159 (GRCm39) Y290H probably damaging Het
Ofcc1 A G 13: 40,417,035 (GRCm39) probably null Het
Or2m12 C A 16: 19,104,726 (GRCm39) G256W probably damaging Het
Or4k51 A T 2: 111,584,750 (GRCm39) D52V probably damaging Het
Or8g34 A G 9: 39,373,183 (GRCm39) Y152C probably damaging Het
Otof C A 5: 30,540,837 (GRCm39) probably benign Het
Pcdh15 G T 10: 74,215,249 (GRCm39) probably null Het
Pgk2 G A 17: 40,518,412 (GRCm39) P339S probably damaging Het
Piezo2 T C 18: 63,186,032 (GRCm39) probably null Het
Prex2 A G 1: 11,168,705 (GRCm39) T234A possibly damaging Het
Rasgrf1 C T 9: 89,826,922 (GRCm39) T177M probably benign Het
Rgs1 A T 1: 144,124,309 (GRCm39) probably null Het
Snx25 T C 8: 46,521,229 (GRCm39) N239S probably damaging Het
Spata31d1a T A 13: 59,849,716 (GRCm39) H804L possibly damaging Het
Spon2 A T 5: 33,371,896 (GRCm39) Y303* probably null Het
Spopfm2 A T 3: 94,082,841 (GRCm39) C323* probably null Het
Thrb G A 14: 18,011,076 (GRCm38) D151N probably benign Het
Tns1 A G 1: 73,975,074 (GRCm39) V1170A probably benign Het
Trbv19 A T 6: 41,155,706 (GRCm39) I26F probably damaging Het
Tstd2 T C 4: 46,120,467 (GRCm39) N311S probably damaging Het
Ttn T A 2: 76,715,746 (GRCm39) probably benign Het
Ugt1a1 CAGAGAGAGAGAGA CAGAGAGAGAGA 1: 88,139,706 (GRCm39) probably benign Het
Vmn1r185 G A 7: 26,310,716 (GRCm39) A263V probably benign Het
Zfp316 T C 5: 143,239,169 (GRCm39) H950R probably damaging Het
Zfp644 T C 5: 106,766,081 (GRCm39) probably benign Het
Other mutations in Zfp51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00420:Zfp51 APN 17 21,683,714 (GRCm39) missense probably benign 0.11
IGL00971:Zfp51 APN 17 21,683,844 (GRCm39) missense probably benign 0.03
IGL02002:Zfp51 APN 17 21,684,221 (GRCm39) missense probably damaging 0.98
IGL02268:Zfp51 APN 17 21,683,681 (GRCm39) nonsense probably null
IGL03249:Zfp51 APN 17 21,683,701 (GRCm39) missense probably damaging 1.00
R1569:Zfp51 UTSW 17 21,676,642 (GRCm39) missense probably benign 0.01
R1853:Zfp51 UTSW 17 21,684,585 (GRCm39) missense probably damaging 1.00
R1989:Zfp51 UTSW 17 21,676,582 (GRCm39) missense possibly damaging 0.90
R2285:Zfp51 UTSW 17 21,684,137 (GRCm39) missense probably damaging 1.00
R2407:Zfp51 UTSW 17 21,684,093 (GRCm39) missense probably damaging 0.98
R2890:Zfp51 UTSW 17 21,684,118 (GRCm39) missense probably damaging 1.00
R3918:Zfp51 UTSW 17 21,683,702 (GRCm39) missense probably benign
R4529:Zfp51 UTSW 17 21,684,998 (GRCm39) missense probably damaging 1.00
R4587:Zfp51 UTSW 17 21,685,178 (GRCm39) nonsense probably null
R4866:Zfp51 UTSW 17 21,682,012 (GRCm39) missense possibly damaging 0.61
R4872:Zfp51 UTSW 17 21,684,933 (GRCm39) missense probably benign 0.26
R5392:Zfp51 UTSW 17 21,685,584 (GRCm39) missense possibly damaging 0.60
R5611:Zfp51 UTSW 17 21,684,354 (GRCm39) missense probably damaging 1.00
R7109:Zfp51 UTSW 17 21,683,831 (GRCm39) missense possibly damaging 0.80
R7129:Zfp51 UTSW 17 21,681,971 (GRCm39) missense probably damaging 1.00
R7269:Zfp51 UTSW 17 21,683,960 (GRCm39) missense probably benign 0.09
R7303:Zfp51 UTSW 17 21,684,058 (GRCm39) missense probably benign 0.24
R7514:Zfp51 UTSW 17 21,683,762 (GRCm39) missense probably benign 0.37
R7665:Zfp51 UTSW 17 21,683,843 (GRCm39) missense probably benign 0.00
R8073:Zfp51 UTSW 17 21,684,294 (GRCm39) missense probably damaging 1.00
R8177:Zfp51 UTSW 17 21,684,129 (GRCm39) missense probably benign 0.05
R8560:Zfp51 UTSW 17 21,685,635 (GRCm39) missense probably benign 0.00
R8877:Zfp51 UTSW 17 21,682,017 (GRCm39) missense probably damaging 1.00
R9032:Zfp51 UTSW 17 21,684,660 (GRCm39) missense probably damaging 1.00
R9085:Zfp51 UTSW 17 21,684,660 (GRCm39) missense probably damaging 1.00
R9307:Zfp51 UTSW 17 21,684,733 (GRCm39) missense probably benign 0.30
R9489:Zfp51 UTSW 17 21,684,291 (GRCm39) missense probably damaging 1.00
R9605:Zfp51 UTSW 17 21,684,291 (GRCm39) missense probably damaging 1.00
R9686:Zfp51 UTSW 17 21,683,871 (GRCm39) missense probably damaging 1.00
R9735:Zfp51 UTSW 17 21,685,413 (GRCm39) nonsense probably null
R9795:Zfp51 UTSW 17 21,682,051 (GRCm39) critical splice donor site probably null
X0062:Zfp51 UTSW 17 21,685,257 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GTGCAGCACCATGGTTGATG -3'
(R):5'- AGTTCTCAATGACTAATGTAACCAC -3'

Sequencing Primer
(F):5'- CAGCACCATGGTTGATGTTGATTTC -3'
(R):5'- ATCAGTCTGGTTAATTTCAGAGTTTG -3'
Posted On 2016-04-27