Incidental Mutation 'R0401:Zfp608'
ID 38258
Institutional Source Beutler Lab
Gene Symbol Zfp608
Ensembl Gene ENSMUSG00000052713
Gene Name zinc finger protein 608
Synonyms 4932417D18Rik
MMRRC Submission 038606-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.899) question?
Stock # R0401 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 55021120-55125627 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 55032066 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 625 (G625R)
Ref Sequence ENSEMBL: ENSMUSP00000068192 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064763]
AlphaFold Q56A10
Predicted Effect probably benign
Transcript: ENSMUST00000064763
AA Change: G625R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000068192
Gene: ENSMUSG00000052713
AA Change: G625R

DomainStartEndE-ValueType
low complexity region 51 61 N/A INTRINSIC
low complexity region 150 184 N/A INTRINSIC
low complexity region 214 234 N/A INTRINSIC
low complexity region 252 266 N/A INTRINSIC
low complexity region 309 326 N/A INTRINSIC
low complexity region 428 445 N/A INTRINSIC
low complexity region 459 471 N/A INTRINSIC
ZnF_C2H2 552 577 1.86e0 SMART
low complexity region 624 636 N/A INTRINSIC
low complexity region 706 718 N/A INTRINSIC
low complexity region 734 773 N/A INTRINSIC
low complexity region 807 822 N/A INTRINSIC
low complexity region 833 846 N/A INTRINSIC
low complexity region 934 956 N/A INTRINSIC
coiled coil region 1028 1054 N/A INTRINSIC
low complexity region 1182 1193 N/A INTRINSIC
low complexity region 1255 1268 N/A INTRINSIC
low complexity region 1439 1450 N/A INTRINSIC
low complexity region 1458 1466 N/A INTRINSIC
low complexity region 1486 1502 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.6%
Validation Efficiency 98% (90/92)
Allele List at MGI
Other mutations in this stock
Total: 91 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A T 3: 137,776,067 (GRCm39) H1752L possibly damaging Het
Abcc5 T C 16: 20,195,308 (GRCm39) K730E probably benign Het
Ahnak A G 19: 8,992,480 (GRCm39) D4588G probably benign Het
AI467606 G A 7: 126,691,608 (GRCm39) R61H probably damaging Het
Apoa4 T A 9: 46,154,356 (GRCm39) V319E probably damaging Het
Ark2n C A 18: 77,761,658 (GRCm39) S218I probably damaging Het
Atad5 T A 11: 80,011,525 (GRCm39) D1297E probably benign Het
BC005624 G A 2: 30,870,021 (GRCm39) T62I probably benign Het
Bcl6 T C 16: 23,791,344 (GRCm39) K337E probably damaging Het
Cad T A 5: 31,231,330 (GRCm39) probably benign Het
Ccdc73 T C 2: 104,821,634 (GRCm39) S528P probably benign Het
Ccng2 T G 5: 93,421,272 (GRCm39) C261G possibly damaging Het
Cdh11 A T 8: 103,400,638 (GRCm39) I110N probably damaging Het
Cgnl1 A G 9: 71,612,521 (GRCm39) V767A probably damaging Het
Cit A G 5: 116,123,538 (GRCm39) T1460A probably benign Het
Clec4b2 C T 6: 123,158,259 (GRCm39) Q42* probably null Het
Clip1 A G 5: 123,791,852 (GRCm39) V106A probably damaging Het
Crb1 T C 1: 139,126,529 (GRCm39) probably benign Het
Cts6 T C 13: 61,346,153 (GRCm39) probably benign Het
Cul9 T C 17: 46,852,630 (GRCm39) E244G probably damaging Het
Dcaf8l C A X: 88,448,815 (GRCm39) R438L probably benign Het
Ddx55 A T 5: 124,706,014 (GRCm39) I480F probably damaging Het
Dixdc1 A G 9: 50,604,974 (GRCm39) S17P possibly damaging Het
Drosha T A 15: 12,926,117 (GRCm39) Y1235* probably null Het
Dsg2 G T 18: 20,725,565 (GRCm39) probably benign Het
E2f5 T C 3: 14,644,085 (GRCm39) probably null Het
Epc2 A G 2: 49,418,986 (GRCm39) T265A probably damaging Het
Etaa1 T G 11: 17,897,514 (GRCm39) D201A probably damaging Het
Fancd2 T C 6: 113,525,304 (GRCm39) I260T possibly damaging Het
Fhdc1 G A 3: 84,351,931 (GRCm39) A1098V probably benign Het
Gpd2 G A 2: 57,230,105 (GRCm39) V286I possibly damaging Het
Gpr141b A T 13: 19,913,664 (GRCm39) noncoding transcript Het
H2-T9 C T 17: 36,439,597 (GRCm39) V128M probably damaging Het
Herc2 A C 7: 55,807,480 (GRCm39) E2523A probably damaging Het
Irag1 G A 7: 110,476,104 (GRCm39) P757S probably benign Het
Jmjd1c G A 10: 67,056,161 (GRCm39) R527H probably damaging Het
Kif12 G A 4: 63,087,762 (GRCm39) probably benign Het
Lrp2 A T 2: 69,309,492 (GRCm39) N2802K probably damaging Het
Mab21l2 C G 3: 86,454,296 (GRCm39) G235R probably benign Het
Mapk8 T C 14: 33,104,165 (GRCm39) E417G probably benign Het
Mapk8ip3 G A 17: 25,128,145 (GRCm39) probably benign Het
Mettl1 A G 10: 126,880,946 (GRCm39) T203A probably benign Het
Mettl9 T C 7: 120,675,536 (GRCm39) V312A probably damaging Het
Mex3d A G 10: 80,222,728 (GRCm39) V176A probably benign Het
Mmp3 T C 9: 7,449,790 (GRCm39) S225P probably damaging Het
Neb G A 2: 52,078,689 (GRCm39) probably benign Het
Ninj2 C T 6: 120,175,012 (GRCm39) A51V possibly damaging Het
Nle1 A G 11: 82,796,205 (GRCm39) probably benign Het
Nol9 T C 4: 152,137,062 (GRCm39) Y532H probably benign Het
Nr2c1 T A 10: 94,007,020 (GRCm39) V286E probably benign Het
Or4b1b A T 2: 90,112,748 (GRCm39) M57K probably damaging Het
Or4c31 T G 2: 88,292,269 (GRCm39) L195R probably damaging Het
Or52e18 T A 7: 104,609,150 (GRCm39) H263L probably damaging Het
Or5p4 T A 7: 107,680,079 (GRCm39) I26N possibly damaging Het
Or6c69 A G 10: 129,747,785 (GRCm39) Y121H probably benign Het
Or6f1 T C 7: 85,970,500 (GRCm39) Y220C probably benign Het
Or9k7 A G 10: 130,046,489 (GRCm39) L170P probably damaging Het
Ovch2 A T 7: 107,400,343 (GRCm39) V15D probably damaging Het
Pate8 G T 9: 36,493,924 (GRCm39) A3E unknown Het
Pclo T G 5: 14,731,748 (GRCm39) S3417A unknown Het
Pex1 T A 5: 3,683,759 (GRCm39) M1085K probably damaging Het
Plscr2 T C 9: 92,164,188 (GRCm39) S6P probably benign Het
Pogz C T 3: 94,784,336 (GRCm39) P722S possibly damaging Het
Pom121l2 A T 13: 22,166,395 (GRCm39) D222V probably benign Het
Prpf40a T C 2: 53,049,325 (GRCm39) Y179C probably damaging Het
R3hdm2 A G 10: 127,294,042 (GRCm39) I179V possibly damaging Het
Ranbp9 A C 13: 43,576,134 (GRCm39) V355G probably damaging Het
Rims2 T C 15: 39,373,028 (GRCm39) probably benign Het
Ryr2 A T 13: 11,720,570 (GRCm39) S2693T probably benign Het
Sbno1 G A 5: 124,548,348 (GRCm39) T111I probably damaging Het
Sdk1 A C 5: 142,031,916 (GRCm39) N997T possibly damaging Het
Setx G T 2: 29,056,301 (GRCm39) E39* probably null Het
Skint7 T A 4: 111,837,559 (GRCm39) N112K probably damaging Het
Slc35e1 T C 8: 73,246,415 (GRCm39) probably benign Het
Slc4a10 A T 2: 62,021,192 (GRCm39) D80V probably benign Het
Susd2 C A 10: 75,474,437 (GRCm39) probably benign Het
Tcam1 G A 11: 106,174,904 (GRCm39) E120K probably benign Het
Tcf3 G T 10: 80,256,992 (GRCm39) S77R probably damaging Het
Tdpoz3 T C 3: 93,733,672 (GRCm39) Y116H probably benign Het
Tex26 C A 5: 149,384,323 (GRCm39) D164E probably benign Het
Thoc5 G A 11: 4,852,213 (GRCm39) probably benign Het
Tiparp A G 3: 65,438,857 (GRCm39) R58G probably benign Het
Trim66 A T 7: 109,074,471 (GRCm39) C597S probably damaging Het
Ugt2a3 T A 5: 87,484,349 (GRCm39) Q225L probably benign Het
Vmn1r25 T A 6: 57,955,696 (GRCm39) I198L probably benign Het
Vmn2r106 A T 17: 20,499,281 (GRCm39) V210D possibly damaging Het
Vmn2r124 T C 17: 18,284,407 (GRCm39) F483L probably damaging Het
Vmn2r78 A G 7: 86,570,519 (GRCm39) K346E probably benign Het
Zfhx4 T A 3: 5,466,221 (GRCm39) S2126R possibly damaging Het
Zkscan5 A G 5: 145,149,385 (GRCm39) D234G probably damaging Het
Zscan10 T A 17: 23,824,889 (GRCm39) V115E probably damaging Het
Other mutations in Zfp608
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00500:Zfp608 APN 18 55,121,405 (GRCm39) missense probably benign
IGL00920:Zfp608 APN 18 55,022,903 (GRCm39) missense probably benign 0.00
IGL01088:Zfp608 APN 18 55,031,159 (GRCm39) missense probably benign 0.03
IGL01447:Zfp608 APN 18 55,032,083 (GRCm39) missense possibly damaging 0.75
IGL01534:Zfp608 APN 18 55,032,004 (GRCm39) missense probably damaging 0.99
IGL01547:Zfp608 APN 18 55,027,521 (GRCm39) critical splice donor site probably null
IGL01933:Zfp608 APN 18 55,120,871 (GRCm39) missense probably benign
IGL01998:Zfp608 APN 18 55,024,890 (GRCm39) missense probably damaging 0.99
IGL02167:Zfp608 APN 18 55,121,296 (GRCm39) missense probably damaging 1.00
IGL02266:Zfp608 APN 18 55,030,653 (GRCm39) missense probably benign 0.08
IGL02335:Zfp608 APN 18 55,030,509 (GRCm39) nonsense probably null
IGL02455:Zfp608 APN 18 55,032,405 (GRCm39) missense probably damaging 1.00
IGL02612:Zfp608 APN 18 55,031,273 (GRCm39) missense probably damaging 1.00
IGL02900:Zfp608 APN 18 55,079,865 (GRCm39) missense probably damaging 1.00
PIT4243001:Zfp608 UTSW 18 55,031,096 (GRCm39) missense probably damaging 1.00
PIT4519001:Zfp608 UTSW 18 55,079,783 (GRCm39) missense possibly damaging 0.71
R0005:Zfp608 UTSW 18 55,028,592 (GRCm39) missense possibly damaging 0.88
R0010:Zfp608 UTSW 18 55,028,286 (GRCm39) splice site probably benign
R0010:Zfp608 UTSW 18 55,028,286 (GRCm39) splice site probably benign
R0064:Zfp608 UTSW 18 55,031,888 (GRCm39) missense probably benign
R0722:Zfp608 UTSW 18 55,033,306 (GRCm39) missense probably damaging 1.00
R1351:Zfp608 UTSW 18 55,031,463 (GRCm39) missense probably benign 0.00
R1512:Zfp608 UTSW 18 55,079,738 (GRCm39) missense probably damaging 1.00
R1554:Zfp608 UTSW 18 55,031,126 (GRCm39) missense probably damaging 1.00
R1622:Zfp608 UTSW 18 55,121,366 (GRCm39) missense probably benign 0.07
R1669:Zfp608 UTSW 18 55,120,811 (GRCm39) missense probably benign 0.09
R1690:Zfp608 UTSW 18 55,120,706 (GRCm39) missense possibly damaging 0.62
R1721:Zfp608 UTSW 18 55,032,321 (GRCm39) missense probably benign
R1826:Zfp608 UTSW 18 55,031,648 (GRCm39) missense probably benign 0.03
R1864:Zfp608 UTSW 18 55,030,983 (GRCm39) missense probably benign 0.00
R1952:Zfp608 UTSW 18 55,030,851 (GRCm39) nonsense probably null
R2049:Zfp608 UTSW 18 55,028,637 (GRCm39) missense probably damaging 1.00
R2051:Zfp608 UTSW 18 55,121,386 (GRCm39) missense probably benign
R2168:Zfp608 UTSW 18 55,031,125 (GRCm39) nonsense probably null
R2218:Zfp608 UTSW 18 55,120,756 (GRCm39) missense probably benign 0.14
R2283:Zfp608 UTSW 18 55,121,446 (GRCm39) missense probably damaging 1.00
R2399:Zfp608 UTSW 18 55,030,974 (GRCm39) missense probably damaging 1.00
R2520:Zfp608 UTSW 18 55,121,578 (GRCm39) missense possibly damaging 0.92
R2961:Zfp608 UTSW 18 55,031,544 (GRCm39) missense possibly damaging 0.60
R4074:Zfp608 UTSW 18 55,031,180 (GRCm39) missense probably damaging 1.00
R4076:Zfp608 UTSW 18 55,031,180 (GRCm39) missense probably damaging 1.00
R4206:Zfp608 UTSW 18 55,121,267 (GRCm39) missense probably damaging 1.00
R4756:Zfp608 UTSW 18 55,027,544 (GRCm39) missense probably damaging 1.00
R4771:Zfp608 UTSW 18 55,121,372 (GRCm39) missense probably benign
R4820:Zfp608 UTSW 18 55,120,756 (GRCm39) missense probably benign 0.14
R4825:Zfp608 UTSW 18 55,031,041 (GRCm39) missense probably benign 0.01
R4912:Zfp608 UTSW 18 55,079,663 (GRCm39) missense probably damaging 1.00
R4975:Zfp608 UTSW 18 55,022,962 (GRCm39) missense probably damaging 1.00
R5138:Zfp608 UTSW 18 55,024,871 (GRCm39) missense probably damaging 1.00
R5192:Zfp608 UTSW 18 55,031,569 (GRCm39) missense probably damaging 1.00
R5557:Zfp608 UTSW 18 55,120,942 (GRCm39) missense possibly damaging 0.81
R5624:Zfp608 UTSW 18 55,031,344 (GRCm39) missense probably damaging 1.00
R5818:Zfp608 UTSW 18 55,028,468 (GRCm39) missense probably benign 0.02
R5840:Zfp608 UTSW 18 55,031,978 (GRCm39) missense probably damaging 1.00
R5992:Zfp608 UTSW 18 55,032,320 (GRCm39) missense probably benign 0.15
R6106:Zfp608 UTSW 18 55,120,944 (GRCm39) missense possibly damaging 0.54
R6174:Zfp608 UTSW 18 55,121,616 (GRCm39) start gained probably benign
R6181:Zfp608 UTSW 18 55,028,700 (GRCm39) missense possibly damaging 0.56
R6517:Zfp608 UTSW 18 55,032,150 (GRCm39) missense possibly damaging 0.94
R6567:Zfp608 UTSW 18 55,030,628 (GRCm39) missense probably damaging 1.00
R6668:Zfp608 UTSW 18 55,031,091 (GRCm39) missense probably damaging 1.00
R6920:Zfp608 UTSW 18 55,121,337 (GRCm39) missense probably damaging 1.00
R7061:Zfp608 UTSW 18 55,121,069 (GRCm39) missense probably benign
R7074:Zfp608 UTSW 18 55,030,454 (GRCm39) missense possibly damaging 0.69
R7087:Zfp608 UTSW 18 55,032,469 (GRCm39) missense probably damaging 1.00
R7391:Zfp608 UTSW 18 55,030,619 (GRCm39) missense possibly damaging 0.49
R7600:Zfp608 UTSW 18 55,121,092 (GRCm39) missense probably damaging 1.00
R7723:Zfp608 UTSW 18 55,030,673 (GRCm39) missense probably damaging 1.00
R8054:Zfp608 UTSW 18 55,032,618 (GRCm39) missense probably benign 0.28
R8236:Zfp608 UTSW 18 55,032,281 (GRCm39) missense probably damaging 1.00
R8260:Zfp608 UTSW 18 55,030,821 (GRCm39) missense possibly damaging 0.60
R8732:Zfp608 UTSW 18 55,121,072 (GRCm39) missense probably benign 0.06
R8781:Zfp608 UTSW 18 55,031,801 (GRCm39) missense probably damaging 1.00
R8851:Zfp608 UTSW 18 55,032,194 (GRCm39) missense possibly damaging 0.94
R8940:Zfp608 UTSW 18 55,033,301 (GRCm39) missense possibly damaging 0.93
R9051:Zfp608 UTSW 18 55,032,266 (GRCm39) missense probably damaging 1.00
R9091:Zfp608 UTSW 18 55,032,190 (GRCm39) missense probably damaging 1.00
R9092:Zfp608 UTSW 18 55,031,648 (GRCm39) missense probably benign 0.03
R9236:Zfp608 UTSW 18 55,032,354 (GRCm39) missense probably benign 0.39
R9270:Zfp608 UTSW 18 55,032,190 (GRCm39) missense probably damaging 1.00
R9283:Zfp608 UTSW 18 55,030,913 (GRCm39) missense possibly damaging 0.50
R9288:Zfp608 UTSW 18 55,033,341 (GRCm39) missense probably benign 0.39
R9463:Zfp608 UTSW 18 55,030,274 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCATTTCCGCCGTTAGATTGCTGTC -3'
(R):5'- TGATTGTCCCCACCCAAACTGC -3'

Sequencing Primer
(F):5'- CTGTCTGTGGCTGAACAAATGTC -3'
(R):5'- TATAAGCACATAAACGGCCTGAG -3'
Posted On 2013-05-23